diff --git a/openadmet/toolkit/cofolding/openfold.py b/openadmet/toolkit/cofolding/openfold.py
new file mode 100644
index 0000000..b3cb207
--- /dev/null
+++ b/openadmet/toolkit/cofolding/openfold.py
@@ -0,0 +1,132 @@
+import gc
+import os
+import tempfile
+import pandas as pd
+from pathlib import Path
+from shutil import copyfile
+from typing import Optional, Union
+import subprocess
+
+import numpy as np
+import torch
+from loguru import logger
+
+from pydantic import Field, field_validator
+
+from openadmet.toolkit.cofolding.cofold_base import CoFoldingEngine
+
+
+try:
+    from openfold3.core.config import config_utils
+    from openfold3.core.data.pipelines.preprocessing.template import TemplatePreprocessor
+    from openfold3.core.data.tools.colabfold_msa_server import preprocess_colabfold_msas
+    from openfold3.entry_points.experiment_runner import (
+        InferenceExperimentRunner,
+        TrainingExperimentRunner,
+    )
+    from openfold3.entry_points.validator import (
+        InferenceExperimentConfig,
+        TrainingExperimentConfig,
+    )
+    from openfold3.projects.of3_all_atom.config.dataset_config_components import (
+        colabfold_msa_settings,
+    )
+    from openfold3.projects.of3_all_atom.config.inference_query_format import (
+        InferenceQuerySet,
+    )
+except ImportError:
+    HAS_OPENFOLD3 = False
+else:
+    HAS_OPENFOLD3 = True
+
+
+class OpenFold3CofoldingEngine(CoFoldingEngine):
+
+    use_msa_server: bool = Field(
+                False, description="Use MSA server for multiple sequence alignment"
+    )
+    num_diffusion_samples: int = Field(None, description="Number of diffusion samples to generate for each query")
+
+    num_model_seeds: int = Field(None, description="Number of model seeds to use for each query")
+
+    use_msa_server: bool = Field(True, description="Use MSA server for multiple sequence alignment")
+
+    use_templates: bool = Field(False, description="Use templates for structure prediction")
+
+    inference_ckpt_path: Path = Field(description="Path to the inference checkpoint")
+
+
+    @field_validator("inference_ckpt_path")
+    def check_inference_ckpt_path(cls, v):
+        # path must exist
+        if not v.exists():
+            raise ValueError(f"inference_ckpt_path must exist, got {v}")
+        return v
+
+    def inference(
+        self,
+        query_json: Path,
+        runner_yaml: Path | None = None,
+    ):
+        if not HAS_OPENFOLD3:
+            raise ImportError("OpenFold3 is not installed.")
+
+        runner_args = config_utils.load_yaml(runner_yaml) if runner_yaml else {}
+
+        expt_config = InferenceExperimentConfig(
+            inference_ckpt_path=self.inference_ckpt_path, **runner_args
+        )
+        expt_runner = InferenceExperimentRunner(
+            expt_config,
+            self.num_diffusion_samples,
+            self.num_model_seeds,
+            self.use_msa_server,
+            self.use_templates,
+            self.output_dir,
+        )
+
+        # Dump experiment runner
+        import json
+
+        with open(self.output_dir / "experiment_config.json", "w") as f:
+            json.dump(expt_config.model_dump_json(indent=2), f)
+
+        # Load inference query set
+        query_set = InferenceQuerySet.from_json(query_json)
+
+        # Perform MSA computation if selected
+        #  update query_set with MSA paths
+        if expt_runner.use_msa_server:
+            logger.info("Using ColabFold MSA server for alignments.")
+            query_set = preprocess_colabfold_msas(
+                inference_query_set=query_set,
+                compute_settings=expt_config.msa_computation_settings,
+            )
+
+            # Update the msa dataset config settings
+            updated_dataset_config_kwargs = expt_config.dataset_config_kwargs.model_copy(
+                update={"msa": colabfold_msa_settings}
+            )
+            expt_config = expt_config.model_copy(
+                update={"dataset_config_kwargs": updated_dataset_config_kwargs}
+            )
+        else:
+            expt_config.msa_computation_settings.cleanup_msa_dir = False
+
+        # Preprocess template alignments and optionally template structures
+        if expt_runner.use_templates:
+            logger.info("Using templates for inference.")
+            template_preprocessor = TemplatePreprocessor(
+                input_set=query_set,
+                config=expt_config.dataset_config_kwargs.template_preprocessor,
+            )
+            template_preprocessor()
+        else:
+            logger.info("Not using templates for inference.")
+
+        # Run the forward pass
+        expt_runner.setup()
+        expt_runner.run(query_set)
+        expt_runner.cleanup()
+
+        logger.info("Inference completed successfully.")