Exploratory DNA methylation analysis using R and minfi, including quality control, normalization, PCA, and differential methylation analysis.
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Updated
Aug 9, 2026 - Jupyter Notebook
Exploratory DNA methylation analysis using R and minfi, including quality control, normalization, PCA, and differential methylation analysis.
An epigenome-wide association study (EWAS) pipeline profiling DNA methylation (5mC) dynamics across post-mortem Alzheimer's brain regions. Investigates cell-type-specific differential methylation and chromatin accessibility correlations, utilizing OLS with robust standard errors and machine learning biomarker panel classification.
GSE142512 450K and EPIC DNA methylation resources for Bioconductor ExperimentHub. DOI: 10.5281/zenodo.21198533
Reproducible cross-array harmonisation and region detection for longitudinal EWAS (Illumina 450K + EPIC), extending the EWASGalaxy suite
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