Real-World Evidence platform for vaccine research scientists.
Live Demo — No sign-up required. Pre-loaded with sample vaccine research data.
Vaccine researchers spend weeks manually assembling study protocols, screening literature, and formatting regulatory submissions. VaxEvidence automates the entire pipeline — from PICO protocol design through PRISMA systematic review to FDA/EMA export — in a single collaborative platform. This is not a todo app with a database; it is a domain-specific tool built for the regulatory complexity of health-tech.
| Feature | What It Does |
|---|---|
| PICO Protocol Builder | Structured study design with version history, diff viewer, and template library |
| PRISMA Screening Pipeline | 4-stage systematic review with duplicate detection (DOI/PMID/fuzzy title) |
| Risk-of-Bias Assessment | RoB 2 (RCTs) and ROBINS-I (observational) with traffic-light visualizations |
| Meta-Analysis | Custom SVG forest plots with CI whiskers, subgroup analysis, pooled effects |
| Regulatory Exports | FDA IND (21 CFR 312.23), eCTD Module 5 (ICH M4E), CDISC SDTM templates |
| Real-Time Collaboration | Yjs CRDT editing, presence cursors, threaded comments with @mentions |
graph TB
subgraph Client["Browser"]
UI[React 19 + shadcn/ui]
RQ[React Query v5]
YJS[Yjs CRDT]
end
subgraph Server["Next.js 16 App Router"]
PROXY[proxy.ts — Auth + Security Headers]
API[76 API Routes]
end
subgraph Supabase
AUTH[Auth — OAuth + Passwordless]
PG[(PostgreSQL — 27 tables + RLS)]
RT[Realtime — Broadcast + Presence]
STOR[Storage]
end
subgraph External
PUBMED[PubMed]
CT[ClinicalTrials.gov]
AI[OpenAI / Google AI]
end
UI --> RQ --> API
YJS -->|Broadcast| RT
PROXY --> API
API --> PG
API --> AUTH
API --> PUBMED & CT & AI
See ARCHITECTURE.md for the full system design, data model, and design decisions.
| Layer | Technology |
|---|---|
| Framework | Next.js 16 (App Router), React 19, TypeScript (strict) |
| Styling | Tailwind CSS v4, OKLCH color space, dark mode default |
| UI | shadcn/ui (New York) + Radix UI + Lucide icons |
| Database | Supabase (PostgreSQL + Auth + RLS + Storage) |
| Data Fetching | @tanstack/react-query v5 |
| Forms | react-hook-form + Zod |
| Real-Time | Yjs (CRDT) + Supabase Realtime (Broadcast + Presence) |
| AI | Vercel AI SDK v6, OpenAI, Google AI |
| Exports | jsPDF, docx, papaparse, exceljs, citation-js, archiver |
| Charts | recharts + custom SVG (forest plots) |
| Monitoring | Sentry (error tracking + source maps) |
| Testing | vitest, Playwright |
| Package Manager | pnpm |
git clone https://github.com/VaxEvidence/vax-evidence-dev.git
cd vax-evidence-dev
pnpm install
cp .env.test.example .env.local # Add your Supabase credentials
pnpm dev # http://localhost:3000The demo mode at /demo works without Supabase credentials.
pnpm test # ~1,400 unit tests + 51 benchmarks (vitest)
pnpm test:integration # 60 integration tests against real Supabase
pnpm test:e2e # 63 E2E tests (Playwright)
pnpm typecheck # TypeScript strict mode
pnpm lint # ESLintComponents 136 (55 shadcn/ui + 81 feature)
API Routes 76 (CRUD, export, search, AI, public REST API)
CRUD Modules 18 (one per domain table)
DB Tables 27 (+ RLS on all)
DB Migrations 23
Unit Tests 1,400+
Integration 60 (RLS policies, CRUD, data integrity)
E2E Tests 63 (Playwright)
Benchmarks 51 (perf regression detection)
Zod Schemas 11 (runtime validation)
Export Formats 9 (PDF, Word, CSV, Excel, ZIP, BibTeX, RIS, APA, MLA)
See ASSESSMENT.md for a candid evaluation of what works well, what doesn't, and known technical debt. No sugarcoating.
| Document | Description |
|---|---|
| ARCHITECTURE.md | System design, data model, design decisions |
| CONTRIBUTING.md | Setup, conventions, PR process |
| SECURITY.md | Security measures and limitations |
| ROADMAP.md | Full product roadmap (12 phases complete) |
| ASSESSMENT.md | Honest technical assessment |
| docs/ | Performance benchmarks, PRDs, QA checklists |