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docs: add SEED-007 Met risk and SEED-005 safety note to ASSAY_PREREGISTRATION - #94

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cschanhniem merged 1 commit into
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feat/assay-prereg-seed-notes
Jun 28, 2026
Merged

cschanhniem merged 1 commit into
mainfrom
feat/assay-prereg-seed-notes

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Summary

Extends the serum stability model limitations block in docs/ASSAY_PREREGISTRATION.md to cover all 7 seed families consistently.

Before: 3 families listed (SEED-003, SEED-008, SEED-009)
After: 5 families listed (SEED-003, SEED-007, SEED-008, SEED-009, SEED-005)

SEED-007 addition

SEED-005 addition

  • Safety score 0.845 (lowest in pilot panel) documented as pre-registered exclusion criterion
  • HC₅₀ < 10× MIC → exclude from Wave 2 (pre-registered decision)

Test plan

  • 1304 tests pass

🤖 Generated with Claude Code

…PREREGISTRATION

SEED-007: 11 AA same-length calibration edge as SEED-003; Met oxidation risk
for all 4 pilot variants (Nle substitution preferred; HPLC purity mandatory).

SEED-005: safety score 0.845 (lowest in panel) documented as pre-registered
exclusion criterion — if HC₅₀ < 10× MIC, exclude from Wave 2.
@cschanhniem
cschanhniem merged commit e9ff99c into main Jun 28, 2026
@cschanhniem
cschanhniem deleted the feat/assay-prereg-seed-notes branch June 28, 2026 18:26
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