A problem of searching principle of Circle-Map

[FeiLiuEM]

Circle-Map is a very good algorithm and help me much.

I have a problem of searching principle:

Is it possible that the predicted eccDNA includes more than one eccDNA?

In other words, after recognizing split records, is it possible for the algorithm to recognize adjacent eccDNA as one eccDNA?

Thanks！

[iprada]

ey FeiLiuEM,

Thanks for you kind words. I appreciate :)

Circle-Map clusters split reads intervals (i.e. eccDNAs) that reciprocally overlap by 0.95 percent. Therefore, if there are nested structures it should capture them (circles inside other circles)

best,

Iñigo

[FeiLiuEM]

Hi Iñigo,

Thank you very much for your answer！

It addresses an important underlying problem in our study.

All the best,

Fei Liu

[iprada]

Glad to hear.

Happy circle hunting!

Iñigo