Time-dependent features

[rachmaninoffpk]

Currently GeoTox uses single exposures and steady-state plasma concentrations to translate exposures to dose-response and mixtures analysis, via the R package httk. Expanding the use of modeling capabilities from httk, time-dependent modelling of response to exposure is possible.

• Simulate population parameters via httk
• Parametrize httk models
• Solve httk models
• Adapt current exposure functions