v0.1.0

STRATA v0.1.0 — Initial release

Spatial Transcription-factor Regulatory Architecture of Tissue Analysis.

• Layer 1: Continuous regulon fields from Xenium transcript coordinates
• Layer 2: Coupling tensor quantifying local co-regulation geometry
• Layer 3: Regulon Stability Index from Jacobian SVD
• Conjecture 5.1 validated: phase boundaries track tissue architecture (r=0.32, r=0.51)
• Melanoma coupling homogenization discovery (variance ↓28%)
• Parameter sensitivity: robust across all 12 BW × δ combinations
• Complete reproducible notebook (Colab, T4 GPU, ~20s runtime)

Data: 10x Genomics Xenium Human Skin Melanoma (382 genes, 13.7M transcripts, CC BY 4.0)