A statistical framework for detecting significant drug combination synergies in cancer. By leveraging tissue-specific reference null distributions across multiple synergy metrics, we compute empirical p-values to standardize synergy detection, uncover novel interactions, and enable rigorous evaluation of drug combinations.
bioinformatics r computational-biology systems-pharmacology multiple-testing high-throughput-screening precision-oncology drug-combination statistical-framework null-distribution synergistic-effect empirical-pvalue
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Updated
Feb 18, 2026 - R