diff --git a/NEWS.md b/NEWS.md
index 714bb2f432..1b12dafb56 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -9,6 +9,7 @@
 * Persisted collapsed state of the properties groups in the session (#4561)
 * Scripting: Added 'tiled.cell' function, 'cell.flags' property and 'TileLayerEdit.setCell' function (#4538)
 * Scripting: Added MapObject.resolvedClassName() (by MatusGuy, #4529)
+* Scripting: Added Tileset.selectedTilesChanged signal (#4615)
 * Fixed crash when the selection becomes empty while starting a move (#4536)
 * Fixed Properties view update on 'Reset Template Instance' and 'Replace With Template' actions
 * Fixed restoring of the layout for maximized windows on startup (#4580)
diff --git a/docs/scripting-doc/index.d.ts b/docs/scripting-doc/index.d.ts
index ba2e6ebb07..7e8989010a 100644
--- a/docs/scripting-doc/index.d.ts
+++ b/docs/scripting-doc/index.d.ts
@@ -4288,6 +4288,13 @@ declare class Tileset extends Asset {
    */
   selectedTiles: Tile[];
 
+  /**
+   * The signal emitted when {@link selectedTiles} changes.
+   *
+   * @since 1.13
+   */
+  readonly selectedTilesChanged: Signal<void>;
+
   /**
    * Constructs a new Tileset.
    */
diff --git a/src/tiled/editableobject.cpp b/src/tiled/editableobject.cpp
index c868124ef4..59913e66f2 100644
--- a/src/tiled/editableobject.cpp
+++ b/src/tiled/editableobject.cpp
@@ -53,7 +53,7 @@ void EditableObject::setPropertyImpl(const QString &name, const QVariant &value)
 {
     if (Document *doc = document())
         asset()->push(new SetProperty(doc, { mObject }, name, propertyValueFromScript(value)));
-    else
+    else if (!checkReadOnly())
         mObject->setProperty(name, propertyValueFromScript(value));
 }
 
@@ -67,7 +67,7 @@ void EditableObject::setPropertyImpl(const QStringList &path, const QVariant &va
     if (Document *doc = document())
         // todo: add support for array indices in path
         asset()->push(new SetProperty(doc, { mObject }, toPropertyPath(path), propertyValueFromScript(value)));
-    else
+    else if (!checkReadOnly())
         mObject->setProperty(toPropertyPath(path), propertyValueFromScript(value));
 }
 
@@ -75,7 +75,7 @@ void EditableObject::setProperties(const QVariantMap &properties)
 {
     if (Document *doc = document())
         asset()->push(new ChangeProperties(doc, QString(), mObject, propertyValueFromScript(properties)));
-    else
+    else if (!checkReadOnly())
         mObject->setProperties(propertyValueFromScript(properties));
 }
 
diff --git a/src/tiled/editabletileset.cpp b/src/tiled/editabletileset.cpp
index 008ab6412e..ef0e6a7dc0 100644
--- a/src/tiled/editabletileset.cpp
+++ b/src/tiled/editabletileset.cpp
@@ -422,6 +422,7 @@ void EditableTileset::setDocument(Document *document)
         connect(doc, &TilesetDocument::tilesAdded, this, &EditableTileset::attachTiles);
         connect(doc, &TilesetDocument::tilesRemoved, this, &EditableTileset::detachTiles);
         connect(doc, &TilesetDocument::tileObjectGroupChanged, this, &EditableTileset::tileObjectGroupChanged);
+        connect(doc, &TilesetDocument::selectedTilesChanged, this, &EditableTileset::selectedTilesChanged);
         connect(doc->wangSetModel(), &TilesetWangSetModel::wangSetAdded, this, &EditableTileset::wangSetAdded);
         connect(doc->wangSetModel(), &TilesetWangSetModel::wangSetRemoved, this, &EditableTileset::wangSetRemoved);
     }
diff --git a/src/tiled/editabletileset.h b/src/tiled/editabletileset.h
index 21f8422183..ca1cd18493 100644
--- a/src/tiled/editabletileset.h
+++ b/src/tiled/editabletileset.h
@@ -60,7 +60,7 @@ class EditableTileset final : public EditableAsset
     Q_PROPERTY(QColor backgroundColor READ backgroundColor WRITE setBackgroundColor)
     Q_PROPERTY(bool collection READ isCollection)   // deprecated
     Q_PROPERTY(bool isCollection READ isCollection)
-    Q_PROPERTY(QList<QObject*> selectedTiles READ selectedTiles WRITE setSelectedTiles)
+    Q_PROPERTY(QList<QObject*> selectedTiles READ selectedTiles WRITE setSelectedTiles NOTIFY selectedTilesChanged)
     Q_PROPERTY(Tileset::TransformationFlags transformationFlags READ transformationFlags WRITE setTransformationFlags)
 
 public:
@@ -188,6 +188,9 @@ public slots:
     void setBackgroundColor(const QColor &color);
     void setTransformationFlags(Tileset::TransformationFlags flags);
 
+signals:
+    void selectedTilesChanged();
+
 protected:
     void setDocument(Document *document) override;
 
diff --git a/src/tiled/tileseteditor.cpp b/src/tiled/tileseteditor.cpp
index 280385d60c..2cf9bb206a 100644
--- a/src/tiled/tileseteditor.cpp
+++ b/src/tiled/tileseteditor.cpp
@@ -562,6 +562,10 @@ void TilesetEditor::selectionChanged()
 
     updateActions();
 
+    // The view is being updated to match the document
+    if (mSynchronizingSelection)
+        return;
+
     const QItemSelectionModel *s = view->selectionModel();
     const QModelIndexList indexes = s->selection().indexes();
     if (indexes.isEmpty())
@@ -574,7 +578,7 @@ void TilesetEditor::selectionChanged()
         if (Tile *tile = model->tileAt(index))
             selectedTiles.append(tile);
 
-    QScopedValueRollback<bool> settingSelectedTiles(mSettingSelectedTiles, true);
+    QScopedValueRollback<bool> synchronizingSelection(mSynchronizingSelection, true);
     mCurrentTilesetDocument->setSelectedTiles(selectedTiles);
 }
 
@@ -655,7 +659,8 @@ void TilesetEditor::tilesetChanged()
 
 void TilesetEditor::selectedTilesChanged()
 {
-    if (mSettingSelectedTiles)
+    // The document is being updated to match the view
+    if (mSynchronizingSelection)
         return;
 
     if (mCurrentTilesetDocument != sender())
@@ -671,6 +676,9 @@ void TilesetEditor::selectedTilesChanged()
         tileSelection.select(modelIndex, modelIndex);
     }
 
+    // Avoid setting the selection on the document again from selectionChanged
+    QScopedValueRollback<bool> synchronizingSelection(mSynchronizingSelection, true);
+
     QItemSelectionModel *selectionModel = tilesetView->selectionModel();
     selectionModel->select(tileSelection, QItemSelectionModel::SelectCurrent);
     if (!tileSelection.isEmpty()) {
diff --git a/src/tiled/tileseteditor.h b/src/tiled/tileseteditor.h
index f36805e506..d9df5b1647 100644
--- a/src/tiled/tileseteditor.h
+++ b/src/tiled/tileseteditor.h
@@ -182,7 +182,7 @@ class TilesetEditor final : public Editor
     TilesetDocument *mCurrentTilesetDocument = nullptr;
 
     Tile *mCurrentTile = nullptr;
-    bool mSettingSelectedTiles = false;
+    bool mSynchronizingSelection = false;
 };
 
 inline QAction *TilesetEditor::addTilesAction() const