diff --git a/sci-biology/multiqc/Manifest b/sci-biology/multiqc/Manifest
index 83aba865300..3cd79506b8f 100644
--- a/sci-biology/multiqc/Manifest
+++ b/sci-biology/multiqc/Manifest
@@ -1 +1 @@
-DIST multiqc-1.29.gh.tar.gz 8544398 BLAKE2B fef22ac8693974a01b7ca36cb827e1dfac70798b6e23c28bbefd7dd0fdd52254e84b8feb56c34060bd1dc9eb01ed7976108293d89f28af59773d42ade559607a SHA512 a051aa70c2ee4e9017354c2a9824e6696acf5331201ca07418fecc71757dca2921a0f5fd7c8edcc98cebbaa5c19d95f26253045d6ac3c0d4ff31c624a4aa6f94
+DIST multiqc-1.33.gh.tar.gz 9512445 BLAKE2B 5e03ca4bf357890429e76956f15ee5bb617e79a8e82c53e8f7d555a294871ff3b1c8d2382d9652b7f15cf62086e77d6eb152d95b81ac75cb2bcf489236178b9c SHA512 7c740a17f366c24ebb70aa1fd040991138dfb5c73d5bc72451b2b52226af51884c854ea9a7bfb608473dec75df418d954055e590c27e5840f648920ae48e55b8
diff --git a/sci-biology/multiqc/multiqc-1.29.ebuild b/sci-biology/multiqc/multiqc-1.33.ebuild
similarity index 91%
rename from sci-biology/multiqc/multiqc-1.29.ebuild
rename to sci-biology/multiqc/multiqc-1.33.ebuild
index b23b3c698dc..c8b16f00215 100644
--- a/sci-biology/multiqc/multiqc-1.29.ebuild
+++ b/sci-biology/multiqc/multiqc-1.33.ebuild
@@ -1,10 +1,10 @@
-# Copyright 1999-2025 Gentoo Authors
+# Copyright 1999-2026 Gentoo Authors
 # Distributed under the terms of the GNU General Public License v2
 
 EAPI=8
 
 DISTUTILS_USE_PEP517=setuptools
-PYTHON_COMPAT=( python3_{11..13} )
+PYTHON_COMPAT=( python3_{12..13} )
 
 inherit distutils-r1
 
@@ -40,6 +40,7 @@ RDEPEND="dev-python/click[${PYTHON_USEDEP}]
 	dev-python/tqdm[${PYTHON_USEDEP}]"
 #	dev-python/tiktoken[${PYTHON_USEDEP}] # not strictly required
 #	dev-python/kaleido[${PYTHON_USEDEP}] # not strictly required
+#	dev-python/boto3[${PYTHON_USEDEP}] # not strictly required
 
 RESTRICT="test" # needs external repository with test data
 distutils_enable_tests pytest