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---
layout: null
section-type: aboutcopy
title: Projects
---
## PROJECTS
<img align="left" width="500" height="500" src="/img/intro-bg.jpg ">
**Assessing synaptic phenotype of STXBP1 syndrome in isogenic iPSC-derived neurons**
<h7> Advisors: Dr. Ruud Toonen </h7>
<h9> January 2020 - August 2020, VU Amsterdam </h9>
<h8>
1. Patch Clamp Electrophysiology on STXBP1(+/+) and STXBP1(-/-) iPSC-derived NGN2 neruons
<br>
2. Investigated using imuunostaining, protein quantication and confocal microscopy
</h8>
<br>
<img align="right" width="500" height="500" src="/img/intro-bg.jpg ">
**Effect of rapamycin treatment on the expression levels of EFEMP1 and MMP13 mRNA in iPSC-derived Tuberous Sclerosis Complex astrocytes**
<!--<h7> Advisors: Dr. Ruud Toonen </h7> -->
<h9> September 2019 </h9>
<h8> Project </h8>
<br>
<img align="left" width="300" height="300" src="/img/labrotation2.jpg ">
**Establishing RNAscope ISH and detection of Lin41 and FoxJ1 mRNA in mouse development**
<h7> Advisors: Dr. Gregory Wulczyn </h7>
<h9> July 2019 - August 2019 </h9>
<h8>
1. Established RNAscope method and optimized the work flow
<br>
2. Analyzed Lin41 and FoxJ1 mRNA presence in mouse tissue at E9.5, E14, P1, P28
<br>
3. Implemented imageJ macros and streamlined data analysis
</h8>
<br>
<img align="right" width="300" height="300" src="/img/labrotation1.jpg ">
**Effect of KCC2 modulation on the excitability of rat and human neocortex tissue using Multi Electrode Arrays**
<h7> Advisors: Dr. Ulf Strauss </h7>
<h9> February 2019 - March 2019 </h9>
<h8>
1. Set up MEA equipment in the lab
<br>
2. Tested the action of VU0463271 and CLP257 on neocortical slices
<br>
3.Optimized recording times, characterized ictal-like events and inter-ictal discharges in MEA recordings
</h8>
<br>
<img align="left" width="300" height="300" src="/img/bachelorthesis.jpg ">
**Premalignant Pancreatic Cancer Detection Using Mass-Spectrometry Data By Computational Methods**
<h7> Advisors: Dr. Satish Babu </h7>
<h9> January 2018 - May 2018 </h9>
<h8>
1. Compared classification of data using KNN, NNA, DTA and SVM methods
</h8>
<br>
<img align="right" width="300" height="300" src="/img/surf.jpg ">
**Presynaptic targeting of the ligand in TRACT systems, Khorana Scholarship**
<h7> Advisors: Dr. Carlos Lois </h7>
<h9> May 2017 - August 2019, California Institute of Technology </h9>
<h8>
1. Tested three presynaptic markers and calculated their efficiencies in the targetting
<br>
2. Performed confocal microscopy and assisted in molecular biology validation
<br>
3. Parallel Project: Functional dynamics of brain restoration in Zebra Finches
</h8>
<br>
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