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13 changes: 8 additions & 5 deletions README.md
Original file line number Diff line number Diff line change
Expand Up @@ -57,11 +57,14 @@ The pipeline is configured to run on task 1 with the `mae_ps_enet` model across
If you use LEAP in your research, please cite our paper:

```bibtex
@article{bodinier2025predicting,
title={Predicting gene essentiality and drug response from perturbation screens in preclinical cancer models with LEAP: Layered Ensemble of Autoencoders and Predictors},
author={Bodinier, Barbara and Dissez, Gaetan and Bleistein, Linus and Dauvin, Antonin},
journal={arXiv preprint arXiv:2502.15646},
year={2025}
@misc{bodinier2025predictinggeneessentialitydrug,
title={Predicting gene essentiality and drug response from perturbation screens in preclinical cancer models with LEAP: Layered Ensemble of Autoencoders and Predictors},
author={Barbara Bodinier and Gaetan Dissez and Lucile Ter-Minassian and Linus Bleistein and Roberta Codato and John Klein and Eric Durand and Antonin Dauvin},
year={2025},
eprint={2502.15646},
archivePrefix={arXiv},
primaryClass={cs.LG},
url={https://arxiv.org/abs/2502.15646},
}
```

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4 changes: 2 additions & 2 deletions configs/get_config_data.py
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Expand Up @@ -146,7 +146,7 @@ def _get_path_list_of_genes_rnaseq(list_of_genes: str) -> Path | None:

if list_of_genes not in possible_gene_lists:
raise ValueError(
f"{list_of_genes} does not exis. Please provide a valid `list_of_genes` in {possible_gene_lists}."
f"{list_of_genes} does not exist. Please provide a valid `list_of_genes` in {possible_gene_lists}."
)

if list_of_genes == "all":
Expand All @@ -172,7 +172,7 @@ def _get_path_list_of_perturbations(list_of_perturbations: str) -> Path | None:
}
if list_of_perturbations not in possible_perturbations:
raise ValueError(
f"{list_of_perturbations} does not exis. Please provide a valid "
f"{list_of_perturbations} does not exist. Please provide a valid "
f"`list_of_perturbations` in {possible_perturbations}."
)

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15 changes: 11 additions & 4 deletions data/README.md
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@@ -1,6 +1,15 @@
# Data

Directory for storing datasets.
Directory for storing the data required to run models.

> [!NOTE]
> Added data files are gitignored. Only this README and the pre-existing lists of genes, perturbations and tissues are tracked.

## Existing Files

The files traked here are lists of genes, perturbation and tissues that are useful to reproduce the different tasks described in the paper.

## Files to download

To run experiments, please download the following files from [DepMap](https://depmap.org/portal/data_page/?tab=allData):
- CRISPRGeneDependency.csv
Expand All @@ -9,6 +18,4 @@ To run experiments, please download the following files from [DepMap](https://de

And [this file](https://www.gsea-msigdb.org/gsea/msigdb/download_file.jsp?filePath=/msigdb/release/2025.1.Hs/c2.all.v2025.1.Hs.json) from MsigDB. This file is the JSON bundle associated with the GCP (chemical and genetic perturbations) gene set.

Save all those file in this directory.

**Note:** Data files are gitignored. Only this README is tracked.
Save all those files in this directory.
3 changes: 2 additions & 1 deletion models/README.md
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Expand Up @@ -2,4 +2,5 @@

Directory for storing trained models.

**Note:** Model files are gitignored. Only this README is tracked.
> [!NOTE]
> Model files are gitignored. Only this README is tracked.
3 changes: 2 additions & 1 deletion results/README.md
Original file line number Diff line number Diff line change
Expand Up @@ -2,4 +2,5 @@

Directory for experiment outputs and results.

**Note:** Result files are gitignored. Only this README is tracked.
> [!NOTE]
> Result files are gitignored. Only this README is tracked.