Repository navigation
v0.5.62 — Pre-Registered Pass/Fail Criteria (Loop 41) - #159
Closed
cschanhniem wants to merge 1 commit into
Closed
cschanhniem wants to merge 1 commit into
cschanhniem wants to merge 1 commit into
Conversation
Machine-readable pass/fail gates for Wave 1 wet-lab batch. Changes: - configs/wave1_pass_fail.yaml -- YAML config: primary endpoint (MIC <= 32, >= 3 candidates), secondary (MIC <= 32 and TI > 10, >= 1), confirmed hit definition, hemolysis safety (0 toxic), positive control range (SEED-001_VAR_064, MIC 4-32), batch requirements (>= 20 tested). - scripts/check_wave1_pass_fail.py -- CLI validation: exit 0/3/2. - tests/test_wave1_pass_fail.py -- 11 tests. - docs/50_LOOP_PLAN.md -- Loop 41 complete, next Loop 42. - docs/ROADMAP.md -- v0.5.62 entry. - docs/METRICS_CURRENT.md -- Pipeline v0.5.62, 1977 tests. 1977 tests passing.
This file contains hidden or bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Sign up for free
to join this conversation on GitHub.
Already have an account?
Sign in to comment
Add this suggestion to a batch that can be applied as a single commit.This suggestion is invalid because no changes were made to the code.Suggestions cannot be applied while the pull request is closed.Suggestions cannot be applied while viewing a subset of changes.Only one suggestion per line can be applied in a batch.Add this suggestion to a batch that can be applied as a single commit.Applying suggestions on deleted lines is not supported.You must change the existing code in this line in order to create a valid suggestion.Outdated suggestions cannot be applied.This suggestion has been applied or marked resolved.Suggestions cannot be applied from pending reviews.Suggestions cannot be applied on multi-line comments.Suggestions cannot be applied while the pull request is queued to merge.Suggestion cannot be applied right now. Please check back later.
Machine-readable pass/fail gates for Wave 1 wet-lab batch. Pre-registered before any wet-lab data is seen.
Primary:
configs/wave1_pass_fail.yaml— pre-registered gates: primary endpoint (MIC ≤32 for ≥3 candidates vs E. coli), secondary (MIC ≤32 and TI >10 for ≥1), confirmed hit definition, hemolysis safety (0 toxic with TI <2), positive control range (SEED-001_VAR_064 MIC 4-32), batch-level (≥20 tested, all controls passed), negative result archive requirements.CLI:
scripts/check_wave1_pass_fail.py— reads lab result JSONs + criteria YAML, reports per-check pass/fail. Exit 0 all pass, 3 any fail, 2 missing files.Tests: 11 tests covering pass, fail, CLI exit codes, output writing, missing files.
Doc updates: 50_LOOP_PLAN (Loop 41 complete, next Loop 42). ROADMAP (v0.5.62). METRICS_CURRENT (v0.5.62, 1977 tests).
1977 tests passing (pre-push full suite).