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fix(docs): correct SEED-009 Met omission + track PRs #105/#106 - #97
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WET_LAB_HANDOFF.md: SEED-009 synthesis guidance said "No Met, no Cys" for all variants, but SEED-009_VAR_033 (RRLPRPGYMPRP) has Met at position 9. Corrected to: - VAR_033: Met×1 at position 9 — Nle substitution + HPLC purity + −80°C inert-atmosphere storage (same as SEED-007 protocol); both MET×1 and PROLINE_RICH_INTRACELLULAR flags fire simultaneously - VAR_027/017/039: no Met, no Cys → standard Fmoc SPPS ROADMAP.md + DISCOVERY_PREDICTION.md: tracking notes for PR #105 (PYROGLUTAMATE_RISK flag) and PR #106 (this correction)
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Summary
Critical doc fix: SEED-009 synthesis guidance had a factual error
docs/WET_LAB_HANDOFF.mdline 409 previously read:This is wrong: SEED-009_VAR_033 (RRLPRPGYMPRP) has Met at position 9. The presynth QC report already flags this with
MET×1(Nle recommendation), but the synthesis guidance section contradicted it — a synthesis team reading only the special notes section would order a standard synthesis and miss the Nle substitution.Corrected to:
MET×1andPROLINE_RICH_INTRACELLULARsimultaneouslyTracking updates
ROADMAP.md: entries for PR docs: consolidate all benchmark and probability references after PR #110 #105 (pyroglutamate flag) and PR docs(sprint1): METRICS_CURRENT.md + CI stale-metric detector + breaking news cleanup #106 (this fix)DISCOVERY_PREDICTION.md: tracking notes for PR docs: consolidate all benchmark and probability references after PR #110 #105 and PR docs(sprint1): METRICS_CURRENT.md + CI stale-metric detector + breaking news cleanup #106Test plan
pytest— 1311/1311 pass (no code changes)grep "VAR_033" docs/WET_LAB_HANDOFF.mdmentions Met at position 9🤖 Generated with Claude Code