I had this issue on Kali and now Debian 12. The keyboard and mouse are blocked after reboot. Have to boot into safe mode and systemctl disable usbguard and usbguard-dbus. Then regular boot enable again. It doesn't happen on every reboot. If I enable usbguard after I log in it is OK. I think it has a timing issue if usbguard is enabled too soon in the booting process. Is there a way to change when the system enables usbguard?