Hi,
I am using your tool to calculate my own summary data from UKB. Because my raw data is the imputed genotype data, i used the UKB_imputed_SVD_eigen99_extraction as panel.
I have calculate about two hundred pairs of diseases and it works well.
But three summary statistics still have error, which is the same format of other summary statistics. Like this:
Analysis starts on Tue Mar 23 16:30:24 2021
1014352 out of 1029876 (98.49%) SNPs in reference panel are available in GWAS 1.
1017202 out of 1029876 (98.77%) SNPs in reference panel are available in GWAS 2.
Warning: More than 1% SNPs in reference panel are missed in GWAS 1. This may generate bias in estimation. Please make sure that you are using correct reference panel.
Warning: More than 1% SNPs in reference panel are missed in GWAS 2. This may generate bias in estimation. Please make sure that you are using correct reference panel.
Estimation is ongoing ... 100%
Integrating piecewise results
Error in HDL.rg(summary1, summary2, :
Algorithm failed to converge after trying different initial values.
Although someone has raise this question similarly, but i checked carefully and couldn't find any other wrong operation.
Looking forward to your reply!
Hi,
I am using your tool to calculate my own summary data from UKB. Because my raw data is the imputed genotype data, i used the UKB_imputed_SVD_eigen99_extraction as panel.
I have calculate about two hundred pairs of diseases and it works well.
But three summary statistics still have error, which is the same format of other summary statistics. Like this:
Analysis starts on Tue Mar 23 16:30:24 2021
1014352 out of 1029876 (98.49%) SNPs in reference panel are available in GWAS 1.
1017202 out of 1029876 (98.77%) SNPs in reference panel are available in GWAS 2.
Warning: More than 1% SNPs in reference panel are missed in GWAS 1. This may generate bias in estimation. Please make sure that you are using correct reference panel.
Warning: More than 1% SNPs in reference panel are missed in GWAS 2. This may generate bias in estimation. Please make sure that you are using correct reference panel.
Estimation is ongoing ... 100%
Integrating piecewise results
Error in HDL.rg(summary1, summary2, :
Algorithm failed to converge after trying different initial values.
Although someone has raise this question similarly, but i checked carefully and couldn't find any other wrong operation.
Looking forward to your reply!