diff --git a/Cargo.lock b/Cargo.lock
index 10ff7ef2..28bb6b29 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -431,11 +431,10 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.24.2"
+version = "0.27.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e5203598f366b11a02b13aa20cab591229ff0a89fd121a308a5df751d5fc9219"
+checksum = "37a6df7eab65fc7bee654a421404947e10a0f7085b6951bf2ea395f4659fb0cf"
 dependencies = [
- "cfg-if",
  "indoc",
  "libc",
  "memoffset",
@@ -449,19 +448,18 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.24.2"
+version = "0.27.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "99636d423fa2ca130fa5acde3059308006d46f98caac629418e53f7ebb1e9999"
+checksum = "f77d387774f6f6eec64a004eac0ed525aab7fa1966d94b42f743797b3e395afb"
 dependencies = [
- "once_cell",
  "target-lexicon",
 ]
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.24.2"
+version = "0.27.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "78f9cf92ba9c409279bc3305b5409d90db2d2c22392d443a87df3a1adad59e33"
+checksum = "2dd13844a4242793e02df3e2ec093f540d948299a6a77ea9ce7afd8623f542be"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -469,9 +467,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.24.2"
+version = "0.27.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0b999cb1a6ce21f9a6b147dcf1be9ffedf02e0043aec74dc390f3007047cecd9"
+checksum = "eaf8f9f1108270b90d3676b8679586385430e5c0bb78bb5f043f95499c821a71"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -481,9 +479,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.24.2"
+version = "0.27.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "822ece1c7e1012745607d5cf0bcb2874769f0f7cb34c4cde03b9358eb9ef911a"
+checksum = "70a3b2274450ba5288bc9b8c1b69ff569d1d61189d4bff38f8d22e03d17f932b"
 dependencies = [
  "heck",
  "proc-macro2",
diff --git a/synpy/Cargo.toml b/synpy/Cargo.toml
index 34cd9d3e..c0f48ae8 100644
--- a/synpy/Cargo.toml
+++ b/synpy/Cargo.toml
@@ -10,5 +10,5 @@ crate-type = ["cdylib"]
 
 [dependencies]
 bitvec = "1.0.1"
-pyo3 = "0.24.2"
+pyo3 = "0.27.1"
 synir = { path = "../synir" }