- 🌱 My research looks how we can use multi-omics to understand brain ageing
- 🌿 I'm working on ENIGMA-Epigenetics Cortical EWAS 2026
- 🏔️ How to reach me: eleanor.conole@bioch.ox.ac.uk
I'm a Junior Research Fellow in Applied AI at the University of Oxford. I work across large-scale longitudinal cohort data (UK Biobank, Generation Scotland, Lothian Birth Cohorts, Stratifying Longitudinal Resilience and Depression Cohort, and Theirworld Edinburgh Birth Cohort) using machine learning to identify epigenomic biomarkers of brain ageing
Previosuly I worked as a postdoc in the Lothian Birth Cohorts group at the University of Edinburgh.
Reviews and perspectives
- Epigenetic clocks and DNA methylation biomarkers of brain health and disease
Nature Reviews Neurology (2025)
https://doi.org/10.1038/s41582-025-01105-7
Review of methylation-based biomarkers for brain ageing and neurological disease, with emphasis on translational and clinical relevance.
Details
- Chronic inflammation and brain health: the case for early monitoring Neurology (2024) https://doi.org/10.1212/WNL.0000000000209613 Editorial on inflammation, prevention, and opportunities for early intervention.'
Original research
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Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles
Translational Psychiatry (2025)
https://doi.org/10.1038/s41398-025-03009-7
Large-scale population neuroimaging study deriving brain maps of general cognitive function and quantifying their spatial correspondence with cortical microstructural and neurobiological profiles -
A comprehensive hierarchical comparison of structural connectomes in major depressive disorder cases versus controls in two large population samples
Psychological Medicine (2024)
https://doi.org/10.1017/S0033291724000606
Multi-cohort comparison of whole-brain structural connectomes identifying reproducible network-level differences associated with major depressive disorder -
Life-course neighbourhood deprivation and brain structure in older adults
Molecular Psychiatry (2024)
https://doi.org/10.1038/s41380-024-02459-3
Analysis of socioeconomic exposures across the lifecourse in relation to later-life brain structure -
Epigenetic scores derived in saliva are associated with gestational age at birth
Clinical Epigenetics (2024)
https://doi.org/10.1186/s13148-024-01618-5
Application of epigenetic scoring approaches in early-life cohorts -
Immuno-epigenetic signature derived in saliva associates with perinatal inflammatory disorders
Brain, Behavior, and Immunity (2023)
https://doi.org/10.1016/j.bbi.2023.03.011
Development and validation of saliva-derived epigenetic signatures of inflammation -
Blood-based epigenome-wide analyses of cognitive abilities
Genome Biology (2022)
https://doi.org/10.1186/s13059-021-02596-8
Epigenome-wide study identifying DNA methylation signatures associated with cognitive ability -
DNA methylation and protein markers of chronic inflammation and their associations with brain and cognitive aging
Neurology (2021)
https://doi.org/10.1212/WNL.0000000000012997
Multi-omic analysis linking inflammatory biomarkers with brain structure and cognitive outcomes -
Structural brain correlates of serum and epigenetic inflammatory markers
Brain, Behavior, and Immunity (2021)
https://doi.org/10.1016/j.bbi.2021.03.020
Neuroimaging study linking circulating and epigenetic markers of inflammation with regional brain structure
A full and up-to-date publication list is available via my Google Scholar:
https://scholar.google.com/citations?user=klj4X0sAAAAJ