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<!DOCTYPE html>
<html lang="zh-CN">
<head>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>TcrDesign - TCR智能设计系统 | ImmunoAI</title>
<link rel="stylesheet" href="style.css">
<style>
* {
margin: 0;
padding: 0;
box-sizing: border-box;
}
body {
font-family: 'Arial', 'Microsoft YaHei', sans-serif;
line-height: 1.6;
color: #333;
background: linear-gradient(135deg, #f8fafc 0%, #e2e8f0 100%);
}
.container {
max-width: 1200px;
margin: 0 auto;
padding: 0 20px;
}
/* Hero Section */
.hero {
background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
min-height: 100vh;
display: flex;
align-items: center;
justify-content: center;
position: relative;
color: white;
text-align: center;
}
.hero::before {
content: '';
position: absolute;
top: 0;
left: 0;
right: 0;
bottom: 0;
background: url('data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100"><defs><pattern id="grid" width="10" height="10" patternUnits="userSpaceOnUse"><path d="M 10 0 L 0 0 0 10" fill="none" stroke="rgba(255,255,255,0.1)" stroke-width="0.5"/></pattern></defs><rect width="100" height="100" fill="url(%23grid)"/></svg>');
opacity: 0.3;
}
.hero-content {
max-width: 800px;
padding: 0 20px;
position: relative;
z-index: 1;
}
.hero h1 {
font-size: 3.5rem;
font-weight: 700;
margin-bottom: 1rem;
animation: fadeInUp 1s ease-out;
}
.hero .subtitle {
font-size: 1.3rem;
margin-bottom: 2rem;
opacity: 0.9;
animation: fadeInUp 1s ease-out 0.3s both;
}
.hero .description {
font-size: 1.1rem;
margin-bottom: 3rem;
opacity: 0.8;
animation: fadeInUp 1s ease-out 0.6s both;
}
.main-title {
font-size: 3rem;
font-weight: 700;
margin-bottom: 20px;
background: linear-gradient(135deg, #63b3ed 0%, #90cdf4 100%);
-webkit-background-clip: text;
-webkit-text-fill-color: transparent;
background-clip: text;
}
.subtitle {
font-size: 1.3rem;
color: #e2e8f0;
font-weight: 300;
max-width: 800px;
margin: 0 auto;
}
.model-image-container {
width: 70%;
border-radius: 15px;
overflow: hidden;
box-shadow: 0 8px 25px rgba(0,0,0,0.15);
transition: all 0.3s ease;
margin: 0 auto;
}
.model-image-container:hover {
transform: scale(1.02);
box-shadow: 0 12px 35px rgba(0,0,0,0.2);
}
.model-image {
width: 100%;
height: auto;
display: block;
transition: all 0.3s ease;
}
.image-placeholder {
width: 100%;
height: 1000px;
background: linear-gradient(135deg, #e2e8f0 0%, #cbd5e0 100%);
border-radius: 15px;
display: flex;
align-items: center;
justify-content: center;
color: #4a5568;
font-size: 1.1rem;
border: 2px dashed #a0aec0;
transition: all 0.3s ease;
}
.image-placeholder:hover {
background: linear-gradient(135deg, #cbd5e0 0%, #a0aec0 100%);
}
/* 主要内容区域 */
main {
padding: 80px 0;
}
.section {
background: white;
margin-bottom: 40px;
border-radius: 20px;
box-shadow: 0 10px 30px rgba(0,0,0,0.1);
overflow: hidden;
transition: transform 0.3s ease, box-shadow 0.3s ease;
}
.section:hover {
transform: translateY(-5px);
box-shadow: 0 20px 40px rgba(0,0,0,0.15);
}
.section-header {
background: linear-gradient(135deg, #3182ce 0%, #2c5282 100%);
color: white;
padding: 30px 40px;
text-align: center;
}
.section-title {
font-size: 2rem;
font-weight: 600;
margin-bottom: 10px;
}
.section-description {
font-size: 1.1rem;
opacity: 0.9;
}
.section-content {
padding: 50px 40px;
}
/* 模型概述部分 */
.overview-content {
display: grid;
grid-template-columns: 1fr;
gap: 40px;
align-items: center;
}
.overview-text {
font-size: 1.1rem;
line-height: 1.8;
color: #4a5568;
}
.highlight-text {
color: #2c5282;
font-weight: 600;
}
/* 性能说明部分 */
.performance-intro {
font-size: 1.2rem;
color: #2d3748;
margin-bottom: 30px;
padding: 25px;
background: linear-gradient(135deg, #f7fafc 0%, #edf2f7 100%);
border-radius: 15px;
border-left: 5px solid #3182ce;
}
.features-grid {
display: grid;
grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
gap: 25px;
margin-top: 40px;
}
.feature-card {
background: linear-gradient(135deg, #f8fafc 0%, #f1f5f9 100%);
padding: 30px;
border-radius: 15px;
border: 1px solid #e2e8f0;
transition: all 0.3s ease;
position: relative;
overflow: hidden;
}
.feature-card::before {
content: '';
position: absolute;
top: 0;
left: 0;
width: 100%;
height: 4px;
background: linear-gradient(135deg, #3182ce 0%, #63b3ed 100%);
}
.feature-card:hover {
transform: translateY(-3px);
box-shadow: 0 15px 35px rgba(0,0,0,0.1);
background: linear-gradient(135deg, #ffffff 0%, #f8fafc 100%);
}
.feature-icon {
font-size: 2.5rem;
margin-bottom: 15px;
}
.feature-title {
font-size: 1.3rem;
font-weight: 600;
color: #2c5282;
margin-bottom: 15px;
}
.feature-description {
color: #4a5568;
line-height: 1.7;
}
/* 开始设计按钮 */
.action-section {
text-align: center;
padding: 60px 0;
background: linear-gradient(135deg, #1a202c 0%, #2d3748 100%);
margin-top: 60px;
border-radius: 20px;
position: relative;
overflow: hidden;
}
.action-section::before {
content: '';
position: absolute;
top: -50%;
left: -50%;
width: 200%;
height: 200%;
background: radial-gradient(circle, rgba(99, 179, 237, 0.1) 0%, transparent 70%);
animation: pulse 4s ease-in-out infinite;
}
@keyframes pulse {
0%, 100% { transform: scale(0.8); opacity: 0.3; }
50% { transform: scale(1.2); opacity: 0.1; }
}
.action-content {
position: relative;
z-index: 2;
}
.action-title {
font-size: 2.2rem;
color: white;
margin-bottom: 20px;
font-weight: 600;
}
.action-subtitle {
font-size: 1.1rem;
color: #e2e8f0;
margin-bottom: 40px;
max-width: 600px;
margin-left: auto;
margin-right: auto;
}
.start-design-btn {
display: inline-block;
padding: 18px 40px;
background: linear-gradient(135deg, #3182ce 0%, #63b3ed 100%);
color: white;
text-decoration: none;
border-radius: 50px;
font-size: 1.2rem;
font-weight: 600;
transition: all 0.3s ease;
box-shadow: 0 8px 25px rgba(49, 130, 206, 0.3);
cursor: pointer;
border: none;
}
.start-design-btn:hover {
transform: translateY(-3px);
box-shadow: 0 12px 35px rgba(49, 130, 206, 0.4);
background: linear-gradient(135deg, #2c5282 0%, #3182ce 100%);
}
/* 联系我们弹窗 */
.modal {
display: none;
position: fixed;
z-index: 1000;
left: 0;
top: 0;
width: 100%;
height: 100%;
background-color: rgba(0, 0, 0, 0.6);
backdrop-filter: blur(5px);
animation: fadeIn 0.3s ease;
}
@keyframes fadeIn {
from { opacity: 0; }
to { opacity: 1; }
}
.modal-content {
background: white;
margin: 5% auto;
padding: 0;
border-radius: 20px;
width: 90%;
max-width: 500px;
box-shadow: 0 25px 60px rgba(0,0,0,0.3);
animation: slideIn 0.3s ease;
overflow: hidden;
}
@keyframes slideIn {
from { transform: translateY(-50px); opacity: 0; }
to { transform: translateY(0); opacity: 1; }
}
.modal-header {
background: linear-gradient(135deg, #3182ce 0%, #2c5282 100%);
color: white;
padding: 25px 30px;
text-align: center;
position: relative;
}
.modal-title {
font-size: 1.5rem;
font-weight: 600;
margin: 0;
}
.close {
position: absolute;
right: 20px;
top: 50%;
transform: translateY(-50%);
color: white;
font-size: 24px;
font-weight: bold;
cursor: pointer;
transition: all 0.3s ease;
width: 30px;
height: 30px;
display: flex;
align-items: center;
justify-content: center;
border-radius: 50%;
}
.close:hover {
background: rgba(255, 255, 255, 0.2);
}
.modal-body {
padding: 30px;
}
.contact-item {
display: flex;
align-items: center;
margin-bottom: 20px;
padding: 15px;
background: #f8fafc;
border-radius: 10px;
border-left: 4px solid #3182ce;
transition: all 0.3s ease;
}
.contact-item:hover {
background: #f1f5f9;
transform: translateX(5px);
}
.contact-icon {
font-size: 1.5rem;
margin-right: 15px;
color: #3182ce;
width: 30px;
text-align: center;
}
.contact-info h4 {
margin: 0 0 5px 0;
color: #2d3748;
font-size: 1.1rem;
}
.contact-info p {
margin: 0;
color: #4a5568;
font-size: 0.95rem;
}
/* 响应式设计 */
@media (max-width: 768px) {
.main-title {
font-size: 2.2rem;
}
.subtitle {
font-size: 1.1rem;
}
.overview-content {
grid-template-columns: 12fr;
gap: 30px;
}
.features-grid {
grid-template-columns: 1fr;
}
.section-content, .section-header {
padding: 30px 25px;
}
.action-title {
font-size: 1.8rem;
}
.modal-content {
margin: 10% auto;
width: 95%;
}
}
</style>
</head>
<body>
<header>
<nav class="container">
<a href="#" class="logo">ImmunoAI</a>
<ul class="nav-links">
<li><a href="index.html">首页</a></li>
<li><a href="index.html#features">核心优势</a></li>
<li class="dropdown">
<a href="#services">数据资源</a>
<div class="dropdown-content">
<a href="tsmpdb.html">肿瘤膜蛋白数据库</a>
<a href="neodb_page.html">肿瘤新抗原数据库</a>
</div>
</li>
<li class="dropdown">
<a href="#tools">AI设计工具</a>
<div class="dropdown-content">
<a href="antibody_design.html">抗体设计</a>
<a href="tcr_design.html">TCR设计</a>
<a href="antide.html">定向进化</a>
</div>
</li>
<li><a href="contact_page.html">联系我们</a></li>
</ul>
</nav>
</header>
<!-- Hero Section -->
<section class="hero">
<div class="hero-content">
<h1>TcrDesign</h1>
<p class="subtitle">基于生成式 AI 的 TCR 智能设计系统</p>
</div>
</section>
<section id="features" class="features">
<div class="container">
<h2 class="section-title">核心优势</h2>
<div class="features-grid">
<div class="feature-card">
<div class="feature-icon">🧬</div>
<h3>结合功能筛选，实现了全流程TCR设计自动化</h3>
</div>
<div class="feature-card">
<div class="feature-icon">🎯</div>
<h3>突破了现有方法仅能生成βCDR3序列的局限</h3>
</div>
<div class="feature-card">
<div class="feature-icon">🚀</div>
<h3>实验验证闭环增强TCR设计的可靠性</h3>
</div>
</div>
</div>
</section>
<main>
<div class="container">
<!-- 模型概述 -->
<section class="section">
<div class="section-header">
<h2 class="section-title">模型概述</h2>
<p class="section-description">行业内首次实现从头生成完整的 TCR 序列</p>
</div>
<div class="section-content">
<div class="model-image-container">
<img src="picture/TcrDesign_model.png" alt="TcrDesign模型架构图" class="model-image">
</div>
<br>
<div class="overview-content">
<div class="overview-text">
<span class="highlight-text">TcrDesign</span>是我们自主研发的基于<span class="highlight-text">生成式 AI </span>的智能 TCR 序列设计系统，其核心亮点在于实现了<span class="highlight-text">TCR 生成与 pMHC 结合预测的端到端一体化管道</span>，通过<span class="highlight-text">双重预训练任务强化 pMHC 特征提取</span>以提升预测精度，并创新性地引入<span class="highlight-text">结构建模辅助筛选</span>，确保确保生成序列的生物学合理性与结合潜力，从而全面提升 TCR 序列设计的效率与准确性。
</div>
</div>
</div>
</section>
<!-- 模型性能说明 -->
<section class="section">
<div class="section-header">
<h2 class="section-title">模型性能说明</h2>
<p class="section-description">行业领先的综合解决方案</p>
</div>
<div class="section-content">
<div class="performance-intro">
<strong>TcrDesign</strong>为 TCR 的从头生成提供了高效可靠的综合解决方案，在以下关键领域均达到行业领先水平：
</div>
<div class="model-image-container">
<img src="picture/TcrDesign_perf.png" alt="DnAbDesign模型性能图" class="model-image">
</div>
<div class="features-grid">
<div class="feature-card">
<div class="feature-icon">🧬</div>
<h3 class="feature-title">全长新抗原特异性 TCR 的生成能力</h3>
<p class="feature-description">TcrDesign-G 模型创新性地采纳了基于注意力机制的 Seq2Seq 架构设计，使其能够从头生成针对特定新抗原的全长 TCR 序列。</p>
</div>
<div class="feature-card">
<div class="feature-icon">🔬</div>
<h3 class="feature-title">基于 BERT 的高精度结合预测</h3>
<p class="feature-description">TcrDesign-B 模型利用大规模公开数据进行训练，并基于预训练的 BERT 模型提取 TCR 序列与 pMHC 复合物的深度特征表示，从而实现了对 TCR-pMHC 结合概率的有效且高精度预测。</p>
</div>
<div class="feature-card">
<div class="feature-icon">⚡</div>
<h3 class="feature-title">多维度实验验证的功能活性</h3>
<p class="feature-description">所生成的 TCR 序列的功能性得到了全面且严格的实验验证，包括但不限于 T 细胞激活检测、TCR-pMHC 分子特异性结合检测、细胞因子释放检测以及 T 细胞肿瘤靶向杀伤检测。</p>
</div>
</div>
</div>
</section>
<!-- 开始设计部分 -->
<div class="action-section">
<div class="action-content">
<h2 class="action-title">开启智能 TCR 设计之旅</h2>
<p class="action-subtitle">立即体验 TcrDesign 的强大功能，让AI助力您的 TCR-T 药物研发</p>
<button class="start-design-btn" onclick="openModal()">开始设计</button>
</div>
</div>
</div>
</main>
<!-- 联系我们弹窗 -->
<div id="contactModal" class="modal">
<div class="modal-content">
<div class="modal-header">
<h3 class="modal-title">联系我们</h3>
<span class="close" onclick="closeModal()">×</span>
</div>
<div class="modal-body">
<div class="contact-item">
<div class="contact-icon">👤</div>
<div class="contact-info">
<h4>联系人</h4>
<p>Dr. 刘雪松 研究员</p>
</div>
</div>
<div class="contact-item">
<div class="contact-icon">📧</div>
<div class="contact-info">
<h4>联系邮箱</h4>
<p>liuxs@shanghaitech.edu.cn</p>
</div>
</div>
<div class="contact-item">
<div class="contact-icon">📍</div>
<div class="contact-info">
<h4>地址</h4>
<p>上海市浦东新区华夏中路393号<br/>上海科技大学生命学院</p>
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<h4>联系电话</h4>
<p>+86-21-20685430</p>
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