Biotechnology graduate (University of Central Punjab, Lahore) working at the intersection of wet-lab biology and computational biology. I build in silico pipelines for drug discovery, transcriptomic analysis, and disease mechanism modeling.
- Comparative transcriptomics of regeneration vs. scarring
- Structure-based drug discovery: docking and stability scans (AutoDock Vina, FoldX)
- Rare disease research: Pelizaeus-Merzbacher disease / PLP1
- Aging biology: mitonuclear imbalance across human tissues
- Bioelectric tissue simulation (BETSE)
| Project | Description |
|---|---|
| plp1-pmd-mechanism-mapping | Classifies 371 pathogenic PLP1 variants by mechanism and maps each to a therapeutic strategy |
| plp1-pmd-digital-twin | Mouse oligodendrocyte-lineage atlas with cell-state modules reporting measured disease-state shifts |
| regen-convergence-v2 | Convergent regenerative programs across mammalian regeneration systems (scRNA-seq, DE, pathways) |
| serum-primed-healing | Docking and transcriptomic prediction of regenerative potential for serum ingredients |
| mito-aging-project | Nuclear-to-mtDNA OXPHOS imbalance with age, and NAMPT as a druggable candidate |
| Bioinformatics-Drug-Discovery-IPF | In silico screening of phytochemicals targeting Integrin-αv for pulmonary fibrosis |
Computational: Python (pandas, SciPy, scikit-learn), R/Bioconductor (DESeq2, GEOquery), AutoDock Vina, FoldX, Git
Wet-lab: qPCR, HPLC, ELISA/immunoassays, collagenase inhibition assays, formulation R&D
Building toward a PhD in bioinformatics / computational biology.