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Parkinson's Disease Progression Analysis

Overview

This project predicts Parkinson's disease progression using voice features from the UCI Parkinson's Telemonitoring Dataset. Models estimate Motor UPDRS and Total UPDRS scores.

Project Structure

  • data/: Raw and preprocessed data
  • figures/: Plots and visualizations
  • results/: Predictions, saved models, and performance summary
  • report/: Final report (PDF)
  • src/: Jupyter Notebooks for analysis
  • environment.yaml: Python dependencies
  • LICENSE: Project license
  • README.md: Project description

Workflow

  1. EDA: Analyze feature distributions and correlations.
  2. Preprocessing: Standardize features and remove multicollinearity.
  3. Modeling: Train and evaluate ElasticNet, KNN, Random Forest, XGBoost, and SVR.
  4. Results: Compare models using RMSE and analyze feature importance with SHAP.
Model Motor UPDRS RMSE Total UPDRS RMSE
Baseline 9.04 11.30
ElasticNet 8.90 11.00
K-Nearest Neighbors (KNN) 8.80 11.10
Random Forest 8.50 10.90
XGBoost 8.00 11.50
SVR (Best) 7.50 10.20

Insights:

  • Age is the most important feature, followed by DFA, HNR, and PPE.

How to Run

  1. Clone this repository:
    git clone https://github.com/YOUR_USERNAME/parkinsons-analysis.git
    cd parkinsons-analysis
    

##Required library versions:

python=3.10.5 matplotlib=3.5.2 pandas=1.4.2 scikit-learn=1.1.1 numpy=1.22.4 xgboost=1.5.1 shap=0.40.0 jupyter_client=7.3.1 jupyter_core=4.10.0 jupyterlab=3.4.2 jupyter_server=1.17.0 jupytext=1.13.8 rise=5.7.1 plotly=5.8.0 ipywidgets=7.7.0

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