Overview: This repository contains data from Heterogeneous Stock (HS) rats that underwent a delay discounting experimental procedure. Here, we provide the phenotype data and processing pipeline for trait calculations for GWAS.
Primary associated publication citation: Lara MK, Chitre AS, Chen D, Johnson BB, Nguyen KM, Cohen KA, Muckadam SA, Lin B, Ziegler S, Beeson A, Sanches TM, Solberg Woods LC, Polesskaya O, Palmer AA, Mitchell SH. Genome-wide association study of delay discounting in Heterogeneous Stock rats. Genes Brain Behav. 2024 Aug;23(4):e12909. doi: 10.1111/gbb.12909. PMID: 39119916; PMCID: PMC11310854.
Related resources: GWAS data, results, and report can be found in the UC San Diego Library Digital Collections under the following citations: Lara, Montana Kay; Chitre, Apurva S.; Chen, Denghui; Johnson, Benjamin B.; Nguyen, Khai‐Minh; Cohen, Katarina A.; Muckadam, Sakina A.; Lin, Bonnie; Ziegler, Shae; Beeson, Angela; Sanches, Thiago M.; Solberg Woods, Leah C.; Polesskaya, Oksana; Palmer, Abraham A.; Mitchell, Suzanne H. (2025). Data from: Genome‐wide association study of delay discounting in Heterogeneous Stock rats. In The Center for GWAS in Outbred Rats Database (C-GORD). UC San Diego Library Digital Collections. https://doi.org/10.6075/J0BG2PDS
Genotype data can be found in the UC San Diego Library Digital Collections under the following citations: Palmer, Abraham A. (2023). Heterogeneous Stock (HS) Rat Genotypes, Version 3. In Genotype Data from: NIDA Center for GWAS in Outbred Rats. UC San Diego Library Digital Collections. https://doi.org/10.6075/J00G3KBX
The GWAS pipeline can be found here: https://github.com/sanchestm/GWAS-pipeline
The protocol for delay discounting can be found here: Montana Kay Lara, Suzanne H. Mitchell 2025. Delay Discounting Measured Using an Adjusting Amount Procedure . protocols.io https://dx.doi.org/10.17504/protocols.io.kqdg3xn7zg25/v1
Description: The 'data' folder contains phenotype information for each HS rat including indifference points at delays 0, 2, 4, 8, 16, and 24. The 'results' folder contains the fitted model information including exponential and hyperbolic k, and AUC.