This is the accompanying repository for publication titled "The Receptor Trap in Proteogenomic MR: How Receptor-Ligand Feedback Loops Can Give Incorrect and Opposite Directions of Effect." Data used in the analysis will only be made available to approved researchers. The code in this repository is to illustrate the analytical steps and parameters.

Harmonized data serving as the dataset to demo the software/code for Mendelian randomization (MR) can be found in Supplementary Table 3,8,10,13. Expected MR output can be found in Supplementary Table 4,9,11,14 (main analyses) and 5,12,15 (sensitivity analyses).