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tracelail/README.md

Hi there, I'm Jimmy T. Lail but I go by Trace👋

About Me

I am currently a Senior Associate Scientist working on AAV gene therapies for rare diseases. Under a mentorship in our computational genetics group, I am passionate about bioinformatics and look forward to new opportunities where I can contribute my skills and knowledge.

Professional Experience

Senior Associate Scientist (Computational Genetics Mentorship) BridgeBio Gene Therapy | Raleigh, May 2023 - Present

  • Completed bioinformatics RNA sequencing differential gene expression and gene ontology analytics project of mouse brain tissue via Jupyter notebook.
  • Created a GitHub repository that aggregates and transforms data from cell culture passaging production bioreactors and analytical assays into an R shiny dashboard.
  • Used AWS EC2 instance for project development and OOP to generate custom plasmid GTF files for nf-core RNAseq pipeline analysis.

Senior Associate Scientist BridgeBio Gene Therapy | Raleigh, Jan 2023 - Present

  • Demonstrated potential and dedication for data science by writing scripts for real-time bioreactor data transformation.
  • Designed and managed execution of small scale program screening and optimization experiments resulting in 3x vg titer increase while reducing residuals.
  • Screened innovative biologics and technologies for drug development.

Scientific Associate II BridgeBio Gene Therapy | Raleigh, Apr 2021 - Jan 2023

  • Utilized Python and R for data management analytics and visualization.
  • Conducted cell culture of HEK293 cells for AAV gene therapies.
  • Collaborated across teams and departments for AAV gene therapy drug candidates development.

Scientific Associate I Seqirus | Holly Springs, Oct 2019 - Mar 2021

  • Provided cell culture support for influenza vaccine development.
  • Operated and troubleshooted Ambr liquid handlers and bioreactors.
  • Utilized DOE and JMP for statistics data analytics.

Volunteer NC State University | Raleigh, Jan 2018 - Jan 2019

  • Maintained and cultured Caco-2 and IPEC-j2 cells.
  • Conducted plasmid DNA extraction and purification.
  • Performed real-time PCR and gel electrophoresis.

Education

  • Master of Science in Physiology
    North Carolina State University, May 2019

  • Bachelor of Science in Biological Sciences
    North Carolina State University, May 2016

Certifications

  • Molecular Biotechnology
    NC State University, May 2019

  • Data Scientist with R
    Datacamp, Jan 2023

Core Skills

  • RNA Sequencing
  • Python (Pandas, Sklearn, Gprofiler)
  • R (Tidyverse)
  • Data Visualization
  • Data Wrangling
  • Suspension Cell Culture
  • Bioinformatics
  • Biotherapeutics
  • Biomedical Sciences

Interests

  • Weight lifting
  • Cinema
  • Exercise
  • The Flash (TV version)

Thank you for visiting my GitHub profile. I am excited about opportunities in bioinformatics and look forward to connecting with like-minded professionals.

Popular repositories Loading

  1. tracelail.github.io tracelail.github.io Public

    HTML 1

  2. code-blog code-blog Public

    Jupyter Notebook

  3. tracelail tracelail Public

    Config files for my GitHub profile.

  4. indigo indigo Public

    Forked from sergiokopplin/indigo

    Minimalist Jekyll Template, dark and light themes

    HTML

  5. resume resume Public

    My current resume/cv

    HTML

  6. pca-on-genotypes pca-on-genotypes Public

    Jupyter Notebook