feat: unified AMP reference library + full novelty audit (Sprint 2)

docs/METRICS_CURRENT.md

@@ -14,7 +14,7 @@
 | Metric | Value | Notes |
 |--------|-------|-------|
 | Benchmark type | Standard (composition-matched decoys) | Default `make validate-scoring` |
-| Positives | **95** public-domain AMPs | 12 taxonomic classes; see `examples/validation/knownd_amps.csv` |
+| Positives | **95** public-domain AMPs | 12 taxonomic classes; see `examples/validation/known_amps.csv` |
 | Negatives | **96** length-matched random decoys | Swiss-Prot residue frequencies, seed=1729 |
 | Total (n) | **191** | Expanded from original 87 (PR #110) |
 | **Pipeline AUROC** | **0.7832** | Bootstrap CI₉₅: 0.72–0.84 (n_bootstrap=2000) |

docs/NOVELTY_AUDIT_FULL.md

@@ -0,0 +1,98 @@
+# Full Novelty Audit
+
+> **Generated:** 2026-06-29T03:15:59Z
+> **Panel:** 20 candidates | **Reference set:** 120 sequences
+> **Thresholds:** EXACT=1.0, KNOWN_VARIANT≥0.70, CLOSE_RELATIVE≥0.50, HIGH_CONFIDENCE_NOVEL≥0.60 novelty
+
+---
+
+## Summary
+
+| Category | Count | Publication strategy |
+|----------|:-----:|---------------------|
+| **HIGH_CONFIDENCE_NOVEL** | 20 | Primary novelty claim — publish as novel family |
+
+**Reference hit frequency (best-match database):**
+
+- REF-TN1-001 (tenecin_1): 20x
+
+## Per-Candidate Classification
+
+| Rank | Candidate | Seed | Ensemble | Novelty | Category | Best reference | Layer |
+|:----:|-----------|:----:|:--------:|:-------:|:--------:|----------------|:----:|
+| 1 | SEED-009_VAR_033 | SEED-009 | 0.807 | 0.862 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 2 | SEED-009_VAR_027 | SEED-009 | 0.808 | 0.828 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 3 | SEED-007_VAR_009 | SEED-007 | 0.849 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 4 | SEED-007_VAR_001 | SEED-007 | 0.824 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 5 | SEED-007_VAR_018 | SEED-007 | 0.815 | 0.862 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 6 | SEED-009_VAR_039 | SEED-009 | 0.796 | 0.862 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 7 | SEED-009_VAR_017 | SEED-009 | 0.798 | 0.862 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 8 | SEED-007_VAR_035 | SEED-007 | 0.806 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 9 | SEED-006_VAR_059 | SEED-006 | 0.821 | 0.931 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 10 | SEED-006_VAR_071 | SEED-006 | 0.828 | 0.931 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 11 | SEED-006_VAR_062 | SEED-006 | 0.841 | 0.828 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 12 | SEED-006_VAR_006 | SEED-006 | 0.812 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 13 | SEED-008_VAR_032 | SEED-008 | 0.857 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 14 | SEED-008_VAR_009 | SEED-008 | 0.849 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 15 | SEED-008_VAR_019 | SEED-008 | 0.845 | 0.862 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 16 | SEED-003_VAR_017 | SEED-003 | 0.816 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 17 | SEED-003_VAR_012 | SEED-003 | 0.807 | 0.862 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 18 | SEED-008_VAR_044 | SEED-008 | 0.832 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 19 | SEED-005_VAR_019 | SEED-005 | 0.808 | 0.828 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+| 20 | SEED-001_VAR_064 | SEED-001 | 0.802 | 0.897 | [HC] HIGH_CONFIDENCE_NOVEL | tenecin_1 | 5 |
+
+## Family-Level Notes
+
+### SEED-001 (1 candidates)
+
+Magainin-1 derivative. Near-identical to known template. Positive control only.
+
+### SEED-003 (2 candidates)
+
+Cationic Trp helix. KNOWN_VARIANT → tachyplesin-like (Tam 2002). Keep as SAR control.
+
+### SEED-005 (1 candidates)
+
+Cecropin-magainin hybrid. CLOSE_RELATIVE to template_seed_1. Conditional novelty.
+
+### SEED-006 (4 candidates)
+
+Mastoparan-X wasp venom. Genuinely novel scaffold. Primary breakthrough target.
+
+### SEED-007 (4 candidates)
+
+Bombolitin-II bumblebee venom. Highest-novelty family in panel.
+
+### SEED-008 (4 candidates)
+
+Puroindoline-a Trp-rich domain. Novel mechanism (indole intercalation).
+
+### SEED-009 (4 candidates)
+
+Bac2A proline-rich intracellular. Novel mechanism (DnaK binding).
+
+
+## Priority for Novelty Claims
+
+| Tier | Category | Candidates | Recommendation |
+|:----:|----------|:----------:|----------------|
+| **1** | HIGH_CONFIDENCE_NOVEL (< 40% sim, no motif concern) | 20 | Primary breakthrough targets. Lead publication. |
+| **2** | NOVEL (< 50% sim) | 0 | Claim as novel family. Verify mechanism unique. |
+| **3** | CLOSE_RELATIVE (50-70% sim) | 0 | Conditional — require mechanism distinction for novelty claim. |
+| **4** | KNOWN_VARIANT (≥70% sim) | 0 | Exclude from novelty claims. Keep as SAR/assay controls. |
+| **5** | EXACT_MATCH (100%) | 0 | Exclude. Positive control only. |
+
+## Caveats
+
+1. **Reference database:** 120 sequences (unified AMP library). This is not APD3 (3,000+) or DRAMP (19,000+).
+2. **Similarity metric:** Levenshtein edit distance. Does not capture structural or functional similarity.
+3. **Patent check:** Not included here — see `outputs/patent_risk_screen.csv` for manual check.
+4. **Competitor sequences:** Not included here — see `docs/COMPETITOR_NON_OVERLAP_REPORT.md`.
+5. **External predictors:** Not included — consensus gate requires ≥3/5 tools positive.
+
+## References
+
+- Curated reference set: `examples/known_reference/amp_curated_references.csv`
+- Expanded AMP set: `examples/validation/known_amps.csv`
+- Levenshtein distance: `scoring/novelty.py`
+- Tool: `scripts/run_novelty_audit.py`

examples/known_reference/amp_library.csv

@@ -0,0 +1,121 @@
+id,sequence,family,source,taxonomy_class,library
+REF-ALA-001,ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ,dermaseptin_s3_fragment,Mor_1994_Biochemistry,frog,curated_72
+REF-API-001,GNRPVYIPQPRPPHPR,apidaecin,Casteels_1989_EMBO_J,insect,curated_72
+REF-AUR-001,GLFDIIKKIAESF,aurein_1,Rozek_2000_Eur_J_Biochem,frog,curated_72
+REF-AUR-002,GLFDIVKKVVGALGSL,aurein_2,Rozek_2000_Eur_J_Biochem,frog,curated_72
+REF-AUR-003,GLFDIIKKIAGSFS,aurein_3,Rozek_2000_Eur_J_Biochem,frog,curated_72
+REF-AUR-004,GLFDIVKKVIGVGL,aurein_4,Jackway_2008_J_Proteome_Res,frog,curated_72
+REF-BMA-001,GRFKRFRKKFKKLFKKLSP,bmap_fragment,Skerlavaj_1999,mammalian,curated_72
+REF-BMA-002,GRFKRFRKKFKKLFKKLSPVIPLLHLG,bmap_27_full,Skerlavaj_1999_J_Immunol,mammalian,curated_72
+REF-BMA-003,GGLRSLGRKILRAWKKYGPIIVPIIRI,bmap_28,Skerlavaj_1999_J_Immunol,mammalian,curated_72
+REF-BOM-001,IIGPVLGLVGSALGGLLKKI,bombinin_h,Halverson_1990,frog,curated_72
+REF-BP1-001,KKLFKKILKYL,bp100_designed,Monroc_2006_Peptides,synthetic,curated_72
+REF-BUF-001,TRSSRAGLQFPVGRVHRLLRK,buforin,Kim_1996_Eur_J_Biochem,frog,curated_72
+REF-BUF-002,RAGLQFPVGRVHRLLRK,buforin_ii,Park_2000_J_Biol_Chem,frog,curated_72
+REF-CAE-001,GLLSVLGSVAKHVLPHVVPVIAEH,caerin,Rozek_2000_Biochemistry,frog,curated_72
+REF-CEC-001,KWKLFKKIEKVGQNIRDGIIKAGPAV,cecropin_a_fragment,Steiner_1981_PNAS,insect,curated_72
+REF-CEC-002,KWKIFKKIEKVGRNVRDGIIKAGP,cecropin_b_fragment,Hultmark_1980_Eur_J_Biochem,insect,curated_72
+REF-CEC-003,SWLSKTAKKLENSAK,cecropin_p1,Lee_1989_Biochemistry,insect,curated_72
+REF-CHI-001,KWKLFKKIGAVLKVLTTGLPALIS,cm15_chimera,Andreu_1992_Biochemistry,synthetic,curated_72
+REF-CLV-001,VFQFLGKIIHHVGNFVHGFSHVF,clavanin,Lee_1997_FEBS_Lett,marine_invertebrate,curated_72
+REF-DER-001,GLWSKIKAAGKAALNAINNLF,dermaseptin_b,Papo_2002_J_Biol_Chem,frog,curated_72
+REF-DER-002,ALWKNMLKGIGKLAGKAALGAVKKLVGAES,dermaseptin_s3,Mor_1994_Biochemistry,frog,curated_72
+REF-ENG-001,RRWVRRVRRWVRRVVRVVRRWVRR,engineered_wr_peptide,Deslouches_2005_AAC,synthetic,curated_72
+REF-ESC-001,GIFSKLAGKKIKNLLISGLKG,esculentin_fragment,Simmaco_1993_J_Biol_Chem,frog,curated_72
+REF-ESC-002,GIFSKLAGKLLESAKKVGQN,esculentin_1a_fragment,Simmaco_1993_J_Biol_Chem,frog,curated_72
+REF-FKK-001,FKKLKKSLKL,klaklak_analog,Javadpour_1996,synthetic,curated_72
+REF-GKA-001,GKAFVGEIMNS,magainin_c_fragment,Westerhoff_1989,frog,curated_72
+REF-GKK-001,GKKLFSKLKK,cecropin_melittin_analog,Gazit_1994,insect,curated_72
+REF-GRM-001,GRMKKVFFKSLRQH,gramicidin_s_like,Fontenot_1993,bacterial,curated_72
+REF-HIS-001,DSHAKRHHGYKRKFHEKHHSHRGY,histatin,Oppenheim_1988_J_Dent_Res,human,curated_72
+REF-HIS-002,KRKFHEKHHSHRGY,histatin_fragment,Xu_1991_J_Biol_Chem,human,curated_72
+REF-HLP-001,HLPKHFKAFVARLIRNAMSN,hlp_fragment,Hiemstra_1993,mammalian,curated_72
+REF-ILK-001,ILKKWPWWPWRRK,indolicidin_lys_analog,Lawyer_1996,mammalian,curated_72
+REF-IND-001,ILPWKWPWWPWRR,indolicidin,Selsted_1992_J_Biol_Chem,mammalian,curated_72
+REF-IND-002,ILPWKWPWWPWRRRR,indolicidin_analog,Falla_1996_J_Biol_Chem,mammalian,curated_72
+REF-KAA-001,KAAAKAAAKAAAK,ala_lys_repeat,Braunstein_2004,synthetic,curated_72
+REF-KFL-001,KFLHSAKKFGKAFV,magainin_core,Maloy_1995,frog,curated_72
+REF-KWK-001,KWKLFKKIGAVLKVL,template_seed_1,Oren_1997_Biochemistry,synthetic,curated_72
+REF-LL37-001,KRIVQRIKDFLR,cathelicidin_ll37_fragment,Wang_2014_J_Biol_Chem,human,curated_72
+REF-LL37-002,FKRIVQRIKDFL,cathelicidin_ll37_fragment,Zhu_2006_J_Biol_Chem,human,curated_72
+REF-LL37-003,FKRIVQRIKDFLRNLV,cathelicidin_ll37_fragment,Kuo_2015_Peptides,human,curated_72
+REF-LL37-004,LLGDFFRKSKEKIGKEFL,cathelicidin_ll37_nterm,Wang_2014_J_Biol_Chem,human,curated_72
+REF-LLL-001,LLRWPWWPWRRK,omiganan_analog,Sader_2004,synthetic,curated_72
+REF-MAC-001,GLFGVLAKVAAHVVPAIAEHF,maculatin,Chia_2000_Eur_J_Biochem,frog,curated_72
+REF-MAG-001,GIGKFLHSAKKFGKAFVGEIMNS,magainin,Zasloff_1987_PNAS,frog,curated_72
+REF-MAG-002,GIGKFLHSAGKFGKAFVGEIMKS,magainin,Zasloff_1987_PNAS,frog,curated_72
+REF-MAG-003,GIGKFLHSAKKFGKAFVGQIMNS,magainin_analog,Chen_1988,frog,curated_72
+REF-MAG-004,KKLKKFGLRIINKIVAAL,magainin_helix,Wieprecht_1997,frog,curated_72
+REF-MAX-001,ILGPVLGLVSDTLDDVLGIL,maximin_h5,Wang_2004_Peptides,frog,curated_72
+REF-MEL-001,GIGAVLKVLTTGLPALISWIKRKRQQ,melittin,Habermann_1972,insect,curated_72
+REF-MSI-001,GIGAFLKEFLHSAKKFGKAFVGEIMKS,msi_594,Oren_1999_Biochemistry,frog,curated_72
+REF-MUR-001,GLLRKGGEKIGEKLKKIG,murine_cramp_fragment,Gallo_1997_PNAS,mammalian,curated_72
+REF-OMI-001,ILRWPWWPWRRK,omiganan,Sader_2004_Antimicrob_Chemother,synthetic,curated_72
+REF-ONC-001,VDKPPYLPRPRPPRRIYNR,proline_rich_oncocin,Kragol_2001_Biochemistry,insect,curated_72
+REF-PEX-001,GIGKFLKKAKKFGKAFVKILKK,pexiganan_analog,Ge_1999_Antimicrob,frog,curated_72
+REF-PHY-001,FLSLIPHAINAVSAIAKHF,phylloseptin,Leite_2005_Biochemistry,frog,curated_72
+REF-PIS-001,FIKHEIVGWMSKFLKWM,piscidin,Cole_1997_J_Biol_Chem,fish,curated_72
+REF-PLA-001,KKVVFKVKFK,short_cationic,Lee_2004,synthetic,curated_72
+REF-PLC-001,GWGSFFKPAHKAMSVGKHF,pleurocidin,Cole_1997_J_Biol_Chem,fish,curated_72
+REF-PYR-001,VDKGSYLPRPTPPRPIYNRN,pyrrhocoricin,Otvos_2000_J_Peptide_Sci,insect,curated_72
+REF-RLK-001,RLKKVWKKWKK,cationic_tryptophan,Parisien_2008,synthetic,curated_72
+REF-RRW-001,RRWQWRMKKLG,tachyplesin_like,Tam_2002_J_Biol_Chem,marine_invertebrate,curated_72
+REF-SCO-001,ILGKIWEGIKSLF,scorpion_isct,Dai_2002_Peptides,insect,curated_72
+REF-SMA-001,SMKQLAHKLKSEKLELSDREQMR,smap_fragment,Tossi_2000,mammalian,curated_72
+REF-TAC-001,KWKKLFKKI,cecropin_core,Andrieu_1996,insect,curated_72
+REF-TMP-001,FLPLIGRVLSGIL,temporin_a,Mangoni_2001_FEBS,frog,curated_72
+REF-TMP-002,FVQWFSKFLGRIL,temporin_l,Mangoni_2001_FEBS,frog,curated_72
+REF-TMP-003,LLPIVGNLLKSLL,temporin_b,Simmaco_1996_Eur_J_Biochem,frog,curated_72
+REF-TMP-004,FLPLLAGLAANFLPKIF,brevinin_like,Conlon_2004_Peptides,frog,curated_72
+REF-TRP-001,VRRFPWWWPFLRR,tryptophan_rich_cathelicidin,Frank_1990_BBRC,human,curated_72
+REF-UPR-001,GVGDLIRKAIASVAGKELG,uperin,Jackway_2008_Peptides,frog,curated_72
+REF-VRG-001,VRGRPIPICSRGGYCFCLPFLPGACHRPSGMC,defensin_like_linear,skipped_disulfide,mammalian,curated_72
+REF-WKL-001,WKLFKKIGAVLKVL,magainin_analog,Dathe_1997,frog,curated_72
+REF-ACE1-001,DKCERSSHLLKGCKMTNFLANIFSNLSFDPKTCEGAVPGC,Ace_AMP1,Tassin_1998,plant,expanded_95
+REF-API1-001,GNNRPVYIPQPRPPHPRI,apidaecin_Ia,Casteels_1989_EMBO_J,insect,expanded_95
+REF-APIB-001,GNNRPVYIPQPRPPHPRL,apidaecin_Ib,Casteels_1989_EMBO_J,insect,expanded_95
+REF-AREN1-001,RWCVYAYVRVRGVLVRYRRCW,arenicin_1,Ovchinnikova_2004,marine_invertebrate,expanded_95
+REF-BAC7-001,RLCRIVVIRVCR,bactenecin_7,Wu_1999,mammalian,expanded_95
+REF-BMAP-001,GRFKRFRKKFKKLFKKLSPVIPLLHL,BMAP_27,Skerlavaj_1996_FEBS_Lett,mammalian,expanded_95
+REF-BRV1-001,FLPVLAGIAAKVVPALFCKITKKC,brevinin_1,Morikawa_1992,frog,expanded_95
+REF-BRV2-001,GLLDSLKGFAATVAKGVAAQVVDKLLKCKLTGKC,brevinin_2,Conlon_2004,frog,expanded_95
+REF-DCD1-001,SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL,dermcidin,Schittek_2001_Nat_Immunol,human,expanded_95
+REF-DEFA-001,ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKGVCVCR,defensin_A,Dimarcq_1998,insect,expanded_95
+REF-DROS-001,GKPRPYSPRPTSHPRPIRV,drosocin,Bulet_1993_JBC,insect,expanded_95
+REF-DRS3-001,ALWKNMLKGIGKLAGQAALGAVKTLVGAETQ,dermaseptin_S3,Mor_1994_BIOCHEM,frog,expanded_95
+REF-EURC-001,GFCVNSPWDDEDLKCHNHCKSINGYKGGYCTKGKAVCKCY,eurocin,Schneider_2010,fungal,expanded_95
+REF-FORM-001,GRPNPVNNKPTPYPHL,formaecin,Vegh_2002,insect,expanded_95
+REF-GAE1-001,SMLSVLKNLGKVGLGFVACKINKIQ,gaegurin,Park_1994_BBRC,frog,expanded_95
+REF-HBD1-001,DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK,beta_defensin,Bensch_1995_FEBS_Lett,mammalian,expanded_95
+REF-HBD2-001,GIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKP,beta_defensin,Harder_1997_Nature,mammalian,expanded_95
+REF-HBD3-001,GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK,beta_defensin,Harder_2001_JBC,mammalian,expanded_95
+REF-HPCN-001,DTHFPICIFCCGCCHRSKCGMCCKT,hepcidin,Park_2001_JBC,human,expanded_95
+REF-JAP1-001,FFPIGVFDKASKVFPTIGV,japonicin,Isaacson_2002,frog,expanded_95
+REF-LL37-002,LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES,cathelicidin,Gudmundsson_1996_PNAS,human,expanded_95
+REF-MOR1-001,FFRHLFRGSFLVGTLIHLRIG,moronecidin,Lauth_2002_JBC,fish,expanded_95
+REF-NGR1-001,GLLSGILGAGKHIQCKIRTC,nigrocin,Park_2001,frog,expanded_95
+REF-NISA-001,ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK,nisin_A,Gross_1971_JACS,bacterial,expanded_95
+REF-OBAC11-001,RLKELFKHPELKTLPKLLKRELEKTLK,OaBac_11,Anderson_2004,mammalian,expanded_95
+REF-OBAC5-001,RFRPPIRRLPPPRFPIRRLFNPGQDI,OaBac_5,Shamova_1999,mammalian,expanded_95
+REF-PHYL-001,FLSLIPHAINAVSAIAKHS,phylloseptin,Leite_2005,frog,expanded_95
+REF-PISC1-001,FFHHIFRGIVHVGKTIHLRLTG,piscidin_1,Silphaduang_2001,fish,expanded_95
+REF-PISC3-001,FFHHIFRGLIHVGLTIHLRITG,piscidin_3,Silphaduang_2001,fish,expanded_95
+REF-PLEC-001,GFGCNGPWNEDDLRCHNHCKSIKGYKGGYCAKGGFVCKCY,plectasin,Mygind_2005_Nature,fungal,expanded_95
+REF-PLUR-001,GWGSFFKKAAHVGKHVGKAALTHYL,pleurocidin,Cole_1997_JBC,fish,expanded_95
+REF-PMAP23-001,RIIDLLWRVRRPQKPKFVTVWV,PMAP_23,Zanetti_1994_FEBS_Lett,mammalian,expanded_95
+REF-POLY1-001,RRWCFRVCYRGFCYRKCR,polyphemusin_I,Miyata_1989,marine_invertebrate,expanded_95
+REF-PR39-001,RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRLPPRFPGKR,PR_39,Agerberth_1991,mammalian,expanded_95
+REF-PRG1-001,RGGRLCYCRRRFCVCVGR,protegrin_1,Kokryakov_1993_FEBS_Lett,mammalian,expanded_95
+REF-PRG2-001,RGGRLCYCRRRFCICVGR,protegrin_2,Kokryakov_1993_FEBS_Lett,mammalian,expanded_95
+REF-PRG3-001,RGGGLCYCRRRFCVCVGR,protegrin_3,Kokryakov_1993_FEBS_Lett,mammalian,expanded_95
+REF-RNX-001,FLGGLIKIVPAMICAVTKKC,ranalexin,Clark_1994_JBC,frog,expanded_95
+REF-RSA1-001,QCQNNEACKKAGKVEKACCLKFDKTCSGACGSGN,RsAFP_1,Terras_1992,plant,expanded_95
+REF-RSA2-001,QCQNNECKKSGKLEKACCEKFDKTCSGACGSGF,RsAFP_2,Terras_1992,plant,expanded_95
+REF-RUGA-001,GFLSIVGALSHALPSLISQIK,rugosin_A,Suzuki_2007,frog,expanded_95
+REF-SMAP-001,RGLRRLGRKIAHGVKKYGPTVLRIIRI,SMAP_29,Brogden_2006,mammalian,expanded_95
+REF-SNAK-001,NAFTCMKCTKKPCKKCVFCKYPFEYYY,snakin_1,Segura_1999,plant,expanded_95
+REF-TACH1-001,KWCFRVCYRGICYRRCR,tachyplesin_I,Nakamura_1988_JBC,marine_invertebrate,expanded_95
+REF-TACH2-001,RWCFRVCYRGICYRKCR,tachyplesin_II,Miyata_1989,marine_invertebrate,expanded_95
+REF-THAN-001,GSKKPVPIIYCNRRSGKCQRM,thanatin,Fehlbaum_1996_PNAS,insect,expanded_95
+REF-TMPG-001,ILSKIFSLLKKVLP,temporin_G,Simmaco_1996_Eur_J_Biochem,frog,expanded_95
+REF-TN1-001,LCNLERCVYGGCDSGTYSGKCTCTEGGFF,tenecin_1,Moon_1994,insect,expanded_95