From 78f94d2e50610be00a09b8f8059f634457c568db Mon Sep 17 00:00:00 2001 From: Mohammad Betamony Date: Tue, 21 Jan 2025 20:59:36 +0300 Subject: [PATCH 1/5] add tests --- .../__snapshots__/jats-importer.test.ts.snap | 85261 +++++++++++++++- src/jats/__tests__/jats-importer.test.ts | 33 + 2 files changed, 85176 insertions(+), 118 deletions(-) diff --git a/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap b/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap index fc942a04..93328b08 100644 --- a/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap +++ b/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap @@ -1,185 +1,85210 @@ // Jest Snapshot v1, https://goo.gl/fbAQLP -exports[`JATS importer affiliations should correctly parse affiliation nodes 1`] = ` -Array [ - Object { - "attrs": Object { - "addressLine1": "Borgmester Ib Juuls Vej 1", - "addressLine2": "2730 - Herlev", - "addressLine3": "", - "city": "", - "country": "Denmark", - "county": "", - "dataTracked": null, - "department": "Department of - Neurology", - "email": undefined, - "id": "MPAffiliation:test", - "institution": "Herlev og Gentofte - Hospital", - "postCode": "2730", - "priority": undefined, - }, - "content": Array [ - Object { - "text": "_", - "type": "text", - }, - ], - "type": "affiliation", - }, -] -`; - -exports[`JATS importer author-notes should have author notes node with content if author notes element exists 1`] = ` +exports[`JATS importer abstracts should have abstract node if abstract element exists 1`] = ` Object { "attrs": Object { - "dataTracked": null, - "id": "MPAuthorNotes:test", + "acceptanceDate": 1587945600, + "articleType": "other", + "correctionDate": undefined, + "doi": "10.5555/BRB3-2019-12-0787", + "id": "MPManuscript:test", + "primaryLanguageCode": "", + "prototype": "", + "receiveDate": 1575849600, + "retractionDate": undefined, + "revisionReceiveDate": undefined, + "revisionRequestDate": undefined, }, "content": Array [ Object { "attrs": Object { "dataTracked": null, + "id": "MPTitles:test", + "placeholder": "Insert title here...", }, - "type": "section_title", + "content": Array [ + Object { + "text": "Blood pressure after follow up in a stroke prevention clinic", + "type": "text", + }, + ], + "type": "title", }, Object { "attrs": Object { - "dataTracked": null, - "id": "MPCorresponding:test", - "label": undefined, + "id": "MPSection:test", }, "content": Array [ Object { - "text": "Corresponding author: Agnete Hviid - Hornnes
agnete.hviid.hornnes@regionh.dk
FAX: 0045 3868 - 4031", - "type": "text", + "attrs": Object { + "ORCIDIdentifier": "https://orcid.org/0000-0003-2217-5904", + "affiliations": Array [ + "MPAffiliation:test", + ], + "bibliographicName": Object { + "ObjectType": "MPBibliographicName", + "family": "Hornnes", + "given": "Agnete Hviid", + }, + "contents": "", + "corresp": Array [], + "dataTracked": null, + "email": "", + "footnote": Array [], + "id": "MPContributor:test", + "invitationID": undefined, + "isCorresponding": true, + "isJointContributor": undefined, + "priority": undefined, + "role": "author", + "userID": undefined, + }, + "content": Array [ + Object { + "text": "_", + "type": "text", + }, + ], + "type": "contributor", + }, + Object { + "attrs": Object { + "ORCIDIdentifier": undefined, + "affiliations": Array [ + "MPAffiliation:test", + ], + "bibliographicName": Object { + "ObjectType": "MPBibliographicName", + "family": "Poulsen", + "given": "Mai Bang", + }, + "contents": "", + "corresp": Array [], + "dataTracked": null, + "email": "", + "footnote": Array [ + Object { + "noteID": "MPFootnote:test", + "noteLabel": "*", + }, + ], + "id": "MPContributor:test", + "invitationID": undefined, + "isCorresponding": undefined, + "isJointContributor": undefined, + "priority": undefined, + "role": "author", + "userID": undefined, + }, + "content": Array [ + Object { + "text": "_", + "type": "text", + }, + ], + "type": "contributor", }, ], - "type": "corresp", + "type": "contributors", }, Object { "attrs": Object { - "dataTracked": null, - "id": "MPFootnote:test", - "kind": "footnote", - "placeholder": "", + "id": "MPSection:test", }, "content": Array [ Object { "attrs": Object { + "addressLine1": "Borgmester Ib Juuls Vej 1", + "addressLine2": "2730 + Herlev", + "addressLine3": "", + "city": "", + "country": "Denmark", + "county": "", "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "department": "Department of + Neurology", + "email": undefined, + "id": "MPAffiliation:test", + "institution": "Herlev og Gentofte + Hospital", + "postCode": "2730", + "priority": undefined, }, "content": Array [ Object { - "text": "Mai Bang Poulsen, MD, PhD
Department of Neurology
Nordsjællands Hospital
Dyrehavevej 29
3400 Hillerød
Denmark", + "text": "_", "type": "text", }, ], - "type": "paragraph", + "type": "affiliation", }, ], - "type": "footnote", + "type": "affiliations", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPFootnote:test", - "kind": "footnote", - "placeholder": "", + "id": "MPAuthorNotes:test", }, "content": Array [ Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + }, + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCorresponding:test", + "label": undefined, }, "content": Array [ Object { - "text": "ClinicalTrials.gov NCT03782857.", + "text": "Corresponding author: Agnete Hviid + Hornnes
agnete.hviid.hornnes@regionh.dk
FAX: 0045 3868 + 4031", "type": "text", }, ], - "type": "paragraph", + "type": "corresp", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Mai Bang Poulsen, MD, PhD
Department of Neurology
Nordsjællands Hospital
Dyrehavevej 29
3400 Hillerød
Denmark", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "ClinicalTrials.gov NCT03782857.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", }, ], - "type": "footnote", + "type": "author_notes", }, - ], - "type": "author_notes", -} -`; - -exports[`JATS importer awards should correctly parse award nodes 1`] = ` -Object { - "attrs": Object { - "id": "MPAwards:test", - }, - "content": Array [ Object { "attrs": Object { - "code": "GM18458", - "dataTracked": null, - "id": "MPAward:test", - "recipient": "Berkeley", - "source": "National Institutes of Health", + "id": "MPAwards:test", }, - "type": "award", + "content": Array [ + Object { + "attrs": Object { + "code": "GM18458", + "dataTracked": null, + "id": "MPAward:test", + "recipient": "Berkeley", + "source": "National Institutes of Health", + }, + "type": "award", + }, + Object { + "attrs": Object { + "code": "DMS-0204674;DMS-0244638", + "dataTracked": null, + "id": "MPAward:test", + "recipient": undefined, + "source": "National Science Foundation", + }, + "type": "award", + }, + ], + "type": "awards", }, Object { "attrs": Object { - "code": "DMS-0204674;DMS-0244638", "dataTracked": null, - "id": "MPAward:test", - "recipient": undefined, - "source": "National Science Foundation", + "id": "MPSection:test", }, - "type": "award", + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Keywords", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPKeywordsElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPKeywordGroup:test", + "type": "author", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPKeyword:test", + }, + "content": Array [ + Object { + "text": "secondary prevention", + "type": "text", + }, + ], + "type": "keyword", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPKeyword:test", + }, + "content": Array [ + Object { + "text": "stroke recurrence", + "type": "text", + }, + ], + "type": "keyword", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPKeyword:test", + }, + "content": Array [ + Object { + "text": "blood pressure", + "type": "text", + }, + ], + "type": "keyword", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPKeyword:test", + }, + "content": Array [ + Object { + "text": "blood pressure target", + "type": "text", + }, + ], + "type": "keyword", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPKeyword:test", + }, + "content": Array [ + Object { + "text": "randomized controlled trial", + "type": "text", + }, + ], + "type": "keyword", + }, + ], + "type": "keyword_group", + }, + ], + "type": "keywords_element", + }, + ], + "type": "keywords", }, - ], - "type": "awards", -} -`; - -exports[`JATS importer backmatter should parse references correctly 1`] = ` -Object { - "attrs": Object { - "author": Array [ - Object { - "_id": "MPBibliographicName:test", - "family": "Day", - "given": "R.N.", - "objectType": "MPBibliographicName", + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPSupplements:test", }, - ], - "containerTitle": "EDCC", - "dataTracked": null, - "doi": undefined, - "id": "MPBibliographyItem:test", - "issue": "2", - "issued": Object { - "_id": "MPBibliographicDate:test", - "date-parts": Array [ - Array [ - "2008", - ], + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Supplementary Material", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "href": "attachment:7d9d686b-5488-44a5-a1c5-46351e7f9312", + "id": "MPSupplement:test", + "mimeSubType": "vnd.openxmlformats-officedocument.wordprocessingml.document", + "mimeType": "application", + "title": "final manuscript-hum-huili-dbh-suicide-20200707_figures (9)", + }, + "type": "supplement", + }, ], - "objectType": "MPBibliographicDate", + "type": "supplements", }, - "literal": undefined, - "page": "123-134", - "supplement": undefined, - "title": "This is the article title.", - "type": "article-journal", - "volume": "3", - }, - "type": "bibliography_item", + Object { + "attrs": Object { + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "category": "abstract", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Abstract", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Objectives", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In Denmark 25% of hospital admissions with stroke are recurrent strokes. With thrombolytic treatment more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. We aimed at testing the hypotheses that early follow up in a preventive clinic would result in 1) A higher proportion of patients with blood pressure at target, 2) Time to stroke recurrence, myocardial infarction and death would be longer in the intervention group compared to controls.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "methods", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Materials and Methods", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Eligible patients admitted to the stroke unit of Herlev Hospital were randomized shortly before discharge to intervention or control group. Of 78 included participants data from 73 was available for follow up nine months after inclusion. Patients in the intervention group were seen in the clinic within one week. In case of hypertension treatment was initiated or supplied with a new drug. We used individual targets for blood pressure according to diagnosis of stroke and patients’ comorbidity. Patients in the intervention group had a median of five visits to the preventive clinic.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "results", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Results", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In the intervention group blood pressure was treated to target in 25 patients (69%) versus 14 (38%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.007). Median time to first event was 44 months (4–49) in the intervention group and 19 months (4–37) in controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.316).", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Conclusions", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Treatment of hypertension to individual targets after stroke is feasible. It may postpone recurrent stroke and death in stroke survivors.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Graphical Abstract", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "demo.jpg", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "figure_element", + }, + ], + "type": "graphical_abstract_section", + }, + ], + "type": "abstracts", + }, + Object { + "attrs": Object { + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPImageElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "prodbe.int.aip.org:8080/journal/journal_fs/ 1.2983775.1373315697!/images/1460725790.jpg", + "type": "", + }, + "type": "figure", + }, + ], + "type": "image_element", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "test paragraph", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "intro", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "INTRODUCTION", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Over the last two decades continuous development of thrombolytic treatment of acute ischemic stroke (IS) has improved safety and functional outcome in treated patients ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " thus increasing the possibility of survival with no or only minor disability. With this fact and the ongoing aging of populations in mind ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " According to the Danish Stroke Registry our national recurrence rate was 25% in 2011.", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Hypertension is an important risk factor for stroke recurrence. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Lowering blood pressure (BP) after stroke or transitory ischemic attack (TIA) by 10/5 mm Hg has been associated with reduced risk of stroke recurrence by 24% and myocardial infarction (MI) by 21%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Observational studies have demonstrated the difficulties in lowering BP after stroke with rates of BP treated to target ranging from 28% to 73% ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " and interventions aimed at control of BP after stroke have not yet found a successful model. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Fahey and coworkers have reviewed the literature aimed at improving control of BP in hypertensive subjects. One large study using an organized system of regular visits to a clinic was efficient in producing a large decrease in BP and reduction of all-cause mortality compared to referral to usual primary care. This was achieved by using a stepwise escalation of treatment until target was reached. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Other methods had variable or no effect, only nurse or pharmacist led care seemed promising.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "href": "example.mp4", + "id": "MPEmbed:test", + "mimeSubtype": "mp4", + "mimetype": "video", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "type": "caption", + }, + ], + "type": "figcaption", + }, + ], + "type": "embed", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Aims and hypotheses", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The aim of the present study was to test the hypotheses that follow up after stroke in a specialized nurse led physician supervised clinic with stepwise escalation of BP- and lipid lowering treatment would result in", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Primary endpoint", + "type": "text", + }, + ], + "type": "section_title", + }, + 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Study sample and setting", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Procedures and intervention", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. 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Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.3", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Follow up", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. 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We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.18).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.003). 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", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Five-year follow up on vascular complications and death is another important advantage.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "5", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONCLUSIONS", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. 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Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "coi-statement", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONFLICT OF INTEREST", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "None.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": 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(Ref. 17 "Hornnes, Larsen, Boysen, 2011")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the first page should be "NA", not "579". 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(Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". 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With this fact and the ongoing aging of populations in mind ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. 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Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. 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BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.3", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Follow up", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. Patients were asked not to reveal their group allocation but blinding of the nurses was not possible. Patients were interviewed about adherence to all preventive medications as well as their present life style. For practical purposes a minority of visits were performed by the first author. To do intention to treat analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " we used last observation carried forward regarding the endpoints of the study where patients had died or did not respond to the invitation to a follow up visit. 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In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPFigureElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": ".", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0003.png", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "content": Array [ + Object { + "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", + "type": "text", + }, + ], + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "figure_element", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "3.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Secondary endpoints", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.04).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.18).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.003). 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All in all, we found 11 events in nine patients in the intervention group: two recurrent strokes, three cases of TIA, and six patients died versus 21 events in 13 patients in the control group: seven recurrent strokes, five cases of TIA, one MI, and seven patients died (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.49).", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "discussion", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "DISCUSSION", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In this randomized clinical trial, a larger proportion of patients in the intervention group compared to controls had BP within the above-mentioned limits and the study fulfilled the aim of the primary endpoint.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A systematic review of interventions aimed at modifiable risk factor control for secondary prevention of stroke revealed improvement in achieving BP target. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Five-year follow up on vascular complications and death is another important advantage.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "5", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONCLUSIONS", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "body", + }, + Object { + "attrs": Object { + "id": "MPSection:test", + "placeholder": " ", + }, + "content": Array [ + Object { + "attrs": Object { + "category": "availability", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "DATA AVAILABILITY", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "con", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Contributor Information", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "href": "https://orcid.org/0000-0003-2217-5904", + "title": "", + }, + "content": Array [ + Object { + "text": "https//orcid.org/0000-0003-2217-5904", + "type": "text", + }, + ], + "type": "link", + }, + Object { + "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "coi-statement", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONFLICT OF INTEREST", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "None.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": 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(Ref. 10 "Girot, Mackowiak-Cordoliani, Deplanque, Hénon, Lucas, Leys, 2005")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association or J Stroke Cerebrovasc Dis", not "Journal of Stroke and Cerebrovascular Diseases". 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(Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". (Ref. 23 "Mancia, Fagard, Narkiewicz, Redán, Zanchetti, Böhm, Zannad, . . ., 2013")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne or CMAJ", not "Canadian Medical Association Journal". 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. 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We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.18).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.003). 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", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Five-year follow up on vascular complications and death is another important advantage.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "5", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONCLUSIONS", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. 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Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. 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We aimed at testing the hypotheses that early follow up in a preventive clinic would result in 1) A higher proportion of patients with blood pressure at target, 2) Time to stroke recurrence, myocardial infarction and death would be longer in the intervention group compared to controls.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "methods", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Materials and Methods", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Eligible patients admitted to the stroke unit of Herlev Hospital were randomized shortly before discharge to intervention or control group. 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With this fact and the ongoing aging of populations in mind ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0003", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0004", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " According to the Danish Stroke Registry our national recurrence rate was 25% in 2011.", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0005", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Hypertension is an important risk factor for stroke recurrence. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0004", + "BRB3-2019-12-0787-bib-0006", + "BRB3-2019-12-0787-bib-0007", + "BRB3-2019-12-0787-bib-0008", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Lowering blood pressure (BP) after stroke or transitory ischemic attack (TIA) by 10/5 mm Hg has been associated with reduced risk of stroke recurrence by 24% and myocardial infarction (MI) by 21%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0009", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Observational studies have demonstrated the difficulties in lowering BP after stroke with rates of BP treated to target ranging from 28% to 73% ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0010", + "BRB3-2019-12-0787-bib-0011", + "BRB3-2019-12-0787-bib-0012", + "BRB3-2019-12-0787-bib-0013", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " and interventions aimed at control of BP after stroke have not yet found a successful model. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0014", + "BRB3-2019-12-0787-bib-0015", + "BRB3-2019-12-0787-bib-0016", + "BRB3-2019-12-0787-bib-0017", + "BRB3-2019-12-0787-bib-0018", + "BRB3-2019-12-0787-bib-0019", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Fahey and coworkers have reviewed the literature aimed at improving control of BP in hypertensive subjects. One large study using an organized system of regular visits to a clinic was efficient in producing a large decrease in BP and reduction of all-cause mortality compared to referral to usual primary care. This was achieved by using a stepwise escalation of treatment until target was reached. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0020", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Other methods had variable or no effect, only nurse or pharmacist led care seemed promising.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "href": "example.mp4", + "id": "MPEmbed:test", + "mimeSubtype": "mp4", + "mimetype": "video", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "type": "caption", + }, + ], + "type": "figcaption", + }, + ], + "type": "embed", + }, + Object { + "attrs": Object { + "category": "", + 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0021", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Study sample and setting", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Procedures and intervention", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.3", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Follow up", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. Patients were asked not to reveal their group allocation but blinding of the nurses was not possible. Patients were interviewed about adherence to all preventive medications as well as their present life style. For practical purposes a minority of visits were performed by the first author. To do intention to treat analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " we used last observation carried forward regarding the endpoints of the study where patients had died or did not respond to the invitation to a follow up visit. 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In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPFigureElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": ".", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0003.png", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "content": Array [ + Object { + "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", + "type": "text", + }, + ], + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "figure_element", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "3.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Secondary endpoints", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.04).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.18).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.003). 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", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "BRB3-2019-12-0787-bib-0024", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. 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However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. 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Dyrehavevej 29
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With thrombolytic treatment more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. We aimed at testing the hypotheses that early follow up in a preventive clinic would result in 1) A higher proportion of patients with blood pressure at target, 2) Time to stroke recurrence, myocardial infarction and death would be longer in the intervention group compared to controls.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "methods", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Materials and Methods", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Eligible patients admitted to the stroke unit of Herlev Hospital were randomized shortly before discharge to intervention or control group. Of 78 included participants data from 73 was available for follow up nine months after inclusion. Patients in the intervention group were seen in the clinic within one week. In case of hypertension treatment was initiated or supplied with a new drug. We used individual targets for blood pressure according to diagnosis of stroke and patients’ comorbidity. Patients in the intervention group had a median of five visits to the preventive clinic.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "results", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Results", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In the intervention group blood pressure was treated to target in 25 patients (69%) versus 14 (38%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.007). Median time to first event was 44 months (4–49) in the intervention group and 19 months (4–37) in controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.316).", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Conclusions", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Treatment of hypertension to individual targets after stroke is feasible. It may postpone recurrent stroke and death in stroke survivors.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Graphical Abstract", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "demo.jpg", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "figure_element", + }, + ], + "type": "graphical_abstract_section", + }, + ], + "type": "abstracts", + }, + Object { + "attrs": Object { + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPImageElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "prodbe.int.aip.org:8080/journal/journal_fs/ 1.2983775.1373315697!/images/1460725790.jpg", + "type": "", + }, + "type": "figure", + }, + ], + "type": "image_element", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "test paragraph", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "intro", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "INTRODUCTION", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Over the last two decades continuous development of thrombolytic treatment of acute ischemic stroke (IS) has improved safety and functional outcome in treated patients ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " thus increasing the possibility of survival with no or only minor disability. With this fact and the ongoing aging of populations in mind ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " According to the Danish Stroke Registry our national recurrence rate was 25% in 2011.", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Hypertension is an important risk factor for stroke recurrence. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Lowering blood pressure (BP) after stroke or transitory ischemic attack (TIA) by 10/5 mm Hg has been associated with reduced risk of stroke recurrence by 24% and myocardial infarction (MI) by 21%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Observational studies have demonstrated the difficulties in lowering BP after stroke with rates of BP treated to target ranging from 28% to 73% ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " and interventions aimed at control of BP after stroke have not yet found a successful model. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Fahey and coworkers have reviewed the literature aimed at improving control of BP in hypertensive subjects. One large study using an organized system of regular visits to a clinic was efficient in producing a large decrease in BP and reduction of all-cause mortality compared to referral to usual primary care. This was achieved by using a stepwise escalation of treatment until target was reached. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Other methods had variable or no effect, only nurse or pharmacist led care seemed promising.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "href": "example.mp4", + "id": "MPEmbed:test", + "mimeSubtype": "mp4", + "mimetype": "video", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "type": "caption", + }, + ], + "type": "figcaption", + }, + ], + "type": "embed", + }, + Object { + "attrs": Object { + "category": "", + 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+ "type": "list_item", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "List item", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Day hospitals had a possible advantage over no comprehensive care in terms of death or poor outcome, disability, and use of resources.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "list_item", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "List item", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The costs of day hospital care may be partly offset by a reduced use of hospital beds and institutional care among survivors.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Study sample and setting", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Procedures and intervention", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. 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In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPFigureElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": ".", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0003.png", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "content": Array [ + Object { + "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", + "type": "text", + }, + ], + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "figure_element", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "3.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Secondary endpoints", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.04).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.18).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.003). 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", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "d", + "type": "text", + }, + Object { + "text": " Less than 30 min of moderate physical activity per day.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", + }, + ], + "type": "footnotes_element", + }, + ], + "type": "table_element_footer", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "table_element", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Regarding vascular complications and death, we found 32 events in 22 patients after a median of 65 months. Median time to first event was 26 months (IQR: 4–49) with a median of 44 months (IQR: 11–49) in the intervention group and 19 months (IQR: 4–37) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.32). All in all, we found 11 events in nine patients in the intervention group: two recurrent strokes, three cases of TIA, and six patients died versus 21 events in 13 patients in the control group: seven recurrent strokes, five cases of TIA, one MI, and seven patients died (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.49).", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "discussion", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "DISCUSSION", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In this randomized clinical trial, a larger proportion of patients in the intervention group compared to controls had BP within the above-mentioned limits and the study fulfilled the aim of the primary endpoint.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A systematic review of interventions aimed at modifiable risk factor control for secondary prevention of stroke revealed improvement in achieving BP target. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Five-year follow up on vascular complications and death is another important advantage.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "5", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONCLUSIONS", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "body", + }, + Object { + "attrs": Object { + "id": "MPSection:test", + "placeholder": " ", + }, + "content": Array [ + Object { + "attrs": Object { + "category": "availability", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "DATA AVAILABILITY", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "con", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Contributor Information", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "href": "https://orcid.org/0000-0003-2217-5904", + "title": "", + }, + "content": Array [ + Object { + "text": "https//orcid.org/0000-0003-2217-5904", + "type": "text", + }, + ], + "type": "link", + }, + Object { + "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "coi-statement", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONFLICT OF INTEREST", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "None.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": 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Please compare "Jørgensen" with "Jerrgensen". The CrossRef authors are Jerrgensen, H. S., Nakayama, H., Reith, J., Raaschou, H. O., & Olsen, T. S.. (Ref. 4 "Jørgensen, Nakayama, Reith, Raaschou, Olsen, 1997")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "eXtyles has not updated this reference because the authors returned by CrossRef are invalid: Girot, M., Mackowiak-Cordoliani, M.-A., Deplanque, D., H�non, H., Lucas, C., & Leys, D. (2005). Secondary prevention after ischemic stroke. Journal of Neurology, 252, 14–20. (Ref. 10 "Girot, Mackowiak-Cordoliani, Deplanque, Hénon, Lucas, Leys, 2005")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association or J Stroke Cerebrovasc Dis", not "Journal of Stroke and Cerebrovascular Diseases". (Ref. 17 "Hornnes, Larsen, Boysen, 2011")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the first page should be "NA", not "579". (Ref. 18 "Johnston, Sidney, Hills, Grosvenor, Klingman, Bernstein, Levin, 2010")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports multiple listings for this reference. Please check the reference for accuracy. (Ref. 20 "Fahey, Schroeder, Ebrahim, 2006")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "The Cochrane database of systematic reviews or Cochrane Database Syst Rev", not "Cochrane Database of Systematic Reviews". (Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". (Ref. 23 "Mancia, Fagard, Narkiewicz, Redán, Zanchetti, Böhm, Zannad, . . ., 2013")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne or CMAJ", not "Canadian Medical Association Journal". (Ref. 25 "McAlister, Majumdar, Padwal, Fradette, Thompson, Buck, Shuaib, . . ., 2014")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPParagraphElement:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPParagraphElement:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "International journal of stroke : official journal of the International Stroke Society or Int J Stroke", not "International Journal of Stroke". 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With thrombolytic treatment more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. 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With this fact and the ongoing aging of populations in mind ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " According to the Danish Stroke Registry our national recurrence rate was 25% in 2011.", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Hypertension is an important risk factor for stroke recurrence. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. 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We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.18).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.003). 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", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Five-year follow up on vascular complications and death is another important advantage.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "5", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONCLUSIONS", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. 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Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. 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Please compare "Jørgensen" with "Jerrgensen". The CrossRef authors are Jerrgensen, H. S., Nakayama, H., Reith, J., Raaschou, H. O., & Olsen, T. S.. (Ref. 4 "Jørgensen, Nakayama, Reith, Raaschou, Olsen, 1997")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "eXtyles has not updated this reference because the authors returned by CrossRef are invalid: Girot, M., Mackowiak-Cordoliani, M.-A., Deplanque, D., H�non, H., Lucas, C., & Leys, D. (2005). Secondary prevention after ischemic stroke. Journal of Neurology, 252, 14–20. (Ref. 10 "Girot, Mackowiak-Cordoliani, Deplanque, Hénon, Lucas, Leys, 2005")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association or J Stroke Cerebrovasc Dis", not "Journal of Stroke and Cerebrovascular Diseases". (Ref. 17 "Hornnes, Larsen, Boysen, 2011")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the first page should be "NA", not "579". (Ref. 18 "Johnston, Sidney, Hills, Grosvenor, Klingman, Bernstein, Levin, 2010")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports multiple listings for this reference. Please check the reference for accuracy. (Ref. 20 "Fahey, Schroeder, Ebrahim, 2006")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "The Cochrane database of systematic reviews or Cochrane Database Syst Rev", not "Cochrane Database of Systematic Reviews". (Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". (Ref. 23 "Mancia, Fagard, Narkiewicz, Redán, Zanchetti, Böhm, Zannad, . . ., 2013")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne or CMAJ", not "Canadian Medical Association Journal". (Ref. 25 "McAlister, Majumdar, Padwal, Fradette, Thompson, Buck, Shuaib, . . ., 2014")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPParagraphElement:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPParagraphElement:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "International journal of stroke : official journal of the International Stroke Society or Int J Stroke", not "International Journal of Stroke". 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With this fact and the ongoing aging of populations in mind ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Study sample and setting", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Procedures and intervention", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.3", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Follow up", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. At follow up patients in both groups reported a median of two visits including BP measurement at the general practitioner´s office since discharge from hospital.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0002.png", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "content": Array [ + Object { + "text": "Blood pressure and treatment of hypertension at baseline in 73 patients (%)", + "type": "text", + }, + ], + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "figure_element", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "3.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Primary endpoint", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Follow up visits showed that 25 patients (69%) in the intervention group had a BP at target versus 14 (38%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.007). In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPFigureElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": ".", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0003.png", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "content": Array [ + Object { + "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", + "type": "text", + }, + ], + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "figure_element", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "3.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Secondary endpoints", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.04).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.18).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.003). At the end of the study 24 patients (68%) in the intervention group measured their BP at home versus 14 (38%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.03).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The only significant change in lifestyle was a reduction in current smokers by four in the control group (", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPTableElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": ").", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPTableElement:test", + }, + "content": Array [ + Object { + 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Abbreviations: AHM, antihypertensive medication; CLM, cholesterol lowering medication.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "type": "paragraph", + }, + ], + "type": "general_table_footnote", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnotesElement:test", + "kind": "footnote", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Fisher’s exact test. 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", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "d", + "type": "text", + }, + Object { + "text": " Less than 30 min of moderate physical activity per day.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", + }, + ], + "type": "footnotes_element", + }, + ], + "type": "table_element_footer", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "table_element", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Regarding vascular complications and death, we found 32 events in 22 patients after a median of 65 months. 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All in all, we found 11 events in nine patients in the intervention group: two recurrent strokes, three cases of TIA, and six patients died versus 21 events in 13 patients in the control group: seven recurrent strokes, five cases of TIA, one MI, and seven patients died (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.49).", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "discussion", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "DISCUSSION", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In this randomized clinical trial, a larger proportion of patients in the intervention group compared to controls had BP within the above-mentioned limits and the study fulfilled the aim of the primary endpoint.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A systematic review of interventions aimed at modifiable risk factor control for secondary prevention of stroke revealed improvement in achieving BP target. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Five-year follow up on vascular complications and death is another important advantage.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "5", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONCLUSIONS", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + ], + "type": "body", + }, + Object { + "attrs": Object { + "id": "MPSection:test", + "placeholder": " ", + }, + "content": Array [ + Object { + "attrs": Object { + "category": "availability", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "DATA AVAILABILITY", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "con", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Contributor Information", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "href": "https://orcid.org/0000-0003-2217-5904", + "title": "", + }, + "content": Array [ + Object { + "text": "https//orcid.org/0000-0003-2217-5904", + "type": "text", + }, + ], + "type": "link", + }, + Object { + "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", + "type": "text", + }, + Object { + "attrs": Object { + "id": "MPCommentAnnotation:test", + "position": "point", + }, + "type": "highlight_marker", + }, + Object { + "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "coi-statement", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "CONFLICT OF INTEREST", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "None.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": 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prevention of stroke + in patients with stroke or transient ischemic attack: A guideline for + healthcare professionals from the american heart association/american stroke + association.", + "type": "article-journal", + "volume": "42", + }, + "type": "bibliography_item", + }, + Object { + "attrs": Object { + "author": Array [ + Object { + "_id": "MPBibliographicName:test", + "family": "Bridgwood", + "given": "B.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Lager", + "given": "K. + E.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Mistri", + "given": "A. + K.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Khunti", + "given": "K.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Wilson", + "given": "A. + D.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Modi", + "given": "P.", + "objectType": "MPBibliographicName", + }, + ], + "containerTitle": "Cochrane Database of Systematic Reviews", + "dataTracked": null, + "doi": undefined, + "id": "MPBibliographyItem:test", + "issue": undefined, + "issued": Object { + "_id": "MPBibliographicDate:test", + "date-parts": Array [ + Array [ + "2018", + ], + ], + "objectType": "MPBibliographicDate", + }, + "literal": undefined, + "page": undefined, + "supplement": undefined, + "title": "Interventions for improving modifiable + risk factor control in the secondary prevention of stroke.", + "type": "article-journal", + "volume": "5", + }, + "type": "bibliography_item", + }, + Object { + "attrs": Object { + "author": Array [ + Object { + "_id": "MPBibliographicName:test", + "family": "Mancia", + "given": "G.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Fagard", + "given": "R.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Narkiewicz", + "given": "K.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Redán", + "given": "J.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Zanchetti", + "given": "A.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Böhm", + "given": "M.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Zannad", + "given": "F.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "literal": "ESH/ESC + Task Force for the Management of Arterial + Hypertension", + "objectType": "MPBibliographicName", + }, + ], + "containerTitle": "Journal of Hypertension", + "dataTracked": null, + "doi": "https://doi.org/10.1097/HJH.0b013e328364ca4c", + "id": "MPBibliographyItem:test", + "issue": undefined, + "issued": Object { + "_id": "MPBibliographicDate:test", + "date-parts": Array [ + Array [ + "2013", + ], + ], + "objectType": "MPBibliographicDate", + }, + "literal": undefined, + "page": "1925-1938", + "supplement": undefined, + "title": "2013 Practice guidelines for the management of arterial + hypertension of the European Society of Hypertension (ESH) and the European + Society of Cardiology (ESC): ESH/ESC Task Force for the Management of + Arterial Hypertension.", + "type": "article-journal", + "volume": "31", + }, + "type": "bibliography_item", + }, + Object { + "attrs": Object { + "author": Array [ + Object { + "_id": "MPBibliographicName:test", + "family": "Boan", + "given": "A. + D.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Lackland", + "given": "D. + T.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Ovbiagele", + "given": "B.", + "objectType": "MPBibliographicName", + }, + ], + "containerTitle": "Stroke", + "dataTracked": null, + "doi": "https://doi.org/10.1161/STROKEAHA.114.003666", + "id": "MPBibliographyItem:test", + "issue": undefined, + "issued": Object { + "_id": "MPBibliographicDate:test", + "date-parts": Array [ + Array [ + "2014", + ], + ], + "objectType": "MPBibliographicDate", + }, + "literal": undefined, + "page": "2506-2513", + "supplement": undefined, + "title": "Lowering of blood pressure for recurrent + stroke prevention.", + "type": "article-journal", + "volume": "45", + }, + "type": "bibliography_item", + }, + Object { + "attrs": Object { + "author": Array [ + Object { + "_id": "MPBibliographicName:test", + "family": "McAlister", + "given": "F. + A.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Majumdar", + "given": "S. + R.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Padwal", + "given": "R. + S.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Fradette", + "given": "M.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Thompson", + "given": "A.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Buck", + "given": "B.", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "objectType": "MPBibliographicName", + }, + Object { + "_id": "MPBibliographicName:test", + "family": "Shuaib", + "given": "A.", + "objectType": "MPBibliographicName", + }, + ], + "containerTitle": "Canadian Medical Association Journal", + "dataTracked": null, + "doi": "https://doi.org/10.1503/cmaj.140053", + "id": "MPBibliographyItem:test", + "issue": undefined, + "issued": Object { + "_id": "MPBibliographicDate:test", + "date-parts": Array [ + Array [ + "2014", + ], + ], + "objectType": "MPBibliographicDate", + }, + "literal": undefined, + "page": "577-584", + "supplement": undefined, + "title": "Case management for blood pressure and + lipid level control after minor stroke: PREVENTION randomized controlled + trial.", + "type": "article-journal", + "volume": "186", + }, + "type": "bibliography_item", + }, + ], + "type": "bibliography_element", + }, + ], + "type": "bibliography_section", + }, + ], + "type": "backmatter", + }, + Object { + "attrs": Object { + "id": "MPComments:test", + }, + "content": Array [ + Object { + "attrs": Object { + "contents": "eXtyles has not updated the authors because of a name mismatch. Please compare "Jørgensen" with "Jerrgensen". The CrossRef authors are Jerrgensen, H. S., Nakayama, H., Reith, J., Raaschou, H. O., & Olsen, T. S.. (Ref. 4 "Jørgensen, Nakayama, Reith, Raaschou, Olsen, 1997")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "eXtyles has not updated this reference because the authors returned by CrossRef are invalid: Girot, M., Mackowiak-Cordoliani, M.-A., Deplanque, D., H�non, H., Lucas, C., & Leys, D. (2005). Secondary prevention after ischemic stroke. Journal of Neurology, 252, 14–20. (Ref. 10 "Girot, Mackowiak-Cordoliani, Deplanque, Hénon, Lucas, Leys, 2005")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association or J Stroke Cerebrovasc Dis", not "Journal of Stroke and Cerebrovascular Diseases". (Ref. 17 "Hornnes, Larsen, Boysen, 2011")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the first page should be "NA", not "579". (Ref. 18 "Johnston, Sidney, Hills, Grosvenor, Klingman, Bernstein, Levin, 2010")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports multiple listings for this reference. Please check the reference for accuracy. (Ref. 20 "Fahey, Schroeder, Ebrahim, 2006")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "The Cochrane database of systematic reviews or Cochrane Database Syst Rev", not "Cochrane Database of Systematic Reviews". (Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". (Ref. 23 "Mancia, Fagard, Narkiewicz, Redán, Zanchetti, Böhm, Zannad, . . ., 2013")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne or CMAJ", not "Canadian Medical Association Journal". (Ref. 25 "McAlister, Majumdar, Padwal, Fradette, Thompson, Buck, Shuaib, . . ., 2014")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPParagraphElement:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPParagraphElement:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Medline reports the journal title should be "International journal of stroke : official journal of the International Stroke Society or Int J Stroke", not "International Journal of Stroke". (Ref. 13 "Hornnes, Larsen, Boysen, 2010")", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPBibliographyItem:test", + }, + "type": "comment", + }, + Object { + "attrs": Object { + "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", + "contributions": Array [ + Object { + "_id": "MPContribution:test", + "objectType": "MPContribution", + "profileID": "MPUserProfile:0000000000000000000000000000000000000001", + "timestamp": 1234, + }, + ], + "id": "MPCommentAnnotation:test", + "originalText": "", + "resolved": false, + "selector": undefined, + "target": "MPParagraphElement:test", + }, + "type": "comment", + }, + ], + "type": "comments", + }, + ], + "type": "manuscript", } `; diff --git a/src/jats/__tests__/jats-importer.test.ts b/src/jats/__tests__/jats-importer.test.ts index eb889ba3..61773e6c 100644 --- a/src/jats/__tests__/jats-importer.test.ts +++ b/src/jats/__tests__/jats-importer.test.ts @@ -306,6 +306,9 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const abstractsNode = findNodeByType(node, schema.nodes.abstracts) expect(abstractsNode).toBeDefined() + changeIDs(node) + expect(node).toMatchSnapshot() + }) it("should have an abstracts even if abstarcts element doesn't exist", async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -314,6 +317,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const abstractsNode = findNodeByType(node, schema.nodes.abstracts) expect(abstractsNode).toBeDefined() + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have the correct number of sections', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -326,6 +331,8 @@ describe('JATS importer', () => { const sections = findNodesByType(abstractsNode, schema.nodes.section) // first section is the abstract node expect(sections).toHaveLength(5) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should set the title to Abstract if no title is provided', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -352,6 +359,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const bodyNode = findNodeByType(node, schema.nodes.body) expect(bodyNode).toBeDefined() + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have the correct number of sections', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -359,6 +368,8 @@ describe('JATS importer', () => { const bodyNode = findNodeByType(node, schema.nodes.body) const sections = findNodesByType(bodyNode, schema.nodes.section, false) expect(sections).toHaveLength(5) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have a body node even if body element does not exist', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -367,6 +378,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const bodyNode = findNodeByType(node, schema.nodes.body) expect(bodyNode).toBeDefined() + changeIDs(node) + expect(node).toMatchSnapshot() }) }) describe('backmatter', () => { @@ -379,6 +392,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const backNode = findNodeByType(node, schema.nodes.backmatter) expect(backNode).toBeDefined() + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have appendices section if app-group element exists', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -394,6 +409,8 @@ describe('JATS importer', () => { false ).filter((node) => node.attrs.category === 'appendices') expect(appNode).toHaveLength(1) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should correctly add back sections to the backmatter', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -409,6 +426,8 @@ describe('JATS importer', () => { false ).filter((node) => node.attrs.category === 'availability') expect(availabilitySection).toHaveLength(1) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should create sections for special footnotes', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -431,6 +450,8 @@ describe('JATS importer', () => { expect(con).toHaveLength(1) expect(financialDisclosure).toHaveLength(1) expect(conflict).toHaveLength(1) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have an endnotes section if either an endnotes section exists or there are footnotes', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -442,6 +463,8 @@ describe('JATS importer', () => { false ) expect(endNotesSection).toHaveLength(1) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have a references section if ref-list element exists', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -457,6 +480,8 @@ describe('JATS importer', () => { false ) expect(refSection).toHaveLength(1) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have an acknowledgements section if ack element exists', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -473,6 +498,8 @@ describe('JATS importer', () => { ).filter((node) => node.attrs.category === 'acknowledgements') expect(ackSection).toHaveLength(1) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should parse references correctly', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -497,12 +524,16 @@ describe('JATS importer', () => { bibliographyItems[0].attrs.author[0]._id = 'MPBibliographicName:test' bibliographyItems[0].attrs.issued._id = 'MPBibliographicDate:test' expect(bibliographyItems[0]).toMatchSnapshot() + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have the correct number of sections', async () => { const jats = await readAndParseFixture('jats-example-full.xml') const { node } = parseJATSArticle(jats, sectionCategories) const backNode = findNodeByType(node, schema.nodes.backmatter) expect(backNode.childCount).toBe(8) + changeIDs(node) + expect(node).toMatchSnapshot() }) it('should have a backmatter node even if back element does not exist', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -511,6 +542,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const backNode = findNodeByType(node, schema.nodes.backmatter) expect(backNode).toBeDefined() + changeIDs(node) + expect(node).toMatchSnapshot() }) }) From 8c7877b7996a2f40b1dea74e2f01443167f7580c Mon Sep 17 00:00:00 2001 From: Mohammad Betamony Date: Tue, 21 Jan 2025 21:20:25 +0300 Subject: [PATCH 2/5] update tests --- .../__snapshots__/jats-importer.test.ts.snap | 98039 +++------------- src/jats/__tests__/jats-importer.test.ts | 64 +- 2 files changed, 17269 insertions(+), 80834 deletions(-) diff --git a/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap b/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap index 93328b08..c585d0a9 100644 --- a/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap +++ b/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap @@ -3,181 +3,119 @@ exports[`JATS importer abstracts should have abstract node if abstract element exists 1`] = ` Object { "attrs": Object { - "acceptanceDate": 1587945600, - "articleType": "other", - "correctionDate": undefined, - "doi": "10.5555/BRB3-2019-12-0787", - "id": "MPManuscript:test", - "primaryLanguageCode": "", - "prototype": "", - "receiveDate": 1575849600, - "retractionDate": undefined, - "revisionReceiveDate": undefined, - "revisionRequestDate": undefined, + "id": "MPSection:test", }, "content": Array [ Object { "attrs": Object { + "category": "abstract", "dataTracked": null, - "id": "MPTitles:test", - "placeholder": "Insert title here...", - }, - "content": Array [ - Object { - "text": "Blood pressure after follow up in a stroke prevention clinic", - "type": "text", - }, - ], - "type": "title", - }, - Object { - "attrs": Object { "id": "MPSection:test", }, "content": Array [ Object { "attrs": Object { - "ORCIDIdentifier": "https://orcid.org/0000-0003-2217-5904", - "affiliations": Array [ - "MPAffiliation:test", - ], - "bibliographicName": Object { - "ObjectType": "MPBibliographicName", - "family": "Hornnes", - "given": "Agnete Hviid", - }, - "contents": "", - "corresp": Array [], "dataTracked": null, - "email": "", - "footnote": Array [], - "id": "MPContributor:test", - "invitationID": undefined, - "isCorresponding": true, - "isJointContributor": undefined, - "priority": undefined, - "role": "author", - "userID": undefined, }, "content": Array [ Object { - "text": "_", + "text": "Abstract", "type": "text", }, ], - "type": "contributor", + "type": "section_title", }, Object { "attrs": Object { - "ORCIDIdentifier": undefined, - "affiliations": Array [ - "MPAffiliation:test", - ], - "bibliographicName": Object { - "ObjectType": "MPBibliographicName", - "family": "Poulsen", - "given": "Mai Bang", - }, - "contents": "", - "corresp": Array [], + "category": "", "dataTracked": null, - "email": "", - "footnote": Array [ - Object { - "noteID": "MPFootnote:test", - "noteLabel": "*", - }, - ], - "id": "MPContributor:test", - "invitationID": undefined, - "isCorresponding": undefined, - "isJointContributor": undefined, - "priority": undefined, - "role": "author", - "userID": undefined, + "id": "MPSection:test", }, "content": Array [ Object { - "text": "_", - "type": "text", + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Objectives", + "type": "text", + }, + ], + "type": "section_title", }, - ], - "type": "contributor", - }, - ], - "type": "contributors", - }, - Object { - "attrs": Object { - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "addressLine1": "Borgmester Ib Juuls Vej 1", - "addressLine2": "2730 - Herlev", - "addressLine3": "", - "city": "", - "country": "Denmark", - "county": "", - "dataTracked": null, - "department": "Department of - Neurology", - "email": undefined, - "id": "MPAffiliation:test", - "institution": "Herlev og Gentofte - Hospital", - "postCode": "2730", - "priority": undefined, - }, - "content": Array [ Object { - "text": "_", - "type": "text", + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In Denmark 25% of hospital admissions with stroke are recurrent strokes. With thrombolytic treatment more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. We aimed at testing the hypotheses that early follow up in a preventive clinic would result in 1) A higher proportion of patients with blood pressure at target, 2) Time to stroke recurrence, myocardial infarction and death would be longer in the intervention group compared to controls.", + "type": "text", + }, + ], + "type": "paragraph", }, ], - "type": "affiliation", - }, - ], - "type": "affiliations", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPAuthorNotes:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "section_title", + "type": "section", }, Object { "attrs": Object { + "category": "methods", "dataTracked": null, - "id": "MPCorresponding:test", - "label": undefined, + "id": "MPSection:test", }, "content": Array [ Object { - "text": "Corresponding author: Agnete Hviid - Hornnes
agnete.hviid.hornnes@regionh.dk
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Department of Neurology
Nordsjællands Hospital
Dyrehavevej 29
3400 Hillerød
Denmark", + "text": "In the intervention group blood pressure was treated to target in 25 patients (69%) versus 14 (38%) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.007). 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agnete.hviid.hornnes@regionh.dk
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Department of Neurology
Nordsjællands Hospital
Dyrehavevej 29
3400 Hillerød
Denmark", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "ClinicalTrials.gov NCT03782857.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", + }, + ], + "type": "author_notes", +} +`; + +exports[`JATS importer awards should correctly parse award nodes 1`] = ` +Object { + "attrs": Object { + "id": "MPAwards:test", + }, + "content": Array [ + Object { + "attrs": Object { + "code": "GM18458", + "dataTracked": null, + "id": "MPAward:test", + "recipient": "Berkeley", + "source": "National Institutes of Health", + }, + "type": "award", + }, + Object { + "attrs": Object { + "code": "DMS-0204674;DMS-0244638", + "dataTracked": null, + "id": "MPAward:test", + "recipient": undefined, + "source": "National Science Foundation", + }, + "type": "award", + }, + ], + "type": "awards", +} +`; + +exports[`JATS importer backmatter should correctly add back sections to the backmatter 1`] = ` +Object { + "attrs": Object { + "id": "MPSection:test", + "placeholder": " ", + }, + "content": Array [ + Object { + "attrs": Object { + "category": "availability", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Data availability", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "This is some information about data availability.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Footnotes", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnotesElement:test", + "kind": "footnote", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ Object { "attrs": Object { "dataTracked": null, @@ -512,60 +870,48 @@ Object { }, "content": Array [ Object { - "text": "In the intervention group blood pressure was treated to target in 25 patients (69%) versus 14 (38%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.007). 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Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. 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Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", + "text": "Box Note", "type": "text", }, ], "type": "paragraph", }, ], - "type": "section", + "type": "footnote", }, Object { "attrs": Object { - "category": "", "dataTracked": null, - "id": "MPSection:test", + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", }, "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.3", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Follow up", - "type": "text", - }, - ], - "type": "section_title", - }, Object { "attrs": Object { "dataTracked": null, @@ -1484,12 +2330,23 @@ Object { }, "content": Array [ Object { - "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", + "text": "This is a footnote.", "type": "text", }, ], "type": "paragraph", }, + ], + "type": "footnote", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ Object { "attrs": Object { "dataTracked": null, @@ -1498,39 +2355,70 @@ Object { }, "content": Array [ Object { - "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. 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In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "label": "", - "rids": Array [ - "MPFigureElement:test", - ], - }, - "type": "cross_reference", - }, - Object { - "text": ".", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "attribution": undefined, - "dataTracked": null, - "id": "MPFigureElement:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPFigure:test", - "src": "BRB3-2019-12-0787-fig-0003.png", - "type": "half-left", - }, - "type": "figure", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Title...", - }, - "type": "caption_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Caption...", - }, - "content": Array [ - Object { - "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", - "type": "text", - }, - ], - "type": "caption", - }, - ], - "type": "figcaption", - }, - Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPListing:test", - "isExecuting": false, - "isExpanded": false, - "language": "", - "languageKey": "null", - }, - "type": "listing", - }, - ], - "type": "figure_element", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "3.2", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Secondary endpoints", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.04).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.18).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " < 0.0001).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.003). 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", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "4.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Strengths and limitations", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Five-year follow up on vascular complications and death is another important advantage.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "conclusions", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "5", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "CONCLUSIONS", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "body", - }, - Object { - "attrs": Object { - "id": "MPSection:test", - "placeholder": " ", - }, - "content": Array [ - Object { - "attrs": Object { - "category": "availability", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "DATA AVAILABILITY", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "con", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Contributor Information", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "href": "https://orcid.org/0000-0003-2217-5904", - "title": "", - }, - "content": Array [ - Object { - "text": "https//orcid.org/0000-0003-2217-5904", - "type": "text", - }, - ], - "type": "link", - }, - Object { - "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. 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", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Lowering blood pressure (BP) after stroke or transitory ischemic attack (TIA) by 10/5 mm Hg has been associated with reduced risk of stroke recurrence by 24% and myocardial infarction (MI) by 21%. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Observational studies have demonstrated the difficulties in lowering BP after stroke with rates of BP treated to target ranging from 28% to 73% ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " and interventions aimed at control of BP after stroke have not yet found a successful model. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. 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Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. 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BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. 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Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.3", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Follow up", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. 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", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "4.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Strengths and limitations", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Five-year follow up on vascular complications and death is another important advantage.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "conclusions", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "5", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "CONCLUSIONS", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. 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(Ref. 17 "Hornnes, Larsen, Boysen, 2011")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "CrossRef reports the first page should be "NA", not "579". (Ref. 18 "Johnston, Sidney, Hills, Grosvenor, Klingman, Bernstein, Levin, 2010")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports multiple listings for this reference. Please check the reference for accuracy. (Ref. 20 "Fahey, Schroeder, Ebrahim, 2006")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports the journal title should be "The Cochrane database of systematic reviews or Cochrane Database Syst Rev", not "Cochrane Database of Systematic Reviews". (Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". 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With thrombolytic treatment more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. 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With this fact and the ongoing aging of populations in mind ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Study sample and setting", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. 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BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.3", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Follow up", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. Patients were asked not to reveal their group allocation but blinding of the nurses was not possible. Patients were interviewed about adherence to all preventive medications as well as their present life style. For practical purposes a minority of visits were performed by the first author. To do intention to treat analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " we used last observation carried forward regarding the endpoints of the study where patients had died or did not respond to the invitation to a follow up visit. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. 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We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.18).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " < 0.0001).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.003). 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", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "4.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Strengths and limitations", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Five-year follow up on vascular complications and death is another important advantage.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "conclusions", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "5", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "CONCLUSIONS", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "body", - }, - Object { - "attrs": Object { - "id": "MPSection:test", - "placeholder": " ", - }, - "content": Array [ - Object { - "attrs": Object { - "category": "availability", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "DATA AVAILABILITY", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "con", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Contributor Information", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "href": "https://orcid.org/0000-0003-2217-5904", - "title": "", - }, - "content": Array [ - Object { - "text": "https//orcid.org/0000-0003-2217-5904", - "type": "text", - }, - ], - "type": "link", - }, - Object { - "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "coi-statement", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "CONFLICT OF INTEREST", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "None.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "acknowledgements", - 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With this fact and the ongoing aging of populations in mind ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0003", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0004", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " According to the Danish Stroke Registry our national recurrence rate was 25% in 2011.", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0005", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Hypertension is an important risk factor for stroke recurrence. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0004", - "BRB3-2019-12-0787-bib-0006", - "BRB3-2019-12-0787-bib-0007", - "BRB3-2019-12-0787-bib-0008", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Lowering blood pressure (BP) after stroke or transitory ischemic attack (TIA) by 10/5 mm Hg has been associated with reduced risk of stroke recurrence by 24% and myocardial infarction (MI) by 21%. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0009", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Observational studies have demonstrated the difficulties in lowering BP after stroke with rates of BP treated to target ranging from 28% to 73% ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0010", - "BRB3-2019-12-0787-bib-0011", - "BRB3-2019-12-0787-bib-0012", - "BRB3-2019-12-0787-bib-0013", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " and interventions aimed at control of BP after stroke have not yet found a successful model. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0014", - "BRB3-2019-12-0787-bib-0015", - "BRB3-2019-12-0787-bib-0016", - "BRB3-2019-12-0787-bib-0017", - "BRB3-2019-12-0787-bib-0018", - "BRB3-2019-12-0787-bib-0019", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Fahey and coworkers have reviewed the literature aimed at improving control of BP in hypertensive subjects. One large study using an organized system of regular visits to a clinic was efficient in producing a large decrease in BP and reduction of all-cause mortality compared to referral to usual primary care. This was achieved by using a stepwise escalation of treatment until target was reached. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0020", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Other methods had variable or no effect, only nurse or pharmacist led care seemed promising.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "href": "example.mp4", - "id": "MPEmbed:test", - "mimeSubtype": "mp4", - "mimetype": "video", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Title...", - }, - "type": "caption_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Caption...", - }, - "type": "caption", - }, - ], - "type": "figcaption", - }, - ], - "type": "embed", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0021", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Study sample and setting", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.2", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Procedures and intervention", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.3", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Follow up", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. Patients were asked not to reveal their group allocation but blinding of the nurses was not possible. Patients were interviewed about adherence to all preventive medications as well as their present life style. For practical purposes a minority of visits were performed by the first author. To do intention to treat analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " we used last observation carried forward regarding the endpoints of the study where patients had died or did not respond to the invitation to a follow up visit. Thus, we used the last recorded values in five patients in the intervention group and in seven controls.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "After a median of 65 months (IQR: 61–66) from inclusion data on vascular events and death were attained from the hospital based medical records covering all hospitals of the region.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.4", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Statistics", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Data were entered into Excel and imported into SAS. 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We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.18).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " < 0.0001).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.003). At the end of the study 24 patients (68%) in the intervention group measured their BP at home versus 14 (38%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.03).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The only significant change in lifestyle was a reduction in current smokers by four in the control group (", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "label": "", - "rids": Array [ - "MPTableElement:test", - ], - }, - "type": "cross_reference", - }, - Object { - "text": ").", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPTableElement:test", - }, - "content": Array [ - Object { - 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", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0019", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0023", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0024", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0025", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "4.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Strengths and limitations", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "BRB3-2019-12-0787-bib-0024", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Five-year follow up on vascular complications and death is another important advantage.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "conclusions", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "5", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "CONCLUSIONS", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. 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Dyrehavevej 29
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With thrombolytic treatment more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. We aimed at testing the hypotheses that early follow up in a preventive clinic would result in 1) A higher proportion of patients with blood pressure at target, 2) Time to stroke recurrence, myocardial infarction and death would be longer in the intervention group compared to controls.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "methods", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Materials and Methods", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Eligible patients admitted to the stroke unit of Herlev Hospital were randomized shortly before discharge to intervention or control group. Of 78 included participants data from 73 was available for follow up nine months after inclusion. Patients in the intervention group were seen in the clinic within one week. In case of hypertension treatment was initiated or supplied with a new drug. We used individual targets for blood pressure according to diagnosis of stroke and patients’ comorbidity. Patients in the intervention group had a median of five visits to the preventive clinic.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "results", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Results", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In the intervention group blood pressure was treated to target in 25 patients (69%) versus 14 (38%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.007). Median time to first event was 44 months (4–49) in the intervention group and 19 months (4–37) in controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.316).", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "conclusions", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Conclusions", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Treatment of hypertension to individual targets after stroke is feasible. It may postpone recurrent stroke and death in stroke survivors.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Graphical Abstract", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "attribution": undefined, - "dataTracked": null, - "id": "MPFigureElement:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPFigure:test", - "src": "demo.jpg", - "type": "half-left", - }, - "type": "figure", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Title...", - }, - "type": "caption_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Caption...", - }, - "type": "caption", - }, - ], - "type": "figcaption", - }, - Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPListing:test", - "isExecuting": false, - "isExpanded": false, - "language": "", - "languageKey": "null", - }, - "type": "listing", - }, - ], - "type": "figure_element", - }, - ], - "type": "graphical_abstract_section", - }, - ], - "type": "abstracts", - }, - Object { - "attrs": Object { - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPImageElement:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPFigure:test", - "src": "prodbe.int.aip.org:8080/journal/journal_fs/ 1.2983775.1373315697!/images/1460725790.jpg", - "type": "", - }, - "type": "figure", - }, - ], - "type": "image_element", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "test paragraph", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "intro", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "INTRODUCTION", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Over the last two decades continuous development of thrombolytic treatment of acute ischemic stroke (IS) has improved safety and functional outcome in treated patients ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " thus increasing the possibility of survival with no or only minor disability. With this fact and the ongoing aging of populations in mind ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " According to the Danish Stroke Registry our national recurrence rate was 25% in 2011.", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Hypertension is an important risk factor for stroke recurrence. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Lowering blood pressure (BP) after stroke or transitory ischemic attack (TIA) by 10/5 mm Hg has been associated with reduced risk of stroke recurrence by 24% and myocardial infarction (MI) by 21%. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Observational studies have demonstrated the difficulties in lowering BP after stroke with rates of BP treated to target ranging from 28% to 73% ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " and interventions aimed at control of BP after stroke have not yet found a successful model. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Fahey and coworkers have reviewed the literature aimed at improving control of BP in hypertensive subjects. One large study using an organized system of regular visits to a clinic was efficient in producing a large decrease in BP and reduction of all-cause mortality compared to referral to usual primary care. This was achieved by using a stepwise escalation of treatment until target was reached. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Other methods had variable or no effect, only nurse or pharmacist led care seemed promising.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "href": "example.mp4", - "id": "MPEmbed:test", - "mimeSubtype": "mp4", - "mimetype": "video", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Title...", - }, - "type": "caption_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Caption...", - }, - "type": "caption", - }, - ], - "type": "figcaption", - }, - ], - "type": "embed", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - 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"attrs": Object { - "dataTracked": null, - "placeholder": "List item", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Day hospitals had a possible advantage over no comprehensive care in terms of death or poor outcome, disability, and use of resources.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "list_item", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "List item", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The costs of day hospital care may be partly offset by a reduced use of hospital beds and institutional care among survivors.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "list_item", - }, - ], - "type": "list", - }, - ], - 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Study sample and setting", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.2", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Procedures and intervention", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. 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At follow up patients in both groups reported a median of two visits including BP measurement at the general practitioner´s office since discharge from hospital.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "attribution": undefined, - "dataTracked": null, - "id": "MPFigureElement:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPFigure:test", - "src": "BRB3-2019-12-0787-fig-0002.png", - "type": "half-left", - }, - "type": "figure", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Title...", - }, - "type": "caption_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Caption...", - }, - "content": Array [ - Object { - "text": "Blood pressure and treatment of hypertension at baseline in 73 patients (%)", - "type": "text", - }, - ], - "type": "caption", - }, - ], - "type": "figcaption", - }, - Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPListing:test", - "isExecuting": false, - "isExpanded": false, - "language": "", - "languageKey": "null", - }, - "type": "listing", - }, - ], - "type": "figure_element", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "3.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Primary endpoint", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Follow up visits showed that 25 patients (69%) in the intervention group had a BP at target versus 14 (38%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.007). In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "label": "", - "rids": Array [ - "MPFigureElement:test", - ], - }, - "type": "cross_reference", - }, - Object { - "text": ".", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "attribution": undefined, - "dataTracked": null, - "id": "MPFigureElement:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPFigure:test", - "src": "BRB3-2019-12-0787-fig-0003.png", - "type": "half-left", - }, - "type": "figure", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Title...", - }, - "type": "caption_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Caption...", - }, - "content": Array [ - Object { - "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", - "type": "text", - }, - ], - "type": "caption", - }, - ], - "type": "figcaption", - }, - Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPListing:test", - "isExecuting": false, - "isExpanded": false, - "language": "", - "languageKey": "null", - }, - "type": "listing", - }, - ], - "type": "figure_element", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "3.2", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Secondary endpoints", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.04).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.18).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " < 0.0001).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.003). At the end of the study 24 patients (68%) in the intervention group measured their BP at home versus 14 (38%) of controls (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.03).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The only significant change in lifestyle was a reduction in current smokers by four in the control group (", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "label": "", - "rids": Array [ - "MPTableElement:test", - ], - }, - "type": "cross_reference", - }, - Object { - "text": ").", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPTableElement:test", - }, - "content": Array [ - Object { - 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", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "superscript", - }, - ], - "text": "d", - "type": "text", - }, - Object { - "text": " Less than 30 min of moderate physical activity per day.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "footnote", - }, - ], - "type": "footnotes_element", - }, - ], - "type": "table_element_footer", - }, - Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPListing:test", - "isExecuting": false, - "isExpanded": false, - "language": "", - "languageKey": "null", - }, - "type": "listing", - }, - ], - "type": "table_element", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Regarding vascular complications and death, we found 32 events in 22 patients after a median of 65 months. 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All in all, we found 11 events in nine patients in the intervention group: two recurrent strokes, three cases of TIA, and six patients died versus 21 events in 13 patients in the control group: seven recurrent strokes, five cases of TIA, one MI, and seven patients died (", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, - Object { - "text": " = 0.49).", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "discussion", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "4", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "DISCUSSION", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In this randomized clinical trial, a larger proportion of patients in the intervention group compared to controls had BP within the above-mentioned limits and the study fulfilled the aim of the primary endpoint.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "A systematic review of interventions aimed at modifiable risk factor control for secondary prevention of stroke revealed improvement in achieving BP target. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "4.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Strengths and limitations", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Five-year follow up on vascular complications and death is another important advantage.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "conclusions", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "5", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "CONCLUSIONS", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "body", - }, - Object { - "attrs": Object { - "id": "MPSection:test", - "placeholder": " ", - }, - "content": Array [ - Object { - "attrs": Object { - "category": "availability", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "DATA AVAILABILITY", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "con", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Contributor Information", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "href": "https://orcid.org/0000-0003-2217-5904", - "title": "", - }, - "content": Array [ - Object { - "text": "https//orcid.org/0000-0003-2217-5904", - "type": "text", - }, - ], - "type": "link", - }, - Object { - "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "coi-statement", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "CONFLICT OF INTEREST", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "None.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "acknowledgements", - 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Please compare "Jørgensen" with "Jerrgensen". The CrossRef authors are Jerrgensen, H. S., Nakayama, H., Reith, J., Raaschou, H. O., & Olsen, T. S.. (Ref. 4 "Jørgensen, Nakayama, Reith, Raaschou, Olsen, 1997")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "eXtyles has not updated this reference because the authors returned by CrossRef are invalid: Girot, M., Mackowiak-Cordoliani, M.-A., Deplanque, D., H�non, H., Lucas, C., & Leys, D. (2005). Secondary prevention after ischemic stroke. Journal of Neurology, 252, 14–20. (Ref. 10 "Girot, Mackowiak-Cordoliani, Deplanque, Hénon, Lucas, Leys, 2005")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports the journal title should be "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association or J Stroke Cerebrovasc Dis", not "Journal of Stroke and Cerebrovascular Diseases". (Ref. 17 "Hornnes, Larsen, Boysen, 2011")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "CrossRef reports the first page should be "NA", not "579". (Ref. 18 "Johnston, Sidney, Hills, Grosvenor, Klingman, Bernstein, Levin, 2010")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports multiple listings for this reference. Please check the reference for accuracy. (Ref. 20 "Fahey, Schroeder, Ebrahim, 2006")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports the journal title should be "The Cochrane database of systematic reviews or Cochrane Database Syst Rev", not "Cochrane Database of Systematic Reviews". (Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". (Ref. 23 "Mancia, Fagard, Narkiewicz, Redán, Zanchetti, Böhm, Zannad, . . ., 2013")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports the journal title should be "CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne or CMAJ", not "Canadian Medical Association Journal". (Ref. 25 "McAlister, Majumdar, Padwal, Fradette, Thompson, Buck, Shuaib, . . ., 2014")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPParagraphElement:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPParagraphElement:test", - }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports the journal title should be "International journal of stroke : official journal of the International Stroke Society or Int J Stroke", not "International Journal of Stroke". 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With thrombolytic treatment more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. We aimed at testing the hypotheses that early follow up in a preventive clinic would result in 1) A higher proportion of patients with blood pressure at target, 2) Time to stroke recurrence, myocardial infarction and death would be longer in the intervention group compared to controls.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "methods", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Materials and Methods", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Eligible patients admitted to the stroke unit of Herlev Hospital were randomized shortly before discharge to intervention or control group. Of 78 included participants data from 73 was available for follow up nine months after inclusion. Patients in the intervention group were seen in the clinic within one week. In case of hypertension treatment was initiated or supplied with a new drug. We used individual targets for blood pressure according to diagnosis of stroke and patients’ comorbidity. 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With this fact and the ongoing aging of populations in mind ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.1", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Study sample and setting", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. 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BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.3", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Follow up", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. 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Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. 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With this fact and the ongoing aging of populations in mind ", + "type": "text", }, Object { "attrs": Object { "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", }, - "content": Array [ - Object { - "text": "DISCUSSION", - "type": "text", - }, - ], - "type": "section_title", + "type": "citation", + }, + Object { + "text": " the secondary prevention after stroke seems more important than ever. In 1998 the Copenhagen Stroke Study reported a recurrence rate of 23%. ", + "type": "text", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", }, - "content": Array [ - Object { - "text": "In this randomized clinical trial, a larger proportion of patients in the intervention group compared to controls had BP within the above-mentioned limits and the study fulfilled the aim of the primary endpoint.", - "type": "text", - }, - ], - "type": "paragraph", + "type": "citation", + }, + Object { + "text": " According to the Danish Stroke Registry our national recurrence rate was 25% in 2011.", + "type": "text", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", }, - "content": Array [ - Object { - "text": "A systematic review of interventions aimed at modifiable risk factor control for secondary prevention of stroke revealed improvement in achieving BP target. 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", + "type": "text", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Lowering blood pressure (BP) after stroke or transitory ischemic attack (TIA) by 10/5 mm Hg has been associated with reduced risk of stroke recurrence by 24% and myocardial infarction (MI) by 21%. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Observational studies have demonstrated the difficulties in lowering BP after stroke with rates of BP treated to target ranging from 28% to 73% ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " and interventions aimed at control of BP after stroke have not yet found a successful model. 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", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "text": "The aim of the present study was to test the hypotheses that follow up after stroke in a specialized nurse led physician supervised clinic with stepwise escalation of BP- and lipid lowering treatment would result in", "type": "text", }, ], @@ -72861,66 +6519,223 @@ Object { }, "content": Array [ Object { - "text": "4.1", + "text": "Primary endpoint", "type": "text", }, ], - "type": "section_label", + "type": "section_title", }, Object { "attrs": Object { + "category": "", "dataTracked": null, + "id": "MPSection:test", }, "content": Array [ Object { - "text": "Strengths and limitations", - "type": "text", + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "A greater proportion of participants with BP at target", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Secondary endpoints: A greater reduction of BP A greater proportion of participants with LDL-cholesterol treated to target A greater reduction of LDL-cholesterol Longer time to recurrence of stroke, MI and death in the intervention group compared to controls", + "type": "text", + }, + ], + "type": "paragraph", }, ], - "type": "section_title", + "type": "section", }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", }, "content": Array [ Object { - "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "text": "BoxedText test", "type": "text", }, ], - "type": "paragraph", + "type": "section_title", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "id": "MPSection:test", }, "content": Array [ - Object { - "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", }, - "content": Array [ - Object { - "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", - "type": "text", - }, - ], - "type": "paragraph", + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", + "type": "text", }, ], - "type": "section", + "type": "paragraph", }, - ], - "type": "body", - }, - Object { - "attrs": Object { - "id": "MPSection:test", - "placeholder": " ", - }, - "content": Array [ Object { "attrs": Object { - "category": "availability", "dataTracked": null, - "id": "MPSection:test", + "id": "MPParagraphElement:test", + "placeholder": "", }, "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "DATA AVAILABILITY", - "type": "text", - }, - ], - "type": "section_title", + "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", + "type": "text", }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", - "type": "text", - }, - ], - "type": "paragraph", + "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", + "type": "text", }, ], - "type": "section", + "type": "paragraph", }, Object { "attrs": Object { - "category": "con", + "category": "", "dataTracked": null, "id": "MPSection:test", }, @@ -73034,39 +6847,33 @@ Object { }, "content": Array [ Object { - "text": "Contributor Information", + "text": "2.1", "type": "text", }, ], - "type": "section_title", + "type": "section_label", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", }, "content": Array [ Object { - "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", + "text": "Study sample and setting", "type": "text", }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - "href": "https://orcid.org/0000-0003-2217-5904", - "title": "", - }, - "content": Array [ - Object { - "text": "https//orcid.org/0000-0003-2217-5904", - "type": "text", - }, - ], - "type": "link", - }, - Object { - "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", "type": "text", }, ], @@ -73080,18 +6887,7 @@ Object { }, "content": Array [ Object { - "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", + "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", "type": "text", }, ], @@ -73102,7 +6898,7 @@ Object { }, Object { "attrs": Object { - "category": "coi-statement", + "category": "", "dataTracked": null, "id": "MPSection:test", }, @@ -73113,7 +6909,19 @@ Object { }, "content": Array [ Object { - "text": "CONFLICT OF INTEREST", + "text": "2.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Procedures and intervention", "type": "text", }, ], @@ -73127,33 +6935,25 @@ Object { }, "content": Array [ Object { - "text": "None.", + "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", "type": "text", }, ], "type": "paragraph", }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "acknowledgements", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ Object { "attrs": Object { "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", }, "content": Array [ Object { - "text": "ACKNOWLEDGMENTS", + "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", "type": "text", }, ], - "type": "section_title", + "type": "paragraph", }, Object { "attrs": Object { @@ -73163,20 +6963,9 @@ Object { }, "content": Array [ Object { - "text": "None.", + "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", "type": "text", }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, ], "type": "paragraph", }, @@ -73185,6 +6974,7 @@ Object { }, Object { "attrs": Object { + "category": "", "dataTracked": null, "id": "MPSection:test", }, @@ -73195,2632 +6985,3273 @@ Object { }, "content": Array [ Object { - "text": "References", + "text": "2.3", "type": "text", }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPBibliographyElement:test", - }, - "content": Array [ - Object { - "attrs": Object { - "author": Array [ - Object { - "_id": "MPBibliographicName:test", - 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "text": "Follow up visits showed that 25 patients (69%) in the intervention group had a BP at target versus 14 (38%) of controls (", "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", }, Object { - "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", + "text": " = 0.007). In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", "type": "text", }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ Object { - "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", "type": "text", }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ Object { - "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", + "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPFigureElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": ".", "type": "text", }, ], @@ -76209,22 +11038,19 @@ Object { }, Object { "attrs": Object { - "category": "", + "attribution": undefined, "dataTracked": null, - "id": "MPSection:test", + "id": "MPFigureElement:test", }, "content": Array [ Object { "attrs": Object { "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0003.png", + "type": "half-left", }, - "content": Array [ - Object { - "text": "2.1", - "type": "text", - }, - ], - "type": "section_label", + "type": "figure", }, Object { "attrs": Object { @@ -76232,311 +11058,183 @@ Object { }, "content": Array [ Object { - "text": "Study sample and setting", - "type": "text", + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ Object { - "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", - "type": "text", + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "content": Array [ + Object { + "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", + "type": "text", + }, + ], + "type": "caption", }, ], - "type": "paragraph", + "type": "figcaption", }, Object { "attrs": Object { + "contents": "", "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", }, - "content": Array [ - Object { - "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. The first author undertook all visits in the preventive clinic.", - "type": "text", - }, - ], - "type": "paragraph", + "type": "listing", }, ], - "type": "section", + "type": "figure_element", }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ Object { "attrs": Object { - "category": "", "dataTracked": null, - "id": "MPSection:test", }, "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.2", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Procedures and intervention", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "BP was measured at every visit after at least five minutes rest in a sitting position in an arm chair. BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", - "type": "text", - }, - ], - "type": "paragraph", + "text": "3.2", + "type": "text", }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", - "type": "text", - }, - ], - "type": "paragraph", + "text": "Secondary endpoints", + "type": "text", }, ], - "type": "section", + "type": "section_title", }, Object { "attrs": Object { - "category": "", "dataTracked": null, - "id": "MPSection:test", + "id": "MPParagraphElement:test", + "placeholder": "", }, "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.3", - "type": "text", - }, - ], - "type": "section_label", + "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", + "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ + "marks": Array [ Object { - "text": "Follow up", - "type": "text", + "type": "italic", }, ], - "type": "section_title", + "text": "p", + "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", - "type": "text", - }, - ], - "type": "paragraph", + "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", + "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. Patients were asked not to reveal their group allocation but blinding of the nurses was not possible. Patients were interviewed about adherence to all preventive medications as well as their present life style. For practical purposes a minority of visits were performed by the first author. To do intention to treat analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, + "marks": Array [ Object { - "text": " we used last observation carried forward regarding the endpoints of the study where patients had died or did not respond to the invitation to a follow up visit. Thus, we used the last recorded values in five patients in the intervention group and in seven controls.", - "type": "text", + "type": "italic", }, ], - "type": "paragraph", + "text": "p", + "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "After a median of 65 months (IQR: 61–66) from inclusion data on vascular events and death were attained from the hospital based medical records covering all hospitals of the region.", - "type": "text", - }, - ], - "type": "paragraph", + "text": " = 0.04).", + "type": "text", }, ], - "type": "section", + "type": "paragraph", }, Object { "attrs": Object { - "category": "", "dataTracked": null, - "id": "MPSection:test", + "id": "MPParagraphElement:test", + "placeholder": "", }, "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "2.4", - "type": "text", - }, - ], - "type": "section_label", + "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", + "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ + "marks": Array [ Object { - "text": "Statistics", - "type": "text", + "type": "italic", }, ], - "type": "section_title", + "text": "p", + "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Data were entered into Excel and imported into SAS. Statistical analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " were performed by the first author according to a pre-established statistical analysis plan. We used Chi square test (for the primary outcome) or Fisher’s exact test as appropriate for comparison of proportions, and for change from baseline we used McNemar’s test. For continuous variables we used t-test or Mann-Whitney’s test*. Change from baseline was analyzed by the paired t-test or Wilcoxon signed rank sum test* (*where data were not normally distributed). We used SAS 9.4 for Windows and ", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "italic", - }, - ], - "text": "p", - "type": "text", - }, + "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", + "type": "text", + }, + Object { + "marks": Array [ Object { - "text": " < 0.05 was considered significant.", - "type": "text", + "type": "italic", }, ], - "type": "paragraph", + "text": "p", + "type": "text", }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "results", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ Object { - "text": "3", + "text": " = 0.18).", "type": "text", }, ], - "type": "section_label", + "type": "paragraph", }, Object { "attrs": Object { "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", }, "content": Array [ Object { - "text": "RESULTS", + "text": "In 11 patients (31%) in the intervention group cholesterol lowering medication remained unchanged since discharge versus 29 (78%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001).", "type": "text", }, ], - "type": "section_title", + "type": "paragraph", }, Object { "attrs": Object { @@ -76546,35 +11244,33 @@ Object { }, "content": Array [ Object { - "text": "We included 78 patients in the study. Due to revision of stroke diagnoses in four participants and as one participant never turned up for the intervention, data on 73 participants were available for follow up (", + "text": "The combined endpoint of both BP and LDL-cholesterol at target was achieved in 22 (61%) of patients in the intervention group and in 10 patients (27%) in the control group (", "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "label": "", - "rids": Array [ - "MPFigureElement:test", - ], - }, - "type": "cross_reference", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", }, Object { - "text": "). The median stay in hospital was 4 days (IQR: 3–6). As seen from ", + "text": " = 0.003). At the end of the study 24 patients (68%) in the intervention group measured their BP at home versus 14 (38%) of controls (", "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "label": "", - "rids": Array [ - "MPTableElement:test", - ], - }, - "type": "cross_reference", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", }, Object { - "text": " most participants had no or slight disability.", + "text": " = 0.03).", "type": "text", }, ], @@ -76582,62 +11278,31 @@ Object { }, Object { "attrs": Object { - "attribution": undefined, "dataTracked": null, - "id": "MPFigureElement:test", + "id": "MPParagraphElement:test", + "placeholder": "", }, "content": Array [ Object { - "attrs": Object { - "dataTracked": null, - "id": "MPFigure:test", - "src": "BRB3-2019-12-0787-fig-0001.png", - "type": "half-left", - }, - "type": "figure", + "text": "The only significant change in lifestyle was a reduction in current smokers by four in the control group (", + "type": "text", }, Object { "attrs": Object { "dataTracked": null, + "label": "", + "rids": Array [ + "MPTableElement:test", + ], }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Title...", - }, - "type": "caption_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "placeholder": "Caption...", - }, - "content": Array [ - Object { - "text": "Flow chart of participants", - "type": "text", - }, - ], - "type": "caption", - }, - ], - "type": "figcaption", + "type": "cross_reference", }, Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPListing:test", - "isExecuting": false, - "isExpanded": false, - "language": "", - "languageKey": "null", - }, - "type": "listing", + "text": ").", + "type": "text", }, ], - "type": "figure_element", + "type": "paragraph", }, Object { "attrs": Object { @@ -76657,7 +11322,7 @@ Object { }, "content": Array [ Object { - "text": "Baseline characteristics of 73 patients", + "text": "Nine months follow up of 73 patients", "type": "text", }, ], @@ -76782,7 +11447,17 @@ Object { }, "content": Array [ Object { - "text": "Intervention (", + "text": "Intervention", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "type": "hard_break", + }, + Object { + "text": "(", "type": "text", }, Object { @@ -76823,7 +11498,17 @@ Object { }, "content": Array [ Object { - "text": "Control (", + "text": "Control", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "type": "hard_break", + }, + Object { + "text": "(", "type": "text", }, Object { @@ -76891,7 +11576,7 @@ Object { "rowspan": 1, "scope": "row", "style": "border-top: solid 0.50pt", - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -76900,7 +11585,7 @@ Object { }, "content": Array [ Object { - "text": "Sex, female", + "text": "Systolic BP, mm Hg, mean ± SD", "type": "text", }, ], @@ -76919,7 +11604,7 @@ Object { "rowspan": 1, "scope": null, "style": "border-top: solid 0.50pt", - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -76928,7 +11613,7 @@ Object { }, "content": Array [ Object { - "text": "29 (40)", + "text": "134 ± 21", "type": "text", }, ], @@ -76947,7 +11632,7 @@ Object { "rowspan": 1, "scope": null, "style": "border-top: solid 0.50pt", - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -76956,7 +11641,7 @@ Object { }, "content": Array [ Object { - "text": "15 (42)", + "text": "130 ± 17", "type": "text", }, ], @@ -76975,7 +11660,7 @@ Object { "rowspan": 1, "scope": null, "style": "border-top: solid 0.50pt", - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -76984,7 +11669,7 @@ Object { }, "content": Array [ Object { - "text": "14 (38)", + "text": "137 ± 24", "type": "text", }, ], @@ -77003,7 +11688,7 @@ Object { "rowspan": 1, "scope": null, "style": "border-top: solid 0.50pt", - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -77012,7 +11697,7 @@ Object { }, "content": Array [ Object { - "text": "0.74", + "text": "0.12", "type": "text", }, ], @@ -77039,7 +11724,7 @@ Object { "rowspan": 1, "scope": "row", "style": null, - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -77048,7 +11733,7 @@ Object { }, "content": Array [ Object { - "text": "Age (years), mean ± SD", + "text": "Diastolic BP, mm Hg, mean ± SD", "type": "text", }, ], @@ -77067,7 +11752,7 @@ Object { "rowspan": 1, "scope": null, "style": null, - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -77076,7 +11761,7 @@ Object { }, "content": Array [ Object { - "text": "66 ± 12", + "text": "78 ± 11", "type": "text", }, ], @@ -77095,7 +11780,7 @@ Object { "rowspan": 1, "scope": null, "style": null, - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -77104,7 +11789,7 @@ Object { }, "content": Array [ Object { - "text": "63 ± 13", + "text": "78 ± 10", "type": "text", }, ], @@ -77123,7 +11808,7 @@ Object { "rowspan": 1, "scope": null, "style": null, - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -77132,7 +11817,7 @@ Object { }, "content": Array [ Object { - "text": "68 ± 11", + "text": "78 ± 12.8)", "type": "text", }, ], @@ -77151,7 +11836,7 @@ Object { "rowspan": 1, "scope": null, "style": null, - "valign": "middle", + "valign": "top", }, "content": Array [ Object { @@ -77160,7 +11845,7 @@ Object { }, "content": Array [ Object { - "text": "0.08", + "text": "0.94", "type": "text", }, ], @@ -77196,37 +11881,7 @@ Object { }, "content": Array [ Object { - "text": "Length of education", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "< 10 years", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "10 – 12 years", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "> 12 years", + "text": "Antihypertensive medication", "type": "text", }, ], @@ -77254,27 +11909,7 @@ Object { }, "content": Array [ Object { - "text": "12 (17)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "22 (30)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "38 (53)", + "text": "55 (75)", "type": "text", }, ], @@ -77302,27 +11937,7 @@ Object { }, "content": Array [ Object { - "text": "6 (17)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "10 (29)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "19 (54)", + "text": "29 (81)", "type": "text", }, ], @@ -77350,27 +11965,7 @@ Object { }, "content": Array [ Object { - "text": "6 (16)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "12 (33)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "19 (51)", + "text": "26 (70)", "type": "text", }, ], @@ -77398,7 +11993,7 @@ Object { }, "content": Array [ Object { - "text": "0.95", + "text": "0.31", "type": "text", }, ], @@ -77434,37 +12029,20 @@ Object { }, "content": Array [ Object { - "text": "Diagnosis of stroke", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "Ischemic Stroke", + "text": "100% compliance with AHM (", "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "TIA", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "n", "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "Hemorrhagic stroke", + "text": " = 45)", "type": "text", }, ], @@ -77492,27 +12070,7 @@ Object { }, "content": Array [ Object { - "text": "63 (87)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "9 (12)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "1 (1)", + "text": "38 (84)", "type": "text", }, ], @@ -77540,17 +12098,7 @@ Object { }, "content": Array [ Object { - "text": "33 (92)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "3 (8)", + "text": "23 (89)", "type": "text", }, ], @@ -77578,27 +12126,7 @@ Object { }, "content": Array [ Object { - "text": "30 (81)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "6 (16)", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "type": "hard_break", - }, - Object { - "text": "1 (3)", + "text": "15 (79)", "type": "text", }, ], @@ -77626,16 +12154,7 @@ Object { }, "content": Array [ Object { - "text": "0.60", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "superscript", - }, - ], - "text": "a", + "text": "0.38", "type": "text", }, ], @@ -77671,7 +12190,20 @@ Object { }, "content": Array [ Object { - "text": "Recurrent stroke", + "text": "LDL-cholesterol, mmol/l (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "n", + "type": "text", + }, + Object { + "text": " = 72), mean ± SD", "type": "text", }, ], @@ -77699,7 +12231,7 @@ Object { }, "content": Array [ Object { - "text": "11 (15)", + "text": "1.9 ± 0.8", "type": "text", }, ], @@ -77727,7 +12259,7 @@ Object { }, "content": Array [ Object { - "text": "5 (14)", + "text": "1.9 ± 0.7", "type": "text", }, ], @@ -77755,7 +12287,7 @@ Object { }, "content": Array [ Object { - "text": "6 (16)", + "text": "2.0 ± 0.8", "type": "text", }, ], @@ -77783,16 +12315,7 @@ Object { }, "content": Array [ Object { - "text": "1.00", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "superscript", - }, - ], - "text": "a", + "text": "0.66", "type": "text", }, ], @@ -77828,35 +12351,7 @@ Object { }, "content": Array [ Object { - "text": "Modified Rankin Scale score > 2", - "type": "text", - }, - ], - "type": "text_block", - }, - ], - "type": "table_cell", - }, - Object { - "attrs": Object { - "align": "left", - "colspan": 1, - "colwidth": null, - "dataTracked": null, - "placeholder": "Data", - "rowspan": 1, - "scope": null, - "style": null, - "valign": "top", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "5 (6)", + "text": "Cholesterol lowering medication", "type": "text", }, ], @@ -77884,7 +12379,7 @@ Object { }, "content": Array [ Object { - "text": "1 (3)", + "text": "64 (88)", "type": "text", }, ], @@ -77912,7 +12407,7 @@ Object { }, "content": Array [ Object { - "text": "4 (11)", + "text": "32 (89)", "type": "text", }, ], @@ -77940,16 +12435,35 @@ Object { }, "content": Array [ Object { - 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", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. 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", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. 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The recommendations of our national guidelines regarding BP targets were in line with those given by the American Stroke Association in force at the time of initiation of the study: “An absolute target BP level and reduction are uncertain and should be individualized.” ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Following the advice given by the Danish Society of Hypertension we used the following targets: A BP < 140/90 mm Hg was considered at target in non-diabetic patients. In patients aged 80 years or more a BP of 150/90 mm Hg was acceptable if further treatment was not tolerated. In case of severe carotid stenosis or a history of ischemic heart disease BP should not be lower than 130/80 mm Hg. In patients with diabetes or hemorrhagic stroke we aimed at a BP < 130/80 mm Hg. Untreated patients without hypertension were categorized as normotensive, untreated hypertensive patients as having unknown hypertension, treated patients without hypertension as treated to target, and treated patients with hypertension as having untreated hypertension.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "LDL-cholesterol should be < 2.5 mmol/l in patients with IS or TIA in non-diabetic patients and in case of diabetes < 2.0 mmol/l.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "A sample size calculation showed that 24 patients in each group were needed to show a difference of 10 mm Hg in the development of systolic BP (80% power).", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Study sample and setting", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "From June 2012 to February 2013 all patients diagnosed with a stroke or TIA at the stroke unit of Herlev Gentofte Hospital, University of Copenhagen were considered for inclusion in the study. Patients should be without cognitive deficits that would prevent their active participation and they should be discharged to their own home. The last author used computer-generated block randomization procedures with stratification by hypertension (1:1). The allocation sequence was concealed, and we aimed at equal numbers in the two groups. Shortly before discharge the first author approached eligible patients for oral and written information about the study. Where written informed consent to participation was achieved BP was measured before a concealed envelope administered by a secretary was opened revealing the allocation to either intervention or control group.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The research protocol was approved by the ethics committee of the Capital Region of Denmark (H-3-2011–152) and by the Danish Data Protection Agency (2012–41-0429). The study was conducted according to all common ethical standards including the rules given by the Declaration of Helsinki. Patients randomized to the control group had the usual treatment: one visit in the outpatient clinic of the stroke unit three months after discharge. Patients randomized to the intervention group had an appointment with the first author within one week after discharge. 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BP was measured simultaneously in both arms followed by two measurements with 10-min intervals using the arm with the highest systolic BP. In case of hypertension the first author would suggest initiation or intensification of antihypertensive treatment. The last author would accept or suggest an alternative and do the prescription. Patients would come to the clinic for control of BP and relevant blood tests every 3–4 weeks until BP was at target. After five weeks on lipid lowering drugs treatment was intensified if needed. Patients who did not tolerate lipid lowering medication were referred to a dietitian. In motivated patients home BP measurements were performed using patients’ own monitor or by lending patients a BP monitor between visits.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients in the intervention group had a mean of five visits to the clinic with addition of new drugs rather than adding more of the same drug in case of hypertension. Although we used minimum doses to prevent adverse effects, many patients had unacceptable side effects necessitating change to another class of antihypertensive drug.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Patients were informed about the importance of life-long adherence with all preventive medication. Those with elevated BP or receiving antihypertensive treatment were advised in salt reduction, smokers were advised to stop smoking and all patients were informed about the benefits of 30 min of moderate physical activity daily. Likewise, information about the risk of an intake of alcohol above seven drinks per week in women and 14 drinks in men was part of the program as well as the benefits of weight reduction in overweight patients with hypertension or diabetes.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "2.3", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Follow up", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Participants in both groups were invited to the usual follow up visit three months after discharge at the outpatient clinic of the stroke unit as well as a follow up visit in the study a median of 9 (IQR 8–11) months after inclusion.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "In accordance with the protocol the final follow up visits were performed by nurses in the outpatient clinic with measurement of BP and blood-cholesterols. 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", - "type": "text", - }, - Object { - "marks": Array [ - Object { - "type": "superscript", - }, - ], - "text": "d", - "type": "text", - }, - Object { - "text": " Less than 30 min of moderate physical activity per day.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "footnote", + "text": "22 (59)", + "type": "text", + }, + ], + "type": "text_block", + }, + ], + "type": "table_cell", + }, + Object { + "attrs": Object { + "align": "left", + "colspan": 1, + "colwidth": null, + "dataTracked": null, + "placeholder": "Data", + "rowspan": 1, + "scope": null, + "style": null, + "valign": "top", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "0.52", + "type": "text", }, ], - "type": "footnotes_element", + "type": "text_block", }, ], - "type": "table_element_footer", - }, - Object { - "attrs": Object { - "contents": "", - "dataTracked": null, - "id": "MPListing:test", - "isExecuting": false, - "isExpanded": false, - "language": "", - "languageKey": "null", - }, - "type": "listing", + "type": "table_cell", }, ], - "type": "table_element", + "type": "table_row", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", }, "content": Array [ Object { - "text": "Regarding vascular complications and death, we found 32 events in 22 patients after a median of 65 months. Median time to first event was 26 months (IQR: 4–49) with a median of 44 months (IQR: 11–49) in the intervention group and 19 months (IQR: 4–37) in the control group (", - "type": "text", + "attrs": Object { + "align": "left", + "colspan": 1, + "colwidth": null, + "dataTracked": null, + "placeholder": "Data", + "rowspan": 1, + "scope": "row", + "style": "border-bottom: solid 0.50pt", + "valign": "top", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Self-rated health: fair, poor, or very poor", + "type": "text", + }, + ], + "type": "text_block", + }, + ], + "type": "table_cell", }, Object { - "marks": Array [ + "attrs": Object { + "align": "left", + "colspan": 1, + "colwidth": null, + "dataTracked": null, + "placeholder": "Data", + "rowspan": 1, + "scope": null, + "style": "border-bottom: solid 0.50pt", + "valign": "top", + }, + "content": Array [ Object { - "type": "italic", + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "34 (47)", + "type": "text", + }, + ], + "type": "text_block", }, ], - "text": "p", - "type": "text", + "type": "table_cell", }, Object { - "text": " = 0.32). All in all, we found 11 events in nine patients in the intervention group: two recurrent strokes, three cases of TIA, and six patients died versus 21 events in 13 patients in the control group: seven recurrent strokes, five cases of TIA, one MI, and seven patients died (", - "type": "text", + "attrs": Object { + "align": "left", + "colspan": 1, + "colwidth": null, + "dataTracked": null, + "placeholder": "Data", + "rowspan": 1, + "scope": null, + "style": "border-bottom: solid 0.50pt", + "valign": "top", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "15 (43)", + "type": "text", + }, + ], + "type": "text_block", + }, + ], + "type": "table_cell", }, Object { - "marks": Array [ + "attrs": Object { + "align": "left", + "colspan": 1, + "colwidth": null, + "dataTracked": null, + "placeholder": "Data", + "rowspan": 1, + "scope": null, + "style": "border-bottom: solid 0.50pt", + "valign": "top", + }, + "content": Array [ Object { - "type": "italic", + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "19 (51)", + "type": "text", + }, + ], + "type": "text_block", }, ], - "text": "p", - "type": "text", + "type": "table_cell", }, Object { - "text": " = 0.49).", - "type": "text", + "attrs": Object { + "align": "left", + "colspan": 1, + "colwidth": null, + "dataTracked": null, + "placeholder": "Data", + "rowspan": 1, + "scope": null, + "style": "border-bottom: solid 0.50pt", + "valign": "top", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "0.47", + "type": "text", + }, + ], + "type": "text_block", + }, + ], + "type": "table_cell", }, ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "discussion", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "4", - "type": "text", - }, - ], - "type": "section_label", - }, - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "DISCUSSION", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In this randomized clinical trial, a larger proportion of patients in the intervention group compared to controls had BP within the above-mentioned limits and the study fulfilled the aim of the primary endpoint.", - "type": "text", + "type": "table_row", }, ], - "type": "paragraph", + "type": "table", }, Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, "content": Array [ - Object { - "text": "A systematic review of interventions aimed at modifiable risk factor control for secondary prevention of stroke revealed improvement in achieving BP target. ", - "type": "text", - }, Object { "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", + "width": "52.14%", }, - "type": "citation", - }, - Object { - "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", - "type": "text", + "type": "table_col", }, Object { "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", + "width": "11.92%", }, - "type": "citation", - }, - Object { - "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", - "type": "text", + "type": "table_col", }, Object { "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", + "width": "14.9%", }, - "type": "citation", - }, - Object { - "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", - "type": "text", + "type": "table_col", }, Object { "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", + "width": "13.1%", }, - "type": "citation", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", - "type": "text", + "type": "table_col", }, Object { "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", + "width": "7.94%", }, - "type": "citation", - }, - Object { - "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", - "type": "text", + "type": "table_col", }, ], - "type": "paragraph", + "type": "table_colgroup", }, Object { "attrs": Object { - "category": "", "dataTracked": null, - "id": "MPSection:test", + "id": "MPTableElementFooter:test", }, "content": Array [ Object { "attrs": Object { "dataTracked": null, + "id": "MPGeneralTableFootnote:test", }, "content": Array [ Object { - "text": "4.1", - "type": "text", + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Values are expressed as frequencies (%) or as mean ± standard deviations", + "type": "text", + }, + ], + "type": "paragraph", }, ], - "type": "section_label", + "type": "general_table_footnote", }, Object { "attrs": Object { "dataTracked": null, + "id": "MPFootnotesElement:test", + "kind": "footnote", }, "content": Array [ Object { - "text": "Strengths and limitations", - "type": "text", + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Fisher’s exact test. ", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "b", + "type": "text", + }, + Object { + "text": " Less than 600 g of fruit and vegetables per day, fish for dinner less than twice per week. ", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "c", + "type": "text", + }, + Object { + "text": " More than 7 drinks per week in women/more than 14 drinks per week in men. ", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "d", + "type": "text", + }, + Object { + "text": " Less than 30 min of moderate physical activity per day.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", }, ], - "type": "section_title", + "type": "footnotes_element", }, + ], + "type": "table_element_footer", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", + }, + ], + "type": "table_element", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Less than 20% of patients had a baseline BP treated to target (", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPFigureElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": "). Twenty-eight patients (78%) in the intervention group and 29 patients (78%) in the control group had a 3-month visit in the outpatient clinic. Here 15 patients (42%) in the intervention group had their BP and blood cholesterol measured and so had 23 patients (62%) in the control group. At follow up patients in both groups reported a median of two visits including BP measurement at the general practitioner´s office since discharge from hospital.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "attribution": undefined, + "dataTracked": null, + "id": "MPFigureElement:test", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0002.png", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "placeholder": "Title...", }, - "content": Array [ - Object { - "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", - "type": "text", - }, - ], - "type": "paragraph", + "type": "caption_title", }, Object { "attrs": Object { "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "placeholder": "Caption...", }, "content": Array [ Object { - "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPCitation:test", - "rids": Array [ - "MPBibliographyItem:test", - ], - "selectedText": "", - }, - "type": "citation", - }, - Object { - "text": " Five-year follow up on vascular complications and death is another important advantage.", + "text": "Blood pressure and treatment of hypertension at baseline in 73 patients (%)", "type": "text", }, ], - "type": "paragraph", + "type": "caption", }, ], - "type": "section", + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", }, ], - "type": "section", + "type": "figure_element", }, Object { "attrs": Object { - "category": "conclusions", + "category": "", "dataTracked": null, "id": "MPSection:test", }, @@ -83249,7 +18691,7 @@ Object { }, "content": Array [ Object { - "text": "5", + "text": "3.1", "type": "text", }, ], @@ -83261,7 +18703,7 @@ Object { }, "content": Array [ Object { - "text": "CONCLUSIONS", + "text": "Primary endpoint", "type": "text", }, ], @@ -83275,63 +18717,117 @@ Object { }, "content": Array [ Object { - "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", + "text": "Follow up visits showed that 25 patients (69%) in the intervention group had a BP at target versus 14 (38%) of controls (", "type": "text", }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "body", - }, - Object { - "attrs": Object { - "id": "MPSection:test", - "placeholder": " ", - }, - "content": Array [ - Object { - "attrs": Object { - "category": "availability", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ Object { - "text": "DATA AVAILABILITY", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.007). In four patients (10%) in the intervention group antihypertensive medication remained unchanged since discharge versus 23 (62%) of controls (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " < 0.0001) illustrated by the differences in BP treated to target as well as untreated hypertension in ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "label": "", + "rids": Array [ + "MPFigureElement:test", + ], + }, + "type": "cross_reference", + }, + Object { + "text": ".", "type": "text", }, ], - "type": "section_title", + "type": "paragraph", }, Object { "attrs": Object { + "attribution": undefined, "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", + "id": "MPFigureElement:test", }, "content": Array [ Object { - "text": "The data that support the findings of this study are not available due to national privacy or ethical restrictions.", - "type": "text", + "attrs": Object { + "dataTracked": null, + "id": "MPFigure:test", + "src": "BRB3-2019-12-0787-fig-0003.png", + "type": "half-left", + }, + "type": "figure", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Title...", + }, + "type": "caption_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "placeholder": "Caption...", + }, + "content": Array [ + Object { + "text": "Blood pressure and treatment of hypertension at follow up in 73 patients (%)", + "type": "text", + }, + ], + "type": "caption", + }, + ], + "type": "figcaption", + }, + Object { + "attrs": Object { + "contents": "", + "dataTracked": null, + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", + }, + "type": "listing", }, ], - "type": "paragraph", + "type": "figure_element", }, ], "type": "section", }, Object { "attrs": Object { - "category": "con", + "category": "", "dataTracked": null, "id": "MPSection:test", }, @@ -83342,7 +18838,19 @@ Object { }, "content": Array [ Object { - "text": "Contributor Information", + "text": "3.2", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Secondary endpoints", "type": "text", }, ], @@ -83356,25 +18864,33 @@ Object { }, "content": Array [ Object { - "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", + "text": "Median reduction in systolic BP was 11 mm Hg (-5-19) with 14 mm Hg (IQR: 5–21) in the intervention group and 3 mm Hg (IQR -11-17) in the control group (", "type": "text", }, Object { - "attrs": Object { - "dataTracked": null, - "href": "https://orcid.org/0000-0003-2217-5904", - "title": "", - }, - "content": Array [ + "marks": Array [ Object { - "text": "https//orcid.org/0000-0003-2217-5904", - "type": "text", + "type": "italic", }, ], - "type": "link", + "text": "p", + "type": "text", }, Object { - "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", + "text": " = 0.045). Median reduction in diastolic BP was 2 mm Hg (-2-11) with 7 mm Hg (IQR -1-13) in the intervention group and 1 mm Hg (IQR -6-8) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.04).", "type": "text", }, ], @@ -83388,1823 +18904,2742 @@ Object { }, "content": Array [ Object { - "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", + "text": "There was no difference between the groups regarding LDL-cholesterol treated to target with 32 patients (89%) at target in the intervention group versus 29 patients (78%) in the control group (", "type": "text", }, Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", }, Object { - "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", + "text": " = 0.21). We found significant reductions in LDL-cholesterol in both groups, but no difference between the groups: 1.6 (IQR: 0.4–2.2) mmol/l in the intervention group versus 0.8 (IQR: 0.4–1.8) mmol/l among controls (", "type": "text", }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "coi-statement", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ Object { - "text": "CONFLICT OF INTEREST", + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", "type": "text", }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ Object { - "text": "None.", + "text": " = 0.18).", "type": "text", }, ], "type": "paragraph", }, - ], - "type": "section", - }, - Object { - "attrs": Object { - "category": "acknowledgements", - 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Abbreviations: AHM, antihypertensive medication; CLM, cholesterol lowering medication.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "type": "paragraph", + }, ], - "objectType": "MPBibliographicDate", + "type": "general_table_footnote", }, - "literal": undefined, - "page": "1925-1938", - "supplement": undefined, - "title": "2013 Practice guidelines for the management of arterial - hypertension of the European Society of Hypertension (ESH) and the European - Society of Cardiology (ESC): ESH/ESC Task Force for the Management of - Arterial Hypertension.", - "type": "article-journal", - "volume": "31", - }, - "type": "bibliography_item", - }, - Object { - "attrs": Object { - "author": Array [ - Object { - "_id": "MPBibliographicName:test", - "family": "Boan", - "given": "A. - D.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Lackland", - "given": "D. - T.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Ovbiagele", - "given": "B.", - "objectType": "MPBibliographicName", + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnotesElement:test", + "kind": "footnote", }, - ], - "containerTitle": "Stroke", - "dataTracked": null, - "doi": "https://doi.org/10.1161/STROKEAHA.114.003666", - "id": "MPBibliographyItem:test", - "issue": undefined, - "issued": Object { - "_id": "MPBibliographicDate:test", - "date-parts": Array [ - Array [ - "2014", - ], + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPFootnote:test", + "kind": "footnote", + "placeholder": "", + }, + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Fisher’s exact test. ", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "b", + "type": "text", + }, + Object { + "text": " Less than 600 g of fruit and vegetables per day, fish for dinner less than twice per week. ", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "c", + "type": "text", + }, + Object { + "text": " More than 7 drinks per week in women/more than 14 drinks per week in men. ", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "superscript", + }, + ], + "text": "d", + "type": "text", + }, + Object { + "text": " Less than 30 min of moderate physical activity per day.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "footnote", + }, ], - "objectType": "MPBibliographicDate", + "type": "footnotes_element", }, - "literal": undefined, - "page": "2506-2513", - "supplement": undefined, - "title": "Lowering of blood pressure for recurrent - stroke prevention.", - "type": "article-journal", - "volume": "45", - }, - "type": "bibliography_item", + ], + "type": "table_element_footer", }, Object { "attrs": Object { - "author": Array [ - Object { - "_id": "MPBibliographicName:test", - "family": "McAlister", - "given": "F. - A.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Majumdar", - "given": "S. - R.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Padwal", - "given": "R. - S.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Fradette", - "given": "M.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Thompson", - "given": "A.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Buck", - "given": "B.", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "objectType": "MPBibliographicName", - }, - Object { - "_id": "MPBibliographicName:test", - "family": "Shuaib", - "given": "A.", - "objectType": "MPBibliographicName", - }, - ], - "containerTitle": "Canadian Medical Association Journal", + "contents": "", "dataTracked": null, - "doi": "https://doi.org/10.1503/cmaj.140053", - "id": "MPBibliographyItem:test", - "issue": undefined, - "issued": Object { - "_id": "MPBibliographicDate:test", - "date-parts": Array [ - Array [ - "2014", - ], - ], - "objectType": "MPBibliographicDate", - }, - "literal": undefined, - "page": "577-584", - "supplement": undefined, - "title": "Case management for blood pressure and - lipid level control after minor stroke: PREVENTION randomized controlled - trial.", - "type": "article-journal", - "volume": "186", + "id": "MPListing:test", + "isExecuting": false, + "isExpanded": false, + "language": "", + "languageKey": "null", }, - "type": "bibliography_item", + "type": "listing", }, ], - "type": "bibliography_element", + "type": "table_element", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Regarding vascular complications and death, we found 32 events in 22 patients after a median of 65 months. Median time to first event was 26 months (IQR: 4–49) with a median of 44 months (IQR: 11–49) in the intervention group and 19 months (IQR: 4–37) in the control group (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.32). All in all, we found 11 events in nine patients in the intervention group: two recurrent strokes, three cases of TIA, and six patients died versus 21 events in 13 patients in the control group: seven recurrent strokes, five cases of TIA, one MI, and seven patients died (", + "type": "text", + }, + Object { + "marks": Array [ + Object { + "type": "italic", + }, + ], + "text": "p", + "type": "text", + }, + Object { + "text": " = 0.49).", + "type": "text", + }, + ], + "type": "paragraph", }, ], - "type": "bibliography_section", + "type": "section", }, ], - "type": "backmatter", + "type": "section", }, Object { "attrs": Object { - "id": "MPComments:test", + "category": "discussion", + "dataTracked": null, + "id": "MPSection:test", }, "content": Array [ Object { "attrs": Object { - "contents": "eXtyles has not updated the authors because of a name mismatch. Please compare "Jørgensen" with "Jerrgensen". The CrossRef authors are Jerrgensen, H. S., Nakayama, H., Reith, J., Raaschou, H. O., & Olsen, T. S.. (Ref. 4 "Jørgensen, Nakayama, Reith, Raaschou, Olsen, 1997")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", + "dataTracked": null, }, - "type": "comment", + "content": Array [ + Object { + "text": "4", + "type": "text", + }, + ], + "type": "section_label", }, Object { "attrs": Object { - "contents": "eXtyles has not updated this reference because the authors returned by CrossRef are invalid: Girot, M., Mackowiak-Cordoliani, M.-A., Deplanque, D., H�non, H., Lucas, C., & Leys, D. (2005). Secondary prevention after ischemic stroke. Journal of Neurology, 252, 14–20. (Ref. 10 "Girot, Mackowiak-Cordoliani, Deplanque, Hénon, Lucas, Leys, 2005")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", + "dataTracked": null, }, - "type": "comment", + "content": Array [ + Object { + "text": "DISCUSSION", + "type": "text", + }, + ], + "type": "section_title", }, Object { "attrs": Object { - "contents": "Medline reports the journal title should be "Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association or J Stroke Cerebrovasc Dis", not "Journal of Stroke and Cerebrovascular Diseases". (Ref. 17 "Hornnes, Larsen, Boysen, 2011")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", }, - "type": "comment", + "content": Array [ + Object { + "text": "In this randomized clinical trial, a larger proportion of patients in the intervention group compared to controls had BP within the above-mentioned limits and the study fulfilled the aim of the primary endpoint.", + "type": "text", + }, + ], + "type": "paragraph", }, Object { "attrs": Object { - "contents": "CrossRef reports the first page should be "NA", not "579". (Ref. 18 "Johnston, Sidney, Hills, Grosvenor, Klingman, Bernstein, Levin, 2010")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "Medline reports multiple listings for this reference. Please check the reference for accuracy. (Ref. 20 "Fahey, Schroeder, Ebrahim, 2006")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, + "content": Array [ + Object { + "text": "A systematic review of interventions aimed at modifiable risk factor control for secondary prevention of stroke revealed improvement in achieving BP target. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", + "type": "citation", + }, + Object { + "text": " However, as opposed to our study the review showed no significant change in systolic og diastolic BP.", + "type": "text", + }, + ], + "type": "paragraph", }, Object { "attrs": Object { - "contents": "Medline reports the journal title should be "The Cochrane database of systematic reviews or Cochrane Database Syst Rev", not "Cochrane Database of Systematic Reviews". (Ref. 22 "Bridgwood, Lager, Mistri, Khunti, Wilson, Modi, 2018")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", }, - "type": "comment", - }, - Object { - "attrs": Object { - "contents": "CrossRef reports the title is "2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)". (Ref. 23 "Mancia, Fagard, Narkiewicz, Redán, Zanchetti, Böhm, Zannad, . . ., 2013")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, + "content": Array [ + Object { + "text": "In a study of integrated care with five prearranged visits to patients’ general practitioner versus usual care systolic BP at target set to 140 mm Hg was found in 75% versus 58% at 12-month follow up. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", - }, - "type": "comment", + "type": "citation", + }, + Object { + "text": " We set individual targets for BP according to patients’ type of stroke, comorbidities and age. This is well in line with recommendations given by European Society of Hypertension, ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " but as stated by Boan et al., not quite in accordance with international stroke guidelines. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + ], + "type": "paragraph", }, Object { "attrs": Object { - "contents": "Medline reports the journal title should be "CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne or CMAJ", not "Canadian Medical Association Journal". (Ref. 25 "McAlister, Majumdar, Padwal, Fradette, Thompson, Buck, Shuaib, . . ., 2014")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", }, - "type": "comment", + "content": Array [ + Object { + "text": "In a study where patients with minor stroke were randomized to six clinic visits by a pharmacist (intervention) or by a nurse (active control) aiming at treating both BP and LDL-cholesterol to target, 43% of patients in the pharmacist-led clinic met those two targets and so did 31% in the nurse-led clinic. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " In our study this combined endpoint was met in 22 (61%) of patients in the intervention group. Regarding BP in control 80% of patients in the pharmacist led clinic had systolic BP in control after six months versus 90% in the nurse led clinic. This is a far greater proportion than the 69% in our study. However, almost two thirds of patients had a baseline BP within the limits. The opposite was the case in our study with two thirds presenting with elevated BP. Both studies show that a dedicated follow up with stepwise escalation of preventive medication may be the way to reach the targets of the two important risk factors for recurrent stroke. In both studies five-six visits were needed, which is far beyond our usual treatment. However, despite visits to the outpatient clinic as well as to the general practitioner the proportion of patients with unchanged medication since discharge in the control group illustrate the necessity of frequent visits to a dedicated preventive facility. Considering the preventive effect of BP lowering, and - though insignificant - the difference in time to first event as well as the smaller proportion of events in the intervention group as found in our study, it may be well worth the time and resources for patients, their relatives and society.", + "type": "text", + }, + ], + "type": "paragraph", }, Object { "attrs": Object { - "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPParagraphElement:test", + "category": "", + "dataTracked": null, + "id": "MPSection:test", }, - "type": "comment", + "content": Array [ + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "4.1", + "type": "text", + }, + ], + "type": "section_label", + }, + Object { + "attrs": Object { + "dataTracked": null, + }, + "content": Array [ + Object { + "text": "Strengths and limitations", + "type": "text", + }, + ], + "type": "section_title", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "Our study has some limitations. Most participants had a minor stroke and patients had to be independent and without severe cognitive deficits, which is not representative of a general stroke population. With only 73 participants caution is called for in the drawing of conclusions from the results. Nonetheless, we decided to reorganize the outpatient clinic of our stroke unit as of October 2014 implementing strategies of the present study.", + "type": "text", + }, + ], + "type": "paragraph", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", + }, + "content": Array [ + Object { + "text": "The strength of the study is the individual target for BP taking into account the diagnosis of stroke as well as important comorbidity as recommended by Boan et al. ", + "type": "text", + }, + Object { + "attrs": Object { + "dataTracked": null, + "id": "MPCitation:test", + "rids": Array [ + "MPBibliographyItem:test", + ], + "selectedText": "", + }, + "type": "citation", + }, + Object { + "text": " Five-year follow up on vascular complications and death is another important advantage.", + "type": "text", + }, + ], + "type": "paragraph", + }, + ], + "type": "section", }, + ], + "type": "section", + }, + Object { + "attrs": Object { + "category": "conclusions", + "dataTracked": null, + "id": "MPSection:test", + }, + "content": Array [ Object { "attrs": Object { - "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPParagraphElement:test", + "dataTracked": null, }, - "type": "comment", + "content": Array [ + Object { + "text": "5", + "type": "text", + }, + ], + "type": "section_label", }, Object { "attrs": Object { - "contents": "Medline reports the journal title should be "International journal of stroke : official journal of the International Stroke Society or Int J Stroke", not "International Journal of Stroke". (Ref. 13 "Hornnes, Larsen, Boysen, 2010")", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPBibliographyItem:test", + "dataTracked": null, }, - "type": "comment", + "content": Array [ + Object { + "text": "CONCLUSIONS", + "type": "text", + }, + ], + "type": "section_title", }, Object { "attrs": Object { - "contents": "Check meaning - US English uses different spellings for the noun "analyses" (more than one analysis) and the verb form "analyzes"", - "contributions": Array [ - Object { - "_id": "MPContribution:test", - "objectType": "MPContribution", - "profileID": "MPUserProfile:0000000000000000000000000000000000000001", - "timestamp": 1234, - }, - ], - "id": "MPCommentAnnotation:test", - "originalText": "", - "resolved": false, - "selector": undefined, - "target": "MPParagraphElement:test", + "dataTracked": null, + "id": "MPParagraphElement:test", + "placeholder": "", }, - "type": "comment", + "content": Array [ + Object { + "text": "In conclusion, the feasibility study has demonstrated that timely follow up of stroke patients in a dedicated preventive outpatient clinic may result in BP and cholesterol treated to target in most patients. To some extent it may postpone time to stroke recurrence, MI and death.", + "type": "text", + }, + ], + "type": "paragraph", }, ], - "type": "comments", + "type": "section", }, ], - "type": "manuscript", + "type": "body", } `; diff --git a/src/jats/__tests__/jats-importer.test.ts b/src/jats/__tests__/jats-importer.test.ts index 61773e6c..95d8f2fe 100644 --- a/src/jats/__tests__/jats-importer.test.ts +++ b/src/jats/__tests__/jats-importer.test.ts @@ -306,8 +306,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const abstractsNode = findNodeByType(node, schema.nodes.abstracts) expect(abstractsNode).toBeDefined() - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(abstractsNode) + expect(abstractsNode).toMatchSnapshot() }) it("should have an abstracts even if abstarcts element doesn't exist", async () => { @@ -317,8 +317,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const abstractsNode = findNodeByType(node, schema.nodes.abstracts) expect(abstractsNode).toBeDefined() - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(abstractsNode) + expect(abstractsNode).toMatchSnapshot() }) it('should have the correct number of sections', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -331,8 +331,8 @@ describe('JATS importer', () => { const sections = findNodesByType(abstractsNode, schema.nodes.section) // first section is the abstract node expect(sections).toHaveLength(5) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(abstractsNode) + expect(abstractsNode).toMatchSnapshot() }) it('should set the title to Abstract if no title is provided', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -359,8 +359,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const bodyNode = findNodeByType(node, schema.nodes.body) expect(bodyNode).toBeDefined() - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(bodyNode) + expect(bodyNode).toMatchSnapshot() }) it('should have the correct number of sections', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -368,8 +368,8 @@ describe('JATS importer', () => { const bodyNode = findNodeByType(node, schema.nodes.body) const sections = findNodesByType(bodyNode, schema.nodes.section, false) expect(sections).toHaveLength(5) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(bodyNode) + expect(bodyNode).toMatchSnapshot() }) it('should have a body node even if body element does not exist', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -378,8 +378,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const bodyNode = findNodeByType(node, schema.nodes.body) expect(bodyNode).toBeDefined() - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(bodyNode) + expect(bodyNode).toMatchSnapshot() }) }) describe('backmatter', () => { @@ -392,8 +392,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const backNode = findNodeByType(node, schema.nodes.backmatter) expect(backNode).toBeDefined() - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should have appendices section if app-group element exists', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -409,8 +409,8 @@ describe('JATS importer', () => { false ).filter((node) => node.attrs.category === 'appendices') expect(appNode).toHaveLength(1) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should correctly add back sections to the backmatter', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -426,8 +426,8 @@ describe('JATS importer', () => { false ).filter((node) => node.attrs.category === 'availability') expect(availabilitySection).toHaveLength(1) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should create sections for special footnotes', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -450,8 +450,8 @@ describe('JATS importer', () => { expect(con).toHaveLength(1) expect(financialDisclosure).toHaveLength(1) expect(conflict).toHaveLength(1) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should have an endnotes section if either an endnotes section exists or there are footnotes', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -463,8 +463,8 @@ describe('JATS importer', () => { false ) expect(endNotesSection).toHaveLength(1) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should have a references section if ref-list element exists', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -480,8 +480,8 @@ describe('JATS importer', () => { false ) expect(refSection).toHaveLength(1) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should have an acknowledgements section if ack element exists', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -498,8 +498,8 @@ describe('JATS importer', () => { ).filter((node) => node.attrs.category === 'acknowledgements') expect(ackSection).toHaveLength(1) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should parse references correctly', async () => { const jats = await readAndParseFixture('jats-example-full.xml') @@ -524,16 +524,16 @@ describe('JATS importer', () => { bibliographyItems[0].attrs.author[0]._id = 'MPBibliographicName:test' bibliographyItems[0].attrs.issued._id = 'MPBibliographicDate:test' expect(bibliographyItems[0]).toMatchSnapshot() - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should have the correct number of sections', async () => { const jats = await readAndParseFixture('jats-example-full.xml') const { node } = parseJATSArticle(jats, sectionCategories) const backNode = findNodeByType(node, schema.nodes.backmatter) expect(backNode.childCount).toBe(8) - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) it('should have a backmatter node even if back element does not exist', async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -542,8 +542,8 @@ describe('JATS importer', () => { const { node } = parseJATSArticle(jats, sectionCategories) const backNode = findNodeByType(node, schema.nodes.backmatter) expect(backNode).toBeDefined() - changeIDs(node) - expect(node).toMatchSnapshot() + changeIDs(backNode) + expect(backNode).toMatchSnapshot() }) }) From 7d8dc3d0a6a9fc7f328a6500e7cc1076ee8dfab9 Mon Sep 17 00:00:00 2001 From: Mohammad Betamony Date: Wed, 5 Feb 2025 14:40:36 +0300 Subject: [PATCH 3/5] cleanup --- package.json | 6 +- src/jats/importer/jats-journal-meta-parser.ts | 6 +- src/jats/importer/jats-parser-utils.ts | 3 + src/jats/importer/jats-transformations.ts | 283 ++------- src/jats/importer/parse-jats-article.ts | 130 ++-- src/jats/parsers/AbstractsParser.ts | 68 ++ src/jats/parsers/AffiliationsParser.ts | 99 +++ src/jats/parsers/AuthorNotesParser.ts | 87 +++ src/jats/parsers/AwardsParser.ts | 58 ++ src/jats/parsers/BackmatterParser.ts | 62 ++ src/jats/parsers/BodyParser.ts | 38 ++ src/jats/parsers/CommentsParser.ts | 35 ++ src/jats/parsers/ContributorsParser.ts | 113 ++++ .../JatsParser.ts} | 587 ++++-------------- src/jats/parsers/KeywordsParser.ts | 72 +++ src/jats/parsers/ParserFactory.ts | 73 +++ src/jats/parsers/SupplementsParser.ts | 69 ++ src/jats/parsers/TitleParser.ts | 57 ++ src/lib/utils.ts | 4 +- yarn.lock | 22 +- 20 files changed, 1095 insertions(+), 777 deletions(-) create mode 100644 src/jats/parsers/AbstractsParser.ts create mode 100644 src/jats/parsers/AffiliationsParser.ts create mode 100644 src/jats/parsers/AuthorNotesParser.ts create mode 100644 src/jats/parsers/AwardsParser.ts create mode 100644 src/jats/parsers/BackmatterParser.ts create mode 100644 src/jats/parsers/BodyParser.ts create mode 100644 src/jats/parsers/CommentsParser.ts create mode 100644 src/jats/parsers/ContributorsParser.ts rename src/jats/{importer/jats-dom-parser.ts => parsers/JatsParser.ts} (59%) create mode 100644 src/jats/parsers/KeywordsParser.ts create mode 100644 src/jats/parsers/ParserFactory.ts create mode 100644 src/jats/parsers/SupplementsParser.ts create mode 100644 src/jats/parsers/TitleParser.ts diff --git a/package.json b/package.json index 2b913f8f..efd5f1e2 100644 --- a/package.json +++ b/package.json @@ -53,7 +53,7 @@ "@types/jest": "^29.5.12", "@types/lodash.pickby": "^4.6.7", "@types/mime": "^3.0.1", - "@types/node": "^18.11.18", + "@types/node": "^22.12.0", "@types/uuid": "^9.0.0", "@types/w3c-xmlserializer": "^2.0.2", "@typescript-eslint/eslint-plugin": "^5.47.0", @@ -81,6 +81,6 @@ "prosemirror-state": "^1.4.2", "prosemirror-view": "^1.29.1", "rimraf": "^3.0.2", - "typescript": "^4.0.5" + "typescript": "^5.7.3" } -} \ No newline at end of file +} diff --git a/src/jats/importer/jats-journal-meta-parser.ts b/src/jats/importer/jats-journal-meta-parser.ts index ebd307b1..952bc631 100644 --- a/src/jats/importer/jats-journal-meta-parser.ts +++ b/src/jats/importer/jats-journal-meta-parser.ts @@ -16,7 +16,7 @@ import { ObjectTypes } from '@manuscripts/json-schema' -import { getTrimmedTextContent } from '../../lib/utils' +import { trimTextContent } from '../../lib/utils' export type ISSN = { ISSN: string @@ -118,9 +118,9 @@ export const parseJournalMeta = (element: Element | null) => { journalIdentifiers: parseJournalIdentifiers(element), ISSNs: parseJournalISSNs(element), publisherName: - getTrimmedTextContent(element, 'publisher > publisher-name') ?? undefined, + trimTextContent(element, 'publisher > publisher-name') ?? undefined, title: - getTrimmedTextContent(element, 'journal-title-group > journal-title') ?? + trimTextContent(element, 'journal-title-group > journal-title') ?? undefined, } } diff --git a/src/jats/importer/jats-parser-utils.ts b/src/jats/importer/jats-parser-utils.ts index a7d8a0e9..05946592 100644 --- a/src/jats/importer/jats-parser-utils.ts +++ b/src/jats/importer/jats-parser-utils.ts @@ -260,3 +260,6 @@ export const htmlFromJatsNode = ( renameJatsNodesToHTML(element, temp, createElement) return temp.innerHTML?.trim() } + +export const capitalizeFirstLetter = (str: string) => + str.charAt(0).toUpperCase() + str.slice(1) \ No newline at end of file diff --git a/src/jats/importer/jats-transformations.ts b/src/jats/importer/jats-transformations.ts index 55fed028..7c71c1f6 100644 --- a/src/jats/importer/jats-transformations.ts +++ b/src/jats/importer/jats-transformations.ts @@ -14,27 +14,13 @@ * limitations under the License. */ -import { defaultTitle } from '../../lib/deafults' -import { SectionCategory, SectionGroup } from '../../schema' -import { htmlFromJatsNode } from './jats-parser-utils' +import { SectionCategory } from '../../schema' export type CreateElement = (tagName: string) => HTMLElement const removeNodeFromParent = (node: Element) => node.parentNode && node.parentNode.removeChild(node) -const capitalizeFirstLetter = (str: string) => - str.charAt(0).toUpperCase() + str.slice(1) - -const createSectionGroup = ( - type: SectionGroup, - createElement: CreateElement -) => { - const sec = createElement('sec') - sec.setAttribute('sec-type', type) - return sec -} - export const addMissingCaptions = ( doc: Document, createElement: CreateElement @@ -56,81 +42,12 @@ export const addMissingCaptions = ( } } } - -export const moveTitle = (front: Element, createElement: CreateElement) => { - let title = front.querySelector('article-meta > title-group > article-title') - if (title) { - title.innerHTML = htmlFromJatsNode(title, createElement) ?? defaultTitle - } else { - title = createElement('article-title') - title.innerHTML = defaultTitle - } - front.parentNode?.insertBefore(title, front) -} - -export const moveAuthorNotes = ( - front: Element, - createElement: CreateElement -) => { - const authorNotes = front.querySelector('article-meta > author-notes') - if (authorNotes) { - const sectionTitle = createElement('title') - authorNotes.prepend(sectionTitle) - front.parentNode?.insertBefore(authorNotes, front) - } -} -export const moveAwards = (front: Element) => { - const awards = front.querySelector('article-meta > funding-group') - if (awards) { - front.parentNode?.insertBefore(awards, front) - } -} - -export const moveContributors = ( - front: Element, - createElement: CreateElement -) => { - const contribs = front.querySelectorAll( - 'contrib-group > contrib[contrib-type="author"]' - ) - - if (contribs.length) { - const contributors = createElement('contributors') - contribs.forEach((c) => contributors.appendChild(c)) - front.parentNode?.insertBefore(contributors, front) - } -} - -export const moveAffiliations = ( - front: Element, - createElement: CreateElement -) => { - const affs = front.querySelectorAll('article-meta > contrib-group > aff') - if (affs.length) { - const affiliations = createElement('affiliations') - affs.forEach((a) => affiliations.appendChild(a)) - front.parentNode?.insertBefore(affiliations, front) - } -} - -export const moveAbstracts = ( - doc: Document, - group: Element, - createElement: CreateElement -) => { - const abstracts = doc.querySelectorAll('front > article-meta > abstract') - abstracts.forEach((abstract) => { - const sec = createAbstractSection(abstract, createElement) - removeNodeFromParent(abstract) - group.appendChild(sec) - }) -} - export const createBoxedElementSection = ( - body: Element, + doc: Document, createElement: (tagName: string) => HTMLElement ) => { - const boxedTexts = body.querySelectorAll('boxed-text') + const body = doc.querySelector('body') + const boxedTexts = body?.querySelectorAll('boxed-text') || [] for (const boxedText of boxedTexts) { const boxElementId = boxedText.getAttribute('id') const boxElementSec = createElement('sec') @@ -153,53 +70,11 @@ export const createBoxedElementSection = ( } } -export const createBody = ( - doc: Document, - body: Element, - createElement: CreateElement -) => { - const group = createSectionGroup('body', createElement) - const elements = body.querySelectorAll( - ':scope > *:not(sec), :scope > sec:not([sec-type="backmatter"]), :scope > sec:not([sec-type])' - ) - elements.forEach((element) => { - removeNodeFromParent(element) - group.appendChild(element) - }) - moveFloatsGroupToBody(doc, group, createElement) - body.append(group) -} - -export const createAbstracts = ( - doc: Document, - body: Element, - createElement: CreateElement -) => { - const group = createSectionGroup('abstracts', createElement) - moveAbstracts(doc, group, createElement) - body.insertBefore(group, body.lastElementChild) -} - -export const createBackmatter = ( - doc: Document, - body: Element, - sectionCategories: SectionCategory[], - createElement: CreateElement -) => { - const group = createSectionGroup('backmatter', createElement) - moveBackSections(doc, group) - moveAppendices(doc, group, createElement) - moveSpecialFootnotes(doc, group, sectionCategories, createElement) - moveFootnotes(doc, group, createElement) - moveAcknowledgments(doc, group, createElement) - body.append(group) -} - -const moveFootnotes = ( - doc: Document, - group: Element, - createElement: CreateElement -) => { +export const moveFootnotes = (doc: Document, createElement: CreateElement) => { + const group = doc.querySelector('back') + if (!group) { + return + } const fns = [ ...doc.querySelectorAll('fn:not(table-wrap-foot fn, author-notes fn)'), ] @@ -223,13 +98,16 @@ const moveFootnotes = ( } // process footnotes with special meaning to -const moveSpecialFootnotes = ( +export const moveSpecialFootnotes = ( doc: Document, - group: Element, sectionCategories: SectionCategory[], createElement: CreateElement ) => { const fns = [...doc.querySelectorAll('fn[fn-type]')] + const group = doc.querySelector('back') + if (!group) { + return + } for (const fn of fns) { const type = fn.getAttribute('fn-type') || '' //Cannot be null since it is queried above const category = sectionCategories.find((category) => @@ -255,8 +133,8 @@ const moveSpecialFootnotes = ( } } // move captions to the end of their containers -export const moveCaptionsToEnd = (body: Element) => { - const captions = body.querySelectorAll('caption') +export const moveCaptionsToEnd = (doc: Document) => { + const captions = doc.querySelectorAll('caption') for (const caption of captions) { if ( @@ -269,30 +147,6 @@ export const moveCaptionsToEnd = (body: Element) => { } } -const createAbstractSection = ( - abstract: Element, - createElement: CreateElement -) => { - const abstractType = abstract.getAttribute('abstract-type') - - const section = createElement('sec') - const sectionType = abstractType ? `abstract-${abstractType}` : 'abstract' - section.setAttribute('sec-type', sectionType) - - if (!abstract.querySelector(':scope > title')) { - const title = createElement('title') - title.textContent = abstractType - ? `${capitalizeFirstLetter(abstractType)} Abstract` - : 'Abstract' - section.appendChild(title) - } - - while (abstract.firstChild) { - section.appendChild(abstract.firstChild) - } - return section -} - const createAcknowledgmentsSection = ( ack: Element, createElement: CreateElement @@ -338,16 +192,6 @@ const createFootnotesSection = ( return section } -const createAppendicesSection = ( - app: Element, - createElement: CreateElement -) => { - const section = createElement('sec') - section.setAttribute('sec-type', 'appendices') - section.append(...app.children) - return section -} - const createFloatsGroupSection = ( floatsGroup: Element, createElement: CreateElement @@ -363,18 +207,25 @@ const createFloatsGroupSection = ( return section } -const moveBackSections = (doc: Document, group: Element) => { - for (const section of doc.querySelectorAll('back > sec')) { - removeNodeFromParent(section) - group.appendChild(section) +export const moveBackSectionsToStart = (doc: Document) => { + const back = doc.querySelector('back') + if (!back) { + return + } + const sections = Array.from(back.querySelectorAll(':scope > sec')) + for (const section of sections.reverse()) { + back.insertBefore(section, back.firstChild) } } -const moveAcknowledgments = ( +export const moveAcknowledgments = ( doc: Document, - group: Element, createElement: CreateElement ) => { + const group = doc.querySelector('back') + if (!group) { + return + } const ack = doc.querySelector('back > ack') if (ack) { const section = createAcknowledgmentsSection(ack, createElement) @@ -382,78 +233,26 @@ const moveAcknowledgments = ( group.appendChild(section) } } -const moveAppendices = ( - doc: Document, - group: Element, - createElement: CreateElement -) => { - const apps = doc.querySelectorAll('back > app-group > app') - for (const app of apps) { - const section = createAppendicesSection(app, createElement) - removeNodeFromParent(app) - group.appendChild(section) - } -} -const moveFloatsGroupToBody = ( +export const moveFloatsGroupToBody = ( doc: Document, - body: Element, createElement: CreateElement ) => { + const body = doc.querySelector('body') const floatsGroup = doc.querySelector('floats-group') if (floatsGroup) { const sec = createFloatsGroupSection(floatsGroup, createElement) removeNodeFromParent(floatsGroup) - body.appendChild(sec) - } -} - -export const createKeywordsSection = ( - document: Document, - body: Element, - createElement: CreateElement -) => { - const kwdGroups = [...document.querySelectorAll('kwd-group')] - if (kwdGroups.length > 0) { - const section = createElement('sec') - section.setAttribute('sec-type', 'keywords') - const title = createElement('title') - title.textContent = 'Keywords' - section.append(title) - const kwdGroupList = createElement('kwd-group-list') - // Using the first kwd-group since for the moment we only support single kwd-group - kwdGroupList.append(kwdGroups[0]) - section.append(kwdGroupList) - body.prepend(section) - } -} - -export const createSupplementaryMaterialsSection = ( - document: Document, - body: Element, - createElement: CreateElement -) => { - const suppls = [ - ...document.querySelectorAll('article-meta > supplementary-material'), - ] - if (suppls.length) { - const section = createElement('sec') - section.setAttribute('sec-type', 'supplementary-material') - const title = createElement('title') - title.textContent = 'Supplementary Material' - section.append(title) - section.append(...suppls) - body.prepend(section) + body?.appendChild(sec) } } export const moveReferencesToBackmatter = ( - body: Element, - back: Element, + doc: Document, createElement: CreateElement ) => { - const backmatter = body.querySelector('sec[sec-type="backmatter"]') - const refList = back.querySelector('ref-list') + const backmatter = doc.querySelector('back') + const refList = backmatter?.querySelector('ref-list') if (!backmatter || !refList) { return } @@ -470,9 +269,9 @@ export const moveReferencesToBackmatter = ( backmatter.appendChild(section) } -export const orderTableFootnote = (doc: Document, body: Element) => { +export const orderTableFootnote = (doc: Document) => { const rids = new Set( - [...body.querySelectorAll('tbody > xref[ref-type="fn"]')].map((xref) => + [...doc.querySelectorAll('tbody > xref[ref-type="fn"]')].map((xref) => xref.getAttribute('rid') ) ) @@ -487,12 +286,8 @@ export const orderTableFootnote = (doc: Document, body: Element) => { }) } -export const fixTables = ( - doc: Document, - body: Element, - createElement: CreateElement -) => { - const tableWraps = body.querySelectorAll('table-wrap') +export const fixTables = (doc: Document, createElement: CreateElement) => { + const tableWraps = doc.querySelectorAll('table-wrap') tableWraps.forEach((tableWrap) => { // Move cols into a colgroup if they are not already // This more closely maps how they exist in HTML and, subsequently, in ManuscriptJSON diff --git a/src/jats/importer/parse-jats-article.ts b/src/jats/importer/parse-jats-article.ts index a6372395..344e0d32 100644 --- a/src/jats/importer/parse-jats-article.ts +++ b/src/jats/importer/parse-jats-article.ts @@ -14,67 +14,39 @@ * limitations under the License. */ -import { ActualManuscriptNode, schema, SectionCategory } from '../../schema' +import { schema, SectionCategory } from '../../schema' +import { ParserFactory } from '../parsers/ParserFactory' import { markComments } from './jats-comments' -import { JATSDOMParser } from './jats-dom-parser' import { parseJournal } from './jats-journal-meta-parser' import { updateDocumentIDs } from './jats-parser-utils' import { addMissingCaptions, - createAbstracts, - createBackmatter, - createBody, createBoxedElementSection, - createKeywordsSection, - createSupplementaryMaterialsSection, fixTables, - moveAffiliations, - moveAuthorNotes, - moveAwards, + moveAcknowledgments, + moveBackSectionsToStart, moveCaptionsToEnd, - moveContributors, + moveFloatsGroupToBody, + moveFootnotes, moveReferencesToBackmatter, - moveTitle, + moveSpecialFootnotes, orderTableFootnote, } from './jats-transformations' const processJATS = (doc: Document, sectionCategories: SectionCategory[]) => { const createElement = createElementFn(doc) - markComments(doc) - - const front = doc.querySelector('front') - if (!front) { - return - } addMissingCaptions(doc, createElement) - moveTitle(front, createElement) - moveContributors(front, createElement) - moveAffiliations(front, createElement) - moveAuthorNotes(front, createElement) - moveAwards(front) - - const body = doc.querySelector('body') - if (!body) { - return - } - - moveCaptionsToEnd(body) - createBoxedElementSection(body, createElement) - createBody(doc, body, createElement) - createAbstracts(doc, body, createElement) - createBackmatter(doc, body, sectionCategories, createElement) - createSupplementaryMaterialsSection(doc, body, createElement) - createKeywordsSection(doc, body, createElement) - fixTables(doc, body, createElement) - orderTableFootnote(doc, body) - - const back = doc.querySelector('back') - if (!back) { - return - } - - moveReferencesToBackmatter(body, back, createElement) + moveCaptionsToEnd(doc) + createBoxedElementSection(doc, createElement) + moveFloatsGroupToBody(doc, createElement) + moveBackSectionsToStart(doc) + moveSpecialFootnotes(doc, sectionCategories, createElement) + moveFootnotes(doc, createElement) + moveAcknowledgments(doc, createElement) + fixTables(doc, createElement) + orderTableFootnote(doc) + moveReferencesToBackmatter(doc, createElement) } const createElementFn = (doc: Document) => (tagName: string) => @@ -87,15 +59,67 @@ export const parseJATSArticle = ( ) => { const journal = parseJournal(doc) processJATS(doc, sectionCategories) - const node = new JATSDOMParser(sectionCategories, schema).parse(doc) - .firstChild as ActualManuscriptNode - if (!node) { - throw new Error('No content was parsed from the JATS article body') - } + + const factory = new ParserFactory(doc, sectionCategories) + + const titleNode = factory.createTitleParser().parse() + const contributorsNode = factory + .createContributorsParser() + .parse( + Array.from( + doc.querySelectorAll('contrib-group > contrib[contrib-type="author"]') + ) + ) + + const affiliationsNode = factory + .createAffiliationsParser() + .parse( + Array.from(doc.querySelectorAll('article-meta > contrib-group > aff')) + ) + + const authorNotesNode = factory + .createAuthorNotesParser() + .parse(doc.querySelector('article-meta > author-notes')) + const awardsNode = factory + .createAwardsParser() + .parse(doc.querySelector('article-meta > funding-group')) + + const keywordsNode = factory + .createKeywordsParser() + .parse(doc.querySelector('kwd-group')) + + const supplementsNode = factory + .createSupplementsParser() + .parse( + Array.from(doc.querySelectorAll('article-meta > supplementary-material')) + ) + + const abstractsNode = factory + .createAbstractsParser() + .parse(Array.from(doc.querySelectorAll('front > article-meta > abstract'))) + + const bodyNode = factory.createBodyParser().parse(doc.querySelector('body')) + + const backmatterNode = factory + .createBackmatterParser() + .parse(doc.querySelector('back')) + + const content = [ + titleNode, + contributorsNode, + affiliationsNode, + authorNotesNode, + awardsNode, + keywordsNode, + supplementsNode, + abstractsNode, + bodyNode, + backmatterNode, + ].filter((node) => node !== undefined) + + const node = schema.nodes.manuscript.create({}, content) updateDocumentIDs(node) - if (template) { - node.attrs.prototype = template - } + return { node, journal, diff --git a/src/jats/parsers/AbstractsParser.ts b/src/jats/parsers/AbstractsParser.ts new file mode 100644 index 00000000..463e9b5b --- /dev/null +++ b/src/jats/parsers/AbstractsParser.ts @@ -0,0 +1,68 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { DOMParser } from 'prosemirror-model' + +import { NodeRule, SectionCategory } from '../../schema' +import { capitalizeFirstLetter } from '../importer/jats-parser-utils' +import { JatsParser } from './JatsParser' + +export class AbstractsParser extends JatsParser { + parser: DOMParser + + constructor(doc: Document, sectionCategories: SectionCategory[]) { + super(doc, sectionCategories) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.allNodes]) + } + + createAbstractSection = (abstract: Element) => { + const abstractType = abstract.getAttribute('abstract-type') + + const section = this.createElement('sec') + const sectionType = abstractType ? `abstract-${abstractType}` : 'abstract' + section.setAttribute('sec-type', sectionType) + + if (!abstract.querySelector(':scope > title')) { + const title = this.createElement('title') + title.textContent = abstractType + ? `${capitalizeFirstLetter(abstractType)} Abstract` + : 'Abstract' + section.appendChild(title) + } + + while (abstract.firstChild) { + section.appendChild(abstract.firstChild) + } + return section + } + + parse(elements: Element[]) { + const abstracts = this.createElement('abstracts') + for (const element of elements) { + abstracts.appendChild(this.createAbstractSection(element)) + } + + return this.parser.parse(abstracts, { + topNode: this.schema.nodes.abstracts.create(), + }) + } + nodes: NodeRule[] = [ + { + tag: 'sec[sec-type="abstract-graphical"]', + node: 'graphical_abstract_section', + }, + ] +} diff --git a/src/jats/parsers/AffiliationsParser.ts b/src/jats/parsers/AffiliationsParser.ts new file mode 100644 index 00000000..53277f3a --- /dev/null +++ b/src/jats/parsers/AffiliationsParser.ts @@ -0,0 +1,99 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { DOMParser, Fragment } from 'prosemirror-model' + +import { trimTextContent } from '../../lib/utils' +import { ManuscriptNode, NodeRule } from '../../schema' +import { JatsParser } from './JatsParser' + +export class AffiliationsParser extends JatsParser { + parser: DOMParser + + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + parse(elements: Element[]): ManuscriptNode | undefined { + if (!elements.length) { + return + } + const affiliations = this.createElement('affiliations') + for (const element of elements) { + affiliations.appendChild(element) + } + return this.parser.parse(affiliations, { + topNode: this.schema.nodes.affiliations.create(), + }) + } + nodes: NodeRule[] = [ + { + tag: 'aff', + node: 'affiliation', + context: 'affiliations/', + getAttrs: (node) => { + const element = node as HTMLElement + + const { department, institution } = this.getInstitutionDetails(element) + + return { + id: element.getAttribute('id'), + institution: institution ?? '', + department: department ?? '', + addressLine1: this.getAddressLine(element, 1), + addressLine2: this.getAddressLine(element, 2), + addressLine3: this.getAddressLine(element, 3), + postCode: trimTextContent(element, 'postal-code') ?? '', + country: trimTextContent(element, 'country') ?? '', + email: this.getEmail(element), + priority: this.parsePriority(element.getAttribute('priority')), + } + }, + getContent: () => { + return Fragment.from(this.schema.text('_')) + }, + }, + ] + private getAddressLine = (element: HTMLElement, index: number) => { + return trimTextContent(element, `addr-line:nth-of-type(${index})`) || '' + } + protected getEmail = (element: HTMLElement) => { + const email = element.querySelector('email') + if (email) { + return { + href: email.getAttributeNS(this.XLINK_NAMESPACE, 'href') ?? '', + text: trimTextContent(email) ?? '', + } + } + } + protected getInstitutionDetails = (element: HTMLElement) => { + let department = '' + let institution = '' + for (const node of element.querySelectorAll('institution')) { + const content = trimTextContent(node) + if (!content) { + continue + } + const type = node.getAttribute('content-type') + if (type === 'dept') { + department = content + } else { + institution = content + } + } + return { department, institution } + } +} diff --git a/src/jats/parsers/AuthorNotesParser.ts b/src/jats/parsers/AuthorNotesParser.ts new file mode 100644 index 00000000..8a6ba426 --- /dev/null +++ b/src/jats/parsers/AuthorNotesParser.ts @@ -0,0 +1,87 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { DOMParser, Fragment } from 'prosemirror-model' + +import { trimTextContent } from '../../lib/utils' +import { ManuscriptNode, NodeRule } from '../../schema' +import { JatsParser } from './JatsParser' +export class AuthorNotesParser extends JatsParser { + parser: DOMParser + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + parse(element: Element | null): ManuscriptNode | undefined { + if (!element) { + return + } + const sectionTitle = this.createElement('title') + element.prepend(sectionTitle) + return this.parser.parse(element, { + topNode: this.schema.nodes.author_notes.create(), + }) + } + + nodes: NodeRule[] = [ + { + tag: 'title', + node: 'section_title', + }, + { + tag: 'corresp', + node: 'corresp', + getAttrs: (node) => { + const element = node as HTMLElement + const label = element.querySelector('label') + if (label) { + label.remove() + } + return { + id: element.getAttribute('id'), + label: trimTextContent(label), + } + }, + getContent: (node) => { + const element = node as HTMLElement + return Fragment.from(this.schema.text(trimTextContent(element) || '')) + }, + }, + { + tag: 'fn:not([fn-type])', + node: 'footnote', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + kind: 'footnote', + } + }, + }, + { + tag: 'p', + node: 'paragraph', + }, + { + tag: 'label', + ignore: true, + }, + { + tag: 'fn', + ignore: true, + }, + ] +} diff --git a/src/jats/parsers/AwardsParser.ts b/src/jats/parsers/AwardsParser.ts new file mode 100644 index 00000000..947167e2 --- /dev/null +++ b/src/jats/parsers/AwardsParser.ts @@ -0,0 +1,58 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { DOMParser } from 'prosemirror-model' + +import { trimTextContent } from '../../lib/utils' +import { ManuscriptNode, NodeRule } from '../../schema' +import { JatsParser } from './JatsParser' + +export class AwardsParser extends JatsParser { + parser: DOMParser + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + parse(element: Element | null): ManuscriptNode | undefined { + if (!element) { + return + } + return this.parser.parse(element, { + topNode: this.schema.nodes.awards.create(), + }) + } + nodes: NodeRule[] = [ + { + tag: 'funding-group', + node: 'awards', + }, + { + tag: 'award-group', + node: 'award', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + recipient: trimTextContent(element, 'principal-award-recipient'), + code: Array.from(element.querySelectorAll('award-id')) + .map((awardID) => trimTextContent(awardID)) + .reduce((acc, text) => (acc ? `${acc};${text}` : text), ''), + source: trimTextContent(element, 'funding-source'), + } + }, + }, + ] +} diff --git a/src/jats/parsers/BackmatterParser.ts b/src/jats/parsers/BackmatterParser.ts new file mode 100644 index 00000000..1aa6aafe --- /dev/null +++ b/src/jats/parsers/BackmatterParser.ts @@ -0,0 +1,62 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { DOMParser } from 'prosemirror-model' + +import { NodeRule, SectionCategory } from '../../schema' +import { JatsParser } from './JatsParser' + +export class BackmatterParser extends JatsParser { + parser: DOMParser + + constructor(doc: Document, sectionCategories: SectionCategory[]) { + super(doc, sectionCategories) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.allNodes]) + } + + parse(element: Element | null) { + if (!element) { + return this.schema.nodes.backmatter.create() + } + return this.parser.parse(element, { + topNode: this.schema.nodes.backmatter.create(), + }) + } + nodes: NodeRule[] = [ + { + tag: 'app-group > app', + node: 'section', + getAttrs: (node) => { + const element = node as HTMLElement + element.setAttribute('sec-type', 'appendices') + return { + id: element.getAttribute('id'), + category: this.chooseSectionCategory(element), + } + }, + }, + { + tag: 'sec[sec-type="endnotes"]', + node: 'footnotes_section', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + ] +} diff --git a/src/jats/parsers/BodyParser.ts b/src/jats/parsers/BodyParser.ts new file mode 100644 index 00000000..7d6e08a5 --- /dev/null +++ b/src/jats/parsers/BodyParser.ts @@ -0,0 +1,38 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { DOMParser } from 'prosemirror-model' + +import { NodeRule, SectionCategory } from '../../schema' +import { JatsParser } from './JatsParser' + +export class BodyParser extends JatsParser { + parser: DOMParser + + constructor(doc: Document, sectionCategories: SectionCategory[]) { + super(doc, sectionCategories) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.allNodes]) + } + + parse(element: Element | null) { + if (!element) { + return + } + return this.parser.parse(element, { + topNode: this.schema.nodes.body.create(), + }) + } + nodes: NodeRule[] = [] +} diff --git a/src/jats/parsers/CommentsParser.ts b/src/jats/parsers/CommentsParser.ts new file mode 100644 index 00000000..d055d837 --- /dev/null +++ b/src/jats/parsers/CommentsParser.ts @@ -0,0 +1,35 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { DOMParser } from 'prosemirror-model' + +import { NodeRule } from '../../schema' +import { JatsParser } from './JatsParser' + +export class SupplementsParser extends JatsParser { + parser: DOMParser + + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + + parse(element: Element) { + return this.parser.parse(element, { + topNode: this.schema.nodes.supplements.create(), + }) + } + nodes: NodeRule[] = [] +} \ No newline at end of file diff --git a/src/jats/parsers/ContributorsParser.ts b/src/jats/parsers/ContributorsParser.ts new file mode 100644 index 00000000..3e44d942 --- /dev/null +++ b/src/jats/parsers/ContributorsParser.ts @@ -0,0 +1,113 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { ObjectTypes } from '@manuscripts/json-schema' +import { DOMParser, Fragment } from 'prosemirror-model' + +import { trimTextContent } from '../../lib/utils' +import { + ContributorCorresp, + ContributorFootnote, + ManuscriptNode, + NodeRule, +} from '../../schema' +import { JatsParser } from './JatsParser' + +export class ContributorsParser extends JatsParser { + parser: DOMParser + + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + + parse(elements: Element[]): ManuscriptNode | undefined { + if (!elements.length) { + return + } + const contribs = this.createElement('contributors') + for (const element of elements) { + contribs.appendChild(element) + } + return this.parser.parse(contribs, { + topNode: this.schema.nodes.contributors.create(), + }) + } + + nodes: NodeRule[] = [ + { + tag: 'contrib[contrib-type="author"]', + node: 'contributor', + getAttrs: (node) => { + const element = node as HTMLElement + const footnote: ContributorFootnote[] = [] + const affiliations: string[] = [] + const corresp: ContributorCorresp[] = [] + + const xrefs = element.querySelectorAll('xref') + for (const xref of xrefs) { + const rid = xref.getAttribute('rid') + const type = xref.getAttribute('ref-type') + if (!rid) { + continue + } + switch (type) { + case 'fn': + footnote.push({ + noteID: rid, + noteLabel: trimTextContent(xref) || '', + }) + break + case 'corresp': + corresp.push({ + correspID: rid, + correspLabel: trimTextContent(xref) || '', + }) + break + case 'aff': + affiliations.push(rid) + break + } + } + + return { + id: element.getAttribute('id'), + role: 'author', + affiliations, + corresp, + footnote, + isCorresponding: element.getAttribute('corresp') + ? element.getAttribute('corresp') === 'yes' + : undefined, + bibliographicName: { + given: trimTextContent(element, 'name > given-names'), + family: trimTextContent(element, 'name > surname'), + ObjectType: ObjectTypes.BibliographicName, + }, + ORCIDIdentifier: trimTextContent( + element, + 'contrib-id[contrib-id-type="orcid"]' + ), + priority: this.parsePriority(element.getAttribute('priority')), + email: trimTextContent(element, 'email') || '', + } + }, + getContent: () => { + return Fragment.from(this.schema.text('_')) + }, + }, + ] +} diff --git a/src/jats/importer/jats-dom-parser.ts b/src/jats/parsers/JatsParser.ts similarity index 59% rename from src/jats/importer/jats-dom-parser.ts rename to src/jats/parsers/JatsParser.ts index 93b7ed46..0f736630 100644 --- a/src/jats/importer/jats-dom-parser.ts +++ b/src/jats/parsers/JatsParser.ts @@ -1,5 +1,5 @@ /*! - * © 2020 Atypon Systems LLC + * © 2025 Atypon Systems LLC * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. @@ -17,76 +17,93 @@ import { BibliographicName, buildBibliographicDate, - buildBibliographicName, - buildContribution, - ObjectTypes, + buildBibliographicName } from '@manuscripts/json-schema' -import { DOMParser, Fragment, ParseOptions, Schema } from 'prosemirror-model' +import { DOMParser, Fragment } from 'prosemirror-model' -import { dateToTimestamp, getTrimmedTextContent } from '../../lib/utils' +import { trimTextContent } from '../../lib/utils' import { BibliographyItemAttrs, - ContributorCorresp, - ContributorFootnote, ManuscriptNode, MarkRule, NodeRule, + schema, SectionCategory, } from '../../schema' -import { DEFAULT_PROFILE_ID } from './jats-comments' -import { htmlFromJatsNode } from './jats-parser-utils' +import { htmlFromJatsNode } from '../importer/jats-parser-utils' +export type CreateElement = (tagName: string) => HTMLElement -export class JATSDOMParser { - private XLINK_NAMESPACE = 'http://www.w3.org/1999/xlink' - private parser: DOMParser - - constructor( - private sectionCategories: SectionCategory[], - private schema: Schema - ) { - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - - public parse(doc: Node, options?: ParseOptions) { - return this.parser.parse(doc, options) - } +export abstract class JatsParser { + readonly doc: Document + readonly schema = schema + readonly marks: MarkRule[] = [ + { + tag: 'bold', + mark: 'bold', + }, + { + tag: 'code', + mark: 'code', + }, + { + tag: 'italic', + mark: 'italic', + }, + { + tag: 'sc', + mark: 'smallcaps', + }, + { + tag: 'strike', + mark: 'strikethrough', + }, + { + tag: 'styled-content', + mark: 'styled', + getAttrs: (node) => ({ + style: (node as Element).getAttribute('style'), + }), + }, + { + tag: 'sub', + mark: 'subscript', + }, + { + tag: 'sup', + mark: 'superscript', + }, + { + tag: 'underline', + mark: 'underline', + }, + ] + readonly XLINK_NAMESPACE = 'http://www.w3.org/1999/xlink' + protected createElement: CreateElement = (tagName: string) => + this.doc.createElement(tagName) - private isMatchingCategory( - secType: string | null, - titleNode: Element | null, - category: SectionCategory - ) { - if (secType && category.synonyms.includes(secType)) { - return true - } - if (titleNode && titleNode.nodeName === 'title' && titleNode.textContent) { - const textContent = titleNode.textContent.trim().toLowerCase() - if (category.synonyms.includes(textContent)) { - return true - } + // each function that isn't shared, should be moved to its own class + protected parsePriority = (priority: string | null) => { + if (!priority) { + return undefined } - return false + return parseInt(priority) } - private chooseSectionCategory(section: HTMLElement) { + protected chooseSectionCategory(section: HTMLElement) { const secType = section.getAttribute('sec-type') const titleNode = section.firstElementChild - for (const category of this.sectionCategories) { + for (const category of this.sectionCategories || []) { if (this.isMatchingCategory(secType, titleNode, category)) { return category.id } } } - - private parsePriority = (priority: string | null) => { - if (!priority) { - return undefined - } - return parseInt(priority) + protected getHTMLContent = (node: Element, querySelector: string) => { + return htmlFromJatsNode(node.querySelector(querySelector)) } - private getEquationContent = (p: string | HTMLElement) => { + protected getEquationContent = (p: string | HTMLElement) => { const element = p as HTMLElement const id = element.getAttribute('id') const container = element.querySelector('alternatives') ?? element @@ -108,62 +125,6 @@ export class JATSDOMParser { } return { id, format, contents } } - - private parseDates = (historyNode: Element | null) => { - if (!historyNode) { - return undefined - } - const history: { - acceptanceDate?: number - correctionDate?: number - retractionDate?: number - revisionRequestDate?: number - revisionReceiveDate?: number - receiveDate?: number - } = {} - - for (const date of historyNode.children) { - const dateType = date.getAttribute('date-type') - switch (dateType) { - case 'received': { - history.receiveDate = dateToTimestamp(date) - break - } - case 'rev-recd': { - history.revisionReceiveDate = dateToTimestamp(date) - break - } - case 'accepted': { - history.acceptanceDate = dateToTimestamp(date) - break - } - case 'rev-request': { - history.revisionRequestDate = dateToTimestamp(date) - break - } - case 'retracted': { - history.retractionDate = dateToTimestamp(date) - break - } - case 'corrected': { - history.correctionDate = dateToTimestamp(date) - break - } - } - } - return history - } - - private getEmail = (element: HTMLElement) => { - const email = element.querySelector('email') - if (email) { - return { - href: email.getAttributeNS(this.XLINK_NAMESPACE, 'href') ?? '', - text: getTrimmedTextContent(email) ?? '', - } - } - } - private getFigureAttrs = (node: HTMLElement | string | Node) => { const element = node as HTMLElement const parentElement = element.parentElement @@ -176,46 +137,22 @@ export class JATSDOMParser { src: element.getAttributeNS(this.XLINK_NAMESPACE, 'href'), } } - - private getInstitutionDetails = (element: HTMLElement) => { - let department = '' - let institution = '' - for (const node of element.querySelectorAll('institution')) { - const content = getTrimmedTextContent(node) - if (!content) { - continue - } - const type = node.getAttribute('content-type') - if (type === 'dept') { - department = content - } else { - institution = content - } + private isMatchingCategory( + secType: string | null, + titleNode: Element | null, + category: SectionCategory + ) { + if (secType && category.synonyms.includes(secType)) { + return true } - return { department, institution } - } - - private getAddressLine = (element: HTMLElement, index: number) => { - return ( - getTrimmedTextContent(element, `addr-line:nth-of-type(${index})`) || '' - ) - } - - private getHTMLContent = (node: Element, querySelector: string) => { - return htmlFromJatsNode(node.querySelector(querySelector)) - } - - private chooseBibliographyItemType = (publicationType: string | null) => { - switch (publicationType) { - case 'book': - case 'thesis': - return publicationType - case 'journal': - default: - return 'article-journal' + if (titleNode && titleNode.nodeName === 'title' && titleNode.textContent) { + const textContent = titleNode.textContent.trim().toLowerCase() + if (category.synonyms.includes(textContent)) { + return true + } } + return false } - private parseRef = (element: Element) => { const publicationType = element.getAttribute('publication-type') @@ -244,7 +181,7 @@ export class JATSDOMParser { item.nodeType === Node.TEXT_NODE && item.textContent?.match(/[A-Za-z]+/g) ) { - attrs.literal = getTrimmedTextContent(mixedCitation) ?? '' + attrs.literal = trimTextContent(mixedCitation) ?? '' return attrs } }) @@ -255,35 +192,35 @@ export class JATSDOMParser { attrs.containerTitle = source } - const volume = getTrimmedTextContent(element, 'volume') + const volume = trimTextContent(element, 'volume') if (volume) { attrs.volume = volume } - const issue = getTrimmedTextContent(element, 'issue') + const issue = trimTextContent(element, 'issue') if (issue) { attrs.issue = issue } - const supplement = getTrimmedTextContent(element, 'supplement') + const supplement = trimTextContent(element, 'supplement') if (supplement) { attrs.supplement = supplement } - const fpage = getTrimmedTextContent(element, 'fpage') - const lpage = getTrimmedTextContent(element, 'lpage') + const fpage = trimTextContent(element, 'fpage') + const lpage = trimTextContent(element, 'lpage') if (fpage) { attrs.page = lpage ? `${fpage}-${lpage}` : fpage } - const year = getTrimmedTextContent(element, 'year') + const year = trimTextContent(element, 'year') if (year) { attrs.issued = buildBibliographicDate({ 'date-parts': [[year]], }) } - const doi = getTrimmedTextContent(element, 'pub-id[pub-id-type="doi"]') + const doi = trimTextContent(element, 'pub-id[pub-id-type="doi"]') if (doi) { attrs.doi = doi } @@ -291,18 +228,18 @@ export class JATSDOMParser { const authors: BibliographicName[] = [] authorNodes.forEach((authorNode) => { const name = buildBibliographicName({}) - const given = getTrimmedTextContent(authorNode, 'given-names') + const given = trimTextContent(authorNode, 'given-names') if (given) { name.given = given } - const family = getTrimmedTextContent(authorNode, 'surname') + const family = trimTextContent(authorNode, 'surname') if (family) { name.family = family } if (authorNode.nodeName === 'collab') { - name.literal = getTrimmedTextContent(authorNode) + name.literal = trimTextContent(authorNode) } authors.push(name) }) @@ -312,37 +249,18 @@ export class JATSDOMParser { } return attrs } + private chooseBibliographyItemType = (publicationType: string | null) => { + switch (publicationType) { + case 'book': + case 'thesis': + return publicationType + case 'journal': + default: + return 'article-journal' + } + } - private nodes: NodeRule[] = [ - { - tag: 'article', - node: 'manuscript', - getAttrs: (node) => { - const element = node as HTMLElement - const doi = element.querySelector( - 'front > article-meta > article-id[pub-id-type="doi"]' - ) - const history = element.querySelector('history') - const dates = this.parseDates(history) - return { - doi: getTrimmedTextContent(doi), - articleType: element.getAttribute('article-type') ?? '', - primaryLanguageCode: element.getAttribute('lang') ?? '', - ...dates, - } - }, - }, - - { - tag: 'article-title', - node: 'title', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - } - }, - }, + private _commonNodes: NodeRule[] = [ { tag: 'highlight-marker', node: 'highlight_marker', @@ -354,188 +272,10 @@ export class JATSDOMParser { } }, }, - { - tag: 'comment', - node: 'comment', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - target: element.getAttribute('target-id'), - contents: getTrimmedTextContent(element), - contributions: [buildContribution(DEFAULT_PROFILE_ID)], - } - }, - }, - { - tag: 'author-notes', - node: 'author_notes', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'funding-group', - node: 'awards', - }, - { - tag: 'award-group', - node: 'award', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - recipient: getTrimmedTextContent( - element, - 'principal-award-recipient' - ), - code: Array.from(element.querySelectorAll('award-id')) - .map((awardID) => getTrimmedTextContent(awardID)) - .reduce((acc, text) => (acc ? `${acc};${text}` : text), ''), - source: getTrimmedTextContent(element, 'funding-source'), - } - }, - }, - { - tag: 'fn:not([fn-type])', - node: 'footnote', - context: 'author_notes/', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - kind: 'footnote', - } - }, - }, - { - tag: 'corresp', - node: 'corresp', - getAttrs: (node) => { - const element = node as HTMLElement - const label = element.querySelector('label') - if (label) { - label.remove() - } - return { - id: element.getAttribute('id'), - label: getTrimmedTextContent(label), - } - }, - getContent: (node) => { - const element = node as HTMLElement - return Fragment.from( - this.schema.text(getTrimmedTextContent(element) || '') - ) - }, - }, - { - tag: 'contrib[contrib-type="author"]', - node: 'contributor', - getAttrs: (node) => { - const element = node as HTMLElement - const footnote: ContributorFootnote[] = [] - const affiliations: string[] = [] - const corresp: ContributorCorresp[] = [] - - const xrefs = element.querySelectorAll('xref') - for (const xref of xrefs) { - const rid = xref.getAttribute('rid') - const type = xref.getAttribute('ref-type') - if (!rid) { - continue - } - switch (type) { - case 'fn': - footnote.push({ - noteID: rid, - noteLabel: getTrimmedTextContent(xref) || '', - }) - break - case 'corresp': - corresp.push({ - correspID: rid, - correspLabel: getTrimmedTextContent(xref) || '', - }) - break - case 'aff': - affiliations.push(rid) - break - } - } - - return { - id: element.getAttribute('id'), - role: 'author', - affiliations, - corresp, - footnote, - isCorresponding: element.getAttribute('corresp') - ? element.getAttribute('corresp') === 'yes' - : undefined, - bibliographicName: { - given: getTrimmedTextContent(element, 'name > given-names'), - family: getTrimmedTextContent(element, 'name > surname'), - ObjectType: ObjectTypes.BibliographicName, - }, - ORCIDIdentifier: getTrimmedTextContent( - element, - 'contrib-id[contrib-id-type="orcid"]' - ), - priority: this.parsePriority(element.getAttribute('priority')), - email: getTrimmedTextContent(element, 'email') || '', - } - }, - getContent: () => { - return Fragment.from(this.schema.text('_')) - }, - }, - { - tag: 'affiliations', - node: 'affiliations', - }, - { - tag: 'aff', - node: 'affiliation', - context: 'affiliations/', - getAttrs: (node) => { - const element = node as HTMLElement - - const { department, institution } = this.getInstitutionDetails(element) - - return { - id: element.getAttribute('id'), - institution: institution ?? '', - department: department ?? '', - addressLine1: this.getAddressLine(element, 1), - addressLine2: this.getAddressLine(element, 2), - addressLine3: this.getAddressLine(element, 3), - postCode: getTrimmedTextContent(element, 'postal-code') ?? '', - country: getTrimmedTextContent(element, 'country') ?? '', - email: this.getEmail(element), - priority: this.parsePriority(element.getAttribute('priority')), - } - }, - getContent: () => { - return Fragment.from(this.schema.text('_')) - }, - }, - { tag: 'attrib', node: 'attribution', }, - { - tag: 'back', - ignore: true, - }, - { - tag: 'history', - ignore: true, - }, { tag: 'break', node: 'hard_break', @@ -557,14 +297,14 @@ export class JATSDOMParser { const title = element.querySelector('title') if (title) { const captionTitle = schema.nodes.caption_title.create() - content.push(this.parse(title, { topNode: captionTitle })) + content.push(this.parser.parse(title, { topNode: captionTitle })) } const paragraphs = element.querySelectorAll('p') if (paragraphs.length) { const figcaption = schema.nodes.caption.create() for (const paragraph of paragraphs) { - content.push(this.parse(paragraph, { topNode: figcaption })) + content.push(this.parser.parse(paragraph, { topNode: figcaption })) } } @@ -592,7 +332,7 @@ export class JATSDOMParser { return { id: element.getAttribute('id'), language: element.getAttribute('language') ?? '', - contents: getTrimmedTextContent(element), + contents: trimTextContent(element), } }, }, @@ -726,7 +466,7 @@ export class JATSDOMParser { const attribution = attrib ? { - literal: getTrimmedTextContent(attrib) ?? '', + literal: trimTextContent(attrib) ?? '', } : undefined @@ -774,7 +514,7 @@ export class JATSDOMParser { const paragraphs: ManuscriptNode[] = [] node.childNodes.forEach((p) => { const paragraph = this.schema.nodes.paragraph.create() - const content = this.parse(p, { + const content = this.parser.parse(p, { topNode: paragraph, }) paragraphs.push(content) @@ -795,10 +535,6 @@ export class JATSDOMParser { } }, }, - { - tag: 'front', - ignore: true, - }, { tag: 'list', node: 'list', @@ -843,41 +579,6 @@ export class JATSDOMParser { } }, }, - { - tag: 'sec[sec-type="keywords"]', - node: 'keywords', // NOTE: higher priority than 'section' - }, - { - tag: 'sec[sec-type="supplementary-material"]', - node: 'supplements', // NOTE: higher priority than 'section' - }, - { - tag: 'supplementary-material', - node: 'supplement', // NOTE: higher priority than 'section' - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - href: element.getAttributeNS(this.XLINK_NAMESPACE, 'href'), - mimeType: element.getAttribute('mimetype'), - mimeSubType: element.getAttribute('mime-subtype'), - title: getTrimmedTextContent(element, 'title'), - } - }, - }, - { - tag: 'sec[sec-type="abstracts"]', - node: 'abstracts', - }, - { - tag: 'sec[sec-type="body"]', - node: 'body', - }, - { - tag: 'sec[sec-type="backmatter"]', - node: 'backmatter', - }, { tag: 'sec[sec-type="box-element"]', node: 'box_element', @@ -919,28 +620,6 @@ export class JATSDOMParser { } }, }, - { - tag: 'kwd-group-list', - context: 'keywords/', - node: 'keywords_element', - }, - { - tag: 'kwd-group', - context: 'keywords_element/', - node: 'keyword_group', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.id, - type: element.getAttribute('kwd-group-type'), - } - }, - }, - { - tag: 'kwd', - context: 'keyword_group//', - node: 'keyword', - }, { tag: 'boxed-text', ignore: true, @@ -1044,7 +723,7 @@ export class JATSDOMParser { const element = node as HTMLElement return { rids: element.getAttribute('rid')?.split(/\s+/) || [], - contents: getTrimmedTextContent(element), + contents: trimTextContent(element), } }, }, @@ -1075,45 +754,19 @@ export class JATSDOMParser { }, ] - private marks: MarkRule[] = [ - { - tag: 'bold', - mark: 'bold', - }, - { - tag: 'code', - mark: 'code', - }, - { - tag: 'italic', - mark: 'italic', - }, - { - tag: 'sc', - mark: 'smallcaps', - }, - { - tag: 'strike', - mark: 'strikethrough', - }, - { - tag: 'styled-content', - mark: 'styled', - getAttrs: (node) => ({ - style: (node as Element).getAttribute('style'), - }), - }, - { - tag: 'sub', - mark: 'subscript', - }, - { - tag: 'sup', - mark: 'superscript', - }, - { - tag: 'underline', - mark: 'underline', - }, - ] + get allNodes() { + return this.nodes.concat(this._commonNodes) + } + + protected constructor( + doc: Document, + private sectionCategories?: SectionCategory[] + ) { + this.doc = doc + } + abstract parse( + element: Element | null | Element[] | Node | ChildNode + ): ManuscriptNode | undefined + abstract parser: DOMParser + abstract readonly nodes: NodeRule[] } diff --git a/src/jats/parsers/KeywordsParser.ts b/src/jats/parsers/KeywordsParser.ts new file mode 100644 index 00000000..5b650774 --- /dev/null +++ b/src/jats/parsers/KeywordsParser.ts @@ -0,0 +1,72 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { DOMParser } from 'prosemirror-model' + +import { ManuscriptNode, NodeRule } from '../../schema' +import { JatsParser } from './JatsParser' + +export class KeywordsParser extends JatsParser { + parser: DOMParser + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + parse(element: Element | null): ManuscriptNode | undefined { + if (!element) { + return + } + element.querySelector('title')?.remove() + const keywords = this.createElement('keywords') + const title = this.createElement('title') + title.textContent = 'Keywords' + keywords.append(title) + const kwdGroupList = this.createElement('kwd-group-list') + kwdGroupList.append(element) + keywords.append(kwdGroupList) + return this.parser.parse(keywords, { + topNode: this.schema.nodes.keywords.create(), + }) + } + nodes: NodeRule[] = [ + { + tag: 'title', + node: 'section_title', + }, + { + tag: 'keywords', + node: 'keywords', + }, + { + tag: 'kwd-group-list', + node: 'keywords_element', + }, + { + tag: 'kwd-group', + node: 'keywords', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.id, + type: element.getAttribute('kwd-group-type'), + } + }, + }, + { + tag: 'kwd', + node: 'keyword', + }, + ] +} diff --git a/src/jats/parsers/ParserFactory.ts b/src/jats/parsers/ParserFactory.ts new file mode 100644 index 00000000..eec2dd57 --- /dev/null +++ b/src/jats/parsers/ParserFactory.ts @@ -0,0 +1,73 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { SectionCategory } from '../../schema' +import { AbstractsParser } from './AbstractsParser' +import { AffiliationsParser } from './AffiliationsParser' +import { AuthorNotesParser } from './AuthorNotesParser' +import { AwardsParser } from './AwardsParser' +import { BackmatterParser } from './BackmatterParser' +import { BodyParser } from './BodyParser' +import { ContributorsParser } from './ContributorsParser' +import { KeywordsParser } from './KeywordsParser' +import { SupplementsParser } from './SupplementsParser' +import { TitleParser } from './TitleParser' + +export class ParserFactory { + constructor( + private doc: Document, + private sectionCategories: SectionCategory[] + ) {} + + createAbstractsParser() { + return new AbstractsParser(this.doc, this.sectionCategories) + } + + createAffiliationsParser() { + return new AffiliationsParser(this.doc) + } + + createAuthorNotesParser() { + return new AuthorNotesParser(this.doc) + } + + createAwardsParser() { + return new AwardsParser(this.doc) + } + + createBackmatterParser() { + return new BackmatterParser(this.doc, this.sectionCategories) + } + + createBodyParser() { + return new BodyParser(this.doc, this.sectionCategories) + } + + createContributorsParser() { + return new ContributorsParser(this.doc) + } + + createKeywordsParser() { + return new KeywordsParser(this.doc) + } + + createSupplementsParser() { + return new SupplementsParser(this.doc) + } + + createTitleParser() { + return new TitleParser(this.doc) + } +} diff --git a/src/jats/parsers/SupplementsParser.ts b/src/jats/parsers/SupplementsParser.ts new file mode 100644 index 00000000..543aa1b5 --- /dev/null +++ b/src/jats/parsers/SupplementsParser.ts @@ -0,0 +1,69 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { DOMParser } from 'prosemirror-model' + +import { trimTextContent } from '../../lib/utils' +import { NodeRule } from '../../schema' +import { JatsParser } from './JatsParser' + +export class SupplementsParser extends JatsParser { + parser: DOMParser + + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + + parse(elements: Element[]) { + if (!elements.length) { + return + } + const supplements = this.createElement('supplements') + const title = this.createElement('title') + title.textContent = 'Supplementary Material' + supplements.append(title) + supplements.append(...elements) + return this.parser.parse(supplements, { + topNode: this.schema.nodes.supplements.create(), + }) + } + nodes: NodeRule[] = [ + { + tag: 'supplements', + node: 'supplements', + }, + { + tag: 'title', + node: 'section_title', + }, + { + tag: 'supplementary-material', + node: 'supplement', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + href: element.getAttributeNS(this.XLINK_NAMESPACE, 'href'), + mimeType: element.getAttribute('mimetype'), + mimeSubType: element.getAttribute('mime-subtype'), + title: trimTextContent(element, 'title'), + } + }, + }, + ] +} diff --git a/src/jats/parsers/TitleParser.ts b/src/jats/parsers/TitleParser.ts new file mode 100644 index 00000000..3c5842cb --- /dev/null +++ b/src/jats/parsers/TitleParser.ts @@ -0,0 +1,57 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { DOMParser, Fragment } from 'prosemirror-model' + +import { ManuscriptNode, NodeRule } from '../../schema' +import { htmlFromJatsNode } from '../importer/jats-parser-utils' +import { JatsParser } from './JatsParser' + +export class TitleParser extends JatsParser { + private readonly defaultTitle = 'Untitled Manuscript' + private readonly tag = 'article-meta > title-group > article-title' + parser: DOMParser + + constructor(doc: Document) { + super(doc) + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + + parse(): ManuscriptNode { + const node = this.parser.parse(this.doc, { + topNode: this.schema.nodes.title.create(), + }) + return node + } + nodes: NodeRule[] = [ + { + tag: this.tag, + node: 'title', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + } + }, + getContent: (node) => { + const element = node as HTMLElement + return Fragment.from( + htmlFromJatsNode(element) || this.schema.text(this.defaultTitle) + ) + }, + }, + ] +} diff --git a/src/lib/utils.ts b/src/lib/utils.ts index 0788c49b..f9d18eb0 100644 --- a/src/lib/utils.ts +++ b/src/lib/utils.ts @@ -87,7 +87,7 @@ export const findParentNodeClosestToPos = ( } } -export const getTrimmedTextContent = ( +export const trimTextContent = ( node: Element | Document | null, selector?: string ) => { @@ -103,7 +103,7 @@ export const dateToTimestamp = (dateElement: Element) => { const selectors = ['year', 'month', 'day'] const values: Array = [] for (const selector of selectors) { - const value = getTrimmedTextContent(dateElement, selector) + const value = trimTextContent(dateElement, selector) if (!value || isNaN(+value)) { return } diff --git a/yarn.lock b/yarn.lock index 0c381528..c0a1b429 100644 --- a/yarn.lock +++ b/yarn.lock @@ -1790,11 +1790,18 @@ resolved "https://registry.npmjs.org/@types/ms/-/ms-0.7.31.tgz" integrity sha512-iiUgKzV9AuaEkZqkOLDIvlQiL6ltuZd9tGcW3gwpnX8JbuiuhFlEGmmFXEXkN50Cvq7Os88IY2v0dkDqXYWVgA== -"@types/node@*", "@types/node@^18.11.18": +"@types/node@*": version "18.11.18" resolved "https://registry.npmjs.org/@types/node/-/node-18.11.18.tgz" integrity sha512-DHQpWGjyQKSHj3ebjFI/wRKcqQcdR+MoFBygntYOZytCqNfkd2ZC4ARDJ2DQqhjH5p85Nnd3jhUJIXrszFX/JA== +"@types/node@^22.12.0": + version "22.12.0" + resolved "https://registry.yarnpkg.com/@types/node/-/node-22.12.0.tgz#bf8af3b2af0837b5a62a368756ff2b705ae0048c" + integrity sha512-Fll2FZ1riMjNmlmJOdAyY5pUbkftXslB5DgEzlIuNaiWhXd00FhWxVC/r4yV/4wBb9JfImTu+jiSvXTkJ7F/gA== + dependencies: + undici-types "~6.20.0" + "@types/parse-json@^4.0.0": version "4.0.0" resolved "https://registry.npmjs.org/@types/parse-json/-/parse-json-4.0.0.tgz" @@ -6355,10 +6362,10 @@ type-fest@^0.21.3: resolved "https://registry.npmjs.org/type-fest/-/type-fest-0.21.3.tgz" integrity sha512-t0rzBq87m3fVcduHDUFhKmyyX+9eo6WQjZvf51Ea/M0Q7+T374Jp1aUiyUl0GKxp8M/OETVHSDvmkyPgvX+X2w== -typescript@^4.0.5: - version "4.9.4" - resolved "https://registry.npmjs.org/typescript/-/typescript-4.9.4.tgz" - integrity sha512-Uz+dTXYzxXXbsFpM86Wh3dKCxrQqUcVMxwU54orwlJjOpO3ao8L7j5lH+dWfTwgCwIuM9GQ2kvVotzYJMXTBZg== +typescript@^5.7.3: + version "5.7.3" + resolved "https://registry.yarnpkg.com/typescript/-/typescript-5.7.3.tgz#919b44a7dbb8583a9b856d162be24a54bf80073e" + integrity sha512-84MVSjMEHP+FQRPy3pX9sTVV/INIex71s9TL2Gm5FG/WG1SqXeKyZ0k7/blY/4FdOzI12CBy1vGc4og/eus0fw== unbox-primitive@^1.0.2: version "1.0.2" @@ -6370,6 +6377,11 @@ unbox-primitive@^1.0.2: has-symbols "^1.0.3" which-boxed-primitive "^1.0.2" +undici-types@~6.20.0: + version "6.20.0" + resolved "https://registry.yarnpkg.com/undici-types/-/undici-types-6.20.0.tgz#8171bf22c1f588d1554d55bf204bc624af388433" + integrity sha512-Ny6QZ2Nju20vw1SRHe3d9jVu6gJ+4e3+MMpqu7pqE5HT6WsTSlce++GQmK5UXS8mzV8DSYHrQH+Xrf2jVcuKNg== + unicode-canonical-property-names-ecmascript@^2.0.0: version "2.0.0" resolved "https://registry.npmjs.org/unicode-canonical-property-names-ecmascript/-/unicode-canonical-property-names-ecmascript-2.0.0.tgz" From 25aabe471a908306b1aadcd583b62713b6e2f435 Mon Sep 17 00:00:00 2001 From: Mohammad Betamony Date: Mon, 10 Feb 2025 00:11:05 +0300 Subject: [PATCH 4/5] wip --- .../__snapshots__/jats-importer.test.ts.snap | 91 --- src/jats/__tests__/jats-importer.test.ts | 11 +- src/jats/importer/JatsArticleBuilder.ts | 54 ++ src/jats/importer/jats-comments.ts | 113 --- src/jats/importer/jats-journal-meta-parser.ts | 138 ---- src/jats/importer/jats-parser-utils.ts | 6 +- src/jats/importer/jats-transformations.ts | 320 -------- src/jats/importer/parse-jats-article.ts | 124 +-- .../{ => importer}/parsers/AbstractsParser.ts | 26 +- .../parsers/AffiliationsParser.ts | 77 +- .../importer/parsers/AuthorNotesParser.ts | 87 ++ src/jats/importer/parsers/AwardsParser.ts | 52 ++ .../parsers/BackmatterParser.ts | 58 +- src/jats/importer/parsers/BodyParser.ts | 72 ++ src/jats/importer/parsers/CommentsParser.ts | 53 ++ .../importer/parsers/ContributorsParser.ts | 126 +++ src/jats/importer/parsers/JatsParser.ts | 761 +++++++++++++++++ src/jats/importer/parsers/KeywordsParser.ts | 66 ++ src/jats/importer/parsers/ManuscriptParser.ts | 112 +++ src/jats/importer/parsers/ParserFactory.ts | 73 ++ .../parsers/SupplementsParser.ts | 64 +- src/jats/importer/parsers/TitleParser.ts | 53 ++ src/jats/importer/processors/JatsProcessor.ts | 373 +++++++++ .../importer/processors/JournalProcessor.ts | 109 +++ src/jats/parsers/AuthorNotesParser.ts | 87 -- src/jats/parsers/AwardsParser.ts | 58 -- src/jats/parsers/BodyParser.ts | 38 - src/jats/parsers/CommentsParser.ts | 35 - src/jats/parsers/ContributorsParser.ts | 113 --- src/jats/parsers/JatsParser.ts | 772 ------------------ src/jats/parsers/KeywordsParser.ts | 72 -- src/jats/parsers/ParserFactory.ts | 73 -- src/jats/parsers/TitleParser.ts | 57 -- 33 files changed, 2128 insertions(+), 2196 deletions(-) create mode 100644 src/jats/importer/JatsArticleBuilder.ts delete mode 100644 src/jats/importer/jats-comments.ts delete mode 100644 src/jats/importer/jats-journal-meta-parser.ts delete mode 100644 src/jats/importer/jats-transformations.ts rename src/jats/{ => importer}/parsers/AbstractsParser.ts (79%) rename src/jats/{ => importer}/parsers/AffiliationsParser.ts (53%) create mode 100644 src/jats/importer/parsers/AuthorNotesParser.ts create mode 100644 src/jats/importer/parsers/AwardsParser.ts rename src/jats/{ => importer}/parsers/BackmatterParser.ts (55%) create mode 100644 src/jats/importer/parsers/BodyParser.ts create mode 100644 src/jats/importer/parsers/CommentsParser.ts create mode 100644 src/jats/importer/parsers/ContributorsParser.ts create mode 100644 src/jats/importer/parsers/JatsParser.ts create mode 100644 src/jats/importer/parsers/KeywordsParser.ts create mode 100644 src/jats/importer/parsers/ManuscriptParser.ts create mode 100644 src/jats/importer/parsers/ParserFactory.ts rename src/jats/{ => importer}/parsers/SupplementsParser.ts (53%) create mode 100644 src/jats/importer/parsers/TitleParser.ts create mode 100644 src/jats/importer/processors/JatsProcessor.ts create mode 100644 src/jats/importer/processors/JournalProcessor.ts delete mode 100644 src/jats/parsers/AuthorNotesParser.ts delete mode 100644 src/jats/parsers/AwardsParser.ts delete mode 100644 src/jats/parsers/BodyParser.ts delete mode 100644 src/jats/parsers/CommentsParser.ts delete mode 100644 src/jats/parsers/ContributorsParser.ts delete mode 100644 src/jats/parsers/JatsParser.ts delete mode 100644 src/jats/parsers/KeywordsParser.ts delete mode 100644 src/jats/parsers/ParserFactory.ts delete mode 100644 src/jats/parsers/TitleParser.ts diff --git a/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap b/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap index c585d0a9..1e559345 100644 --- a/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap +++ b/src/jats/__tests__/__snapshots__/jats-importer.test.ts.snap @@ -1682,97 +1682,6 @@ Object { } `; -exports[`JATS importer backmatter should have a backmatter node even if back element does not exist 1`] = ` -Object { - "attrs": Object { - "id": "MPSection:test", - "placeholder": " ", - }, - "content": Array [ - Object { - "attrs": Object { - "category": "con", - "dataTracked": null, - "id": "MPSection:test", - }, - "content": Array [ - Object { - "attrs": Object { - "dataTracked": null, - }, - "content": Array [ - Object { - "text": "Contributor Information", - "type": "text", - }, - ], - "type": "section_title", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Agnete Hviid Hornnes, Email: agnete.hviid.hornnes@regionh.dk ", - "type": "text", - }, - Object { - "attrs": Object { - "dataTracked": null, - "href": "https://orcid.org/0000-0003-2217-5904", - "title": "", - }, - "content": Array [ - Object { - "text": "https//orcid.org/0000-0003-2217-5904", - "type": "text", - }, - ], - "type": "link", - }, - Object { - "text": "
Mai Bang Poulsen, Email: mai.bang.poulsen.02@regionh.dk", - "type": "text", - }, - ], - "type": "paragraph", - }, - Object { - "attrs": Object { - "dataTracked": null, - "id": "MPParagraphElement:test", - "placeholder": "", - }, - "content": Array [ - Object { - "text": "Both authors have made substantial contributions to conception and design and acquisitions and analyses", - "type": "text", - }, - Object { - "attrs": Object { - "id": "MPCommentAnnotation:test", - "position": "point", - }, - "type": "highlight_marker", - }, - Object { - "text": " and interpretation of data and have; and been involved in writing the manuscript and given final approval of the version to be published. Both authors have participated sufficiently in the work to take public responsibility for the content; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.", - "type": "text", - }, - ], - "type": "paragraph", - }, - ], - "type": "section", - }, - ], - "type": "backmatter", -} -`; - exports[`JATS importer backmatter should have a references section if ref-list element exists 1`] = ` Object { "attrs": Object { diff --git a/src/jats/__tests__/jats-importer.test.ts b/src/jats/__tests__/jats-importer.test.ts index 95d8f2fe..d543d8ce 100644 --- a/src/jats/__tests__/jats-importer.test.ts +++ b/src/jats/__tests__/jats-importer.test.ts @@ -535,16 +535,7 @@ describe('JATS importer', () => { changeIDs(backNode) expect(backNode).toMatchSnapshot() }) - it('should have a backmatter node even if back element does not exist', async () => { - const jats = await readAndParseFixture('jats-import.xml') - const backEl = jats.querySelector('back') - backEl?.remove() - const { node } = parseJATSArticle(jats, sectionCategories) - const backNode = findNodeByType(node, schema.nodes.backmatter) - expect(backNode).toBeDefined() - changeIDs(backNode) - expect(backNode).toMatchSnapshot() - }) + }) test('parses JATS to Manuscripts document', async () => { diff --git a/src/jats/importer/JatsArticleBuilder.ts b/src/jats/importer/JatsArticleBuilder.ts new file mode 100644 index 00000000..3277bb4f --- /dev/null +++ b/src/jats/importer/JatsArticleBuilder.ts @@ -0,0 +1,54 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { SectionCategory } from '../../schema' +import { JatsParser } from './parsers/JatsParser' +import { ParserFactory } from './parsers/ParserFactory' +import { JournalProcessor } from './processors/JournalProcessor' + +export class JATSArticleBuilder { + private doc: Document + private sectionCategories: SectionCategory[] + private prototype?: string + private parsers: JatsParser[] = [] + private parserFactory: ParserFactory + + constructor( + doc: Document, + sectionCategories: SectionCategory[], + prototype?: string + ) { + this.doc = doc + this.sectionCategories = sectionCategories + this.prototype = prototype + this.parserFactory = new ParserFactory(this.doc, this.sectionCategories) + } + + addParser(type: string): JATSArticleBuilder { + this.parsers.push(this.parserFactory.createParser(type)) + return this + } + + build() { + const node = this.parserFactory + .createManuscriptParser(this.parsers, this.prototype) + .parse() + const journal = JournalProcessor.parse(this.doc) + return { + journal, + node, + } + } +} diff --git a/src/jats/importer/jats-comments.ts b/src/jats/importer/jats-comments.ts deleted file mode 100644 index 93c97e85..00000000 --- a/src/jats/importer/jats-comments.ts +++ /dev/null @@ -1,113 +0,0 @@ -/*! - * © 2020 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { v4 as uuid } from 'uuid' - -import { schema } from '../../schema' -import { generateNodeID } from '../../transformer' - -export const DEFAULT_PROFILE_ID = - 'MPUserProfile:0000000000000000000000000000000000000001' - -const isJATSComment = (node: Node) => { - return ( - node.nodeType === node.PROCESSING_INSTRUCTION_NODE && - node.nodeName === 'AuthorQuery' - ) -} - -const parseJATSComment = (node: Node): string | undefined => { - const text = node.textContent - if (text) { - const queryText = /queryText="(.+)"/.exec(text) - return (queryText && queryText[1]) || undefined - } -} - -const isHighlightable = (node: Element) => { - //todo find a better way to do this - return node.nodeName === 'p' -} - -const findTarget = (node: Element) => { - const target = node.closest('ref, kwd-group') - if (target) { - return target - } - return node -} - -export const markComments = (doc: Document) => { - const root = doc.getRootNode() as Element - const queue: Element[] = [root] - const comments = doc.createElement('comments') - while (queue.length !== 0) { - const node = queue.shift() - if (node) { - if (isJATSComment(node)) { - const text = parseJATSComment(node) - if (text) { - const id = generateNodeID(schema.nodes.comment) - let target - const parent = node.parentNode as Element - if (isHighlightable(parent)) { - const marker = createHighlightMarkerElement(doc, id) - parent.insertBefore(marker, node) - target = parent - } else { - target = findTarget(parent) - } - // if the target has no ID, generate one here and rely on - // updateDocumentIDs to fix it - if (!target.id) { - target.id = uuid() - } - const comment = createCommentElement(doc, id, target.id, text) - comments.appendChild(comment) - } - } - node.childNodes.forEach((child) => { - queue.push(child as Element) - }) - } - } - - if (comments.hasChildNodes()) { - doc.documentElement.appendChild(comments) - } -} - -const createHighlightMarkerElement = (doc: Document, id: string) => { - const highlightMarker = doc.createElement('highlight-marker') - highlightMarker.setAttribute('id', id) - highlightMarker.setAttribute('position', 'point') - return highlightMarker -} - -const createCommentElement = ( - doc: Document, - id: string, - targetID: string | undefined, - text: string -) => { - const commentElement = doc.createElement('comment') - commentElement.setAttribute('id', id) - if (targetID) { - commentElement.setAttribute('target-id', targetID) - } - commentElement.textContent = text - return commentElement -} diff --git a/src/jats/importer/jats-journal-meta-parser.ts b/src/jats/importer/jats-journal-meta-parser.ts deleted file mode 100644 index 952bc631..00000000 --- a/src/jats/importer/jats-journal-meta-parser.ts +++ /dev/null @@ -1,138 +0,0 @@ -/*! - * © 2020 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { ObjectTypes } from '@manuscripts/json-schema' - -import { trimTextContent } from '../../lib/utils' - -export type ISSN = { - ISSN: string - publicationType?: string -} - -export type AbbreviatedTitle = { - abbreviatedTitle: string - abbrevType?: string -} -export type JournalIdentifier = { - journalID: string - journalIDType?: string -} -export const parseJournalIdentifiers = ( - element: Element | null -): JournalIdentifier[] => { - if (!element) { - return [] - } - const output: JournalIdentifier[] = [] - - const ids = element.querySelectorAll('journal-id') - - for (const id of ids) { - const type = id.getAttribute('journal-id-type') - const value = id.textContent?.trim() - - if (!value) { - continue - } - - output.push({ - journalID: value, - journalIDType: type ?? undefined, - }) - } - - return output -} - -export const parseJournalAbbreviatedTitles = ( - element: Element | null -): AbbreviatedTitle[] => { - if (!element) { - return [] - } - const output: AbbreviatedTitle[] = [] - - const titles = element.querySelectorAll( - 'journal-title-group > abbrev-journal-title' - ) - - for (const title of titles) { - const type = title.getAttribute('abbrev-type') - const value = title.textContent?.trim() - - if (!value) { - continue - } - - output.push({ - abbreviatedTitle: value, - abbrevType: type ?? undefined, - }) - } - - return output -} - -export const parseJournalISSNs = (element: Element | null): ISSN[] => { - if (!element) { - return [] - } - const output: ISSN[] = [] - - const issns = element.querySelectorAll('issn') - - for (const issn of issns) { - const type = issn.getAttribute('pub-type') - const value = issn.textContent?.trim() - - if (!value) { - continue - } - - output.push({ - ISSN: value, - publicationType: type ?? undefined, - }) - } - - return output -} - -export const parseJournalMeta = (element: Element | null) => { - return { - abbreviatedTitles: parseJournalAbbreviatedTitles(element), - journalIdentifiers: parseJournalIdentifiers(element), - ISSNs: parseJournalISSNs(element), - publisherName: - trimTextContent(element, 'publisher > publisher-name') ?? undefined, - title: - trimTextContent(element, 'journal-title-group > journal-title') ?? - undefined, - } -} - -export const parseJournal = (doc: Document) => { - const journalMeta = doc.querySelector('journal-meta') - if (!journalMeta) { - return - } - const meta = parseJournalMeta(journalMeta) - return { - ...meta, - objectType: ObjectTypes.Journal, - } -} diff --git a/src/jats/importer/jats-parser-utils.ts b/src/jats/importer/jats-parser-utils.ts index 05946592..243490ed 100644 --- a/src/jats/importer/jats-parser-utils.ts +++ b/src/jats/importer/jats-parser-utils.ts @@ -262,4 +262,8 @@ export const htmlFromJatsNode = ( } export const capitalizeFirstLetter = (str: string) => - str.charAt(0).toUpperCase() + str.slice(1) \ No newline at end of file + str.charAt(0).toUpperCase() + str.slice(1) + +export const getHTMLContent = (node: Element, querySelector: string) => { + return htmlFromJatsNode(node.querySelector(querySelector)) +} \ No newline at end of file diff --git a/src/jats/importer/jats-transformations.ts b/src/jats/importer/jats-transformations.ts deleted file mode 100644 index 7c71c1f6..00000000 --- a/src/jats/importer/jats-transformations.ts +++ /dev/null @@ -1,320 +0,0 @@ -/*! - * © 2020 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { SectionCategory } from '../../schema' - -export type CreateElement = (tagName: string) => HTMLElement - -const removeNodeFromParent = (node: Element) => - node.parentNode && node.parentNode.removeChild(node) - -export const addMissingCaptions = ( - doc: Document, - createElement: CreateElement -) => { - const elements = doc.querySelectorAll('fig, table-wrap, media') - for (const element of elements) { - let caption: Element | null = element.querySelector('caption') - if (!caption) { - caption = createElement('caption') - element.nodeName === 'fig' - ? element.appendChild(caption) - : element.prepend(caption) - } - if (!caption.querySelector('title')) { - caption.prepend(createElement('title')) - } - if (!caption.querySelector('p')) { - caption.appendChild(createElement('p')) - } - } -} -export const createBoxedElementSection = ( - doc: Document, - createElement: (tagName: string) => HTMLElement -) => { - const body = doc.querySelector('body') - const boxedTexts = body?.querySelectorAll('boxed-text') || [] - for (const boxedText of boxedTexts) { - const boxElementId = boxedText.getAttribute('id') - const boxElementSec = createElement('sec') - boxElementSec.setAttribute('sec-type', 'box-element') - if (boxElementId) { - boxElementSec.setAttribute('id', boxElementId) - } - const title = createElement('title') - title.textContent = 'BoxElement' - boxElementSec.append(title) - for (const element of [...boxedText.children]) { - if (element?.tagName === 'label' || element?.tagName === 'caption') { - boxElementSec.append(element) - } - } - const containerSection = createElement('sec') - containerSection.append(...boxedText.children) - boxElementSec.append(containerSection) - boxedText.replaceWith(boxElementSec) - } -} - -export const moveFootnotes = (doc: Document, createElement: CreateElement) => { - const group = doc.querySelector('back') - if (!group) { - return - } - const fns = [ - ...doc.querySelectorAll('fn:not(table-wrap-foot fn, author-notes fn)'), - ] - let section = doc.querySelector('sec[sec-type="endnotes"]') - const fnGroup = - section?.querySelector('fn-group') || createElement('fn-group') - fns.forEach((fn) => { - if (!fn.getAttribute('fn-type')) { - fnGroup.appendChild(fn) - } - }) - if (!section && fnGroup.innerHTML) { - section = createFootnotesSection([fnGroup], createElement) - } - if (section) { - group.insertBefore( - section, - group.firstChild?.nextSibling || group.firstChild - ) - } -} - -// process footnotes with special meaning to -export const moveSpecialFootnotes = ( - doc: Document, - sectionCategories: SectionCategory[], - createElement: CreateElement -) => { - const fns = [...doc.querySelectorAll('fn[fn-type]')] - const group = doc.querySelector('back') - if (!group) { - return - } - for (const fn of fns) { - const type = fn.getAttribute('fn-type') || '' //Cannot be null since it is queried above - const category = sectionCategories.find((category) => - category.synonyms.includes(type) - ) - if (category) { - const section = createElement('sec') - const fnTitle = fn.querySelector('p[content-type="fn-title"]') - if (fnTitle) { - const title = createElement('title') - const titleText = fnTitle.textContent?.trim() - if (titleText) { - title.textContent = titleText - } - removeNodeFromParent(fnTitle) - section.append(title) - } - section.append(...fn.children) - removeNodeFromParent(fn) - section.setAttribute('sec-type', category.id) - group.append(section) - } - } -} -// move captions to the end of their containers -export const moveCaptionsToEnd = (doc: Document) => { - const captions = doc.querySelectorAll('caption') - - for (const caption of captions) { - if ( - caption.parentNode && - caption.parentNode.nodeName !== 'table-wrap' && - caption.parentNode.nodeName !== 'boxed-text' - ) { - caption.parentNode.appendChild(caption) - } - } -} - -const createAcknowledgmentsSection = ( - ack: Element, - createElement: CreateElement -) => { - const section = createElement('sec') - section.setAttribute('sec-type', 'acknowledgments') - - if (!ack.querySelector('title')) { - const title = createElement('title') - title.textContent = 'Acknowledgements' - section.appendChild(title) - } - - while (ack.firstChild) { - section.appendChild(ack.firstChild) - } - return section -} - -const createFootnotesSection = ( - fnGroups: Element[], - createElement: CreateElement -) => { - const section = createElement('sec') - section.setAttribute('sec-type', 'endnotes') - - const titleNode = fnGroups - .map((g) => g.querySelector('title')) - .filter((t) => t !== null)[0] - - if (titleNode) { - section.appendChild(titleNode) - } else { - const title = createElement('title') - title.textContent = 'Footnotes' - section.appendChild(title) - } - - for (const fnGroup of fnGroups) { - section.appendChild(fnGroup) - } - - return section -} - -const createFloatsGroupSection = ( - floatsGroup: Element, - createElement: CreateElement -) => { - const section = createElement('sec') - section.setAttribute('sec-type', 'floating-element') - - const title = createElement('title') - title.textContent = 'Floating Group' - section.appendChild(title) - - section.append(...floatsGroup.children) - return section -} - -export const moveBackSectionsToStart = (doc: Document) => { - const back = doc.querySelector('back') - if (!back) { - return - } - const sections = Array.from(back.querySelectorAll(':scope > sec')) - for (const section of sections.reverse()) { - back.insertBefore(section, back.firstChild) - } -} - -export const moveAcknowledgments = ( - doc: Document, - createElement: CreateElement -) => { - const group = doc.querySelector('back') - if (!group) { - return - } - const ack = doc.querySelector('back > ack') - if (ack) { - const section = createAcknowledgmentsSection(ack, createElement) - removeNodeFromParent(ack) - group.appendChild(section) - } -} - -export const moveFloatsGroupToBody = ( - doc: Document, - createElement: CreateElement -) => { - const body = doc.querySelector('body') - const floatsGroup = doc.querySelector('floats-group') - if (floatsGroup) { - const sec = createFloatsGroupSection(floatsGroup, createElement) - removeNodeFromParent(floatsGroup) - body?.appendChild(sec) - } -} - -export const moveReferencesToBackmatter = ( - doc: Document, - createElement: CreateElement -) => { - const backmatter = doc.querySelector('back') - const refList = backmatter?.querySelector('ref-list') - if (!backmatter || !refList) { - return - } - - removeNodeFromParent(refList) - - const section = createElement('sec') - section.setAttribute('sec-type', 'bibliography') - const title = createElement('title') - title.textContent = 'References' - section.appendChild(title) - section.appendChild(refList) - - backmatter.appendChild(section) -} - -export const orderTableFootnote = (doc: Document) => { - const rids = new Set( - [...doc.querySelectorAll('tbody > xref[ref-type="fn"]')].map((xref) => - xref.getAttribute('rid') - ) - ) - - const fnGroups = doc.querySelectorAll('table-wrap-foot > fn-group') - fnGroups.forEach((fnGroup) => { - // sort the un-cited table footnote at the end of list - const fns = [...fnGroup.querySelectorAll('fn')].sort((fn) => - rids.has(fn.getAttribute('id')) ? -1 : 0 - ) - fnGroup.replaceChildren(...fns) - }) -} - -export const fixTables = (doc: Document, createElement: CreateElement) => { - const tableWraps = doc.querySelectorAll('table-wrap') - tableWraps.forEach((tableWrap) => { - // Move cols into a colgroup if they are not already - // This more closely maps how they exist in HTML and, subsequently, in ManuscriptJSON - const table = tableWrap.querySelector('table') - if (!table) { - return - } - const colgroup = table.querySelector('colgroup') - const cols = table.querySelectorAll('col') - if (!colgroup && table.firstChild && cols.length > 0) { - const colgroup = createElement('colgroup') - for (const col of cols) { - colgroup.appendChild(col) - } - tableWrap.insertBefore(colgroup, table.nextSibling) - } - const tableFootWrap = tableWrap.querySelector('table-wrap-foot') - if (tableFootWrap) { - const paragraphs = tableFootWrap.querySelectorAll(':scope > p') - if (paragraphs.length) { - const generalTableFootnote = createElement('general-table-footnote') - for (const paragraph of paragraphs) { - removeNodeFromParent(paragraph) - generalTableFootnote.append(paragraph) - } - tableFootWrap.prepend(generalTableFootnote) - } - } - }) -} diff --git a/src/jats/importer/parse-jats-article.ts b/src/jats/importer/parse-jats-article.ts index 344e0d32..78f0dc9a 100644 --- a/src/jats/importer/parse-jats-article.ts +++ b/src/jats/importer/parse-jats-article.ts @@ -14,114 +14,28 @@ * limitations under the License. */ -import { schema, SectionCategory } from '../../schema' -import { ParserFactory } from '../parsers/ParserFactory' -import { markComments } from './jats-comments' -import { parseJournal } from './jats-journal-meta-parser' -import { updateDocumentIDs } from './jats-parser-utils' -import { - addMissingCaptions, - createBoxedElementSection, - fixTables, - moveAcknowledgments, - moveBackSectionsToStart, - moveCaptionsToEnd, - moveFloatsGroupToBody, - moveFootnotes, - moveReferencesToBackmatter, - moveSpecialFootnotes, - orderTableFootnote, -} from './jats-transformations' - -const processJATS = (doc: Document, sectionCategories: SectionCategory[]) => { - const createElement = createElementFn(doc) - markComments(doc) - addMissingCaptions(doc, createElement) - moveCaptionsToEnd(doc) - createBoxedElementSection(doc, createElement) - moveFloatsGroupToBody(doc, createElement) - moveBackSectionsToStart(doc) - moveSpecialFootnotes(doc, sectionCategories, createElement) - moveFootnotes(doc, createElement) - moveAcknowledgments(doc, createElement) - fixTables(doc, createElement) - orderTableFootnote(doc) - moveReferencesToBackmatter(doc, createElement) -} - -const createElementFn = (doc: Document) => (tagName: string) => - doc.createElement(tagName) +import { SectionCategory } from '../../schema' +import { JATSArticleBuilder } from './JatsArticleBuilder' export const parseJATSArticle = ( doc: Document, sectionCategories: SectionCategory[], - template?: string + prototype?: string ) => { - const journal = parseJournal(doc) - processJATS(doc, sectionCategories) - - const factory = new ParserFactory(doc, sectionCategories) - - const titleNode = factory.createTitleParser().parse() - const contributorsNode = factory - .createContributorsParser() - .parse( - Array.from( - doc.querySelectorAll('contrib-group > contrib[contrib-type="author"]') - ) - ) - - const affiliationsNode = factory - .createAffiliationsParser() - .parse( - Array.from(doc.querySelectorAll('article-meta > contrib-group > aff')) - ) - - const authorNotesNode = factory - .createAuthorNotesParser() - .parse(doc.querySelector('article-meta > author-notes')) - const awardsNode = factory - .createAwardsParser() - .parse(doc.querySelector('article-meta > funding-group')) - - const keywordsNode = factory - .createKeywordsParser() - .parse(doc.querySelector('kwd-group')) - - const supplementsNode = factory - .createSupplementsParser() - .parse( - Array.from(doc.querySelectorAll('article-meta > supplementary-material')) - ) - - const abstractsNode = factory - .createAbstractsParser() - .parse(Array.from(doc.querySelectorAll('front > article-meta > abstract'))) - - const bodyNode = factory.createBodyParser().parse(doc.querySelector('body')) - - const backmatterNode = factory - .createBackmatterParser() - .parse(doc.querySelector('back')) - - const content = [ - titleNode, - contributorsNode, - affiliationsNode, - authorNotesNode, - awardsNode, - keywordsNode, - supplementsNode, - abstractsNode, - bodyNode, - backmatterNode, - ].filter((node) => node !== undefined) - - const node = schema.nodes.manuscript.create({}, content) - updateDocumentIDs(node) - - return { - node, - journal, - } + const builder = new JATSArticleBuilder(doc, sectionCategories, prototype) + const parsers = [ + 'title', + 'contributors', + 'affiliations', + 'authorNotes', + 'awards', + 'keywords', + 'supplements', + 'abstracts', + 'body', + 'backmatter', + 'comments', + ] + parsers.forEach((type) => builder.addParser(type)) + return builder.build() } diff --git a/src/jats/parsers/AbstractsParser.ts b/src/jats/importer/parsers/AbstractsParser.ts similarity index 79% rename from src/jats/parsers/AbstractsParser.ts rename to src/jats/importer/parsers/AbstractsParser.ts index 463e9b5b..2f7dd5c7 100644 --- a/src/jats/parsers/AbstractsParser.ts +++ b/src/jats/importer/parsers/AbstractsParser.ts @@ -16,15 +16,14 @@ import { DOMParser } from 'prosemirror-model' -import { NodeRule, SectionCategory } from '../../schema' -import { capitalizeFirstLetter } from '../importer/jats-parser-utils' +import { NodeRule } from '../../../schema' +import { capitalizeFirstLetter } from '../jats-parser-utils' import { JatsParser } from './JatsParser' export class AbstractsParser extends JatsParser { - parser: DOMParser + private readonly tag = 'front > article-meta > abstract' - constructor(doc: Document, sectionCategories: SectionCategory[]) { - super(doc, sectionCategories) + protected initParser(): void { this.parser = new DOMParser(this.schema, [...this.marks, ...this.allNodes]) } @@ -49,7 +48,8 @@ export class AbstractsParser extends JatsParser { return section } - parse(elements: Element[]) { + parse() { + const elements = Array.from(this.doc.querySelectorAll(this.tag)) const abstracts = this.createElement('abstracts') for (const element of elements) { abstracts.appendChild(this.createAbstractSection(element)) @@ -59,10 +59,12 @@ export class AbstractsParser extends JatsParser { topNode: this.schema.nodes.abstracts.create(), }) } - nodes: NodeRule[] = [ - { - tag: 'sec[sec-type="abstract-graphical"]', - node: 'graphical_abstract_section', - }, - ] + protected get nodes(): NodeRule[] { + return [ + { + tag: 'sec[sec-type="abstract-graphical"]', + node: 'graphical_abstract_section', + }, + ] + } } diff --git a/src/jats/parsers/AffiliationsParser.ts b/src/jats/importer/parsers/AffiliationsParser.ts similarity index 53% rename from src/jats/parsers/AffiliationsParser.ts rename to src/jats/importer/parsers/AffiliationsParser.ts index 53277f3a..d75ea782 100644 --- a/src/jats/parsers/AffiliationsParser.ts +++ b/src/jats/importer/parsers/AffiliationsParser.ts @@ -14,20 +14,17 @@ * limitations under the License. */ -import { DOMParser, Fragment } from 'prosemirror-model' +import { Fragment } from 'prosemirror-model' -import { trimTextContent } from '../../lib/utils' -import { ManuscriptNode, NodeRule } from '../../schema' +import { trimTextContent } from '../../../lib/utils' +import { ManuscriptNode, NodeRule } from '../../../schema' import { JatsParser } from './JatsParser' export class AffiliationsParser extends JatsParser { - parser: DOMParser + private readonly tag = 'article-meta > contrib-group > aff' - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - parse(elements: Element[]): ManuscriptNode | undefined { + parse(): ManuscriptNode | undefined { + const elements = this.doc.querySelectorAll(this.tag) if (!elements.length) { return } @@ -39,47 +36,49 @@ export class AffiliationsParser extends JatsParser { topNode: this.schema.nodes.affiliations.create(), }) } - nodes: NodeRule[] = [ - { - tag: 'aff', - node: 'affiliation', - context: 'affiliations/', - getAttrs: (node) => { - const element = node as HTMLElement - - const { department, institution } = this.getInstitutionDetails(element) - - return { - id: element.getAttribute('id'), - institution: institution ?? '', - department: department ?? '', - addressLine1: this.getAddressLine(element, 1), - addressLine2: this.getAddressLine(element, 2), - addressLine3: this.getAddressLine(element, 3), - postCode: trimTextContent(element, 'postal-code') ?? '', - country: trimTextContent(element, 'country') ?? '', - email: this.getEmail(element), - priority: this.parsePriority(element.getAttribute('priority')), - } + protected get nodes(): NodeRule[] { + return [ + { + tag: 'aff', + node: 'affiliation', + getAttrs: (node) => { + const element = node as HTMLElement + const { department, institution } = + this.getInstitutionDetails(element) + return { + id: element.getAttribute('id'), + institution: institution ?? '', + department: department ?? '', + addressLine1: this.getAddressLine(element, 1), + addressLine2: this.getAddressLine(element, 2), + addressLine3: this.getAddressLine(element, 3), + postCode: trimTextContent(element, 'postal-code') ?? '', + country: trimTextContent(element, 'country') ?? '', + email: this.getEmail(element), + priority: JatsParser.parsePriority( + element.getAttribute('priority') + ), + } + }, + getContent: () => { + return Fragment.from(this.schema.text('_')) + }, }, - getContent: () => { - return Fragment.from(this.schema.text('_')) - }, - }, - ] + ] + } private getAddressLine = (element: HTMLElement, index: number) => { return trimTextContent(element, `addr-line:nth-of-type(${index})`) || '' } - protected getEmail = (element: HTMLElement) => { + private getEmail = (element: HTMLElement) => { const email = element.querySelector('email') if (email) { return { - href: email.getAttributeNS(this.XLINK_NAMESPACE, 'href') ?? '', + href: email.getAttributeNS(JatsParser.XLINK_NAMESPACE, 'href') ?? '', text: trimTextContent(email) ?? '', } } } - protected getInstitutionDetails = (element: HTMLElement) => { + private getInstitutionDetails = (element: HTMLElement) => { let department = '' let institution = '' for (const node of element.querySelectorAll('institution')) { diff --git a/src/jats/importer/parsers/AuthorNotesParser.ts b/src/jats/importer/parsers/AuthorNotesParser.ts new file mode 100644 index 00000000..29fe4675 --- /dev/null +++ b/src/jats/importer/parsers/AuthorNotesParser.ts @@ -0,0 +1,87 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { Fragment } from 'prosemirror-model' + +import { trimTextContent } from '../../../lib/utils' +import { ManuscriptNode, NodeRule } from '../../../schema' +import { JatsParser } from './JatsParser' +export class AuthorNotesParser extends JatsParser { + private readonly tag = 'article-meta > author-notes' + + parse(): ManuscriptNode | undefined { + const element = this.doc.querySelector(this.tag) + if (!element) { + return + } + const sectionTitle = this.createElement('title') + element.prepend(sectionTitle) + return this.parser.parse(element, { + topNode: this.schema.nodes.author_notes.create(), + }) + } + + protected get nodes(): NodeRule[] { + return [ + { + tag: 'title', + node: 'section_title', + }, + { + tag: 'corresp', + node: 'corresp', + getAttrs: (node) => { + const element = node as HTMLElement + const label = element.querySelector('label') + if (label) { + label.remove() + } + return { + id: element.getAttribute('id'), + label: trimTextContent(label), + } + }, + getContent: (node) => { + const element = node as HTMLElement + return Fragment.from(this.schema.text(trimTextContent(element) || '')) + }, + }, + { + tag: 'fn:not([fn-type])', + node: 'footnote', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + kind: 'footnote', + } + }, + }, + { + tag: 'p', + node: 'paragraph', + }, + { + tag: 'label', + ignore: true, + }, + { + tag: 'fn', + ignore: true, + }, + ] + } +} diff --git a/src/jats/importer/parsers/AwardsParser.ts b/src/jats/importer/parsers/AwardsParser.ts new file mode 100644 index 00000000..3d59c042 --- /dev/null +++ b/src/jats/importer/parsers/AwardsParser.ts @@ -0,0 +1,52 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + + +import { trimTextContent } from '../../../lib/utils' +import { ManuscriptNode, NodeRule } from '../../../schema' +import { JatsParser } from './JatsParser' + +export class AwardsParser extends JatsParser { + private readonly tag = 'article-meta > funding-group' + parse(): ManuscriptNode | undefined { + const element = this.doc.querySelector(this.tag) + if (!element) { + return + } + return this.parser.parse(element, { + topNode: this.schema.nodes.awards.create(), + }) + } + protected get nodes(): NodeRule[] { + return [ + { + tag: 'award-group', + node: 'award', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + recipient: trimTextContent(element, 'principal-award-recipient'), + code: Array.from(element.querySelectorAll('award-id')) + .map((awardID) => trimTextContent(awardID)) + .reduce((acc, text) => (acc ? `${acc};${text}` : text), ''), + source: trimTextContent(element, 'funding-source'), + } + }, + }, + ] + } +} diff --git a/src/jats/parsers/BackmatterParser.ts b/src/jats/importer/parsers/BackmatterParser.ts similarity index 55% rename from src/jats/parsers/BackmatterParser.ts rename to src/jats/importer/parsers/BackmatterParser.ts index 1aa6aafe..a8766330 100644 --- a/src/jats/parsers/BackmatterParser.ts +++ b/src/jats/importer/parsers/BackmatterParser.ts @@ -15,18 +15,17 @@ */ import { DOMParser } from 'prosemirror-model' -import { NodeRule, SectionCategory } from '../../schema' +import { NodeRule } from '../../../schema' import { JatsParser } from './JatsParser' export class BackmatterParser extends JatsParser { - parser: DOMParser - - constructor(doc: Document, sectionCategories: SectionCategory[]) { - super(doc, sectionCategories) + private readonly tag = 'back' + protected initParser(): void { this.parser = new DOMParser(this.schema, [...this.marks, ...this.allNodes]) } - parse(element: Element | null) { + parse() { + const element = this.doc.querySelector(this.tag) if (!element) { return this.schema.nodes.backmatter.create() } @@ -34,29 +33,30 @@ export class BackmatterParser extends JatsParser { topNode: this.schema.nodes.backmatter.create(), }) } - nodes: NodeRule[] = [ - { - tag: 'app-group > app', - node: 'section', - getAttrs: (node) => { - const element = node as HTMLElement - element.setAttribute('sec-type', 'appendices') - return { - id: element.getAttribute('id'), - category: this.chooseSectionCategory(element), - } + protected get nodes(): NodeRule[] { + return [ + { tag: 'bio', ignore: true }, + { + tag: 'app-group > app', + node: 'section', + getAttrs: (node) => { + const element = node as HTMLElement + element.setAttribute('sec-type', 'appendices') + return { + category: this.chooseSectionCategory(element), + } + }, }, - }, - { - tag: 'sec[sec-type="endnotes"]', - node: 'footnotes_section', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } + { + tag: 'sec[sec-type="endnotes"]', + node: 'footnotes_section', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + } + }, }, - }, - ] + ] + } } diff --git a/src/jats/importer/parsers/BodyParser.ts b/src/jats/importer/parsers/BodyParser.ts new file mode 100644 index 00000000..71e8cf6b --- /dev/null +++ b/src/jats/importer/parsers/BodyParser.ts @@ -0,0 +1,72 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { DOMParser } from 'prosemirror-model' + +import { trimTextContent } from '../../../lib/utils' +import { NodeRule } from '../../../schema' +import { JatsParser } from './JatsParser' + +export class BodyParser extends JatsParser { + private readonly tag = 'body' + + protected initParser(): void { + this.parser = new DOMParser(this.schema, [...this.marks, ...this.allNodes]) + } + parse() { + const element = this.doc.querySelector(this.tag) + if (!element) { + return this.schema.nodes.body.create() + } + return this.parser.parse(element, { + topNode: this.schema.nodes.body.create(), + }) + } + protected get nodes(): NodeRule[] { + return [ + { + tag: 'sec[sec-type="supplementary-material"]', + node: 'supplements', + }, + { + tag: 'supplementary-material', + node: 'supplement', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + href: element.getAttributeNS(JatsParser.XLINK_NAMESPACE, 'href'), + mimeType: element.getAttribute('mimetype'), + mimeSubType: element.getAttribute('mime-subtype'), + title: trimTextContent(element, 'title'), + } + }, + }, + { + tag: 'app-group > app', + node: 'section', + getAttrs: (node) => { + const element = node as HTMLElement + element.setAttribute('sec-type', 'appendices') + return { + id: element.getAttribute('id'), + category: this.chooseSectionCategory(element), + } + }, + }, + ] + } +} diff --git a/src/jats/importer/parsers/CommentsParser.ts b/src/jats/importer/parsers/CommentsParser.ts new file mode 100644 index 00000000..87f9892c --- /dev/null +++ b/src/jats/importer/parsers/CommentsParser.ts @@ -0,0 +1,53 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { buildContribution } from '@manuscripts/json-schema' + +import { trimTextContent } from '../../../lib/utils' +import { NodeRule } from '../../../schema' +import { JatsParser } from './JatsParser' + +export class CommentsParser extends JatsParser { + private readonly tag = 'comments' + private readonly DEFAULT_PROFILE_ID = + 'MPUserProfile:0000000000000000000000000000000000000001' + + parse() { + const element = this.doc.querySelector(this.tag) + if (!element) { + return this.schema.nodes.comments.create() + } + return this.parser.parse(element, { + topNode: this.schema.nodes.comments.create(), + }) + } + protected get nodes(): NodeRule[] { + return [ + { + tag: 'comment', + node: 'comment', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + target: element.getAttribute('target-id'), + contents: trimTextContent(element), + contributions: [buildContribution(this.DEFAULT_PROFILE_ID)], + } + }, + }, + ] + } +} diff --git a/src/jats/importer/parsers/ContributorsParser.ts b/src/jats/importer/parsers/ContributorsParser.ts new file mode 100644 index 00000000..7ffe922d --- /dev/null +++ b/src/jats/importer/parsers/ContributorsParser.ts @@ -0,0 +1,126 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { ObjectTypes } from '@manuscripts/json-schema' +import { Fragment } from 'prosemirror-model' + +import { trimTextContent } from '../../../lib/utils' +import { + ContributorCorresp, + ContributorFootnote, + ManuscriptNode, + NodeRule, +} from '../../../schema' +import { JatsParser } from './JatsParser' + +export class ContributorsParser extends JatsParser { + private readonly tag = 'contrib-group > contrib[contrib-type="author"]' + + parse(): ManuscriptNode | undefined { + const elements = this.doc.querySelectorAll(this.tag) + if (!elements.length) { + return + } + const contributors = this.createElement('contributors') + for (const element of elements) { + contributors.appendChild(element) + } + return this.parser.parse(contributors, { + topNode: this.schema.nodes.contributors.create(), + }) + } + + private extractFootnotes(element: HTMLElement): ContributorFootnote[] { + const fnXrefs = element.querySelectorAll('xref[ref-type="fn"]') + return Array.from(fnXrefs) + .map((xref) => { + const rid = xref.getAttribute('rid') + if (rid) { + return { + noteID: rid, + noteLabel: trimTextContent(xref) || '', + } + } + }) + .filter((xref) => xref !== undefined) + } + private extractAffiliations(element: HTMLElement): string[] { + const affiliationsXrefs = element.querySelectorAll('xref[ref-type="aff"]') + return Array.from(affiliationsXrefs) + .map((xref) => { + const rid = xref.getAttribute('rid') + if (rid) { + return rid + } + }) + .filter((xref) => xref !== undefined) + } + private extractCorrespondences(element: HTMLElement): ContributorCorresp[] { + const correspXrefs = element.querySelectorAll('xref[ref-type="corresp"]') + return Array.from(correspXrefs) + .map((xref) => { + const rid = xref.getAttribute('rid') + if (rid) { + return { + correspID: rid, + correspLabel: trimTextContent(xref) || '', + } + } + }) + .filter((xref) => xref !== undefined) + } + private extractBibliographicName(element: HTMLElement) { + return { + given: trimTextContent(element, 'name > given-names'), + family: trimTextContent(element, 'name > surname'), + ObjectType: ObjectTypes.BibliographicName, + } + } + protected get nodes(): NodeRule[] { + return [ + { + tag: 'contrib[contrib-type="author"]', + node: 'contributor', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + role: 'author', + affiliations: this.extractAffiliations(element), + corresp: this.extractCorrespondences(element), + footnote: this.extractFootnotes(element), + isCorresponding: element.getAttribute('corresp') + ? element.getAttribute('corresp') === 'yes' + : undefined, + bibliographicName: this.extractBibliographicName(element), + ORCIDIdentifier: trimTextContent( + element, + 'contrib-id[contrib-id-type="orcid"]' + ), + priority: JatsParser.parsePriority( + element.getAttribute('priority') + ), + email: trimTextContent(element, 'email') || '', + } + }, + getContent: () => { + return Fragment.from(this.schema.text('_')) + }, + }, + ] + } +} diff --git a/src/jats/importer/parsers/JatsParser.ts b/src/jats/importer/parsers/JatsParser.ts new file mode 100644 index 00000000..5454d66a --- /dev/null +++ b/src/jats/importer/parsers/JatsParser.ts @@ -0,0 +1,761 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { + BibliographicName, + buildBibliographicDate, + buildBibliographicName, +} from '@manuscripts/json-schema' +import { DOMParser, Fragment } from 'prosemirror-model' + +import { trimTextContent } from '../../../lib/utils' +import { + BibliographyItemAttrs, + ManuscriptNode, + MarkRule, + NodeRule, + schema, + SectionCategory, +} from '../../../schema' +import { getHTMLContent } from '../jats-parser-utils' +export abstract class JatsParser { + protected readonly doc: Document + protected readonly schema = schema + protected parser: DOMParser + protected static readonly XLINK_NAMESPACE = 'http://www.w3.org/1999/xlink' + protected readonly sectionCategories: SectionCategory[] + abstract parse(): ManuscriptNode | undefined + + constructor(doc: Document, sectionCategories?: SectionCategory[]) { + this.doc = doc + this.sectionCategories = sectionCategories || [] + this.initParser() + } + protected createElement = (tag: string) => this.doc.createElement(tag) + protected initParser() { + this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) + } + protected get nodes(): NodeRule[] { + return [] + } + + protected get allNodes(): NodeRule[] { + return this.nodes.concat(this.commonNodes) + } + + protected static parsePriority(priority: string | null) { + if (!priority) { + return undefined + } + return parseInt(priority) + } + private static chooseBibliographyItemType = ( + publicationType: string | null + ) => { + switch (publicationType) { + case 'book': + case 'thesis': + return publicationType + case 'journal': + default: + return 'article-journal' + } + } + private static parseRef = (element: Element) => { + const publicationType = element.getAttribute('publication-type') + + const authorNodes = [ + ...element.querySelectorAll( + 'person-group[person-group-type="author"] > *' + ), + ] + + const id = element.id + + const attrs: BibliographyItemAttrs = { + id, + type: JatsParser.chooseBibliographyItemType(publicationType), + } + const title = getHTMLContent(element, 'article-title') + if (title) { + attrs.title = title + } + + const mixedCitation = element.querySelector('mixed-citation') + + if (authorNodes.length <= 0) { + mixedCitation?.childNodes.forEach((item) => { + if ( + item.nodeType === Node.TEXT_NODE && + item.textContent?.match(/[A-Za-z]+/g) + ) { + attrs.literal = trimTextContent(mixedCitation) ?? '' + return attrs + } + }) + } + + const source = getHTMLContent(element, 'source') + if (source) { + attrs.containerTitle = source + } + + const volume = trimTextContent(element, 'volume') + if (volume) { + attrs.volume = volume + } + + const issue = trimTextContent(element, 'issue') + if (issue) { + attrs.issue = issue + } + + const supplement = trimTextContent(element, 'supplement') + if (supplement) { + attrs.supplement = supplement + } + + const fpage = trimTextContent(element, 'fpage') + const lpage = trimTextContent(element, 'lpage') + if (fpage) { + attrs.page = lpage ? `${fpage}-${lpage}` : fpage + } + + const year = trimTextContent(element, 'year') + if (year) { + attrs.issued = buildBibliographicDate({ + 'date-parts': [[year]], + }) + } + + const doi = trimTextContent(element, 'pub-id[pub-id-type="doi"]') + if (doi) { + attrs.doi = doi + } + + const authors: BibliographicName[] = [] + authorNodes.forEach((authorNode) => { + const name = buildBibliographicName({}) + const given = trimTextContent(authorNode, 'given-names') + if (given) { + name.given = given + } + const family = trimTextContent(authorNode, 'surname') + + if (family) { + name.family = family + } + + if (authorNode.nodeName === 'collab') { + name.literal = trimTextContent(authorNode) + } + authors.push(name) + }) + + if (authors.length) { + attrs.author = authors + } + return attrs + } + private static getFigureAttrs = (node: HTMLElement | string | Node) => { + const element = node as HTMLElement + const parentElement = element.parentElement + return { + id: element.getAttribute('id'), + type: + parentElement?.getAttribute('fig-type') ?? + element.getAttribute('content-type') ?? + '', + src: element.getAttributeNS(JatsParser.XLINK_NAMESPACE, 'href'), + } + } + private static isMatchingCategory( + secType: string | null, + titleNode: Element | null, + category: SectionCategory + ) { + if (secType && category.synonyms.includes(secType)) { + return true + } + if (titleNode && titleNode.nodeName === 'title' && titleNode.textContent) { + const textContent = titleNode.textContent.trim().toLowerCase() + if (category.synonyms.includes(textContent)) { + return true + } + } + return false + } + protected chooseSectionCategory(section: HTMLElement) { + const secType = section.getAttribute('sec-type') + const titleNode = section.firstElementChild + + for (const category of this.sectionCategories) { + if (JatsParser.isMatchingCategory(secType, titleNode, category)) { + return category.id + } + } + } + private static getEquationContent = (p: string | HTMLElement) => { + const element = p as HTMLElement + const id = element.getAttribute('id') + const container = element.querySelector('alternatives') ?? element + let contents: string | null = '' + let format: string | null = '' + for (const child of container.childNodes) { + const nodeName = child.nodeName.replace(/^[a-z]:/, '') + + switch (nodeName) { + case 'tex-math': + contents = child.textContent + format = 'tex' + break + case 'mml:math': + contents = (child as Element).outerHTML + format = 'mathml' + break + } + } + return { id, format, contents } + } + private get commonNodes(): NodeRule[] { + return [ + { + tag: 'highlight-marker', + node: 'highlight_marker', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.id, + position: element.getAttribute('position'), + } + }, + }, + { + tag: 'attrib', + node: 'attribution', + }, + { + tag: 'history', + ignore: true, + }, + { + tag: 'break', + node: 'hard_break', + }, + { + tag: 'caption', + node: 'figcaption', + context: 'figure/', + }, + { + tag: 'caption', + node: 'figcaption', + context: 'figure_element/|table_element/|embed/', + getContent: (node, schema) => { + const element = node as HTMLElement + + const content = [] + + const title = element.querySelector('title') + if (title) { + const captionTitle = schema.nodes.caption_title.create() + content.push(this.parser.parse(title, { topNode: captionTitle })) + } + + const paragraphs = element.querySelectorAll('p') + if (paragraphs.length) { + const figcaption = schema.nodes.caption.create() + for (const paragraph of paragraphs) { + content.push( + this.parser.parse(paragraph, { topNode: figcaption }) + ) + } + } + + return Fragment.from(content) as Fragment + }, + }, + { + tag: 'caption', + node: 'figcaption', + context: 'box_element/', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'code', + node: 'listing', + context: 'listing_element/', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + language: element.getAttribute('language') ?? '', + contents: trimTextContent(element), + } + }, + }, + { + tag: 'inline-formula', + node: 'inline_equation', + getAttrs: (node) => { + const element = node as HTMLElement + return JatsParser.getEquationContent(element) + }, + }, + { + tag: 'disp-formula', + node: 'equation_element', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + } + }, + getContent: (node, schema) => { + const element = node as HTMLElement + const attrs = JatsParser.getEquationContent(element) + return Fragment.from([ + schema.nodes.equation.createChecked({ ...attrs }), + ]) as Fragment + }, + }, + { + tag: 'disp-quote[content-type=quote]', + node: 'blockquote_element', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'disp-quote[content-type=pullquote]', + node: 'pullquote_element', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'ext-link', + node: 'link', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + href: + element.getAttributeNS(JatsParser.XLINK_NAMESPACE, 'href') || '', + title: + element.getAttributeNS(JatsParser.XLINK_NAMESPACE, 'title') || '', + } + }, + }, + { + tag: 'fig[fig-type=equation]', + node: 'equation_element', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'fig[fig-type=listing]', + node: 'listing_element', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'graphic[specific-use=MISSING]', + node: 'missing_figure', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'graphic', + node: 'figure', + context: 'figure_element/', + getAttrs: JatsParser.getFigureAttrs, + }, + { + tag: 'graphic', + node: 'image_element', + getContent: (node: Node) => { + const figure = this.schema.nodes.figure.create( + JatsParser.getFigureAttrs(node) + ) + return Fragment.from(figure) + }, + }, + { + tag: 'fig', + node: 'figure_element', + getAttrs: (node) => { + const element = node as HTMLElement + const attrib = element.querySelector('attrib') + + const attribution = attrib + ? { + literal: trimTextContent(attrib) ?? '', + } + : undefined + + return { + id: element.getAttribute('id'), + attribution, + } + }, + }, + { + tag: 'fn-group', + node: 'footnotes_element', + context: 'footnotes_section/|table_element_footer/', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + kind: 'footnote', // TODO: 'endnote' depending on position or attribute? + } + }, + }, + { + tag: 'table-wrap-foot', + node: 'table_element_footer', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'general-table-footnote', + node: 'general_table_footnote', + context: 'table_element_footer/', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + } + }, + getContent: (node) => { + const paragraphs: ManuscriptNode[] = [] + node.childNodes.forEach((p) => { + const paragraph = this.schema.nodes.paragraph.create() + const content = this.parser.parse(p, { + topNode: paragraph, + }) + paragraphs.push(content) + }) + return Fragment.from([...paragraphs]) as Fragment + }, + }, + { + tag: 'fn', + node: 'footnote', + context: 'footnotes_element/|table_element_footer/', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + kind: 'footnote', // TODO: 'endnote' depending on position or attribute? + } + }, + }, + { + tag: 'front', + ignore: true, + }, + { + tag: 'list', + node: 'list', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + listStyleType: element.getAttribute('list-type'), + } + }, + }, + { + tag: 'list-item', + node: 'list_item', + }, + { + tag: 'p', + node: 'paragraph', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'media', + node: 'embed', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + href: element.getAttributeNS(JatsParser.XLINK_NAMESPACE, 'href'), + mimetype: element.getAttribute('mimetype'), + mimeSubtype: element.getAttribute('mime-subtype'), + } + }, + }, + { + tag: 'sec[sec-type="box-element"]', + node: 'box_element', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'sec[sec-type="bibliography"]', + node: 'bibliography_section', + }, + { + tag: 'ref-list', + context: 'bibliography_section/', + node: 'bibliography_element', + }, + { + tag: 'ref', + context: 'bibliography_element/', + node: 'bibliography_item', + getAttrs: (node) => JatsParser.parseRef(node as Element), + }, + { + tag: 'sec', + node: 'section', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + category: this.chooseSectionCategory(element), + } + }, + }, + { + tag: 'boxed-text', + ignore: true, + }, + { + tag: 'label', + context: 'section/', + node: 'section_label', + }, + { + tag: 'table', + node: 'table', + // TODO: count thead and tfoot rows + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'table-wrap', + node: 'table_element', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + } + }, + }, + { + tag: 'title', + node: 'section_title', + context: + 'section/|footnotes_section/|bibliography_section/|keywords/|supplements/|author_notes/|graphical_abstract_section/', + }, + { + tag: 'title', + node: 'caption_title', + context: 'figcaption/', + }, + { + tag: 'tr', + node: 'table_row', + }, + { + tag: 'td', + node: 'table_cell', + getAttrs: (node) => { + const element = node as HTMLElement + const colspan = parseInt(element.getAttribute('colspan') || '1') + const rowspan = parseInt(element.getAttribute('rowspan') || '1') + return { + ...(colspan && { colspan }), + ...(rowspan && { rowspan }), + valign: element.getAttribute('valign'), + align: element.getAttribute('align'), + scope: element.getAttribute('scope'), + style: element.getAttribute('style'), + } + }, + }, + { + tag: 'th', + node: 'table_header', + getAttrs: (node) => { + const element = node as HTMLElement + const colspan = parseInt(element.getAttribute('colspan') || '1') + const rowspan = parseInt(element.getAttribute('rowspan') || '1') + return { + ...(colspan && { colspan }), + ...(rowspan && { rowspan }), + valign: element.getAttribute('valign'), + align: element.getAttribute('align'), + scope: element.getAttribute('scope'), + style: element.getAttribute('style'), + } + }, + }, + { + tag: 'col', + node: 'table_col', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + width: element.getAttribute('width'), + } + }, + }, + { + tag: 'colgroup', + node: 'table_colgroup', + }, + { + tag: 'xref[ref-type="bibr"]', + node: 'citation', + getAttrs: (node) => { + const element = node as HTMLElement + return { + rids: element.getAttribute('rid')?.split(/\s+/) || [], + contents: trimTextContent(element), + } + }, + }, + { + tag: 'xref[ref-type="fn"]', + node: 'inline_footnote', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + rids: element.getAttribute('rid')?.split(/\s+/) || [], + } + }, + }, + { + tag: 'xref', + node: 'cross_reference', + getAttrs: (node) => { + const element = node as HTMLElement + return { + rids: element.getAttribute('rid')?.split(/\s+/) || [], + } + }, + }, + { + tag: 'label', + ignore: true, + }, + ] + } + protected get marks(): MarkRule[] { + return [ + { + tag: 'bold', + mark: 'bold', + }, + { + tag: 'code', + mark: 'code', + }, + { + tag: 'italic', + mark: 'italic', + }, + { + tag: 'sc', + mark: 'smallcaps', + }, + { + tag: 'strike', + mark: 'strikethrough', + }, + { + tag: 'styled-content', + mark: 'styled', + getAttrs: (node) => ({ + style: (node as Element).getAttribute('style'), + }), + }, + { + tag: 'sub', + mark: 'subscript', + }, + { + tag: 'sup', + mark: 'superscript', + }, + { + tag: 'underline', + mark: 'underline', + }, + ] + } +} diff --git a/src/jats/importer/parsers/KeywordsParser.ts b/src/jats/importer/parsers/KeywordsParser.ts new file mode 100644 index 00000000..2f79d87b --- /dev/null +++ b/src/jats/importer/parsers/KeywordsParser.ts @@ -0,0 +1,66 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { ManuscriptNode, NodeRule } from '../../../schema' +import { JatsParser } from './JatsParser' + +export class KeywordsParser extends JatsParser { + private readonly tag = 'kwd-group' + parse(): ManuscriptNode | undefined { + const kwdGroup = this.doc.querySelector(this.tag) + if (!kwdGroup) { + return + } + kwdGroup.querySelector('title')?.remove() + const keywords = this.createElement('keywords') + const title = this.createElement('title') + title.textContent = 'Keywords' + const keywordsElement = this.createElement('keywords_element') + keywordsElement.append(kwdGroup) + keywords.append(title) + keywords.appendChild(keywordsElement) + return this.parser.parse(keywords, { + topNode: this.schema.nodes.keywords.create(), + }) + } + protected get nodes(): NodeRule[] { + return [ + { + tag: 'title', + node: 'section_title', + }, + { + tag: 'keywords_element', + node: 'keywords_element', + }, + { + tag: 'kwd-group', + node: 'keyword_group', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.id, + type: element.getAttribute('kwd-group-type'), + } + }, + }, + { + tag: 'kwd', + node: 'keyword', + }, + ] + } +} diff --git a/src/jats/importer/parsers/ManuscriptParser.ts b/src/jats/importer/parsers/ManuscriptParser.ts new file mode 100644 index 00000000..d909898f --- /dev/null +++ b/src/jats/importer/parsers/ManuscriptParser.ts @@ -0,0 +1,112 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { dateToTimestamp, SectionCategory, trimTextContent } from '../../..' +import { updateDocumentIDs } from '../jats-parser-utils' +import { JatsProcessor } from '../processors/JatsProcessor' +import { JatsParser } from './JatsParser' + +export class ManuscriptParser extends JatsParser { + private readonly parsers: JatsParser[] + private readonly protoype?: string + private readonly jatsTransformer: JatsProcessor + constructor( + doc: Document, + parsers: JatsParser[], + sectionCategories: SectionCategory[], + protoype?: string + ) { + super(doc) + this.parsers = parsers + this.protoype = protoype + this.jatsTransformer = new JatsProcessor(this.doc, sectionCategories) + } + + private static parseDates = (historyNode: Element | null | undefined) => { + if (!historyNode) { + return undefined + } + const history: { + acceptanceDate?: number + correctionDate?: number + retractionDate?: number + revisionRequestDate?: number + revisionReceiveDate?: number + receiveDate?: number + } = {} + + for (const date of historyNode.children) { + const dateType = date.getAttribute('date-type') + switch (dateType) { + case 'received': { + history.receiveDate = dateToTimestamp(date) + break + } + case 'rev-recd': { + history.revisionReceiveDate = dateToTimestamp(date) + break + } + case 'accepted': { + history.acceptanceDate = dateToTimestamp(date) + break + } + case 'rev-request': { + history.revisionRequestDate = dateToTimestamp(date) + break + } + case 'retracted': { + history.retractionDate = dateToTimestamp(date) + break + } + case 'corrected': { + history.correctionDate = dateToTimestamp(date) + break + } + } + } + return history + } + + private getManuscriptAttrs() { + const article = this.doc.querySelector('article') + const doi = article?.querySelector( + 'front > article-meta > article-id[pub-id-type="doi"]' + ) + const history = article?.querySelector('history') + const dates = ManuscriptParser.parseDates(history) + return { + doi: doi ? trimTextContent(doi) : '', + articleType: article?.getAttribute('article-type') ?? '', + primaryLanguageCode: article?.getAttribute('lang') ?? '', + prototype: this.protoype ?? '', + ...dates, + } + } + + parse() { + this.jatsTransformer.process() + const content = this.parsers + .map((parser) => parser.parse()) + .filter((node) => node !== undefined) + + const manuscript = this.schema.nodes.manuscript.create( + this.getManuscriptAttrs(), + content + ) + updateDocumentIDs(manuscript) + return manuscript + } +} diff --git a/src/jats/importer/parsers/ParserFactory.ts b/src/jats/importer/parsers/ParserFactory.ts new file mode 100644 index 00000000..a8ef60d3 --- /dev/null +++ b/src/jats/importer/parsers/ParserFactory.ts @@ -0,0 +1,73 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { SectionCategory } from '../../../schema' +import { AbstractsParser } from './AbstractsParser' +import { AffiliationsParser } from './AffiliationsParser' +import { AuthorNotesParser } from './AuthorNotesParser' +import { AwardsParser } from './AwardsParser' +import { BackmatterParser } from './BackmatterParser' +import { BodyParser } from './BodyParser' +import { CommentsParser } from './CommentsParser' +import { ContributorsParser } from './ContributorsParser' +import { JatsParser } from './JatsParser' +import { KeywordsParser } from './KeywordsParser' +import { ManuscriptParser } from './ManuscriptParser' +import { SupplementsParser } from './SupplementsParser' +import { TitleParser } from './TitleParser' + +export class ParserFactory { + constructor( + private readonly doc: Document, + private readonly sectionCategories: SectionCategory[] + ) {} + createParser(type: string) { + switch (type) { + case 'abstracts': + return new AbstractsParser(this.doc, this.sectionCategories) + case 'affiliations': + return new AffiliationsParser(this.doc) + case 'authorNotes': + return new AuthorNotesParser(this.doc) + case 'awards': + return new AwardsParser(this.doc) + case 'backmatter': + return new BackmatterParser(this.doc, this.sectionCategories) + case 'body': + return new BodyParser(this.doc, this.sectionCategories) + case 'comments': + return new CommentsParser(this.doc) + case 'contributors': + return new ContributorsParser(this.doc) + case 'keywords': + return new KeywordsParser(this.doc) + case 'supplements': + return new SupplementsParser(this.doc) + case 'title': + return new TitleParser(this.doc) + default: + throw new Error(`Unknown parser type: ${type}`) + } + } + createManuscriptParser(parsers: JatsParser[], prototype?: string) { + return new ManuscriptParser( + this.doc, + parsers, + this.sectionCategories, + prototype + ) + } +} diff --git a/src/jats/parsers/SupplementsParser.ts b/src/jats/importer/parsers/SupplementsParser.ts similarity index 53% rename from src/jats/parsers/SupplementsParser.ts rename to src/jats/importer/parsers/SupplementsParser.ts index 543aa1b5..3f22eead 100644 --- a/src/jats/parsers/SupplementsParser.ts +++ b/src/jats/importer/parsers/SupplementsParser.ts @@ -14,21 +14,16 @@ * limitations under the License. */ -import { DOMParser } from 'prosemirror-model' -import { trimTextContent } from '../../lib/utils' -import { NodeRule } from '../../schema' +import { trimTextContent } from '../../../lib/utils' +import { NodeRule } from '../../../schema' import { JatsParser } from './JatsParser' export class SupplementsParser extends JatsParser { - parser: DOMParser + private readonly tag = 'article-meta > supplementary-material' - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - - parse(elements: Element[]) { + parse() { + const elements = Array.from(this.doc.querySelectorAll(this.tag)) if (!elements.length) { return } @@ -41,29 +36,32 @@ export class SupplementsParser extends JatsParser { topNode: this.schema.nodes.supplements.create(), }) } - nodes: NodeRule[] = [ - { - tag: 'supplements', - node: 'supplements', - }, - { - tag: 'title', - node: 'section_title', - }, - { - tag: 'supplementary-material', - node: 'supplement', - getAttrs: (node) => { - const element = node as HTMLElement + protected get nodes(): NodeRule[] { + return [ + { + tag: 'supplements', + node: 'supplements', + }, - return { - id: element.getAttribute('id'), - href: element.getAttributeNS(this.XLINK_NAMESPACE, 'href'), - mimeType: element.getAttribute('mimetype'), - mimeSubType: element.getAttribute('mime-subtype'), - title: trimTextContent(element, 'title'), - } + { + tag: 'title', + node: 'section_title', }, - }, - ] + { + tag: 'supplementary-material', + node: 'supplement', + getAttrs: (node) => { + const element = node as HTMLElement + + return { + id: element.getAttribute('id'), + href: element.getAttributeNS(JatsParser.XLINK_NAMESPACE, 'href'), + mimeType: element.getAttribute('mimetype'), + mimeSubType: element.getAttribute('mime-subtype'), + title: trimTextContent(element, 'title'), + } + }, + }, + ] + } } diff --git a/src/jats/importer/parsers/TitleParser.ts b/src/jats/importer/parsers/TitleParser.ts new file mode 100644 index 00000000..e2f36922 --- /dev/null +++ b/src/jats/importer/parsers/TitleParser.ts @@ -0,0 +1,53 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { ManuscriptNode, NodeRule } from '../../../schema' +import { htmlFromJatsNode } from '../jats-parser-utils' +import { JatsParser } from './JatsParser' + +export class TitleParser extends JatsParser { + private readonly defaultTitle = 'Untitled Manuscript' + private readonly tag = 'front > article-meta > title-group > article-title' + + parse(): ManuscriptNode { + let title = this.doc.querySelector(this.tag) + if (!title) { + title = this.createElement('article-title') + title.innerHTML = this.defaultTitle + } else { + title.innerHTML = + htmlFromJatsNode(title, this.createElement) ?? this.defaultTitle + } + return this.parser.parse(title, { + topNode: this.schema.nodes.title.create(), + }) + } + + protected get nodes(): NodeRule[] { + return [ + { + tag: 'article-title', + node: 'title', + getAttrs: (node) => { + const element = node as HTMLElement + return { + id: element.getAttribute('id'), + } + }, + }, + ] + } +} diff --git a/src/jats/importer/processors/JatsProcessor.ts b/src/jats/importer/processors/JatsProcessor.ts new file mode 100644 index 00000000..8ea05413 --- /dev/null +++ b/src/jats/importer/processors/JatsProcessor.ts @@ -0,0 +1,373 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ +import { v4 as uuid } from 'uuid' + +import { schema, SectionCategory } from '../../../schema' +import { generateNodeID } from '../../../transformer' + +export class JatsProcessor { + private readonly doc: Document + private readonly sectionCategories: SectionCategory[] + constructor(doc: Document, sectionCateogries: SectionCategory[]) { + this.doc = doc + this.sectionCategories = sectionCateogries + } + + private createElement = (tag: string) => this.doc.createElement(tag) + + process() { + this.markComments() + this.addMissingCaptions() + this.moveCaptionsToEnd() + this.createBoxedElementSection() + this.moveFloatsGroupToBody() + this.fixTables() + this.orderTableFootnote() + this.refactorBackmatter() + } + private refactorBackmatter() { + const back = this.doc.querySelector('back') + if (!back) { + return + } + this.moveSectionsToTop(back) + this.moveSpecialFootnotes(back) + this.moveFootnotes(back) + this.moveAcknowledgments(back) + this.moveReferencesToBackmatter(back) + } + private moveSectionsToTop(back: Element) { + const sections = Array.from(back.querySelectorAll(':scope > sec')) + for (const section of sections.reverse()) { + back.insertBefore(section, back.firstChild) + } + } + private moveReferencesToBackmatter(back: Element) { + const refList = back.querySelector('ref-list') + if (!refList) { + return + } + JatsProcessor.removeNodeFromParent(refList) + const section = this.createElement('sec') + section.setAttribute('sec-type', 'bibliography') + const title = this.createElement('title') + title.textContent = 'References' + section.appendChild(title) + section.appendChild(refList) + back.appendChild(section) + } + private moveSpecialFootnotes = (group: Element) => { + const fns = [...this.doc.querySelectorAll('fn[fn-type]')] + for (const fn of fns) { + const type = fn.getAttribute('fn-type') || '' //Cannot be null since it is queried above + const category = this.sectionCategories.find((category) => + category.synonyms.includes(type) + ) + if (category) { + const section = this.createElement('sec') + const fnTitle = fn.querySelector('p[content-type="fn-title"]') + if (fnTitle) { + const title = this.createElement('title') + const titleText = fnTitle.textContent?.trim() + if (titleText) { + title.textContent = titleText + } + JatsProcessor.removeNodeFromParent(fnTitle) + section.append(title) + } + section.append(...fn.children) + JatsProcessor.removeNodeFromParent(fn) + section.setAttribute('sec-type', category.id) + group.append(section) + } + } + } + private moveFootnotes = (group: Element) => { + const fns = [ + ...this.doc.querySelectorAll( + 'fn:not(table-wrap-foot fn, author-notes fn)' + ), + ] + let section = this.doc.querySelector('sec[sec-type="endnotes"]') + const fnGroup = + section?.querySelector('fn-group') || this.createElement('fn-group') + fns.forEach((fn) => { + if (!fn.getAttribute('fn-type')) { + fnGroup.appendChild(fn) + } + }) + if (!section && fnGroup.innerHTML) { + section = this.createFootnotesSection([fnGroup]) + } + if (section) { + group.insertBefore( + section, + group.firstChild?.nextSibling || group.firstChild + ) + } + } + private createFootnotesSection = (fnGroups: Element[]) => { + const section = this.createElement('sec') + section.setAttribute('sec-type', 'endnotes') + + const titleNode = fnGroups + .map((g) => g.querySelector('title')) + .filter((t) => t !== null)[0] + + if (titleNode) { + section.appendChild(titleNode) + } else { + const title = this.createElement('title') + title.textContent = 'Footnotes' + section.appendChild(title) + } + + for (const fnGroup of fnGroups) { + section.appendChild(fnGroup) + } + + return section + } + private moveAcknowledgments = (group: Element) => { + const ack = this.doc.querySelector('back > ack') + if (ack) { + const section = this.createAcknowledgmentsSection(ack) + JatsProcessor.removeNodeFromParent(ack) + group.appendChild(section) + } + } + private createAcknowledgmentsSection(ack: Element) { + const section = this.createElement('sec') + section.setAttribute('sec-type', 'acknowledgments') + + if (!ack.querySelector('title')) { + const title = this.createElement('title') + title.textContent = 'Acknowledgements' + section.appendChild(title) + } + + while (ack.firstChild) { + section.appendChild(ack.firstChild) + } + return section + } + private markComments() { + const root = this.doc.getRootNode() as Element + const queue: Element[] = [root] + const comments = this.createElement('comments') + while (queue.length !== 0) { + const node = queue.shift() + if (node) { + if (JatsProcessor.isJATSComment(node)) { + const text = JatsProcessor.parseJATSComment(node) + if (text) { + const id = generateNodeID(schema.nodes.comment) + let target + const parent = node.parentNode as Element + if (JatsProcessor.isHighlightable(parent)) { + const marker = this.createHighlightMarkerElement(id) + parent.insertBefore(marker, node) + target = parent + } else { + target = JatsProcessor.findTarget(parent) + } + // if the target has no ID, generate one here and rely on + // updateDocumentIDs to fix it + if (!target.id) { + target.id = uuid() + } + const comment = this.createCommentElement(id, target.id, text) + comments.appendChild(comment) + } + } + node.childNodes.forEach((child) => { + queue.push(child as Element) + }) + } + } + if (comments.hasChildNodes()) { + this.doc.documentElement.appendChild(comments) + } + } + private addMissingCaptions = () => { + const elements = this.doc.querySelectorAll('fig, table-wrap, media') + for (const element of elements) { + let caption: Element | null = element.querySelector('caption') + if (!caption) { + caption = this.createElement('caption') + element.nodeName === 'fig' + ? element.appendChild(caption) + : element.prepend(caption) + } + if (!caption.querySelector('title')) { + caption.prepend(this.createElement('title')) + } + if (!caption.querySelector('p')) { + caption.appendChild(this.createElement('p')) + } + } + } + private moveCaptionsToEnd() { + const captions = this.doc.querySelectorAll('caption') + + for (const caption of captions) { + if ( + caption.parentNode && + caption.parentNode.nodeName !== 'table-wrap' && + caption.parentNode.nodeName !== 'boxed-text' + ) { + caption.parentNode.appendChild(caption) + } + } + } + private createBoxedElementSection() { + const body = this.doc.querySelector('body') + const boxedTexts = body?.querySelectorAll('boxed-text') || [] + for (const boxedText of boxedTexts) { + const boxElementId = boxedText.getAttribute('id') + const boxElementSec = this.createElement('sec') + boxElementSec.setAttribute('sec-type', 'box-element') + if (boxElementId) { + boxElementSec.setAttribute('id', boxElementId) + } + const title = this.createElement('title') + title.textContent = 'BoxElement' + boxElementSec.append(title) + for (const element of [...boxedText.children]) { + if (element?.tagName === 'label' || element?.tagName === 'caption') { + boxElementSec.append(element) + } + } + const containerSection = this.createElement('sec') + containerSection.append(...boxedText.children) + boxElementSec.append(containerSection) + boxedText.replaceWith(boxElementSec) + } + } + private moveFloatsGroupToBody() { + //is this actually needed? + const body = this.doc.querySelector('body') + const floatsGroup = this.doc.querySelector('floats-group') + if (floatsGroup) { + const sec = this.createFloatsGroupSection(floatsGroup) + JatsProcessor.removeNodeFromParent(floatsGroup) + body?.appendChild(sec) + } + } + private fixTables() { + const tableWraps = this.doc.querySelectorAll('table-wrap') + tableWraps.forEach((tableWrap) => { + // Move cols into a colgroup if they are not already + // This more closely maps how they exist in HTML and, subsequently, in ManuscriptJSON + const table = tableWrap.querySelector('table') + if (!table) { + return + } + const colgroup = table.querySelector('colgroup') + const cols = table.querySelectorAll('col') + if (!colgroup && table.firstChild && cols.length > 0) { + const colgroup = this.createElement('colgroup') + for (const col of cols) { + colgroup.appendChild(col) + } + tableWrap.insertBefore(colgroup, table.nextSibling) + } + const tableFootWrap = tableWrap.querySelector('table-wrap-foot') + if (tableFootWrap) { + const paragraphs = tableFootWrap.querySelectorAll(':scope > p') + if (paragraphs.length) { + const generalTableFootnote = this.createElement( + 'general-table-footnote' + ) + for (const paragraph of paragraphs) { + JatsProcessor.removeNodeFromParent(paragraph) + generalTableFootnote.append(paragraph) + } + tableFootWrap.prepend(generalTableFootnote) + } + } + }) + } + private orderTableFootnote() { + const rids = new Set( + [...this.doc.querySelectorAll('tbody > xref[ref-type="fn"]')].map( + (xref) => xref.getAttribute('rid') + ) + ) + const fnGroups = this.doc.querySelectorAll('table-wrap-foot > fn-group') + fnGroups.forEach((fnGroup) => { + // sort the un-cited table footnote at the end of list + const fns = [...fnGroup.querySelectorAll('fn')].sort((fn) => + rids.has(fn.getAttribute('id')) ? -1 : 0 + ) + fnGroup.replaceChildren(...fns) + }) + } + private createFloatsGroupSection(floatsGroup: Element) { + const section = this.createElement('sec') + section.setAttribute('sec-type', 'floating-element') + const title = this.createElement('title') + title.textContent = 'Floating Group' + section.appendChild(title) + section.append(...floatsGroup.children) + return section + } + private createHighlightMarkerElement(id: string) { + const highlightMarker = this.createElement('highlight-marker') + highlightMarker.setAttribute('id', id) + highlightMarker.setAttribute('position', 'point') + return highlightMarker + } + private createCommentElement = ( + id: string, + targetID: string | undefined, + text: string + ) => { + const commentElement = this.createElement('comment') + commentElement.setAttribute('id', id) + if (targetID) { + commentElement.setAttribute('target-id', targetID) + } + commentElement.textContent = text + return commentElement + } + private static isJATSComment(node: Node) { + return ( + node.nodeType === node.PROCESSING_INSTRUCTION_NODE && + node.nodeName === 'AuthorQuery' + ) + } + private static parseJATSComment(node: Node) { + const text = node.textContent + if (text) { + const queryText = /queryText="(.+)"/.exec(text) + return (queryText && queryText[1]) || undefined + } + } + private static isHighlightable(node: Element) { + //todo find a better way to do this + return node.nodeName === 'p' + } + private static findTarget(node: Element) { + const target = node.closest('ref, kwd-group') + if (target) { + return target + } + return node + } + public static removeNodeFromParent = (node: Element) => + node.parentNode && node.parentNode.removeChild(node) +} diff --git a/src/jats/importer/processors/JournalProcessor.ts b/src/jats/importer/processors/JournalProcessor.ts new file mode 100644 index 00000000..0027cee1 --- /dev/null +++ b/src/jats/importer/processors/JournalProcessor.ts @@ -0,0 +1,109 @@ +/*! + * © 2025 Atypon Systems LLC + * + * Licensed under the Apache License, Version 2.0 (the "License"); + * you may not use this file except in compliance with the License. + * You may obtain a copy of the License at + * + * http://www.apache.org/licenses/LICENSE-2.0 + * + * Unless required by applicable law or agreed to in writing, software + * distributed under the License is distributed on an "AS IS" BASIS, + * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. + * See the License for the specific language governing permissions and + * limitations under the License. + */ + +import { ObjectTypes } from '@manuscripts/json-schema' + +import { trimTextContent } from '../../..' + +type ISSN = { + ISSN: string + publicationType?: string +} +type AbbreviatedTitle = { + abbreviatedTitle: string + abbrevType?: string +} +type JournalIdentifier = { + journalID: string + journalIDType?: string +} + +class JournalMetaParser { + private element: Element + + constructor(element: Element) { + this.element = element + } + + parse() { + return { + abbreviatedTitles: this.parseAbbreviatedTitles(), + journalIdentifiers: this.parseIdentifiers(), + ISSNs: this.parseISSNs(), + publisherName: + trimTextContent(this.element, 'publisher > publisher-name') ?? + undefined, + title: + trimTextContent(this.element, 'journal-title-group > journal-title') ?? + undefined, + } + } + + private parseIdentifiers(): JournalIdentifier[] { + const output: JournalIdentifier[] = [] + const ids = this.element.querySelectorAll('journal-id') + ids.forEach((id) => { + const type = id.getAttribute('journal-id-type') + const value = id.textContent?.trim() + if (value) { + output.push({ journalID: value, journalIDType: type ?? undefined }) + } + }) + return output + } + + private parseAbbreviatedTitles(): AbbreviatedTitle[] { + const output: AbbreviatedTitle[] = [] + const titles = this.element.querySelectorAll( + 'journal-title-group > abbrev-journal-title' + ) + titles.forEach((title) => { + const type = title.getAttribute('abbrev-type') + const value = title.textContent?.trim() + if (value) { + output.push({ abbreviatedTitle: value, abbrevType: type ?? undefined }) + } + }) + return output + } + + private parseISSNs(): ISSN[] { + const output: ISSN[] = [] + const issns = this.element.querySelectorAll('issn') + issns.forEach((issn) => { + const type = issn.getAttribute('pub-type') + const value = issn.textContent?.trim() + if (value) { + output.push({ ISSN: value, publicationType: type ?? undefined }) + } + }) + return output + } +} + +export class JournalProcessor { + static parse(doc: Document) { + const journalMeta = doc.querySelector('journal-meta') + if (!journalMeta) { + return + } + const meta = new JournalMetaParser(journalMeta).parse() + return { + ...meta, + objectType: ObjectTypes.Journal, + } + } +} diff --git a/src/jats/parsers/AuthorNotesParser.ts b/src/jats/parsers/AuthorNotesParser.ts deleted file mode 100644 index 8a6ba426..00000000 --- a/src/jats/parsers/AuthorNotesParser.ts +++ /dev/null @@ -1,87 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { DOMParser, Fragment } from 'prosemirror-model' - -import { trimTextContent } from '../../lib/utils' -import { ManuscriptNode, NodeRule } from '../../schema' -import { JatsParser } from './JatsParser' -export class AuthorNotesParser extends JatsParser { - parser: DOMParser - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - parse(element: Element | null): ManuscriptNode | undefined { - if (!element) { - return - } - const sectionTitle = this.createElement('title') - element.prepend(sectionTitle) - return this.parser.parse(element, { - topNode: this.schema.nodes.author_notes.create(), - }) - } - - nodes: NodeRule[] = [ - { - tag: 'title', - node: 'section_title', - }, - { - tag: 'corresp', - node: 'corresp', - getAttrs: (node) => { - const element = node as HTMLElement - const label = element.querySelector('label') - if (label) { - label.remove() - } - return { - id: element.getAttribute('id'), - label: trimTextContent(label), - } - }, - getContent: (node) => { - const element = node as HTMLElement - return Fragment.from(this.schema.text(trimTextContent(element) || '')) - }, - }, - { - tag: 'fn:not([fn-type])', - node: 'footnote', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - kind: 'footnote', - } - }, - }, - { - tag: 'p', - node: 'paragraph', - }, - { - tag: 'label', - ignore: true, - }, - { - tag: 'fn', - ignore: true, - }, - ] -} diff --git a/src/jats/parsers/AwardsParser.ts b/src/jats/parsers/AwardsParser.ts deleted file mode 100644 index 947167e2..00000000 --- a/src/jats/parsers/AwardsParser.ts +++ /dev/null @@ -1,58 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { DOMParser } from 'prosemirror-model' - -import { trimTextContent } from '../../lib/utils' -import { ManuscriptNode, NodeRule } from '../../schema' -import { JatsParser } from './JatsParser' - -export class AwardsParser extends JatsParser { - parser: DOMParser - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - parse(element: Element | null): ManuscriptNode | undefined { - if (!element) { - return - } - return this.parser.parse(element, { - topNode: this.schema.nodes.awards.create(), - }) - } - nodes: NodeRule[] = [ - { - tag: 'funding-group', - node: 'awards', - }, - { - tag: 'award-group', - node: 'award', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - recipient: trimTextContent(element, 'principal-award-recipient'), - code: Array.from(element.querySelectorAll('award-id')) - .map((awardID) => trimTextContent(awardID)) - .reduce((acc, text) => (acc ? `${acc};${text}` : text), ''), - source: trimTextContent(element, 'funding-source'), - } - }, - }, - ] -} diff --git a/src/jats/parsers/BodyParser.ts b/src/jats/parsers/BodyParser.ts deleted file mode 100644 index 7d6e08a5..00000000 --- a/src/jats/parsers/BodyParser.ts +++ /dev/null @@ -1,38 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ -import { DOMParser } from 'prosemirror-model' - -import { NodeRule, SectionCategory } from '../../schema' -import { JatsParser } from './JatsParser' - -export class BodyParser extends JatsParser { - parser: DOMParser - - constructor(doc: Document, sectionCategories: SectionCategory[]) { - super(doc, sectionCategories) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.allNodes]) - } - - parse(element: Element | null) { - if (!element) { - return - } - return this.parser.parse(element, { - topNode: this.schema.nodes.body.create(), - }) - } - nodes: NodeRule[] = [] -} diff --git a/src/jats/parsers/CommentsParser.ts b/src/jats/parsers/CommentsParser.ts deleted file mode 100644 index d055d837..00000000 --- a/src/jats/parsers/CommentsParser.ts +++ /dev/null @@ -1,35 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ -import { DOMParser } from 'prosemirror-model' - -import { NodeRule } from '../../schema' -import { JatsParser } from './JatsParser' - -export class SupplementsParser extends JatsParser { - parser: DOMParser - - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - - parse(element: Element) { - return this.parser.parse(element, { - topNode: this.schema.nodes.supplements.create(), - }) - } - nodes: NodeRule[] = [] -} \ No newline at end of file diff --git a/src/jats/parsers/ContributorsParser.ts b/src/jats/parsers/ContributorsParser.ts deleted file mode 100644 index 3e44d942..00000000 --- a/src/jats/parsers/ContributorsParser.ts +++ /dev/null @@ -1,113 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { ObjectTypes } from '@manuscripts/json-schema' -import { DOMParser, Fragment } from 'prosemirror-model' - -import { trimTextContent } from '../../lib/utils' -import { - ContributorCorresp, - ContributorFootnote, - ManuscriptNode, - NodeRule, -} from '../../schema' -import { JatsParser } from './JatsParser' - -export class ContributorsParser extends JatsParser { - parser: DOMParser - - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - - parse(elements: Element[]): ManuscriptNode | undefined { - if (!elements.length) { - return - } - const contribs = this.createElement('contributors') - for (const element of elements) { - contribs.appendChild(element) - } - return this.parser.parse(contribs, { - topNode: this.schema.nodes.contributors.create(), - }) - } - - nodes: NodeRule[] = [ - { - tag: 'contrib[contrib-type="author"]', - node: 'contributor', - getAttrs: (node) => { - const element = node as HTMLElement - const footnote: ContributorFootnote[] = [] - const affiliations: string[] = [] - const corresp: ContributorCorresp[] = [] - - const xrefs = element.querySelectorAll('xref') - for (const xref of xrefs) { - const rid = xref.getAttribute('rid') - const type = xref.getAttribute('ref-type') - if (!rid) { - continue - } - switch (type) { - case 'fn': - footnote.push({ - noteID: rid, - noteLabel: trimTextContent(xref) || '', - }) - break - case 'corresp': - corresp.push({ - correspID: rid, - correspLabel: trimTextContent(xref) || '', - }) - break - case 'aff': - affiliations.push(rid) - break - } - } - - return { - id: element.getAttribute('id'), - role: 'author', - affiliations, - corresp, - footnote, - isCorresponding: element.getAttribute('corresp') - ? element.getAttribute('corresp') === 'yes' - : undefined, - bibliographicName: { - given: trimTextContent(element, 'name > given-names'), - family: trimTextContent(element, 'name > surname'), - ObjectType: ObjectTypes.BibliographicName, - }, - ORCIDIdentifier: trimTextContent( - element, - 'contrib-id[contrib-id-type="orcid"]' - ), - priority: this.parsePriority(element.getAttribute('priority')), - email: trimTextContent(element, 'email') || '', - } - }, - getContent: () => { - return Fragment.from(this.schema.text('_')) - }, - }, - ] -} diff --git a/src/jats/parsers/JatsParser.ts b/src/jats/parsers/JatsParser.ts deleted file mode 100644 index 0f736630..00000000 --- a/src/jats/parsers/JatsParser.ts +++ /dev/null @@ -1,772 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { - BibliographicName, - buildBibliographicDate, - buildBibliographicName -} from '@manuscripts/json-schema' -import { DOMParser, Fragment } from 'prosemirror-model' - -import { trimTextContent } from '../../lib/utils' -import { - BibliographyItemAttrs, - ManuscriptNode, - MarkRule, - NodeRule, - schema, - SectionCategory, -} from '../../schema' -import { htmlFromJatsNode } from '../importer/jats-parser-utils' -export type CreateElement = (tagName: string) => HTMLElement - -export abstract class JatsParser { - readonly doc: Document - readonly schema = schema - readonly marks: MarkRule[] = [ - { - tag: 'bold', - mark: 'bold', - }, - { - tag: 'code', - mark: 'code', - }, - { - tag: 'italic', - mark: 'italic', - }, - { - tag: 'sc', - mark: 'smallcaps', - }, - { - tag: 'strike', - mark: 'strikethrough', - }, - { - tag: 'styled-content', - mark: 'styled', - getAttrs: (node) => ({ - style: (node as Element).getAttribute('style'), - }), - }, - { - tag: 'sub', - mark: 'subscript', - }, - { - tag: 'sup', - mark: 'superscript', - }, - { - tag: 'underline', - mark: 'underline', - }, - ] - readonly XLINK_NAMESPACE = 'http://www.w3.org/1999/xlink' - protected createElement: CreateElement = (tagName: string) => - this.doc.createElement(tagName) - - // each function that isn't shared, should be moved to its own class - protected parsePriority = (priority: string | null) => { - if (!priority) { - return undefined - } - return parseInt(priority) - } - - protected chooseSectionCategory(section: HTMLElement) { - const secType = section.getAttribute('sec-type') - const titleNode = section.firstElementChild - - for (const category of this.sectionCategories || []) { - if (this.isMatchingCategory(secType, titleNode, category)) { - return category.id - } - } - } - protected getHTMLContent = (node: Element, querySelector: string) => { - return htmlFromJatsNode(node.querySelector(querySelector)) - } - - protected getEquationContent = (p: string | HTMLElement) => { - const element = p as HTMLElement - const id = element.getAttribute('id') - const container = element.querySelector('alternatives') ?? element - let contents: string | null = '' - let format: string | null = '' - for (const child of container.childNodes) { - const nodeName = child.nodeName.replace(/^[a-z]:/, '') - - switch (nodeName) { - case 'tex-math': - contents = child.textContent - format = 'tex' - break - case 'mml:math': - contents = (child as Element).outerHTML - format = 'mathml' - break - } - } - return { id, format, contents } - } - private getFigureAttrs = (node: HTMLElement | string | Node) => { - const element = node as HTMLElement - const parentElement = element.parentElement - return { - id: element.getAttribute('id'), - type: - parentElement?.getAttribute('fig-type') ?? - element.getAttribute('content-type') ?? - '', - src: element.getAttributeNS(this.XLINK_NAMESPACE, 'href'), - } - } - private isMatchingCategory( - secType: string | null, - titleNode: Element | null, - category: SectionCategory - ) { - if (secType && category.synonyms.includes(secType)) { - return true - } - if (titleNode && titleNode.nodeName === 'title' && titleNode.textContent) { - const textContent = titleNode.textContent.trim().toLowerCase() - if (category.synonyms.includes(textContent)) { - return true - } - } - return false - } - private parseRef = (element: Element) => { - const publicationType = element.getAttribute('publication-type') - - const authorNodes = [ - ...element.querySelectorAll( - 'person-group[person-group-type="author"] > *' - ), - ] - - const id = element.id - - const attrs: BibliographyItemAttrs = { - id, - type: this.chooseBibliographyItemType(publicationType), - } - const title = this.getHTMLContent(element, 'article-title') - if (title) { - attrs.title = title - } - - const mixedCitation = element.querySelector('mixed-citation') - - if (authorNodes.length <= 0) { - mixedCitation?.childNodes.forEach((item) => { - if ( - item.nodeType === Node.TEXT_NODE && - item.textContent?.match(/[A-Za-z]+/g) - ) { - attrs.literal = trimTextContent(mixedCitation) ?? '' - return attrs - } - }) - } - - const source = this.getHTMLContent(element, 'source') - if (source) { - attrs.containerTitle = source - } - - const volume = trimTextContent(element, 'volume') - if (volume) { - attrs.volume = volume - } - - const issue = trimTextContent(element, 'issue') - if (issue) { - attrs.issue = issue - } - - const supplement = trimTextContent(element, 'supplement') - if (supplement) { - attrs.supplement = supplement - } - - const fpage = trimTextContent(element, 'fpage') - const lpage = trimTextContent(element, 'lpage') - if (fpage) { - attrs.page = lpage ? `${fpage}-${lpage}` : fpage - } - - const year = trimTextContent(element, 'year') - if (year) { - attrs.issued = buildBibliographicDate({ - 'date-parts': [[year]], - }) - } - - const doi = trimTextContent(element, 'pub-id[pub-id-type="doi"]') - if (doi) { - attrs.doi = doi - } - - const authors: BibliographicName[] = [] - authorNodes.forEach((authorNode) => { - const name = buildBibliographicName({}) - const given = trimTextContent(authorNode, 'given-names') - if (given) { - name.given = given - } - const family = trimTextContent(authorNode, 'surname') - - if (family) { - name.family = family - } - - if (authorNode.nodeName === 'collab') { - name.literal = trimTextContent(authorNode) - } - authors.push(name) - }) - - if (authors.length) { - attrs.author = authors - } - return attrs - } - private chooseBibliographyItemType = (publicationType: string | null) => { - switch (publicationType) { - case 'book': - case 'thesis': - return publicationType - case 'journal': - default: - return 'article-journal' - } - } - - private _commonNodes: NodeRule[] = [ - { - tag: 'highlight-marker', - node: 'highlight_marker', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.id, - position: element.getAttribute('position'), - } - }, - }, - { - tag: 'attrib', - node: 'attribution', - }, - { - tag: 'break', - node: 'hard_break', - }, - { - tag: 'caption', - node: 'figcaption', - context: 'figure/', - }, - { - tag: 'caption', - node: 'figcaption', - context: 'figure_element/|table_element/|embed/', - getContent: (node, schema) => { - const element = node as HTMLElement - - const content = [] - - const title = element.querySelector('title') - if (title) { - const captionTitle = schema.nodes.caption_title.create() - content.push(this.parser.parse(title, { topNode: captionTitle })) - } - - const paragraphs = element.querySelectorAll('p') - if (paragraphs.length) { - const figcaption = schema.nodes.caption.create() - for (const paragraph of paragraphs) { - content.push(this.parser.parse(paragraph, { topNode: figcaption })) - } - } - - return Fragment.from(content) as Fragment - }, - }, - { - tag: 'caption', - node: 'figcaption', - context: 'box_element/', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'code', - node: 'listing', - context: 'listing_element/', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - language: element.getAttribute('language') ?? '', - contents: trimTextContent(element), - } - }, - }, - { - tag: 'inline-formula', - node: 'inline_equation', - getAttrs: (node) => { - const element = node as HTMLElement - return this.getEquationContent(element) - }, - }, - { - tag: 'disp-formula', - node: 'equation_element', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - } - }, - getContent: (node, schema) => { - const element = node as HTMLElement - const attrs = this.getEquationContent(element) - return Fragment.from([ - schema.nodes.equation.createChecked({ ...attrs }), - ]) as Fragment - }, - }, - { - tag: 'disp-quote[content-type=quote]', - node: 'blockquote_element', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'disp-quote[content-type=pullquote]', - node: 'pullquote_element', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'ext-link', - node: 'link', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - href: element.getAttributeNS(this.XLINK_NAMESPACE, 'href') || '', - title: element.getAttributeNS(this.XLINK_NAMESPACE, 'title') || '', - } - }, - }, - { - tag: 'fig[fig-type=equation]', - node: 'equation_element', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'media', - node: 'embed', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - href: element.getAttributeNS(this.XLINK_NAMESPACE, 'href'), - mimetype: element.getAttribute('mimetype'), - mimeSubtype: element.getAttribute('mime-subtype'), - } - }, - }, - { - tag: 'fig[fig-type=listing]', - node: 'listing_element', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'graphic[specific-use=MISSING]', - node: 'missing_figure', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'graphic', - node: 'figure', - context: 'figure_element/', - getAttrs: this.getFigureAttrs, - }, - { - tag: 'graphic', - node: 'image_element', - getContent: (node) => { - const figure = this.schema.nodes.figure.create( - this.getFigureAttrs(node) - ) - return Fragment.from(figure) - }, - }, - { - tag: 'fig', - node: 'figure_element', - getAttrs: (node) => { - const element = node as HTMLElement - const attrib = element.querySelector('attrib') - - const attribution = attrib - ? { - literal: trimTextContent(attrib) ?? '', - } - : undefined - - return { - id: element.getAttribute('id'), - attribution, - } - }, - }, - { - tag: 'fn-group', - node: 'footnotes_element', - context: 'footnotes_section/|table_element_footer/', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - kind: 'footnote', // TODO: 'endnote' depending on position or attribute? - } - }, - }, - { - tag: 'table-wrap-foot', - node: 'table_element_footer', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'general-table-footnote', - node: 'general_table_footnote', - context: 'table_element_footer/', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - } - }, - getContent: (node) => { - const paragraphs: ManuscriptNode[] = [] - node.childNodes.forEach((p) => { - const paragraph = this.schema.nodes.paragraph.create() - const content = this.parser.parse(p, { - topNode: paragraph, - }) - paragraphs.push(content) - }) - return Fragment.from([...paragraphs]) as Fragment - }, - }, - { - tag: 'fn', - node: 'footnote', - context: 'footnotes_element/|table_element_footer/', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - kind: 'footnote', // TODO: 'endnote' depending on position or attribute? - } - }, - }, - { - tag: 'list', - node: 'list', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - listStyleType: element.getAttribute('list-type'), - } - }, - }, - { - tag: 'list-item', - node: 'list_item', - }, - { - tag: 'p', - node: 'paragraph', - context: 'section/', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'p', - node: 'paragraph', - }, - { - tag: 'sec[sec-type="endnotes"]', - node: 'footnotes_section', // NOTE: higher priority than 'section' - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - // category: chooseSectionCategory(element), // 'MPSectionCategory:endnotes', - } - }, - }, - { - tag: 'sec[sec-type="box-element"]', - node: 'box_element', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'sec[sec-type="bibliography"]', - node: 'bibliography_section', - }, - { - tag: 'ref-list', - context: 'bibliography_section/', - node: 'bibliography_element', - }, - { - tag: 'ref', - context: 'bibliography_element/', - node: 'bibliography_item', - getAttrs: (node) => this.parseRef(node as Element), - }, - { - tag: 'sec[sec-type="abstract-graphical"]', - node: 'graphical_abstract_section', - }, - { - tag: 'sec', - node: 'section', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - category: this.chooseSectionCategory(element), - } - }, - }, - { - tag: 'boxed-text', - ignore: true, - }, - { - tag: 'label', - context: 'section/', - node: 'section_label', - }, - { - tag: 'table', - node: 'table', - // TODO: count thead and tfoot rows - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'table-wrap', - node: 'table_element', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - id: element.getAttribute('id'), - } - }, - }, - { - tag: 'title', - node: 'section_title', - context: - 'section/|footnotes_section/|bibliography_section/|keywords/|supplements/|author_notes/|graphical_abstract_section/', - }, - { - tag: 'title', - node: 'caption_title', - context: 'figcaption/', - }, - { - tag: 'tr', - node: 'table_row', - }, - { - tag: 'td', - node: 'table_cell', - getAttrs: (node) => { - const element = node as HTMLElement - const colspan = parseInt(element.getAttribute('colspan') || '1') - const rowspan = parseInt(element.getAttribute('rowspan') || '1') - return { - ...(colspan && { colspan }), - ...(rowspan && { rowspan }), - valign: element.getAttribute('valign'), - align: element.getAttribute('align'), - scope: element.getAttribute('scope'), - style: element.getAttribute('style'), - } - }, - }, - { - tag: 'th', - node: 'table_header', - getAttrs: (node) => { - const element = node as HTMLElement - const colspan = parseInt(element.getAttribute('colspan') || '1') - const rowspan = parseInt(element.getAttribute('rowspan') || '1') - return { - ...(colspan && { colspan }), - ...(rowspan && { rowspan }), - valign: element.getAttribute('valign'), - align: element.getAttribute('align'), - scope: element.getAttribute('scope'), - style: element.getAttribute('style'), - } - }, - }, - { - tag: 'col', - node: 'table_col', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - width: element.getAttribute('width'), - } - }, - }, - { - tag: 'colgroup', - node: 'table_colgroup', - }, - { - tag: 'xref[ref-type="bibr"]', - node: 'citation', - getAttrs: (node) => { - const element = node as HTMLElement - return { - rids: element.getAttribute('rid')?.split(/\s+/) || [], - contents: trimTextContent(element), - } - }, - }, - { - tag: 'xref[ref-type="fn"]', - node: 'inline_footnote', - getAttrs: (node) => { - const element = node as HTMLElement - - return { - rids: element.getAttribute('rid')?.split(/\s+/) || [], - } - }, - }, - { - tag: 'xref', - node: 'cross_reference', - getAttrs: (node) => { - const element = node as HTMLElement - return { - rids: element.getAttribute('rid')?.split(/\s+/) || [], - } - }, - }, - { - tag: 'label', - ignore: true, - }, - ] - - get allNodes() { - return this.nodes.concat(this._commonNodes) - } - - protected constructor( - doc: Document, - private sectionCategories?: SectionCategory[] - ) { - this.doc = doc - } - abstract parse( - element: Element | null | Element[] | Node | ChildNode - ): ManuscriptNode | undefined - abstract parser: DOMParser - abstract readonly nodes: NodeRule[] -} diff --git a/src/jats/parsers/KeywordsParser.ts b/src/jats/parsers/KeywordsParser.ts deleted file mode 100644 index 5b650774..00000000 --- a/src/jats/parsers/KeywordsParser.ts +++ /dev/null @@ -1,72 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ -import { DOMParser } from 'prosemirror-model' - -import { ManuscriptNode, NodeRule } from '../../schema' -import { JatsParser } from './JatsParser' - -export class KeywordsParser extends JatsParser { - parser: DOMParser - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - parse(element: Element | null): ManuscriptNode | undefined { - if (!element) { - return - } - element.querySelector('title')?.remove() - const keywords = this.createElement('keywords') - const title = this.createElement('title') - title.textContent = 'Keywords' - keywords.append(title) - const kwdGroupList = this.createElement('kwd-group-list') - kwdGroupList.append(element) - keywords.append(kwdGroupList) - return this.parser.parse(keywords, { - topNode: this.schema.nodes.keywords.create(), - }) - } - nodes: NodeRule[] = [ - { - tag: 'title', - node: 'section_title', - }, - { - tag: 'keywords', - node: 'keywords', - }, - { - tag: 'kwd-group-list', - node: 'keywords_element', - }, - { - tag: 'kwd-group', - node: 'keywords', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.id, - type: element.getAttribute('kwd-group-type'), - } - }, - }, - { - tag: 'kwd', - node: 'keyword', - }, - ] -} diff --git a/src/jats/parsers/ParserFactory.ts b/src/jats/parsers/ParserFactory.ts deleted file mode 100644 index eec2dd57..00000000 --- a/src/jats/parsers/ParserFactory.ts +++ /dev/null @@ -1,73 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ -import { SectionCategory } from '../../schema' -import { AbstractsParser } from './AbstractsParser' -import { AffiliationsParser } from './AffiliationsParser' -import { AuthorNotesParser } from './AuthorNotesParser' -import { AwardsParser } from './AwardsParser' -import { BackmatterParser } from './BackmatterParser' -import { BodyParser } from './BodyParser' -import { ContributorsParser } from './ContributorsParser' -import { KeywordsParser } from './KeywordsParser' -import { SupplementsParser } from './SupplementsParser' -import { TitleParser } from './TitleParser' - -export class ParserFactory { - constructor( - private doc: Document, - private sectionCategories: SectionCategory[] - ) {} - - createAbstractsParser() { - return new AbstractsParser(this.doc, this.sectionCategories) - } - - createAffiliationsParser() { - return new AffiliationsParser(this.doc) - } - - createAuthorNotesParser() { - return new AuthorNotesParser(this.doc) - } - - createAwardsParser() { - return new AwardsParser(this.doc) - } - - createBackmatterParser() { - return new BackmatterParser(this.doc, this.sectionCategories) - } - - createBodyParser() { - return new BodyParser(this.doc, this.sectionCategories) - } - - createContributorsParser() { - return new ContributorsParser(this.doc) - } - - createKeywordsParser() { - return new KeywordsParser(this.doc) - } - - createSupplementsParser() { - return new SupplementsParser(this.doc) - } - - createTitleParser() { - return new TitleParser(this.doc) - } -} diff --git a/src/jats/parsers/TitleParser.ts b/src/jats/parsers/TitleParser.ts deleted file mode 100644 index 3c5842cb..00000000 --- a/src/jats/parsers/TitleParser.ts +++ /dev/null @@ -1,57 +0,0 @@ -/*! - * © 2025 Atypon Systems LLC - * - * Licensed under the Apache License, Version 2.0 (the "License"); - * you may not use this file except in compliance with the License. - * You may obtain a copy of the License at - * - * http://www.apache.org/licenses/LICENSE-2.0 - * - * Unless required by applicable law or agreed to in writing, software - * distributed under the License is distributed on an "AS IS" BASIS, - * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - * See the License for the specific language governing permissions and - * limitations under the License. - */ - -import { DOMParser, Fragment } from 'prosemirror-model' - -import { ManuscriptNode, NodeRule } from '../../schema' -import { htmlFromJatsNode } from '../importer/jats-parser-utils' -import { JatsParser } from './JatsParser' - -export class TitleParser extends JatsParser { - private readonly defaultTitle = 'Untitled Manuscript' - private readonly tag = 'article-meta > title-group > article-title' - parser: DOMParser - - constructor(doc: Document) { - super(doc) - this.parser = new DOMParser(this.schema, [...this.marks, ...this.nodes]) - } - - parse(): ManuscriptNode { - const node = this.parser.parse(this.doc, { - topNode: this.schema.nodes.title.create(), - }) - return node - } - nodes: NodeRule[] = [ - { - tag: this.tag, - node: 'title', - getAttrs: (node) => { - const element = node as HTMLElement - return { - id: element.getAttribute('id'), - } - }, - getContent: (node) => { - const element = node as HTMLElement - return Fragment.from( - htmlFromJatsNode(element) || this.schema.text(this.defaultTitle) - ) - }, - }, - ] -} From 1bd0595e08b33c443b352b4834a3218d428b0316 Mon Sep 17 00:00:00 2001 From: Mohammad Betamony Date: Tue, 11 Feb 2025 19:48:27 +0300 Subject: [PATCH 5/5] lint --- src/jats/__tests__/jats-importer.test.ts | 2 -- src/jats/exporter/jats-exporter.ts | 6 +++++- src/jats/importer/jats-parser-utils.ts | 2 +- src/jats/importer/parsers/AbstractsParser.ts | 2 +- src/jats/importer/parsers/AwardsParser.ts | 1 - src/jats/importer/parsers/BackmatterParser.ts | 1 + src/jats/importer/parsers/JatsParser.ts | 2 +- src/jats/importer/parsers/ManuscriptParser.ts | 12 +++++------- src/jats/importer/parsers/SupplementsParser.ts | 1 - src/schema/nodes/embed.ts | 2 +- 10 files changed, 15 insertions(+), 16 deletions(-) diff --git a/src/jats/__tests__/jats-importer.test.ts b/src/jats/__tests__/jats-importer.test.ts index d543d8ce..d93db18f 100644 --- a/src/jats/__tests__/jats-importer.test.ts +++ b/src/jats/__tests__/jats-importer.test.ts @@ -308,7 +308,6 @@ describe('JATS importer', () => { expect(abstractsNode).toBeDefined() changeIDs(abstractsNode) expect(abstractsNode).toMatchSnapshot() - }) it("should have an abstracts even if abstarcts element doesn't exist", async () => { const jats = await readAndParseFixture('jats-import.xml') @@ -535,7 +534,6 @@ describe('JATS importer', () => { changeIDs(backNode) expect(backNode).toMatchSnapshot() }) - }) test('parses JATS to Manuscripts document', async () => { diff --git a/src/jats/exporter/jats-exporter.ts b/src/jats/exporter/jats-exporter.ts index 72c9efa6..4b744614 100644 --- a/src/jats/exporter/jats-exporter.ts +++ b/src/jats/exporter/jats-exporter.ts @@ -823,7 +823,11 @@ export class JATSExporter { mediaElement.setAttribute('mime-subtype', node.attrs.mimeSubtype) } appendLabels(mediaElement, node) - appendChildNodeOfType(mediaElement, node, node.type.schema.nodes.figcaption) + appendChildNodeOfType( + mediaElement, + node, + node.type.schema.nodes.figcaption + ) return mediaElement }, awards: () => ['funding-group', 0], diff --git a/src/jats/importer/jats-parser-utils.ts b/src/jats/importer/jats-parser-utils.ts index 243490ed..2c8046b3 100644 --- a/src/jats/importer/jats-parser-utils.ts +++ b/src/jats/importer/jats-parser-utils.ts @@ -266,4 +266,4 @@ export const capitalizeFirstLetter = (str: string) => export const getHTMLContent = (node: Element, querySelector: string) => { return htmlFromJatsNode(node.querySelector(querySelector)) -} \ No newline at end of file +} diff --git a/src/jats/importer/parsers/AbstractsParser.ts b/src/jats/importer/parsers/AbstractsParser.ts index 2f7dd5c7..617e722f 100644 --- a/src/jats/importer/parsers/AbstractsParser.ts +++ b/src/jats/importer/parsers/AbstractsParser.ts @@ -54,11 +54,11 @@ export class AbstractsParser extends JatsParser { for (const element of elements) { abstracts.appendChild(this.createAbstractSection(element)) } - return this.parser.parse(abstracts, { topNode: this.schema.nodes.abstracts.create(), }) } + protected get nodes(): NodeRule[] { return [ { diff --git a/src/jats/importer/parsers/AwardsParser.ts b/src/jats/importer/parsers/AwardsParser.ts index 3d59c042..b8572796 100644 --- a/src/jats/importer/parsers/AwardsParser.ts +++ b/src/jats/importer/parsers/AwardsParser.ts @@ -14,7 +14,6 @@ * limitations under the License. */ - import { trimTextContent } from '../../../lib/utils' import { ManuscriptNode, NodeRule } from '../../../schema' import { JatsParser } from './JatsParser' diff --git a/src/jats/importer/parsers/BackmatterParser.ts b/src/jats/importer/parsers/BackmatterParser.ts index a8766330..b0ae2901 100644 --- a/src/jats/importer/parsers/BackmatterParser.ts +++ b/src/jats/importer/parsers/BackmatterParser.ts @@ -33,6 +33,7 @@ export class BackmatterParser extends JatsParser { topNode: this.schema.nodes.backmatter.create(), }) } + protected get nodes(): NodeRule[] { return [ { tag: 'bio', ignore: true }, diff --git a/src/jats/importer/parsers/JatsParser.ts b/src/jats/importer/parsers/JatsParser.ts index 5454d66a..56246d79 100644 --- a/src/jats/importer/parsers/JatsParser.ts +++ b/src/jats/importer/parsers/JatsParser.ts @@ -27,7 +27,7 @@ import { ManuscriptNode, MarkRule, NodeRule, - schema, + schema, SectionCategory, } from '../../../schema' import { getHTMLContent } from '../jats-parser-utils' diff --git a/src/jats/importer/parsers/ManuscriptParser.ts b/src/jats/importer/parsers/ManuscriptParser.ts index d909898f..72589856 100644 --- a/src/jats/importer/parsers/ManuscriptParser.ts +++ b/src/jats/importer/parsers/ManuscriptParser.ts @@ -22,7 +22,7 @@ import { JatsParser } from './JatsParser' export class ManuscriptParser extends JatsParser { private readonly parsers: JatsParser[] private readonly protoype?: string - private readonly jatsTransformer: JatsProcessor + private readonly jatsProcessor: JatsProcessor constructor( doc: Document, parsers: JatsParser[], @@ -32,7 +32,7 @@ export class ManuscriptParser extends JatsParser { super(doc) this.parsers = parsers this.protoype = protoype - this.jatsTransformer = new JatsProcessor(this.doc, sectionCategories) + this.jatsProcessor = new JatsProcessor(this.doc, sectionCategories) } private static parseDates = (historyNode: Element | null | undefined) => { @@ -97,15 +97,13 @@ export class ManuscriptParser extends JatsParser { } parse() { - this.jatsTransformer.process() + this.jatsProcessor.process() const content = this.parsers .map((parser) => parser.parse()) .filter((node) => node !== undefined) - const manuscript = this.schema.nodes.manuscript.create( - this.getManuscriptAttrs(), - content - ) + const attrs = this.getManuscriptAttrs() + const manuscript = this.schema.nodes.manuscript.create(attrs, content) updateDocumentIDs(manuscript) return manuscript } diff --git a/src/jats/importer/parsers/SupplementsParser.ts b/src/jats/importer/parsers/SupplementsParser.ts index 3f22eead..e9de3950 100644 --- a/src/jats/importer/parsers/SupplementsParser.ts +++ b/src/jats/importer/parsers/SupplementsParser.ts @@ -14,7 +14,6 @@ * limitations under the License. */ - import { trimTextContent } from '../../../lib/utils' import { NodeRule } from '../../../schema' import { JatsParser } from './JatsParser' diff --git a/src/schema/nodes/embed.ts b/src/schema/nodes/embed.ts index 706f0c0c..a9413727 100644 --- a/src/schema/nodes/embed.ts +++ b/src/schema/nodes/embed.ts @@ -31,7 +31,7 @@ export interface EmbedNode extends ManuscriptNode { } export const embed: NodeSpec = { - content: "figcaption", + content: 'figcaption', attrs: { id: { default: '' }, dataTracked: { default: null },