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docs: add SEED-007 Met risk and SEED-005 safety note to ASSAY_PREREGISTRATION #94

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cschanhniem merged 1 commit into from
Jun 28, 2026
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docs: add SEED-007 Met risk and SEED-005 safety note to ASSAY_PREREGISTRATION #94

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8 changes: 6 additions & 2 deletions docs/ASSAY_PREREGISTRATION.md
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Expand Up @@ -137,9 +137,13 @@ TI = HC50 (µg/mL) / MIC (µg/mL)
> in any resulting publication.
>
> Families with known model limitations (score may underestimate actual stability):
> - SEED-003 (11 AA, <15 AA calibration edge)
> - SEED-008 (13 AA, model calibrated for 18–30 AA)
> - SEED-003 (11 AA, <15 AA calibration edge; model scores 0.35–0.38 likely underestimate actual t½)
> - SEED-007 (11 AA; same length as SEED-003; Met at position 6 in all 4 pilot variants — HPLC
> purity mandatory at receipt; Nle substitution preferred for oxidation-resistant synthesis)
> - SEED-008 (13 AA, model calibrated for 18–30 AA; Trp steric effect expected to improve t½)
> - SEED-009 (Pro-X protease resistance not captured by model; expected to exceed model score)
> - SEED-005 (safety score 0.845 — lowest in pilot panel; hemolysis assay at MIC/3 mandatory;
> if HC₅₀ < 10× MIC, exclude from Wave 2)

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