The Allelic Fold Change (aFC) estimates for all independent cis-eQTLs across 49 tissues in GTEx v8 release.
The aFC-n model is the multi-variant generalization of the aFC approach, to accurately estimate the cis-regulatory effect size in genes associated with multiple conditionally independent eQTLs. Notably, aFC-n is the first method that allows for predicting genetically regulated gene expression in a haplotype-specific fashion, paving the way for a future class of genome association studies that can systematically incorporate allele dosage effects.
This dataset is generated using aFC-n software package, 10.5281/zenodo.8412460, to calculate effect sizes for ~half a million independent cis-eQTLs across 49 tissues in the GTEx v8 release as described in the manuscript.
- gene_id : Ensembl gene ID
- variant_id : eQTL ID associated to the gene
- log2_aFC : The log2 of eQTL effect sizes measured as allelic Fold Change (aFC).
- log2_aFC_min_95_interv : Lower bound 95% confidence interval
- log2_aFC_plus_95_interv: Upper bound 95% confidence interval