Dears,
I want to test ESMFold2 for mAb-antigen predictions, and I wonder if you have a recommended way to assess binding affinities given the results of an ESMFold2 prediction?
Is there a difference between inputting the heavy VH + light VL + antigen protein sequences versus stitching together the VH+VL with a linker, as described in the scFv examples in the paper/preprint?
Dears,
I want to test ESMFold2 for mAb-antigen predictions, and I wonder if you have a recommended way to assess binding affinities given the results of an ESMFold2 prediction?
Is there a difference between inputting the heavy VH + light VL + antigen protein sequences versus stitching together the VH+VL with a linker, as described in the scFv examples in the paper/preprint?