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HHblits run stuck at the prefiltering stage #381

Description

@rayab1993

Dear Authors,
I am having an issue from last couple of weeks for which I am unable to run hhblits_mpi for a list of protein sequences with UNICLUST30 as database:

My hhblits command is as follows:

mpirun hhblits_mpi -i ARDB -d "$DB" -oa3m ARDB_a3m -n 2 -cpu 48 -v 2

However the program is stuck at the prefiltering stage and never finishes the a3m files:

  • 14:49:05.541 INFO: Prefiltering database

  • 14:49:05.558 INFO: Prefiltering database

  • 14:49:05.580 INFO: Prefiltering database

  • 14:49:05.648 INFO: Prefiltering database

  • 14:49:05.666 INFO: Prefiltering database

  • 14:49:06.060 INFO: Searching 36293491 column state sequences.

  • 14:49:06.125 INFO: AR0080 is in A2M, A3M or FASTA format

  • 14:49:06.125 INFO: Iteration 1

  • 14:49:06.144 INFO: Searching 36293491 column state sequences.

  • 14:49:06.200 INFO: Searching 36293491 column state sequences.

  • 14:49:06.208 INFO: AR0087 is in A2M, A3M or FASTA format

  • 14:49:06.208 INFO: Iteration 1

  • 14:49:06.216 INFO: Prefiltering database

  • 14:49:06.264 INFO: AR0093 is in A2M, A3M or FASTA format

  • 14:49:06.265 INFO: Iteration 1

  • 14:49:06.281 INFO: Prefiltering database

  • 14:49:06.337 INFO: Prefiltering database

After this part the program doesnt seem to do anything.

The alignment files are all blank

Just to be clear , my input is a series of unrelated sequences in ffindex,ffdata format

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