Milestone objective
Extend bmyCure4MM from aggregate tumour/healthy-cell dynamics to a multiscale, hypothesis-aware representation of clonal evolution, residual disease, marrow ecology, immune recovery, bone disease, organ state, and patient function.
Work items
Exit definition
MULTISCALE_STATE_SCHEMA = versioned
SINGLE_TUMOUR_SCALAR_AS_LONG_TERM_CORE = false
CLONAL_EVOLUTION = implemented_and_tested
RESERVOIR_HYPOTHESES = compared_not_assumed
NICHE_STATE = explicit
NORMAL_LINEAGE_AND_IMMUNE_RECOVERY = explicit
BONE_AND_ORGAN_STATES = explicit
MODEL_REDUCTION_AND_IDENTIFIABILITY = reported
UNCERTAINTY_AND_ABLATION = complete
Evidence required
- model cards and evidence links;
- equations and code correspondence;
- dimensional and invariant tests;
- synthetic falsification scenarios;
- model-comparison, sensitivity, uncertainty, and ablation reports;
- explicit lists of non-identifiable states and unsupported assumptions.
Completion rule
The milestone is complete when the multiscale framework is executable, versioned, falsifiable, and clearly labelled as a research model rather than a validated biological replica.
Milestone objective
Extend bmyCure4MM from aggregate tumour/healthy-cell dynamics to a multiscale, hypothesis-aware representation of clonal evolution, residual disease, marrow ecology, immune recovery, bone disease, organ state, and patient function.
Work items
Exit definition
Evidence required
Completion rule
The milestone is complete when the multiscale framework is executable, versioned, falsifiable, and clearly labelled as a research model rather than a validated biological replica.