diff --git a/Mouse/Adult/Colon_SCP2038.RData b/Mouse/Adult/Colon_SCP2038.RData new file mode 100644 index 0000000..70f40aa Binary files /dev/null and b/Mouse/Adult/Colon_SCP2038.RData differ diff --git a/Mouse/MouseAdult_CellTypes.xlsx b/Mouse/MouseAdult_CellTypes.xlsx index 5bcb653..0f649db 100644 Binary files a/Mouse/MouseAdult_CellTypes.xlsx and b/Mouse/MouseAdult_CellTypes.xlsx differ diff --git a/Mouse/Mouse_datasets_metadata.csv b/Mouse/Mouse_datasets_metadata.csv index c2bd51f..5c50d61 100644 --- a/Mouse/Mouse_datasets_metadata.csv +++ b/Mouse/Mouse_datasets_metadata.csv @@ -1,42 +1,43 @@ -Profile Matrix,Tissue,Species,Strain,Age,Age Group,URL,Citation -MCA,Bladder,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,BoneMarrow,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,BoneMarrow_cKit,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +Profile Matrix,Tissue,Species,Strain,Age,Age Group,URL,Citation +MCA,Bladder,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,BoneMarrow,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,BoneMarrow_cKit,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." AllenBrainAtlas,Brain,Mouse,"C57BL/6J, Nkx2.1-CreERT2;Ai14",8 weeks,Adult,"https://www.biorxiv.org/content/10.1101/2020.03.30.015214v1.full#F1 -https://portal.brain-map.org/atlases-and-data/rnaseq/mouse-whole-cortex-and-hippocampus-10x","Yao, Z. et al. A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation. bioRxiv 2020.03.30.015214 (2020) doi:10.1101/2020.03.30.015214." -MCA,Brain,Mouse,"C57BL/6","6-10 weeks",Adult,"https://pubmed.ncbi.nlm.nih.gov/29474909/","Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -ImmGen,ImmuneAtlas,Mouse,"C57BL/6, B6.Rorc.tm2Litt",5-6 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/30686579/,"Yoshida, H. et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell 176, 897-912.e20 (2019)." -ImmGen_cellFamily,ImmuneAtlas,Mouse,"C57BL/6, B6.Rorc.tm2Litt",5-6 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/30686579/,"Yoshida, H. et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell 176, 897-912.e20 (2019)." -MCA,Kidney,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Liver,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Lung,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,MammaryGland_Involution,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,MammaryGland_Lactation,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,MammaryGland_Pregnancy,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,MammaryGland_Virgin,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Muscle,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Ovary,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Pancreas,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,PeripheralBlood,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Placenta,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Prostate,Mouse,C57BL/6,8-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,SmallIntestine,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Spleen,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Stomach,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Testis,Mouse,C57BL/6,8-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Thymus,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Uterus,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,EmbryonicMesenchyme,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +https://portal.brain-map.org/atlases-and-data/rnaseq/mouse-whole-cortex-and-hippocampus-10x","Yao, Z. et al. A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation. bioRxiv 2020.03.30.015214 (2020) doi:10.1101/2020.03.30.015214." +MCA,Brain,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +ImmGen,ImmuneAtlas,Mouse,"C57BL/6, B6.Rorc.tm2Litt",5-6 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/30686579/,"Yoshida, H. et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell 176, 897-912.e20 (2019)." +ImmGen_cellFamily,ImmuneAtlas,Mouse,"C57BL/6, B6.Rorc.tm2Litt",5-6 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/30686579/,"Yoshida, H. et al. The cis-Regulatory Atlas of the Mouse Immune System. Cell 176, 897-912.e20 (2019)." +MCA,Kidney,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Liver,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Lung,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,MammaryGland_Involution,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,MammaryGland_Lactation,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,MammaryGland_Pregnancy,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,MammaryGland_Virgin,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Muscle,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Ovary,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Pancreas,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,PeripheralBlood,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Placenta,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Prostate,Mouse,C57BL/6,8-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,SmallIntestine,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Spleen,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Stomach,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Testis,Mouse,C57BL/6,8-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Thymus,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Uterus,Mouse,C57BL/6,6-10 weeks,Adult,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,EmbryonicMesenchyme,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." MOCA,FetalAtlas,Mouse,C57BL/6,9.5 and 13.5 days,Fetal/E9.5-13.5,"https://doi.org/10.1038/s41586-019-0969-x -https://oncoscape.v3.sttrcancer.org/atlas.gs.washington.edu.mouse.rna/downloads","Cao, J. et al. The single cell transcriptional landscape of mammalian organogenesis. Nature 566, 496–502 (2019)." -MCA,Brain,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Intestine,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Liver,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Lung,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Stomach,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Calvaria,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Heart,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Muscle,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Pancreas,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Rib,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." -MCA,Skin,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +https://oncoscape.v3.sttrcancer.org/atlas.gs.washington.edu.mouse.rna/downloads","Cao, J. et al. The single cell transcriptional landscape of mammalian organogenesis. Nature 566, 496–502 (2019)." +MCA,Brain,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Intestine,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Liver,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Lung,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Stomach,Mouse,C57BL/6,14.5 days,Fetal/E14.5,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Calvaria,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Heart,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Muscle,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Pancreas,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Rib,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +MCA,Skin,Mouse,C57BL/6,1 day,Neonatal,https://pubmed.ncbi.nlm.nih.gov/29474909/,"Han, X. et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell 172, 1091-1107.e17 (2018)." +SCP2038,Colon,Mouse,"KRAS^LSL-G12D/+,APC^fl/fl, Rosa26^LSL-tdTomato, Trp53^fl/fl,Villin^CreERT2",6-10 weeks,Adult,"https://www.biorxiv.org/content/10.1101/2022.10.02.508492v1.full.pdf, https://www.nature.com/articles/s41587-023-01657-3, https://singlecell.broadinstitute.org/single_cell/study/SCP2038/single-cell-and-spatial-transcriptomics-of-mouse-colon?hiddenTraces=2020-09-14_Puck_200701_20#study-summary","Avraham-Davidi, I. et al. Integrative single cell and spatial transcriptomics of colorectal cancer reveals multicellular functional units that support tumor progression. Preprint at bioRxiv (2022) https://www.biorxiv.org/content/10.1101/2022.10.02.508492v1 (2022)."