This repository contains historical DDI mechanism code and the public reproducibility assets for the 2026 Applied Clinical Informatics manuscript:
Clinical Relevance Over Statistical Association: An Interpretable Probabilistic Layer for Prioritizing Drug-Drug Interaction Alerts
The submission-specific materials are in aci2026/.
Important boundary: the full continuous-feature matrix and some source-level clinical-reference material depend on licensed DrugBank/UMLS or commercial-reference content and are not redistributed here. The repository therefore exposes the evaluation harness and non-restricted derived summaries needed to inspect the evaluation design and reported aggregate results.
Nothing in this repository is a prescribing recommendation or a substitute for current clinical drug-interaction resources.
The ACI submission assets were checked on 22 September 2026. See aci2026/SUBMISSION_QA_20260922.md for the frozen public values and interpretation boundaries used in the resubmission.