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Original file line number Diff line number Diff line change
Expand Up @@ -53,9 +53,9 @@ Expect no change in ranking performance.
## Thresholds
The following thresholds are equivalent GICAM thresholds to GENMOD (-30,+51 range):

Genmod threshold 20 -> 0.618 normaliserat -> 0.85 recall -> 0.932 gicam threshold
Genmod threshold 20 -> 0.618 normalized -> 0.85 recall -> 0.946 gicam threshold

genmod threshold 15 -> 0.556 normaliserat -> 0.911 recall -> 0.757 gicam threshold
genmod threshold 15 -> 0.556 normalized -> 0.911 recall -> 0.743 gicam threshold

genmod threshold 10 -> 0.494 normaliserat -> 0.927 recall -> 0.730 gicam threshold
genmod threshold 10 -> 0.494 normalized -> 0.927 recall -> 0.703 gicam threshold

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2 changes: 2 additions & 0 deletions src/rdds/variant_rank_score/model/model.py
Original file line number Diff line number Diff line change
Expand Up @@ -1040,6 +1040,8 @@ def get_num_feature(variant: ParsableVariant,
clinvar_clnsig = str(variant.__getattribute__('CSQ_CLINVAR_CLNSIG')).lower()
if 'uncertain' in clinvar_clnsig or 'conflicting' in clinvar_clnsig:
str_data = b''
if clinvar_clnsig == 'other' or clinvar_clnsig == 'association':
str_data = b''
except AttributeError:
pass
input_dict[tensor_spec.name].append(str_data)
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