diff --git a/pyproject.toml b/pyproject.toml
index 2d76a35..ffda14d 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,6 +1,6 @@
 [project]
 name = "pickmix"
-version = "0.4.0"
+version = "0.4.1"
 description = "Multi-kind particle picking GUI for cryo-ET sub-tomogram averaging workflows."
 readme = "README.md"
 authors = [
diff --git a/src/pickmix/gui/components/range_slider.py b/src/pickmix/gui/components/range_slider.py
index f393c4f..b9c230d 100644
--- a/src/pickmix/gui/components/range_slider.py
+++ b/src/pickmix/gui/components/range_slider.py
@@ -4,7 +4,7 @@
 
 # Import external dependencies
 from typing import Literal
-from PySide6.QtCore import QPointF, QRectF, QSize, Qt, Signal
+from PySide6.QtCore import QEvent, QPointF, QRectF, QSize, Qt, Signal
 from PySide6.QtGui import QKeyEvent, QMouseEvent, QPainter, QPaintEvent, QPen
 from PySide6.QtWidgets import QSizePolicy, QWidget
 
@@ -50,6 +50,13 @@ def set_values(self, low: int, high: int, *, emit: bool = False) -> None:
         if changed and emit:
             self.valueChanged.emit(low, high)
 
+    # event: claim up and down keys before a window shortcut can
+    def event(self, event: QEvent) -> bool:
+        if event.type() == QEvent.Type.ShortcutOverride and isinstance(event, QKeyEvent) and event.key() in (Qt.Key.Key_Up, Qt.Key.Key_Down):
+            event.accept()
+            return True
+        return super().event(event)
+
     # keyPressEvent: Left and Right move the active handle, Up and Down switch handle, PageUp and PageDown move by a tenth
     def keyPressEvent(self, event: QKeyEvent) -> None:
         small, large = max(1, (self._max - self._min) // 100), max(1, (self._max - self._min) // 10)
diff --git a/src/pickmix/gui/tabs/pick_tab.py b/src/pickmix/gui/tabs/pick_tab.py
index ab54023..56ee998 100644
--- a/src/pickmix/gui/tabs/pick_tab.py
+++ b/src/pickmix/gui/tabs/pick_tab.py
@@ -6,6 +6,7 @@
 import numpy as np
 from concurrent.futures import Future
 from PySide6.QtCore import Qt
+from PySide6.QtGui import QKeySequence, QShortcut
 from PySide6.QtWidgets import (
     QButtonGroup, QCheckBox, QFormLayout, QFrame, QGridLayout, QGroupBox, QHBoxLayout, QHeaderView, QLabel, QPushButton,
     QScrollBar, QSlider, QSplitter, QTableWidget, QTableWidgetItem, QToolButton, QVBoxLayout, QWidget,
@@ -51,7 +52,7 @@ def __init__(self) -> None:
         self._range = (0.0, 1.0)
         self.canvas = SliceCanvas()
         self.title = title()
-        self.help = hint('Enter: next tomogram. Shift+Enter: previous tomogram.')
+        self.help = hint('Enter: next tomogram. Shift+Enter: previous tomogram. Up/Down: change Z slice; Shift+Up/Down: change Z slice by 10.')
         self.status = QLabel()
         self.match_pane = MatchPane()
         self.tomo = TomoPane()
@@ -184,6 +185,8 @@ def __init__(self) -> None:
         self.canvas.move_requested.connect(self._move)
         self.canvas.marker_clicked.connect(self._clicked)
         self.canvas.z_scrolled.connect(lambda steps: self.z_slider.setValue(self.z_slider.value() + steps))
+        for keys, step in (('Up', 1), ('Down', -1), ('Shift+Up', 10), ('Shift+Down', -10)):
+            QShortcut(QKeySequence(keys), self, context=Qt.ShortcutContext.WidgetWithChildrenShortcut).activated.connect(lambda step=step: self._step_z(step))
         self.table.cellClicked.connect(self._row_clicked)
         self.match_pane.scan_requested.connect(self._scan)
         self.match_pane.stop_requested.connect(self._stop_scan)
@@ -396,6 +399,10 @@ def _open_done(self, name: str, future: Future[Opened]) -> None:
         if self.session.index + 1 < len(self.session.names):
             self.loader.prefetch(self.session.names[self.session.index + 1])
 
+    # _step_z: move the slice by steps
+    def _step_z(self, steps: int) -> None:
+        self.z_slider.setValue(self.z_slider.value() + steps)
+
     # _show_z: show slice z, from the cache or after reading it in the background
     def _show_z(self, z: int) -> None:
         if self.opened is None or self.loader is None:
diff --git a/tests/gui/test_main_window.py b/tests/gui/test_main_window.py
index c0fd225..30e655a 100644
--- a/tests/gui/test_main_window.py
+++ b/tests/gui/test_main_window.py
@@ -226,7 +226,8 @@ def test_pick_keys_are_window_wide(self, qtbot: QtBot) -> None:
         qtbot.addWidget(window)
         keys = {s.key().toString(): s for s in window.findChildren(QShortcut)}
         assert all(str(i) in keys for i in range(1, 10)) and 'Del' in keys and 'Backspace' in keys and 'A' in keys
-        assert all(s.context() == Qt.ShortcutContext.WindowShortcut for s in keys.values())
+        wanted = [*(str(i) for i in range(1, 10)), 'Del', 'Backspace', 'A']
+        assert all(keys[k].context() == Qt.ShortcutContext.WindowShortcut for k in wanted)
 
     # test_hotkey_and_delete_from_other_focus: with focus off the canvas, a hotkey still picks the kind and delete still removes the pick
     def test_hotkey_and_delete_from_other_focus(self, qtbot: QtBot, make_config: Callable[..., Path]) -> None:
diff --git a/tests/gui/test_pick_tab.py b/tests/gui/test_pick_tab.py
index 3c7003a..3b903f2 100644
--- a/tests/gui/test_pick_tab.py
+++ b/tests/gui/test_pick_tab.py
@@ -108,6 +108,51 @@ def test_scroll_z(self, setup: Callable[..., tuple[PickTab, Session]]) -> None:
         tab.canvas.z_scrolled.emit(-9)
         assert tab.z == 0
 
+    # test_arrow_keys_scroll_z: Up and Down move one slice and Shift ten, clamped to the tomogram
+    def test_arrow_keys_scroll_z(self, qtbot: QtBot, setup: Callable[..., tuple[PickTab, Session]]) -> None:
+        tab, _ = setup()
+        tab.show()
+        qtbot.waitExposed(tab)
+        tab.activateWindow()
+        qtbot.waitUntil(tab.isActiveWindow, timeout=3000)
+        tab.canvas.setFocus()
+        qtbot.keyClick(tab.canvas, Qt.Key.Key_Down)
+        assert tab.z == 1
+        qtbot.keyClick(tab.canvas, Qt.Key.Key_Up)
+        qtbot.keyClick(tab.canvas, Qt.Key.Key_Up)
+        assert tab.z == 3
+        qtbot.keyClick(tab.canvas, Qt.Key.Key_Up)
+        assert tab.z == 3
+        qtbot.keyClick(tab.canvas, Qt.Key.Key_Down, Qt.KeyboardModifier.ShiftModifier)
+        assert tab.z == 0
+
+    # test_arrow_keys_from_table: arrows scroll z even when the pick table has focus
+    def test_arrow_keys_from_table(self, qtbot: QtBot, setup: Callable[..., tuple[PickTab, Session]]) -> None:
+        tab, session = setup()
+        tab.pick_kind(0)
+        tab._add(1.0, 1.0)
+        tab.show()
+        qtbot.waitExposed(tab)
+        tab.activateWindow()
+        qtbot.waitUntil(tab.isActiveWindow, timeout=3000)
+        tab.table.setFocus()
+        before = tab.z
+        qtbot.keyClick(tab.table, Qt.Key.Key_Up)
+        assert tab.z == before + 1
+        assert session.store.total() == 1
+
+    # test_arrow_keys_leave_contrast_slider: Up and Down still switch the active handle of the contrast slider
+    def test_arrow_keys_leave_contrast_slider(self, qtbot: QtBot, setup: Callable[..., tuple[PickTab, Session]]) -> None:
+        tab, _ = setup()
+        tab.show()
+        qtbot.waitExposed(tab)
+        tab.activateWindow()
+        qtbot.waitUntil(tab.isActiveWindow, timeout=3000)
+        tab.contrast.setFocus()
+        before = tab.z
+        qtbot.keyClick(tab.contrast, Qt.Key.Key_Up)
+        assert tab.z == before
+
     # test_delete_needs_selection: Delete is greyed until a pick is selected and again once it is gone
     def test_delete_needs_selection(self, setup: Callable[..., tuple[PickTab, Session]]) -> None:
         tab, _ = setup()
diff --git a/uv.lock b/uv.lock
index ad5b491..9050010 100644
--- a/uv.lock
+++ b/uv.lock
@@ -137,7 +137,7 @@ wheels = [
 
 [[package]]
 name = "pickmix"
-version = "0.4.0"
+version = "0.4.1"
 source = { editable = "." }
 dependencies = [
     { name = "imageio" },