diff --git a/README.txt b/README.md similarity index 82% rename from README.txt rename to README.md index 893d30b..e4952ab 100644 --- a/README.txt +++ b/README.md @@ -1,16 +1,16 @@ NEURON model files from the paper M. Migliore, L. Messineo, M. Cardaci, G.F. Ayala, Quantitative modeling of perception and production of time intervals, -J.Neurophysiol. 86, 2754-2760 (2001). +*J.Neurophysiol.* 86, 2754-2760 (2001). -Using a basic biophysical model of a timekeeping system, +- Using a basic biophysical model of a timekeeping system, and experimental data on time intervals produced or estimated under different conditions, the paper shows that experimental values, variability, and distributions, can be quantitatively explained in terms of a background synaptic activity such as that generated by attention. The paper suggests a possible link between behavioral data and neural mechanisms at the single neuron level. -The mod files include a POINT_PROCESS that generates synaptic pulses +- The mod files include a POINT_PROCESS that generates synaptic pulses according to a Poissonian distribution, modified in such a way that its mean ISI could be drawn from a normal distribution. We used this mechanism to model intervals produced or estimated by different subjects, @@ -18,21 +18,29 @@ whereas different cognitive loads were modeled by the strength of inhibition. See the paper for more details on the underlying assumptions. Under unix systems: +------------------- compile the mod files using the command -nrnivmodl +``` nrnivmodl ``` and run the simulation hoc file with the command -nrngui timing_db.hoc +``` nrngui timing_db.hoc ``` This will open a window from which a simulation of 5 subjects producing a 0.5 sec interval can be run. Change "inhibition" to model different experimental conditions and cognitive loads. Under Windows: +-------------- to compile the mod files use the "mknrndll DOS box" and follow on-screen instructions. A double click on the simulation file timing_db.hoc will open the simulation window. +\ Questions on how to use this model should be directed to michele.migliore@pa.ibf.cnr.it +\ +Changelog +--------- +2024-10: Converted readme to markdown +