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MIAPE-QC

Minimum information about a proteomics experiment - Quality Control

Overview

Quality control (QC) is increasingly recognized as a crucial aspect of mass spectrometry based proteomics. As a result, software tools for computing quality control metrics for mass spectrometry data started to proliferate in recent years. However, As the different tools that compute the diverse metrics from experimental LC-MS/MS data can extract only a limited number of QC features, it is a challenging task to compare and interactively analyze the outputs of these tools. In addition, the data reported by different individuals is often missing key pieces essential for a full understanding of the experiment and the possibility of meta-analysis. Here, we propose MIAPE-QC, the Minimal Information. Adherence to this reporting guideline will result in increased clarity of publications and support the effectiveness and accuracy of investigations based on the experimental proteomics data.

Main content

  • Collected qc metrics and mapping metrics throuh existing CVs.
  • Extracted minimal metrics for MIAPE-QC (extracted 40 QC metrics from all the metrics collected from QC tools and 9 essential parameters/descriptors from experimental reprots and MIAPE-like documents)
  • Added title, authors and abstract as a start point of MIAPE-QC based on Martin's suggestion.
  • Added some metrics to the QC Wishing list after talked with experts and experimenters in Beijing (Phenix Center).
  • Updated the old version of MIAPE-QC list.
  • Adjust the classification of metrics and parameters in MIAPE-QC.
  • Complete the definition/details/reasons of all the terms shown in the checklist.

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Minimum information about a proteomics experiment - Quality Control

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