[cschanhniem]

Implements E5 from NEXT_100_PR_MAP: non-protocol pilot pre-registration schema.

What

• pilot_preregistration.py: PilotPreregistration + ScoreThreshold + PreregistrationValidationResult
• validate_pilot_preregistration(): 14 validation rules
• format_pilot_preregistration(): human-readable output with VALID/INVALID/NOTICE
• VALID_OUTCOME_METRICS: 8 controlled vocabulary terms
• VALID_AMENDMENT_REASONS: 5 controlled terms
• Key gates: dry_lab_only_declaration=True required, score thresholds declared before experiment, positive/negative controls required
• 63 tests; BASELINE 7402→7465

Why

Post-hoc threshold adjustment is the most common form of silent overclaiming in computational-to-experimental pipelines. A locked PRR- record with frozen thresholds is the contract between dry-lab selection and wet-lab execution. Without pre-registration, "we selected candidates with score > 0.7" can become "score > 0.5 (after checking results)" with no audit trail.

Disconfirming pass

• Threshold values are frozen at pre-registration time; amendment_reasons vocabulary limits what can be changed and why
• Locked records with amendments produce a warning (surfaces amendment history, doesn't block)
• No safety/release policy changed; no calibration policy touched