diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index 6f5364d..f529e74 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -12,9 +12,9 @@ jobs:
   test:
     strategy:
       matrix:
-        python-version: ["pypy-3.10", "3.10", "3.11", "3.12", "3.13"]
+        python-version: ["pypy-3.11", "3.10", "3.11", "3.12", "3.13", "3.14"]
         extras:
-          - "[test,docs]"
+          - "[test,docs,zodb,test-zodb]"
 
     runs-on: ubuntu-latest
     steps:
@@ -37,10 +37,14 @@ jobs:
         coverage combine || true
         coverage report -i || true
     - name: Lint
-      if: matrix.python-version == '3.12'
+      if: matrix.python-version == '3.14'
       run: |
         python -m pip install -U pylint
         pylint src
+    - name: Test No ZODB
+      run: |
+        python -m pip uninstall -y ZODB zope.site persistent
+        python -m zope.testrunner --test-path=src  --auto-color --auto-progress
     - name: Submit to Coveralls
       # This is a container action, which only runs on Linux.
       uses: AndreMiras/coveralls-python-action@develop
diff --git a/CHANGES.rst b/CHANGES.rst
index bcdbc17..381e153 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -2,10 +2,11 @@
  Changes
 =========
 
-4.3.1 (unreleased)
+4.4.0 (unreleased)
 ==================
 
-- Nothing changed yet.
+- Move ZODB and related dependencies to the optional 'zodb' extra.
+- Add support for Python 3.14.
 
 
 4.3.0 (2025-04-22)
diff --git a/setup.py b/setup.py
index 0042769..75bcaa8 100755
--- a/setup.py
+++ b/setup.py
@@ -13,7 +13,6 @@
 
 TESTS_REQUIRE = [
     'Acquisition',
-    'zope.site',
     'zope.testrunner',
     'testgres >= 1.11',
     'psycopg2-binary; python_implementation != "PyPy"',
@@ -47,6 +46,7 @@ def _read(fname):
         'Programming Language :: Python :: 3.11',
         'Programming Language :: Python :: 3.12',
         'Programming Language :: Python :: 3.13',
+        'Programming Language :: Python :: 3.14',
         'Programming Language :: Python :: Implementation :: CPython',
         'Programming Language :: Python :: Implementation :: PyPy',
         'Topic :: Software Development :: Testing',
@@ -56,7 +56,6 @@ def _read(fname):
     packages=find_namespace_packages(where='src'),
     package_dir={'': 'src'},
     install_requires=[
-        'ZODB >= 5.6.0',
         # Error messages changed in 5.1, reprs changed <= 5.4
         'zope.interface >= 5.4.0',
         'pyhamcrest',
@@ -72,7 +71,13 @@ def _read(fname):
     entry_points=entry_points,
     include_package_data=True,
     extras_require={
+        'zodb': [
+            'ZODB >= 5.6.0',
+        ],
         'test': TESTS_REQUIRE,
+        'test-zodb': [
+            'zope.site',
+        ],
         'docs': [
             'Sphinx',
             'furo',
diff --git a/src/nti/testing/tests/test_base.py b/src/nti/testing/tests/test_base.py
index fb25d01..29d9b6b 100644
--- a/src/nti/testing/tests/test_base.py
+++ b/src/nti/testing/tests/test_base.py
@@ -89,7 +89,10 @@ def test_thing(self):
 
 
     def test_configuring_base(self):
-        import zope.traversing.tests.test_traverser
+        try:
+            import zope.traversing.tests.test_traverser
+        except ModuleNotFoundError:
+            self.skipTest('zope.traversing not installed')
         class MyTest(base.ConfiguringTestBase):
             set_up_packages = ('zope.component',
                                ('configure.zcml', 'zope.component'),
@@ -104,7 +107,10 @@ def test_thing(self):
         mt.tearDown() # pylint:disable=no-value-for-parameter
 
     def test_shared_configuring_base(self):
-        import zope.traversing.tests.test_traverser
+        try:
+            import zope.traversing.tests.test_traverser
+        except ModuleNotFoundError:
+            self.skipTest('zope.traversing not installed')
         class MyTest(base.SharedConfiguringTestBase):
             layer = None # replaced by metaclass
             set_up_packages = ('zope.component',
diff --git a/src/nti/testing/tests/test_main.py b/src/nti/testing/tests/test_main.py
index d1327ad..3c53073 100644
--- a/src/nti/testing/tests/test_main.py
+++ b/src/nti/testing/tests/test_main.py
@@ -32,16 +32,22 @@ def test_suite():
     here = os.path.dirname(__file__)
 
     suite = unittest.defaultTestLoader.loadTestsFromName(__name__)
-    suite.addTest(doctest.DocFileSuite(
-        'test_component_cleanup_broken.txt'))
+    try:
+        import zope.site as has_zope_site
+    except ModuleNotFoundError:
+        has_zope_site = None
+    else:
+        suite.addTest(doctest.DocFileSuite(
+            'test_component_cleanup_broken.txt'))
 
     readmedir = here
     while not os.path.exists(os.path.join(readmedir, 'setup.py')):
         readmedir = os.path.dirname(readmedir)
     readme = os.path.join(readmedir, 'README.rst')
-    suite.addTest(doctest.DocFileSuite(
-        readme,
-        module_relative=False,
-        optionflags=doctest.ELLIPSIS,
-    ))
+    if has_zope_site:
+        suite.addTest(doctest.DocFileSuite(
+            readme,
+            module_relative=False,
+            optionflags=doctest.ELLIPSIS,
+        ))
     return suite
diff --git a/src/nti/testing/tests/test_zodb.py b/src/nti/testing/tests/test_zodb.py
index 2a77698..abda355 100644
--- a/src/nti/testing/tests/test_zodb.py
+++ b/src/nti/testing/tests/test_zodb.py
@@ -14,7 +14,13 @@
 import transaction
 from transaction.interfaces import NoTransaction
 from zope import interface
-from nti.testing import zodb
+try:
+    from nti.testing import zodb
+    base_mock_db_trans = zodb.mock_db_trans
+except ModuleNotFoundError as ex:
+    assert ex.name == 'ZODB'
+    zodb = None
+    base_mock_db_trans = object
 
 # pylint:disable=protected-access,pointless-string-statement
 
@@ -41,7 +47,7 @@ def cacheMinimize(self):
         self.minimized = True
 
 
-class MockDBTrans(zodb.mock_db_trans):
+class MockDBTrans(base_mock_db_trans):
 
     def __init__(self, db=None):
         if db is None:
@@ -52,6 +58,8 @@ def __init__(self, db=None):
 class TestMockDBTrans(unittest.TestCase):
 
     def setUp(self):
+        if zodb is None:
+            self.skipTest("ZODB not installed")
         self._was_explicit = transaction.manager.explicit
         transaction.manager.explicit = False
 
@@ -226,7 +234,7 @@ def __bool__(self):
         class MyMock(MockDBTrans):
             seen_tx = None
             aborted = False
-            def on_connection_opened(self, conn):
+            def on_connection_opened(self, _conn):
                 # pylint:disable=no-member
                 self.seen_tx = self._mock_db_trans__current_transaction
                 abort = self.seen_tx.abort
@@ -255,7 +263,13 @@ def _abort():
 
 class TestZODBLayer(unittest.TestCase):
 
-    layer = zodb.ZODBLayer
+    if zodb is not None:
+        layer = zodb.ZODBLayer
+
+    def setUp(self):
+        super().setUp()
+        if zodb is None:
+            self.skipTest("ZODB not installed")
 
     def test_registration(self):
         from ZODB.interfaces import IDatabase
@@ -288,10 +302,14 @@ def __init__(self, *args):
         pass
 
 class TestResetDbCaches(unittest.TestCase):
-    layer = zodb.ZODBLayer
+
+    if zodb is not None:
+        layer = zodb.ZODBLayer
 
     def setUp(self):
         super().setUp()
+        if zodb is None:
+            self.skipTest("ZODB not installed")
         gc.disable()
 
     def tearDown(self):
diff --git a/tox.ini b/tox.ini
index 67f3847..fb7253a 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,6 +4,8 @@ envlist = py38,py39,py310,py311,py312,pypy3,coverage,docs
 [testenv]
 extras =
      test
+     zodb
+     test-zodb
 commands =
          zope-testrunner --test-path=src  --auto-color --auto-progress [] # substitute with tox positional args
 setenv =
@@ -20,6 +22,10 @@ commands =
 deps =
     coverage
 
+[testenv:py314]
+extras =
+    test
+
 [testenv:docs]
 commands =
     sphinx-build -b html -d docs/_build/doctrees docs docs/_build/html