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A collection of Jupyter notebooks and tools for analyzing water behavior and protein-ligand interactions from molecular dynamics (MD) simulations. Includes scripts for water residence time, density mapping, contact analysis, and visualization using MDAnalysis.

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pushyaraga12/Post-processing-MD-trajectory

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Post processing MD trajectory Water Analysis

  • RDF of water molecules in specified regions
  • Residence time calculations
  • 3D water density maps

Protein-Ligand Interaction

  • Percentage of Specific interaction (Hydrogen bond and hydrophobic interaction tracking)
  • Atom wise Contact maps of Ligand over time
  • Ligand residence time
  • Ligand torsional angle changes

The aim of this repository is to provide a transparent and reproducible framework for the analyses presented in the manuscript "Hydrophobicity and Water-Mediated Interactions Modulate Residue Contributions to Binding Dynamics of Viral Protease-Hyperin Complexes"

Pushyaraga P. Venugopal, Omkar Singh, Vinod, "Hydrophobicity and water-mediated interactions modulate residue contributions to binding dynamics of viral protease-hyperin complexes", Journal of Molecular Liquids, Volume 438, Part A, 2025, 128684, ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2025.128684. (https://www.sciencedirect.com/science/article/pii/S0167732225018616)

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A collection of Jupyter notebooks and tools for analyzing water behavior and protein-ligand interactions from molecular dynamics (MD) simulations. Includes scripts for water residence time, density mapping, contact analysis, and visualization using MDAnalysis.

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