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test(qc): regression guard for SEED-009_VAR_033 dual MET+PROLINE flags #98

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Merged
cschanhniem merged 1 commit into from
Jun 28, 2026
Merged

test(qc): regression guard for SEED-009_VAR_033 dual MET+PROLINE flags #98

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11 changes: 11 additions & 0 deletions tests/test_presynth_qc.py
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Original file line number Diff line number Diff line change
Expand Up @@ -834,6 +834,17 @@ def test_seed009_pilot_sequences_get_flag(self):
qc = check_sequence("s9", seq)
assert any("PROLINE_RICH" in f for f in qc.flags), f"missing flag for {seq}"

def test_seed009_var033_gets_met_and_proline_flags_simultaneously(self):
# VAR_033 (RRLPRPGYMPRP) is the only SEED-009 pilot with Met at position 9.
# Both MET×1 (Nle recommendation) and PROLINE_RICH_INTRACELLULAR must fire together.
# Regression guard for WET_LAB_HANDOFF correction in PR #106.
qc = check_sequence("SEED-009_VAR_033", "RRLPRPGYMPRP")
flag_texts = " ".join(qc.flags)
assert "MET" in flag_texts, "VAR_033 must carry Met oxidation flag"
assert "Nle" in flag_texts, "VAR_033 Met flag must recommend Nle substitution"
assert "PROLINE_RICH" in flag_texts, "VAR_033 must carry PROLINE_RICH_INTRACELLULAR flag"
assert qc.methionine_count == 1


# ---------------------------------------------------------------------------
# LONG_PEPTIDE flag (> 30 AA)
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