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Primer design fixes#1

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daz10000 wants to merge 9 commits intoAmyris:masterfrom

demetrixbio:primer_dimer

Commits on Oct 30, 2017

CHK: added test for primer dimer problem that fails
Darren Platt
committed

Commits on Oct 31, 2017

ENH: primercore checks for primer dimer ends when designing left anchored primers
Darren Platt
committed

Commits on Nov 2, 2017

BUG,TST: added more tests for primer dimer and gc clamp checking. GC clamping could produce suboptimal result
Darren Platt
committed
ENH: added primerdimer check to the floating CENTER primer design
Darren Platt
committed
MIN: some debugging messages escaping into production
Darren Platt
committed

Commits on Nov 3, 2017

BUG: gc clamp was unnecessarily moving when it already had one
Darren Platt
committed
OOPS: missing update to the tests for the primer fixes
Darren Platt
committed

Commits on Nov 18, 2017

LNT: response to feedback on PR
Darren Platt
committed
MIN: reverting project to .net 4.5
Darren Platt
committed