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Qasim-Hussain-Code / crohns_disease_gut_microbiome_mbwas

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A multivariable MbWAS pipeline identifying taxonomic biomarkers of gut dysbiosis in Crohn's Disease. Implements zero-replaced Centered Log-Ratio (CLR) transformations and two-part hurdle regression models integrated via the Cauchy combination test to contrast the HMP2 / IBDMDB cohort.

crohns-disease compositional-data microbial-ecology gut-microbiome 16s-rrna dysbiosis mbwas taxonomic-biomarkers hurdle-regression cauchy-combination-test hmp2 ibdmdb
  • Updated Jun 11, 2026
  • Python

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