Hello,
I am planning to use AutoHiC to process Omni-C data.
As Omni-C uses DNase I and does not rely on a specific restriction enzyme, the resulting fragments are not defined by a particular recognition site.
When using other tools like Juicer, there is typically a none option for the restriction enzyme parameter to handle this type of data.
However, in the AutoHiC configuration, selecting a restriction enzyme seems to be a mandatory field.
Could you please advise on the correct procedure for processing Omni-C data? Is there a specific setting I should use, or a workaround for datasets that do not use a restriction enzyme?
Thank you for your time and assistance.
Hello,
I am planning to use AutoHiC to process Omni-C data.
As Omni-C uses DNase I and does not rely on a specific restriction enzyme, the resulting fragments are not defined by a particular recognition site.
When using other tools like Juicer, there is typically a none option for the restriction enzyme parameter to handle this type of data.
However, in the AutoHiC configuration, selecting a restriction enzyme seems to be a mandatory field.
Could you please advise on the correct procedure for processing Omni-C data? Is there a specific setting I should use, or a workaround for datasets that do not use a restriction enzyme?
Thank you for your time and assistance.